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Research Output 1998 2019

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2019
1 Citation (Scopus)

BRL37344 stimulates GLUT4 translocation and glucose uptake in skeletal muscle via β 2 -adrenoceptors without causing classical receptor desensitization

Mukaida, S., Sato, M., Öberg, A. I., Dehvari, N., Olsen, J. M., Kocan, M., Halls, M. L., Merlin, J., Sandström, A. L., Csikasz, R. I., Evans, B. A., Summers, R. J., Hutchinson, D. S. & Bengtsson, T., 1 May 2019, In : American journal of physiology. Regulatory, integrative and comparative physiology. 316, 5, p. R666-R677 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas

Ostrovskaya, A., Hick, C., Hutchinson, D. S., Stringer, B. W., Wookey, P. J., Wootten, D., Sexton, P. M. & Furness, S. G. B., 18 Feb 2019, In : BMC Cancer. 19, 1, 12 p., 157.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Therapeutic blockade of activin-A improves NK cell function and antitumor immunity

Rautela, J., Dagley, L. F., De Oliveira, C. C., Schuster, I. S., Hediyeh-Zadeh, S., Delconte, R. B., Cursons, J., Hennessy, R., Hutchinson, D. S., Harrison, C., Kita, B., Vivier, E., Webb, A. I., Degli-Esposti, M. A., Davis, M. J., Huntington, N. D. & Souza-Fonseca-Guimaraes, F., 27 Aug 2019, In : Science Signaling. 12, 596, 13 p., aat7527.

Research output: Contribution to journalArticleResearchpeer-review

2018

Effects of hypoxia-ischemia and inotropes on expression of cardiac adrenoceptors in the preterm fetal sheep

Hutchinson, D. S., Brew, N., Vu, T., Merlin, J., Hale, N., Walker, D. W. & Wong, F. Y., 1 Nov 2018, In : Journal of Applied Physiology. 125, 5, p. 1368-1377 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

INSL5 activates multiple signalling pathways and regulates GLP-1 secretion in NCI-H716 cells

Ang, S. Y., Evans, B. A., Poole, D. P., Bron, R., DiCello, J. J., Bathgate, R. A. D., Kocan, M., Hutchinson, D. S. & Summers, R. J., 1 Apr 2018, In : Journal of Molecular Endocrinology. 60, 3, p. 213-224 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)

Rosiglitazone and a β3-adrenoceptor agonist are both required for functional browning of white adipocytes in culture

Merlin, J., Sato, M., Chia, L. Y., Fahey, R., Pakzad, M., Nowell, C. J., Summers, R. J., Bengtsson, T., Evans, B. A. & Hutchinson, D. S., 30 May 2018, In : Frontiers in Endocrinology. 9, MAY, 17 p., 249.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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12 Citations (Scopus)

The PPARγ agonist rosiglitazone promotes the induction of brite adipocytes, increasing β-adrenoceptor-mediated mitochondrial function and glucose uptake

Merlin, J., Sato, M., Nowell, C., Pakzad, M., Fahey, R., Gao, J., Dehvari, N., Summers, R. J., Bengtsson, T., Evans, B. A. & Hutchinson, D. S., 1 Jan 2018, In : Cellular Signalling. 42, p. 54-66 13 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

α1A-Adrenoceptors activate mTOR signalling and glucose uptake in cardiomyocytes

Sato, M., Evans, B. A., Sandström, A. L., Chia, L. Y., Mukaida, S., Thai, B. S., Nguyen, A., Lim, L., Tan, C. Y. R., Baltos, J. A., White, P. J., May, L. T., Hutchinson, D. S., Summers, R. J. & Bengtsson, T., 1 Feb 2018, In : Biochemical Pharmacology. 148, p. 27-40 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017
8 Citations (Scopus)

Adrenoceptors promote glucose uptake into adipocytes and muscle by an insulin-independent signaling pathway involving mechanistic target of rapamycin complex 2

Mukaida, S., Evans, B. A., Bengtsson, T., Hutchinson, D. S. & Sato, M., 1 Feb 2017, In : Pharmacological Research. 116, p. 87-92 6 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus

Jiao, Y., Preston, S., Song, H., Jabbar, A., Liu, Y., Baell, J., Hofmann, A., Hutchinson, D., Wang, T., Koehler, A. V., Fisher, G. M., Andrews, K. T., Laleu, B., Palmer, M. J., Burrows, J. N., Wells, T. N. C., Wang, Q. & Gasser, R. B., 31 May 2017, In : Parasites and Vectors. 10, 1, 272.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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8 Citations (Scopus)

