19982022
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Research Output 1998 2019

Adrenoceptor mediated phosphorylation of AMPK differs between brown adipose tissue and skeletal muscle

Hutchinson, D. S. & Cannon, B., 2006, p. 1276 - 1276. 1 p.

Research output: Contribution to conferenceAbstractOther

1 Citation (Scopus)

Adrenoceptor regulation of the mechanistic target of rapamycin in muscle and adipose tissue

Chia, L. Y., Evans, B., Mukaida, S., Bengtsson, T., Hutchinson, D. & Sato, M., 1 Jul 2019, In : British Journal of Pharmacology. 176, 14, p. 2433-2448 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Adrenoceptors in white, brown, and brite adipocytes

Evans, B. A., Merlin, J., Bengtsson, T. & Hutchinson, D. S., 1 Jul 2019, In : British Journal of Pharmacology. 176, 14, p. 2416-2432 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

8 Citations (Scopus)

Adrenoceptors promote glucose uptake into adipocytes and muscle by an insulin-independent signaling pathway involving mechanistic target of rapamycin complex 2

Mukaida, S., Evans, B. A., Bengtsson, T., Hutchinson, D. S. & Sato, M., 1 Feb 2017, In : Pharmacological Research. 116, p. 87-92 6 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Agonist effects of zinterol at the mouse and human beta3-adrenoceptor

Hutchinson, D. S., Chernogubova, E., Sato, M., Summers, R. J. & Bengtsson, T., 2006, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 373, 2, p. 158 - 168 11 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

alpha{2}-Adrenoceptors activate noradrenaline-mediated glycogen turnover in chick astrocytes

Hutchinson, D. S., Catus, S. L., Merlin, J., Summers, R. J. & Gibbs, M. E., 2011, In : Journal of Neurochemistry. 117, 5, p. 915 - 926 12 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Alpha1A-adrenoceptors activate glucose uptake in L6 muscle cells through a phospholipase C-, phosphatidylinositol-3 kinase-, and atypical protein kinase C-dependent pathway

Hutchinson, D. S. & Bengtsson, T., 2005, In : Endocrinology. 146, 2, p. 901 - 912 12 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Alpha1- and beta1-adrenoceptor signaling fully compensates for beta3-adrenoceptor deficiency in brown adipocyte norepinephrine-stimulated glucose uptake

Chernogubova, E., Hutchinson, D. S., Nedergaard, J. & Bengtsson, T., 2005, In : Endocrinology. 146, 5, p. 2271 - 2284 14 p.

Research output: Contribution to journalArticleResearchpeer-review

63 Citations (Scopus)

Altered regulation of the PINK1 locus: a link between type 2 diabetes and neurodegeneration?

Scheele, C., Nielsen, A. R., Walden, T. B., Sewell, D. A., Fischer, C. P., Brogan, R. J., Petrovic, N., Larsson, O., Tesch, P. A., Wennmalm, K., Hutchinson, D. S., Cannon, B., Wahlestedt, C., Pedersen, B. & Timmons, J. A., 2007, In : FASEB Journal. 21, 13, p. 3653 - 3665 13 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

AMP-activated protein kinase activation by adrenoceptors in L6 skeletal muscle cells: Mediation by alpha1-adrenoceptors causing glucose uptake

Hutchinson, D. S. & Bengtsson, T., 2006, In : Diabetes. 55, p. 682 - 690 9 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus

Jiao, Y., Preston, S., Song, H., Jabbar, A., Liu, Y., Baell, J., Hofmann, A., Hutchinson, D., Wang, T., Koehler, A. V., Fisher, G. M., Andrews, K. T., Laleu, B., Palmer, M. J., Burrows, J. N., Wells, T. N. C., Wang, Q. & Gasser, R. B., 31 May 2017, In : Parasites and Vectors. 10, 1, 272.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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105 Citations (Scopus)

Astrocytic involvement in learning and memory consolidation

Gibbs, M. E., Hutchinson, D. S. & Hertz, L., 2008, In : Neuroscience and Biobehavioral Reviews. 32, 5, p. 927 - 944 18 p.

