19982022
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Research Output 1998 2019

3 Citations (Scopus)

βs-Adrenoceptors: Their role and regulation in the gastrointestinal tract

Summers, R. J., Roberts, S. J., Hutchinson, D. S. & Evans, B. A., 1 Dec 1999, In : Proceedings of the Western Pharmacology Society. 42, p. 115-117 3 p.

Research output: Contribution to journalArticleResearchpeer-review

β3-Andrenoceptors: Differential regulation and novel subtypes

Summers, R. J., Hutchinson, D. S. & Evans, B. A., 1 Jan 1998, In : Pharmacology and Toxicology, Supplement. 83, 1, p. 37-39 3 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

β3-adrenoceptor regulation and relaxation responses in mouse ileum

Hutchinson, D. S., Evans, B. A. & Summers, R. J., 1 Jan 2000, In : British Journal of Pharmacology. 129, 6, p. 1251-1259 9 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

β2-adrenergic activation increases glycogen synthesis in L6 skeletal muscle cells through a signalling pathway independent of cyclic AMP

Yamamoto, D. L., Hutchinson, D. S. & Bengtsson, T., 2007, In : Diabetologia. 50, 1, p. 158 - 167 10 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

β1-adrenoceptors compensate for β3-adrenoceptors in ileum from β3-adrenoceptor knock-out mice

Hutchinson, D. S., Evans, B. A. & Summers, R. J., 1 Jan 2001, In : British Journal of Pharmacology. 132, 2, p. 433-442 10 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

β1-adrenergic receptors increase UCP1 in human MADS brown adipocytes and rescue cold-acclimated β3-adrenergic receptor knockout mice via nonshivering thermogenesis

Mattsson, C. L., Csikasz, R. I., Chernogubova, E., Yamamoto, D. L., Hogberg, H. T., Amri, E-Z., Hutchinson, D. S. & Bengtsson, T., Dec 2011, In : American Journal of Physiology - Endocrinology and Metabolism. 301, 6, 11 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

α1A-Adrenoceptors activate mTOR signalling and glucose uptake in cardiomyocytes

Sato, M., Evans, B. A., Sandström, A. L., Chia, L. Y., Mukaida, S., Thai, B. S., Nguyen, A., Lim, L., Tan, C. Y. R., Baltos, J. A., White, P. J., May, L. T., Hutchinson, D. S., Summers, R. J. & Bengtsson, T., 1 Feb 2018, In : Biochemical Pharmacology. 148, p. 27-40 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The role of the C-terminal domain in mouse beta(3)-adrenoceptor signalling

Society, S. (ed.), Horinouchi, T., Sato, M., Hutchinson, D. S., Evans, B. A. & Summers, R. J., 2006, p. 126 - 126. 1 p.

Research output: Contribution to conferenceAbstractOther

Therapeutic blockade of activin-A improves NK cell function and antitumor immunity

Rautela, J., Dagley, L. F., De Oliveira, C. C., Schuster, I. S., Hediyeh-Zadeh, S., Delconte, R. B., Cursons, J., Hennessy, R., Hutchinson, D. S., Harrison, C., Kita, B., Vivier, E., Webb, A. I., Degli-Esposti, M. A., Davis, M. J., Huntington, N. D. & Souza-Fonseca-Guimaraes, F., 27 Aug 2019, In : Science Signaling. 12, 596, 13 p., aat7527.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

The PPARγ agonist rosiglitazone promotes the induction of brite adipocytes, increasing β-adrenoceptor-mediated mitochondrial function and glucose uptake

Merlin, J., Sato, M., Nowell, C., Pakzad, M., Fahey, R., Gao, J., Dehvari, N., Summers, R. J., Bengtsson, T., Evans, B. A. & Hutchinson, D. S., 1 Jan 2018, In : Cellular Signalling. 42, p. 54-66 13 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

The M3-muscarinic acetylcholine receptor stimulates glucose uptake in L6 skeletal muscle cells by a CaMKK-AMPK-dependent mechanism

Merlin, J., Evans, B. A., Csikasz, R. I., Bengtsson, T., Summers, R. J. & Hutchinson, D. S., 2010, In : Cellular Signalling. 22, 7, p. 1104 - 1113 10 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

