19982022
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Research Output 1998 2019

1998

B3 -adrenorecoptors: differential regulations and novel subtypes

Summers, R. J., Hutchinson, D. S. & Evans, B. A., 1998, Pharmacology and Toxicology. Copenhagan Denmark: Nordic Pharmacological Society, p. 37 - 39 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Cloing and expression of two isoforms of the b3 -adrenoceptor which are differentially expressed in mouse tissues

Evans, B. A., Hutchinson, D. S., Papaioannou, M., Hamilton, S. & Summers, R. J., 1998, p. 130 - 130. 1 p.

Research output: Contribution to conferenceAbstractOther

β3-Andrenoceptors: Differential regulation and novel subtypes

Summers, R. J., Hutchinson, D. S. & Evans, B. A., 1 Jan 1998, In : Pharmacology and Toxicology, Supplement. 83, 1, p. 37-39 3 p.

Research output: Contribution to journalArticleResearchpeer-review

1999

Characterization of ileal beta-adrenoceptor mediated responses in beta3-adrenoceptor knockout mice

Hutchinson, D. S. & Summers, R. J., 1999, p. 104 - Post 1-64. 1 p.

Research output: Contribution to conferenceAbstractOther

3 Citations (Scopus)

βs-Adrenoceptors: Their role and regulation in the gastrointestinal tract

Summers, R. J., Roberts, S. J., Hutchinson, D. S. & Evans, B. A., 1 Dec 1999, In : Proceedings of the Western Pharmacology Society. 42, p. 115-117 3 p.

Research output: Contribution to journalArticleResearchpeer-review

2000

Beta3-adrenoceptor regulation and relaxation responses in mouse ileum

Hutchinson, D. S., Evans, B. A. & Summers, R. J., 2000, In : British Journal of Pharmacology. p. 1251 - 1259 9 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

β3-adrenoceptor regulation and relaxation responses in mouse ileum

Hutchinson, D. S., Evans, B. A. & Summers, R. J., 1 Jan 2000, In : British Journal of Pharmacology. 129, 6, p. 1251-1259 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2001

b1-Adrenoceptors compensate for b3-adrenoceptors in ileum from b3-adrenoceptor knock-out mice

Hutchinson, D. S., Evans, B. A. & Summers, R. J., 2001, In : British Journal of Pharmacology. 132, 2, p. 433 - 442 10 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

β1-adrenoceptors compensate for β3-adrenoceptors in ileum from β3-adrenoceptor knock-out mice

Hutchinson, D. S., Evans, B. A. & Summers, R. J., 1 Jan 2001, In : British Journal of Pharmacology. 132, 2, p. 433-442 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2002

Mouse 3a- and 3b- adrenoceptors expressed in Chinese hamster ovary cells display identical pharmacology but utilize distinct signalling pathways

Hutchinson, D. S., Bengtsson, T., Evans, B. A. & Summers, R. J., 2002, In : British Journal of Pharmacology. 135, p. 1903 - 1914 12 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Mouse β3a and β3b-adrenoceptors expressed in Chinese hamster ovary cells display identical pharmacology but utilize distinct signalling pathways

Hutchinson, D. S., Bengtsson, T., Evans, B. A. & Summers, R. J., 1 Jan 2002, In : British Journal of Pharmacology. 135, 8, p. 1903-1914 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2004
11 Citations (Scopus)

Stereoselectivity for interactions of agonists and antagonists at mouse, rat and human 3-adrenoceptors

Popp, B. D., Hutchinson, D. S., Evans, B. A. & Summers, R. J., 2004, In : European Journal of Pharmacology. 484, 2-3, p. 323 - 331 9 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

The Janus faces of adrenoceptors: factors controlling the coupling of adrenoceptors to multiple signal transduction pathways

Summers, R. J., Broxton, N., Hutchinson, D. S. & Evans, B. A., 2004, In : Clinical and Experimental Pharmacology and Physiology. 31, 11, p. 822 - 827 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2005
40 Citations (Scopus)

Alpha1A-adrenoceptors activate glucose uptake in L6 muscle cells through a phospholipase C-, phosphatidylinositol-3 kinase-, and atypical protein kinase C-dependent pathway

Hutchinson, D. S. & Bengtsson, T., 2005, In : Endocrinology. 146, 2, p. 901 - 912 12 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Alpha1- and beta1-adrenoceptor signaling fully compensates for beta3-adrenoceptor deficiency in brown adipocyte norepinephrine-stimulated glucose uptake

Chernogubova, E., Hutchinson, D. S., Nedergaard, J. & Bengtsson, T., 2005, In : Endocrinology. 146, 5, p. 2271 - 2284 14 p.