Factors influencing biased agonism in recombinant cells expressing the human α1A-adrenoceptor

da Silva Junior, E. D., Sato, M., Merlin, J., Broxton, N., Hutchinson, D. S., Ventura, S., Evans, B. A. & Summers, R. J., 1 Jul 2017, In : British Journal of Pharmacology. 174, 14, p. 2318-2333 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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14 Citations (Scopus)

ML290 is a biased allosteric agonist at the relaxin receptor RXFP1

Kocan, M., Sarwar, M., Ang, S. Y., Xiao, J., Marugan, J., Hossain, M. A., Wang, C., Hutchinson, D. S., Samuel, C. S., Agoulnik, A. I., Bathgate, R. A. D. & Summers, R. J., 1 Dec 2017, In : Scientific Reports. 7, 1, 14 p., 2968.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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13 Citations (Scopus)

Signal transduction pathways activated by insulin-like peptide 5 at the relaxin family peptide RXFP4 receptor

Ang, S. Y., Hutchinson, D. S., Patil, N., Evans, B. A., Bathgate, R. A. D., Halls, M. L., Hossain, M. A., Summers, R. J. & Kocan, M., 1 May 2017, In : British Journal of Pharmacology. 174, 10, p. 1077-1089 13 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

The actions of relaxin family peptides on signal transduction pathways activated by the relaxin family peptide receptor RXFP4

Ang, S. Y., Hutchinson, D. S., Evans, B. A., Hossain, M. A., Patil, N., Bathgate, R. A. D., Kocan, M. & Summers, R. J., Jan 2017, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 390, 1, p. 105-111 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2016
73 Citations (Scopus)

CIS is a potent checkpoint in NK cell-mediated tumor immunity

Delconte, R. B., Kolesnik, T. B., Dagley, L. F., Rautela, J., Shi, W., Putz, E. M., Stannard, K., Zhang, J. G., Teh, C. E-Y., Firth, M., Ushiki, T., Andoniou, C. E., Degli-Esposti, M. A., Sharp, P. P., Sanvitale, C. E., Infusini, G., Liau, N. P. D., Linossi, E. M., Burns, C. J., Carotta, S. & 12 others, Gray, D. H. D., Seillet, C., Hutchinson, D. S., Belz, G. T., Webb, A. I., Alexander, W. S., Li, S. S., Bullock, A. N., Babon, J. J., Smyth, M. J., Nicholson, S. E. & Huntington, N. D., 21 Jun 2016, In : Nature Immunology. 17, 7, p. 816-824 9 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis

Merlin, J., Evans, B. A., Dehvari, N., Sato, M., Bengtsson, T. & Hutchinson, D. S., 2016, In : Molecular Nutrition and Food Research. 60, 1, p. 18-42 25 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15

Delconte, R. B., Shi, W., Sathe, P., Ushiki, T., Seillet, C., Minnich, M., Kolesnik, T. B., Rankin, L. C., Mielke, L. A., Zhang, J-G., Busslinger, M., Smyth, M. J., Hutchinson, D. S., Nutt, S. L., Nicholson, S. E., Alexander, W. S., Corcoran, L. M., Vivier, E., Belz, G. T., Carotta, S. & 1 others, Huntington, N. D., 19 Jan 2016, In : Immunity. 44, 1, p. 103-115 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2015
49 Citations (Scopus)

DNAM-1 expression marks an alternative program of NK cell maturation

Martinet, L., de Andrade, L. F., Guillerey, C., Lee, J. S., Liu, J., Souza-Fonseca-Guimaraes, F., Hutchinson, D. S., Kolesnik, T. B., Nicholson, S. E., Huntington, N. D. & Smyth, M. J., 2015, In : Cell Reports. 11, 1, p. 85 - 97 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2014
71 Citations (Scopus)

Glucose uptake in brown fat cells is dependent on mTOR complex 2-promoted GLUT1 translocation

Olsen, J. M., Sato, M., Dallner, O. S., Sandstrom, A. L., Pisani, D. F., Chambard, J-C., Amri, E-Z., Hutchinson, D. S. & Bengtsson, T., 2014, In : Journal of Cell Biology. 207, 3, p. 365 - 374 10 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Improving type 2 diabetes through a distinct adrenergic signaling pathway involving mTORC2 that mediates glucose uptake in skeletal muscle

Sato, M., Dehvari, N., Oberg, A., Dallner, O. S., Sandstrom, A. L., Olsen, J. M., Csikasz, R. I., Summers, R. J., Hutchinson, D. S. & Bengtsson, T., 2014, In : Diabetes. 63, 12, p. 4115 - 4129 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2013
5 Citations (Scopus)

Orthosteric binding of rho-Da1a, a natural peptide of snake venom interacting selectively with the alpha(1A)-Adrenoceptor