The Janus faces of adrenoceptors: factors controlling the coupling of adrenoceptors to multiple signal transduction pathways

Summers, R. J., Broxton, N., Hutchinson, D. S. & Evans, B. A., 2004, In : Clinical and Experimental Pharmacology and Physiology. 31, 11, p. 822 - 827 6 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15

Delconte, R. B., Shi, W., Sathe, P., Ushiki, T., Seillet, C., Minnich, M., Kolesnik, T. B., Rankin, L. C., Mielke, L. A., Zhang, J-G., Busslinger, M., Smyth, M. J., Hutchinson, D. S., Nutt, S. L., Nicholson, S. E., Alexander, W. S., Corcoran, L. M., Vivier, E., Belz, G. T., Carotta, S. & 1 others, Huntington, N. D., 19 Jan 2016, In : Immunity. 44, 1, p. 103-115 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

The actions of relaxin family peptides on signal transduction pathways activated by the relaxin family peptide receptor RXFP4

Ang, S. Y., Hutchinson, D. S., Evans, B. A., Hossain, M. A., Patil, N., Bathgate, R. A. D., Kocan, M. & Summers, R. J., Jan 2017, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 390, 1, p. 105-111 7 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Stereoselectivity for interactions of agonists and antagonists at mouse, rat and human 3-adrenoceptors

Popp, B. D., Hutchinson, D. S., Evans, B. A. & Summers, R. J., 2004, In : European Journal of Pharmacology. 484, 2-3, p. 323 - 331 9 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Signal transduction pathways activated by insulin-like peptide 5 at the relaxin family peptide RXFP4 receptor

Ang, S. Y., Hutchinson, D. S., Patil, N., Evans, B. A., Bathgate, R. A. D., Halls, M. L., Hossain, M. A., Summers, R. J. & Kocan, M., 1 May 2017, In : British Journal of Pharmacology. 174, 10, p. 1077-1089 13 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Shikonin increases glucose uptake in skeletal muscle cells and improves plasma glucose levels in diabetic goto-kakizaki rats

Oberg, A., Yassin, K., Csikasz, R., Dehvari, N., Shabalina, I., Hutchinson, D., Wilcke, M., Goran-Ostenson, C. & Bengtsson, T., 2011, In : PLoS ONE. 6, 7, 10 p., e22510.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
6 Citations (Scopus)

Rosiglitazone and a β3-adrenoceptor agonist are both required for functional browning of white adipocytes in culture

Merlin, J., Sato, M., Chia, L. Y., Fahey, R., Pakzad, M., Nowell, C. J., Summers, R. J., Bengtsson, T., Evans, B. A. & Hutchinson, D. S., 30 May 2018, In : Frontiers in Endocrinology. 9, MAY, 17 p., 249.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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52 Citations (Scopus)

Role of beta-Adrenoceptors in Memory Consolidation: beta3-Adrenoceptors Act on Glucose Uptake and beta2-Adrenoceptors on Glycogenolysis

Gibbs, M. E., Hutchinson, D. S. & Summers, R. J., 2008, In : Neuropsychopharmacology. 33, p. 2384 - 2397 13 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Role of beta-adrenoceptors in glucose uptake in astrocytes using beta-adrenoceptor knockout mice

Catus, S. L., Gibbs, M. E., Sato, M., Summers, R. J. & Hutchinson, D. S., 2011, In : British Journal of Pharmacology. 162, 8, p. 1700 - 1715 16 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)

Regulation of AMP-activated protein kinase activity by G-protein coupled receptors: Potential utility in treatment of diabetes and heart disease

Hutchinson, D. S., Summers, R. J. & Bengtsson, T., 2008, In : Pharmacology and Therapeutics. 119, 3, p. 291 - 310 20 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Rapid turnover of glycogen in memory formation

Gibbs, M. E. & Hutchinson, D. S., 2012, In : Neurochemical Research. 37, 11, p. 2456 - 2463 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Quantification of functional selectivity at the human α1A- adrenoceptor (Molecular Pharmacology (2011) 79, (298-307))