Research output: Contribution to journalArticleResearchpeer-review

73 Citations (Scopus)

beta-Adrenoceptors, but not alpha-adrenoceptors, stimulate AMP-activated protein kinase in brown adipocytes independently of uncoupling protein-1

Hutchinson, D. S., Chernogubova, E., Dallner, O. S., Cannon, B. & Bengtsson, T., 2005, In : Diabetologia. 48, p. 2386 - 2395 10 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Functional domains of the mouse beta3-adrenoceptor associated with differential G-protein coupling

Sato, M., Hutchinson, D. S., Bengtsson, T., Floren, A., Langel, U., Horinouchi, T., Evans, B. A. & Summers, R. J., 2005, In : Journal of Pharmacology and Experimental Therapeutics. 315, 3, p. 1354 - 1361 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

Adrenoceptor mediated phosphorylation of AMPK differs between brown adipose tissue and skeletal muscle

Hutchinson, D. S. & Cannon, B., 2006, p. 1276 - 1276. 1 p.

Research output: Contribution to conferenceAbstractOther

15 Citations (Scopus)

Agonist effects of zinterol at the mouse and human beta3-adrenoceptor

Hutchinson, D. S., Chernogubova, E., Sato, M., Summers, R. J. & Bengtsson, T., 2006, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 373, 2, p. 158 - 168 11 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

AMP-activated protein kinase activation by adrenoceptors in L6 skeletal muscle cells: Mediation by alpha1-adrenoceptors causing glucose uptake

Hutchinson, D. S. & Bengtsson, T., 2006, In : Diabetes. 55, p. 682 - 690 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Multiple signalling pathways of the mouse beta(3)-adrenoceptor stably expressed in CHO-K1 cells

Sato, M., Horinouchi, T., Hutchinson, D. S. & Evans, B. A., 2006, p. 410 - 410. 1 p.

Research output: Contribution to conferenceAbstractOther

The role of the C-terminal domain in mouse beta(3)-adrenoceptor signalling

Society, S. (ed.), Horinouchi, T., Sato, M., Hutchinson, D. S., Evans, B. A. & Summers, R. J., 2006, p. 126 - 126. 1 p.

Research output: Contribution to conferenceAbstractOther

2007
63 Citations (Scopus)

Altered regulation of the PINK1 locus: a link between type 2 diabetes and neurodegeneration?

Scheele, C., Nielsen, A. R., Walden, T. B., Sewell, D. A., Fischer, C. P., Brogan, R. J., Petrovic, N., Larsson, O., Tesch, P. A., Wennmalm, K., Hutchinson, D. S., Cannon, B., Wahlestedt, C., Pedersen, B. & Timmons, J. A., 2007, In : FASEB Journal. 21, 13, p. 3653 - 3665 13 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

beta2- and beta3-Adrenoceptors activate glucose uptake in chick astrocytes by distinct mechanisms: A mechanism for memory enhancement?

Hutchinson, D. S., Summers, R. J. & Gibbs, M. E., 2007, In : Journal of Neurochemistry. 103, 3, p. 997 - 1008 12 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Diphenylene iodonium stimulates glucose uptake in skeletal muscle cells through mitochondrial complex I inhibition and activation of AMP-activated protein kinase

Hutchinson, D. S., Csikasz, R. I., Yamamoto, D. L., Shabalina, I. G., Wikstrom, P., Wilcke, M. & Bengtsson, T., 2007, In : Cellular Signalling. 19, 7, p. 1610 - 1620 11 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Functional domains of the mouse beta3-adrenoceptor associated with differential G-protein coupling

Sato, M., Hutchinson, D. S., Evans, B. A. & Summers, R. J., 2007, In : Biochemical Society Transactions. 35, Pt 5, p. 1035 - 1037 3 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)
22 Citations (Scopus)

β2-adrenergic activation increases glycogen synthesis in L6 skeletal muscle cells through a signalling pathway independent of cyclic AMP

Yamamoto, D. L., Hutchinson, D. S. & Bengtsson, T., 2007, In : Diabetologia. 50, 1, p. 158 - 167 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2008
105 Citations (Scopus)

Astrocytic involvement in learning and memory consolidation

Gibbs, M. E., Hutchinson, D. S. & Hertz, L., 2008, In : Neuroscience and Biobehavioral Reviews. 32, 5, p. 927 - 944 18 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Energy metabolism and memory processing: Role of glucose transport and glycogen in responses to adrenoceptor activation in the chicken

Hutchinson, D. S., Summers, R. J. & Gibbs, M. E., 2008, In : Brain Research Bulletin. 76, 3, p. 224 - 234 11 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Memory processing in the avian hippocampus involves interactions between beta-adrenoceptors, glutamate receptors, and metabolism

Gibbs, M. E., Bowser, D. N., Hutchinson, D. S., Loiacono, R. & Summers, R. J., 2008, In : Neuropsychopharmacology. 33, 12, p. 2831 - 2846 16 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)

Regulation of AMP-activated protein kinase activity by G-protein coupled receptors: Potential utility in treatment of diabetes and heart disease