Maiga, A., Merlin, J., Marcon, E., Rouget, C., Larregola, M., Gilquin, B., Fruchart-Gaillard, C., Lajeunesse, E., Marchetti, C., Lorphelin, A., Bellanger, L., Summers, R. J., Hutchinson, D. S., Evans, B. A., Servent, D. & Gilles, N., 2013, In : PLoS ONE. 8, 7, 11 p., e68841.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2012
17 Citations (Scopus)

Beta(2)-adrenoceptors increase translocation of GLUT4 via GPCR kinase sites in the receptor C-terminal tail

Dehvari, N., Hutchinson, D., Nevzorova, J., Dallner, O., Sato, M., Kocan, M., Merlin, J., Evans, B., Summers, R. & Bengtsson, T., 2012, In : British Journal of Pharmacology. 165, 5, p. 1442 - 1456 15 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Interaction with caveolin-1 modulates G protein coupling of the mouse beta3-adrenoceptor

Sato, M., Hutchinson, D. S., Halls, M. L., Furness, S. G. B., Bengtsson, T., Evans, B. A. & Summers, R. J., 2012, In : Journal of Biological Chemistry. 287, 24, p. 20674 - 20688 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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22 Citations (Scopus)

Rapid turnover of glycogen in memory formation

Gibbs, M. E. & Hutchinson, D. S., 2012, In : Neurochemical Research. 37, 11, p. 2456 - 2463 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2011
20 Citations (Scopus)

alpha{2}-Adrenoceptors activate noradrenaline-mediated glycogen turnover in chick astrocytes

Hutchinson, D. S., Catus, S. L., Merlin, J., Summers, R. J. & Gibbs, M. E., 2011, In : Journal of Neurochemistry. 117, 5, p. 915 - 926 12 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Quantification of functional selectivity at the human {alpha}1A-adrenoceptor

Evans, B. A., Broxton, N., Merlin, J., Sato, M., Hutchinson, D. S., Christopoulos, A. & Summers, R. J., 2011, In : Molecular Pharmacology. 79, 2, p. 298 - 307 10 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Role of beta-adrenoceptors in glucose uptake in astrocytes using beta-adrenoceptor knockout mice

Catus, S. L., Gibbs, M. E., Sato, M., Summers, R. J. & Hutchinson, D. S., 2011, In : British Journal of Pharmacology. 162, 8, p. 1700 - 1715 16 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Shikonin increases glucose uptake in skeletal muscle cells and improves plasma glucose levels in diabetic goto-kakizaki rats

Oberg, A., Yassin, K., Csikasz, R., Dehvari, N., Shabalina, I., Hutchinson, D., Wilcke, M., Goran-Ostenson, C. & Bengtsson, T., 2011, In : PLoS ONE. 6, 7, 10 p., e22510.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
35 Citations (Scopus)

β1-adrenergic receptors increase UCP1 in human MADS brown adipocytes and rescue cold-acclimated β3-adrenergic receptor knockout mice via nonshivering thermogenesis

Mattsson, C. L., Csikasz, R. I., Chernogubova, E., Yamamoto, D. L., Hogberg, H. T., Amri, E-Z., Hutchinson, D. S. & Bengtsson, T., Dec 2011, In : American Journal of Physiology - Endocrinology and Metabolism. 301, 6, 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2010
106 Citations (Scopus)

Ligand-directed signalling at beta-adrenoceptors

Evans, B., Sato, M., Sarwar, M., Hutchinson, D. & Summers, R., 2010, In : British Journal of Pharmacology. 159, 5, p. 1022 - 1038 17 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Noradrenaline release in the locus coeruleus modulates memory formation and consolidation; roles for alpha- and beta-adrenergic receptors

Gibbs, M. E., Hutchinson, D. S. & Summers, R. J., 2010, In : Neuroscience. 170, 4, p. 1209 - 1222 14 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

The M3-muscarinic acetylcholine receptor stimulates glucose uptake in L6 skeletal muscle cells by a CaMKK-AMPK-dependent mechanism

Merlin, J., Evans, B. A., Csikasz, R. I., Bengtsson, T., Summers, R. J. & Hutchinson, D. S., 2010, In : Cellular Signalling. 22, 7, p. 1104 - 1113 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2009
2 Citations (Scopus)

Importance of adrenergic receptors in prenatally induced cognitive impairment in the domestic chick

Gibbs, M. E., Rodricks, C. L., Hutchinson, D. S., Summers, R. J. & Miller, S. L., 2009, In : International Journal of Developmental Neuroscience. 27, p. 27 - 35 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2008
106 Citations (Scopus)

Astrocytic involvement in learning and memory consolidation

Gibbs, M. E., Hutchinson, D. S. & Hertz, L., 2008, In : Neuroscience and Biobehavioral Reviews. 32, 5, p. 927 - 944 18 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Energy metabolism and memory processing: Role of glucose transport and glycogen in responses to adrenoceptor activation in the chicken