Evans, B. A., Broxton, N., Merlin, J., Sato, M., Hutchinson, D. S., Christopoulos, A. & Summers, R. J., Mar 2011, In : Molecular Pharmacology. 79, 3, p. 627 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

49 Citations (Scopus)

Quantification of functional selectivity at the human {alpha}1A-adrenoceptor

Evans, B. A., Broxton, N., Merlin, J., Sato, M., Hutchinson, D. S., Christopoulos, A. & Summers, R. J., 2011, In : Molecular Pharmacology. 79, 2, p. 298 - 307 10 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Peripheral modulation of the endocannabinoid system in metabolic disease

Shrestha, N., Cuffe, J. S. M., Hutchinson, D. S., Headrick, J. P., Perkins, A. V., McAinch, A. J. & Hryciw, D. H., 1 Mar 2018, In : Drug Discovery Today. 23, 3, p. 592-604 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

5 Citations (Scopus)

Orthosteric binding of rho-Da1a, a natural peptide of snake venom interacting selectively with the alpha(1A)-Adrenoceptor

Maiga, A., Merlin, J., Marcon, E., Rouget, C., Larregola, M., Gilquin, B., Fruchart-Gaillard, C., Lajeunesse, E., Marchetti, C., Lorphelin, A., Bellanger, L., Summers, R. J., Hutchinson, D. S., Evans, B. A., Servent, D. & Gilles, N., 2013, In : PLoS ONE. 8, 7, 11 p., e68841.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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54 Citations (Scopus)

Noradrenaline release in the locus coeruleus modulates memory formation and consolidation; roles for alpha- and beta-adrenergic receptors

Gibbs, M. E., Hutchinson, D. S. & Summers, R. J., 2010, In : Neuroscience. 170, 4, p. 1209 - 1222 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Multiple signalling pathways of the mouse beta(3)-adrenoceptor stably expressed in CHO-K1 cells

Sato, M., Horinouchi, T., Hutchinson, D. S. & Evans, B. A., 2006, p. 410 - 410. 1 p.

Research output: Contribution to conferenceAbstractOther

48 Citations (Scopus)

Mouse β3a and β3b-adrenoceptors expressed in Chinese hamster ovary cells display identical pharmacology but utilize distinct signalling pathways

Hutchinson, D. S., Bengtsson, T., Evans, B. A. & Summers, R. J., 1 Jan 2002, In : British Journal of Pharmacology. 135, 8, p. 1903-1914 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Mouse 3a- and 3b- adrenoceptors expressed in Chinese hamster ovary cells display identical pharmacology but utilize distinct signalling pathways

Hutchinson, D. S., Bengtsson, T., Evans, B. A. & Summers, R. J., 2002, In : British Journal of Pharmacology. 135, p. 1903 - 1914 12 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

ML290 is a biased allosteric agonist at the relaxin receptor RXFP1

Kocan, M., Sarwar, M., Ang, S. Y., Xiao, J., Marugan, J., Hossain, M. A., Wang, C., Hutchinson, D. S., Samuel, C. S., Agoulnik, A. I., Bathgate, R. A. D. & Summers, R. J., 1 Dec 2017, In : Scientific Reports. 7, 1, 14 p., 2968.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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10 Citations (Scopus)

Mirabegron: potential off target effects and uses beyond the bladder

Dehvari, N., Dantas da Silva Junior, E., Bengtsson, T. & Hutchinson, D. S., 1 Nov 2018, In : British Journal of Pharmacology. 175, 21, p. 4072-4082 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

24 Citations (Scopus)

Memory processing in the avian hippocampus involves interactions between beta-adrenoceptors, glutamate receptors, and metabolism

Gibbs, M. E., Bowser, D. N., Hutchinson, D. S., Loiacono, R. & Summers, R. J., 2008, In : Neuropsychopharmacology. 33, 12, p. 2831 - 2846 16 p.