Hutchinson, D. S., Summers, R. J. & Bengtsson, T., 2008, In : Pharmacology and Therapeutics. 119, 3, p. 291 - 310 20 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Role of beta-Adrenoceptors in Memory Consolidation: beta3-Adrenoceptors Act on Glucose Uptake and beta2-Adrenoceptors on Glycogenolysis

Gibbs, M. E., Hutchinson, D. S. & Summers, R. J., 2008, In : Neuropsychopharmacology. 33, p. 2384 - 2397 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2009
2 Citations (Scopus)

Importance of adrenergic receptors in prenatally induced cognitive impairment in the domestic chick

Gibbs, M. E., Rodricks, C. L., Hutchinson, D. S., Summers, R. J. & Miller, S. L., 2009, In : International Journal of Developmental Neuroscience. 27, p. 27 - 35 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2010
105 Citations (Scopus)

Ligand-directed signalling at beta-adrenoceptors

Evans, B., Sato, M., Sarwar, M., Hutchinson, D. & Summers, R., 2010, In : British Journal of Pharmacology. 159, 5, p. 1022 - 1038 17 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

Noradrenaline release in the locus coeruleus modulates memory formation and consolidation; roles for alpha- and beta-adrenergic receptors

Gibbs, M. E., Hutchinson, D. S. & Summers, R. J., 2010, In : Neuroscience. 170, 4, p. 1209 - 1222 14 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

The M3-muscarinic acetylcholine receptor stimulates glucose uptake in L6 skeletal muscle cells by a CaMKK-AMPK-dependent mechanism

Merlin, J., Evans, B. A., Csikasz, R. I., Bengtsson, T., Summers, R. J. & Hutchinson, D. S., 2010, In : Cellular Signalling. 22, 7, p. 1104 - 1113 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2011
20 Citations (Scopus)

alpha{2}-Adrenoceptors activate noradrenaline-mediated glycogen turnover in chick astrocytes

Hutchinson, D. S., Catus, S. L., Merlin, J., Summers, R. J. & Gibbs, M. E., 2011, In : Journal of Neurochemistry. 117, 5, p. 915 - 926 12 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Quantification of functional selectivity at the human {alpha}1A-adrenoceptor

Evans, B. A., Broxton, N., Merlin, J., Sato, M., Hutchinson, D. S., Christopoulos, A. & Summers, R. J., 2011, In : Molecular Pharmacology. 79, 2, p. 298 - 307 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Quantification of functional selectivity at the human α1A- adrenoceptor (Molecular Pharmacology (2011) 79, (298-307))

Evans, B. A., Broxton, N., Merlin, J., Sato, M., Hutchinson, D. S., Christopoulos, A. & Summers, R. J., Mar 2011, In : Molecular Pharmacology. 79, 3, p. 627 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

30 Citations (Scopus)

Role of beta-adrenoceptors in glucose uptake in astrocytes using beta-adrenoceptor knockout mice

Catus, S. L., Gibbs, M. E., Sato, M., Summers, R. J. & Hutchinson, D. S., 2011, In : British Journal of Pharmacology. 162, 8, p. 1700 - 1715 16 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Shikonin increases glucose uptake in skeletal muscle cells and improves plasma glucose levels in diabetic goto-kakizaki rats

Oberg, A., Yassin, K., Csikasz, R., Dehvari, N., Shabalina, I., Hutchinson, D., Wilcke, M., Goran-Ostenson, C. & Bengtsson, T., 2011, In : PLoS ONE. 6, 7, 10 p., e22510.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
35 Citations (Scopus)

β1-adrenergic receptors increase UCP1 in human MADS brown adipocytes and rescue cold-acclimated β3-adrenergic receptor knockout mice via nonshivering thermogenesis

Mattsson, C. L., Csikasz, R. I., Chernogubova, E., Yamamoto, D. L., Hogberg, H. T., Amri, E-Z., Hutchinson, D. S. & Bengtsson, T., Dec 2011, In : American Journal of Physiology - Endocrinology and Metabolism. 301, 6, 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2012
16 Citations (Scopus)

Beta(2)-adrenoceptors increase translocation of GLUT4 via GPCR kinase sites in the receptor C-terminal tail

Dehvari, N., Hutchinson, D., Nevzorova, J., Dallner, O., Sato, M., Kocan, M., Merlin, J., Evans, B., Summers, R. & Bengtsson, T., 2012, In : British Journal of Pharmacology. 165, 5, p. 1442 - 1456 15 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Interaction with caveolin-1 modulates G protein coupling of the mouse beta3-adrenoceptor

Sato, M., Hutchinson, D. S., Halls, M. L., Furness, S. G. B., Bengtsson, T., Evans, B. A. & Summers, R. J., 2012, In : Journal of Biological Chemistry. 287, 24, p. 20674 - 20688 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
21 Citations (Scopus)

Rapid turnover of glycogen in memory formation

Gibbs, M. E. & Hutchinson, D. S., 2012, In : Neurochemical Research. 37, 11, p. 2456 - 2463 8 p.

Research output: Contribution to journalArticleResearchpeer-review