Research output: Contribution to journalArticleResearchpeer-review

b1-Adrenoceptors compensate for b3-adrenoceptors in ileum from b3-adrenoceptor knock-out mice

Hutchinson, D. S., Evans, B. A. & Summers, R. J., 2001, In : British Journal of Pharmacology. 132, 2, p. 433 - 442 10 p.

Research output: Contribution to journalArticleResearchpeer-review

B3 -adrenorecoptors: differential regulations and novel subtypes

Summers, R. J., Hutchinson, D. S. & Evans, B. A., 1998, Pharmacology and Toxicology. Copenhagan Denmark: Nordic Pharmacological Society, p. 37 - 39 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

16 Citations (Scopus)

Beta(2)-adrenoceptors increase translocation of GLUT4 via GPCR kinase sites in the receptor C-terminal tail

Dehvari, N., Hutchinson, D., Nevzorova, J., Dallner, O., Sato, M., Kocan, M., Merlin, J., Evans, B., Summers, R. & Bengtsson, T., 2012, In : British Journal of Pharmacology. 165, 5, p. 1442 - 1456 15 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

beta2- and beta3-Adrenoceptors activate glucose uptake in chick astrocytes by distinct mechanisms: A mechanism for memory enhancement?

Hutchinson, D. S., Summers, R. J. & Gibbs, M. E., 2007, In : Journal of Neurochemistry. 103, 3, p. 997 - 1008 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Beta3-adrenoceptor regulation and relaxation responses in mouse ileum

Hutchinson, D. S., Evans, B. A. & Summers, R. J., 2000, In : British Journal of Pharmacology. p. 1251 - 1259 9 p.

Research output: Contribution to journalArticleResearchpeer-review

73 Citations (Scopus)

beta-Adrenoceptors, but not alpha-adrenoceptors, stimulate AMP-activated protein kinase in brown adipocytes independently of uncoupling protein-1

Hutchinson, D. S., Chernogubova, E., Dallner, O. S., Cannon, B. & Bengtsson, T., 2005, In : Diabetologia. 48, p. 2386 - 2395 10 p.

Research output: Contribution to journalArticleResearchpeer-review

BRL37344 stimulates GLUT4 translocation and glucose uptake in skeletal muscle via β 2 -adrenoceptors without causing classical receptor desensitization

Mukaida, S., Sato, M., Öberg, A. I., Dehvari, N., Olsen, J. M., Kocan, M., Halls, M. L., Merlin, J., Sandström, A. L., Csikasz, R. I., Evans, B. A., Summers, R. J., Hutchinson, D. S. & Bengtsson, T., 1 May 2019, In : American journal of physiology. Regulatory, integrative and comparative physiology. 316, 5, p. R666-R677 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Characterization of ileal beta-adrenoceptor mediated responses in beta3-adrenoceptor knockout mice

Hutchinson, D. S. & Summers, R. J., 1999, p. 104 - Post 1-64. 1 p.

Research output: Contribution to conferenceAbstractOther

71 Citations (Scopus)

CIS is a potent checkpoint in NK cell-mediated tumor immunity

Delconte, R. B., Kolesnik, T. B., Dagley, L. F., Rautela, J., Shi, W., Putz, E. M., Stannard, K., Zhang, J. G., Teh, C. E-Y., Firth, M., Ushiki, T., Andoniou, C. E., Degli-Esposti, M. A., Sharp, P. P., Sanvitale, C. E., Infusini, G., Liau, N. P. D., Linossi, E. M., Burns, C. J., Carotta, S. & 12 others, Gray, D. H. D., Seillet, C., Hutchinson, D. S., Belz, G. T., Webb, A. I., Alexander, W. S., Li, S. S., Bullock, A. N., Babon, J. J., Smyth, M. J., Nicholson, S. E. & Huntington, N. D., 21 Jun 2016, In : Nature Immunology. 17, 7, p. 816-824 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Cloing and expression of two isoforms of the b3 -adrenoceptor which are differentially expressed in mouse tissues

Evans, B. A., Hutchinson, D. S., Papaioannou, M., Hamilton, S. & Summers, R. J., 1998, p. 130 - 130. 1 p.