Research output: Contribution to journalArticleResearchpeer-review

106 Citations (Scopus)

Ligand-directed signalling at beta-adrenoceptors

Evans, B., Sato, M., Sarwar, M., Hutchinson, D. & Summers, R., 2010, In : British Journal of Pharmacology. 159, 5, p. 1022 - 1038 17 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)
17 Citations (Scopus)

Interaction with caveolin-1 modulates G protein coupling of the mouse beta3-adrenoceptor

Sato, M., Hutchinson, D. S., Halls, M. L., Furness, S. G. B., Bengtsson, T., Evans, B. A. & Summers, R. J., 2012, In : Journal of Biological Chemistry. 287, 24, p. 20674 - 20688 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

INSL5 activates multiple signalling pathways and regulates GLP-1 secretion in NCI-H716 cells

Ang, S. Y., Evans, B. A., Poole, D. P., Bron, R., DiCello, J. J., Bathgate, R. A. D., Kocan, M., Hutchinson, D. S. & Summers, R. J., 1 Apr 2018, In : Journal of Molecular Endocrinology. 60, 3, p. 213-224 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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44 Citations (Scopus)

Improving type 2 diabetes through a distinct adrenergic signaling pathway involving mTORC2 that mediates glucose uptake in skeletal muscle

Sato, M., Dehvari, N., Oberg, A., Dallner, O. S., Sandstrom, A. L., Olsen, J. M., Csikasz, R. I., Summers, R. J., Hutchinson, D. S. & Bengtsson, T., 2014, In : Diabetes. 63, 12, p. 4115 - 4129 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Importance of adrenergic receptors in prenatally induced cognitive impairment in the domestic chick

Gibbs, M. E., Rodricks, C. L., Hutchinson, D. S., Summers, R. J. & Miller, S. L., 2009, In : International Journal of Developmental Neuroscience. 27, p. 27 - 35 8 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

G protein coupled receptor 18: a potential role for endocannabinoid signaling in metabolic dysfunction

Rajaraman, G., Simcocks, A., Hryciw, D. H., Hutchinson, D. S. & McAinch, A. J., 1 Jan 2016, In : Molecular Nutrition and Food Research. 60, 1, p. 92-102 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

71 Citations (Scopus)

Glucose uptake in brown fat cells is dependent on mTOR complex 2-promoted GLUT1 translocation

Olsen, J. M., Sato, M., Dallner, O. S., Sandstrom, A. L., Pisani, D. F., Chambard, J-C., Amri, E-Z., Hutchinson, D. S. & Bengtsson, T., 2014, In : Journal of Cell Biology. 207, 3, p. 365 - 374 10 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Functional domains of the mouse beta3-adrenoceptor associated with differential G-protein coupling

Sato, M., Hutchinson, D. S., Evans, B. A. & Summers, R. J., 2007, In : Biochemical Society Transactions. 35, Pt 5, p. 1035 - 1037 3 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Functional domains of the mouse beta3-adrenoceptor associated with differential G-protein coupling

Sato, M., Hutchinson, D. S., Bengtsson, T., Floren, A., Langel, U., Horinouchi, T., Evans, B. A. & Summers, R. J., 2005, In : Journal of Pharmacology and Experimental Therapeutics. 315, 3, p. 1354 - 1361 8 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Factors influencing biased agonism in recombinant cells expressing the human α1A-adrenoceptor

da Silva Junior, E. D., Sato, M., Merlin, J., Broxton, N., Hutchinson, D. S., Ventura, S., Evans, B. A. & Summers, R. J., 1 Jul 2017, In : British Journal of Pharmacology. 174, 14, p. 2318-2333 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas

Ostrovskaya, A., Hick, C., Hutchinson, D. S., Stringer, B. W., Wookey, P. J., Wootten, D., Sexton, P. M. & Furness, S. G. B., 18 Feb 2019, In : BMC Cancer. 19, 1, 12 p., 157.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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27 Citations (Scopus)

Energy metabolism and memory processing: Role of glucose transport and glycogen in responses to adrenoceptor activation in the chicken

Hutchinson, D. S., Summers, R. J. & Gibbs, M. E., 2008, In : Brain Research Bulletin. 76, 3, p. 224 - 234 11 p.

Research output: Contribution to journalArticleResearchpeer-review