Hutchinson, D. S., Summers, R. J. & Gibbs, M. E., 2008, In : Brain Research Bulletin. 76, 3, p. 224 - 234 11 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Memory processing in the avian hippocampus involves interactions between beta-adrenoceptors, glutamate receptors, and metabolism

Gibbs, M. E., Bowser, D. N., Hutchinson, D. S., Loiacono, R. & Summers, R. J., 2008, In : Neuropsychopharmacology. 33, 12, p. 2831 - 2846 16 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)

Regulation of AMP-activated protein kinase activity by G-protein coupled receptors: Potential utility in treatment of diabetes and heart disease

Hutchinson, D. S., Summers, R. J. & Bengtsson, T., 2008, In : Pharmacology and Therapeutics. 119, 3, p. 291 - 310 20 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Role of beta-Adrenoceptors in Memory Consolidation: beta3-Adrenoceptors Act on Glucose Uptake and beta2-Adrenoceptors on Glycogenolysis

Gibbs, M. E., Hutchinson, D. S. & Summers, R. J., 2008, In : Neuropsychopharmacology. 33, p. 2384 - 2397 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2007
63 Citations (Scopus)

Altered regulation of the PINK1 locus: a link between type 2 diabetes and neurodegeneration?

Scheele, C., Nielsen, A. R., Walden, T. B., Sewell, D. A., Fischer, C. P., Brogan, R. J., Petrovic, N., Larsson, O., Tesch, P. A., Wennmalm, K., Hutchinson, D. S., Cannon, B., Wahlestedt, C., Pedersen, B. & Timmons, J. A., 2007, In : FASEB Journal. 21, 13, p. 3653 - 3665 13 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

beta2- and beta3-Adrenoceptors activate glucose uptake in chick astrocytes by distinct mechanisms: A mechanism for memory enhancement?

Hutchinson, D. S., Summers, R. J. & Gibbs, M. E., 2007, In : Journal of Neurochemistry. 103, 3, p. 997 - 1008 12 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Diphenylene iodonium stimulates glucose uptake in skeletal muscle cells through mitochondrial complex I inhibition and activation of AMP-activated protein kinase

Hutchinson, D. S., Csikasz, R. I., Yamamoto, D. L., Shabalina, I. G., Wikstrom, P., Wilcke, M. & Bengtsson, T., 2007, In : Cellular Signalling. 19, 7, p. 1610 - 1620 11 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Functional domains of the mouse beta3-adrenoceptor associated with differential G-protein coupling

Sato, M., Hutchinson, D. S., Evans, B. A. & Summers, R. J., 2007, In : Biochemical Society Transactions. 35, Pt 5, p. 1035 - 1037 3 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)
22 Citations (Scopus)

β2-adrenergic activation increases glycogen synthesis in L6 skeletal muscle cells through a signalling pathway independent of cyclic AMP

Yamamoto, D. L., Hutchinson, D. S. & Bengtsson, T., 2007, In : Diabetologia. 50, 1, p. 158 - 167 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2006
15 Citations (Scopus)

Agonist effects of zinterol at the mouse and human beta3-adrenoceptor

Hutchinson, D. S., Chernogubova, E., Sato, M., Summers, R. J. & Bengtsson, T., 2006, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 373, 2, p. 158 - 168 11 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

AMP-activated protein kinase activation by adrenoceptors in L6 skeletal muscle cells: Mediation by alpha1-adrenoceptors causing glucose uptake

Hutchinson, D. S. & Bengtsson, T., 2006, In : Diabetes. 55, p. 682 - 690 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2005
40 Citations (Scopus)

Alpha1A-adrenoceptors activate glucose uptake in L6 muscle cells through a phospholipase C-, phosphatidylinositol-3 kinase-, and atypical protein kinase C-dependent pathway

Hutchinson, D. S. & Bengtsson, T., 2005, In : Endocrinology. 146, 2, p. 901 - 912 12 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Alpha1- and beta1-adrenoceptor signaling fully compensates for beta3-adrenoceptor deficiency in brown adipocyte norepinephrine-stimulated glucose uptake

Chernogubova, E., Hutchinson, D. S., Nedergaard, J. & Bengtsson, T., 2005, In : Endocrinology. 146, 5, p. 2271 - 2284 14 p.

Research output: Contribution to journalArticleResearchpeer-review

73 Citations (Scopus)

beta-Adrenoceptors, but not alpha-adrenoceptors, stimulate AMP-activated protein kinase in brown adipocytes independently of uncoupling protein-1

Hutchinson, D. S., Chernogubova, E., Dallner, O. S., Cannon, B. & Bengtsson, T., 2005, In : Diabetologia. 48, p. 2386 - 2395 10 p.

Research output: Contribution to journalArticleResearchpeer-review