Research output: Contribution to conferenceAbstractOther

22 Citations (Scopus)

Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis

Merlin, J., Evans, B. A., Dehvari, N., Sato, M., Bengtsson, T. & Hutchinson, D. S., 2016, In : Molecular Nutrition and Food Research. 60, 1, p. 18-42 25 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Diphenylene iodonium stimulates glucose uptake in skeletal muscle cells through mitochondrial complex I inhibition and activation of AMP-activated protein kinase

Hutchinson, D. S., Csikasz, R. I., Yamamoto, D. L., Shabalina, I. G., Wikstrom, P., Wilcke, M. & Bengtsson, T., 2007, In : Cellular Signalling. 19, 7, p. 1610 - 1620 11 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

DNAM-1 expression marks an alternative program of NK cell maturation

Martinet, L., de Andrade, L. F., Guillerey, C., Lee, J. S., Liu, J., Souza-Fonseca-Guimaraes, F., Hutchinson, D. S., Kolesnik, T. B., Nicholson, S. E., Huntington, N. D. & Smyth, M. J., 2015, In : Cell Reports. 11, 1, p. 85 - 97 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Effects of hypoxia-ischemia and inotropes on expression of cardiac adrenoceptors in the preterm fetal sheep

Hutchinson, D. S., Brew, N., Vu, T., Merlin, J., Hale, N., Walker, D. W. & Wong, F. Y., 1 Nov 2018, In : Journal of Applied Physiology. 125, 5, p. 1368-1377 10 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Energy metabolism and memory processing: Role of glucose transport and glycogen in responses to adrenoceptor activation in the chicken

Hutchinson, D. S., Summers, R. J. & Gibbs, M. E., 2008, In : Brain Research Bulletin. 76, 3, p. 224 - 234 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas

Ostrovskaya, A., Hick, C., Hutchinson, D. S., Stringer, B. W., Wookey, P. J., Wootten, D., Sexton, P. M. & Furness, S. G. B., 18 Feb 2019, In : BMC Cancer. 19, 1, 12 p., 157.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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8 Citations (Scopus)

Factors influencing biased agonism in recombinant cells expressing the human α1A-adrenoceptor

da Silva Junior, E. D., Sato, M., Merlin, J., Broxton, N., Hutchinson, D. S., Ventura, S., Evans, B. A. & Summers, R. J., 1 Jul 2017, In : British Journal of Pharmacology. 174, 14, p. 2318-2333 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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13 Citations (Scopus)

Functional domains of the mouse beta3-adrenoceptor associated with differential G-protein coupling

Sato, M., Hutchinson, D. S., Evans, B. A. & Summers, R. J., 2007, In : Biochemical Society Transactions. 35, Pt 5, p. 1035 - 1037 3 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Functional domains of the mouse beta3-adrenoceptor associated with differential G-protein coupling

Sato, M., Hutchinson, D. S., Bengtsson, T., Floren, A., Langel, U., Horinouchi, T., Evans, B. A. & Summers, R. J., 2005, In : Journal of Pharmacology and Experimental Therapeutics. 315, 3, p. 1354 - 1361 8 p.

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)

Glucose uptake in brown fat cells is dependent on mTOR complex 2-promoted GLUT1 translocation

Olsen, J. M., Sato, M., Dallner, O. S., Sandstrom, A. L., Pisani, D. F., Chambard, J-C., Amri, E-Z., Hutchinson, D. S. & Bengtsson, T., 2014, In : Journal of Cell Biology. 207, 3, p. 365 - 374 10 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

G protein coupled receptor 18: a potential role for endocannabinoid signaling in metabolic dysfunction

Rajaraman, G., Simcocks, A., Hryciw, D. H., Hutchinson, D. S. & McAinch, A. J., 1 Jan 2016, In : Molecular Nutrition and Food Research. 60, 1, p. 92-102 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2 Citations (Scopus)

Importance of adrenergic receptors in prenatally induced cognitive impairment in the domestic chick

Gibbs, M. E., Rodricks, C. L., Hutchinson, D. S., Summers, R. J. & Miller, S. L., 2009, In : International Journal of Developmental Neuroscience. 27, p. 27 - 35 8 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Improving type 2 diabetes through a distinct adrenergic signaling pathway involving mTORC2 that mediates glucose uptake in skeletal muscle

Sato, M., Dehvari, N., Oberg, A., Dallner, O. S., Sandstrom, A. L., Olsen, J. M., Csikasz, R. I., Summers, R. J., Hutchinson, D. S. & Bengtsson, T., 2014, In : Diabetes. 63, 12, p. 4115 - 4129 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

INSL5 activates multiple signalling pathways and regulates GLP-1 secretion in NCI-H716 cells

Ang, S. Y., Evans, B. A., Poole, D. P., Bron, R., DiCello, J. J., Bathgate, R. A. D., Kocan, M., Hutchinson, D. S. & Summers, R. J., 1 Apr 2018, In : Journal of Molecular Endocrinology. 60, 3, p. 213-224 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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17 Citations (Scopus)

Interaction with caveolin-1 modulates G protein coupling of the mouse beta3-adrenoceptor

Sato, M., Hutchinson, D. S., Halls, M. L., Furness, S. G. B., Bengtsson, T., Evans, B. A. & Summers, R. J., 2012, In : Journal of Biological Chemistry. 287, 24, p. 20674 - 20688 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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54 Citations (Scopus)
106 Citations (Scopus)

Ligand-directed signalling at beta-adrenoceptors

Evans, B., Sato, M., Sarwar, M., Hutchinson, D. & Summers, R., 2010, In : British Journal of Pharmacology. 159, 5, p. 1022 - 1038 17 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Memory processing in the avian hippocampus involves interactions between beta-adrenoceptors, glutamate receptors, and metabolism

Gibbs, M. E., Bowser, D. N., Hutchinson, D. S., Loiacono, R. & Summers, R. J., 2008, In : Neuropsychopharmacology. 33, 12, p. 2831 - 2846 16 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Mirabegron: potential off target effects and uses beyond the bladder

Dehvari, N., Dantas da Silva Junior, E., Bengtsson, T. & Hutchinson, D. S., 1 Nov 2018, In : British Journal of Pharmacology. 175, 21, p. 4072-4082 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

14 Citations (Scopus)

ML290 is a biased allosteric agonist at the relaxin receptor RXFP1

Kocan, M., Sarwar, M., Ang, S. Y., Xiao, J., Marugan, J., Hossain, M. A., Wang, C., Hutchinson, D. S., Samuel, C. S., Agoulnik, A. I., Bathgate, R. A. D. & Summers, R. J., 1 Dec 2017, In : Scientific Reports. 7, 1, 14 p., 2968.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Mouse 3a- and 3b- adrenoceptors expressed in Chinese hamster ovary cells display identical pharmacology but utilize distinct signalling pathways

Hutchinson, D. S., Bengtsson, T., Evans, B. A. & Summers, R. J., 2002, In : British Journal of Pharmacology. 135, p. 1903 - 1914 12 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Mouse β3a and β3b-adrenoceptors expressed in Chinese hamster ovary cells display identical pharmacology but utilize distinct signalling pathways

Hutchinson, D. S., Bengtsson, T., Evans, B. A. & Summers, R. J., 1 Jan 2002, In : British Journal of Pharmacology. 135, 8, p. 1903-1914 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Multiple signalling pathways of the mouse beta(3)-adrenoceptor stably expressed in CHO-K1 cells

Sato, M., Horinouchi, T., Hutchinson, D. S. & Evans, B. A., 2006, p. 410 - 410. 1 p.

Research output: Contribution to conferenceAbstractOther

53 Citations (Scopus)

Noradrenaline release in the locus coeruleus modulates memory formation and consolidation; roles for alpha- and beta-adrenergic receptors

Gibbs, M. E., Hutchinson, D. S. & Summers, R. J., 2010, In : Neuroscience. 170, 4, p. 1209 - 1222 14 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Orthosteric binding of rho-Da1a, a natural peptide of snake venom interacting selectively with the alpha(1A)-Adrenoceptor

Maiga, A., Merlin, J., Marcon, E., Rouget, C., Larregola, M., Gilquin, B., Fruchart-Gaillard, C., Lajeunesse, E., Marchetti, C., Lorphelin, A., Bellanger, L., Summers, R. J., Hutchinson, D. S., Evans, B. A., Servent, D. & Gilles, N., 2013, In : PLoS ONE. 8, 7, 11 p., e68841.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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