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Research Output 2002 2018

2018
5 Citations (Scopus)

(−)-Epigallocatechin-3-gallate and EZH2 inhibitor GSK343 have similar inhibitory effects and mechanisms of action on colorectal cancer cells

Ying, L., Yan, F., Williams, B. R. G., Xu, P., Li, X., Zhao, Y., Hu, Y., Wang, Y., Xu, D. & Dai, J., 1 Jan 2018, In : Clinical and Experimental Pharmacology and Physiology. 45, 1, p. 58-67 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Large-scale comparative assessment of computational predictors for lysine post-translational modification sites

Chen, Z., Liu, X., Li, F., Li, C., Marquez-Lago, T., Leier, A., Akutsu, T., Webb, G. I., Xu, D., Smith, A. I., Li, L., Chou, K-C. & Song, J., 4 Oct 2018, (Accepted/In press) In : Briefings in Bioinformatics. 24 p., bby089.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)

PD-L1 expression is a prognostic factor in subgroups of gastric cancer patients stratified according to their levels of CD8 and FOXP3 immune markers

Ying, L., Yan, F., Meng, Q., Yu, L., Yuan, X., Gantier, M. P., Williams, B. R. G., Chan, D. W., Shi, L., Tu, Y., Ni, P., Wang, X., Chen, W., Zang, X., Xu, D. & Hu, Y., 20 Feb 2018, In : OncoImmunology. 7, 6, 11 p., e1433520.

Research output: Contribution to journalArticleResearchpeer-review

2017
19 Citations (Scopus)

A non-canonical function of Ezh2 preserves immune homeostasis

Vasanthakumar, A., Xu, D., Lun, A. T. L., Kueh, A. J., van Gisbergen, K. P. J. M., Iannarella, N., Li, X., Yu, L., Wang, D., Williams, B. RG., Lee, S. C. W., Majewski, I. J., Godfrey, D. I., Smyth, G. K., Alexander, W. S., Herold, M. J., Kallies, A., Nutt, S. L. & Allan, R. S., 1 Apr 2017, In : EMBO Reports. 18, 4, p. 619-631 13 p.

Research output: Contribution to journalArticleResearchpeer-review

DLX1 acts as a crucial target of FOXM1 to promote ovarian cancer aggressiveness by enhancing TGF-β/SMAD4 signaling

Chan, DW., Hui, W. W. Y., Wang, J. J., Yung, M. M. H., Hui, LMN., Qin, Y., Liang, RR., Leung, T. H. Y., Xu, D., Chan, KKL., Yao, K-M., Tsang, B. K. & Ngan, H. Y. S., 1 Mar 2017, In : Oncogene. 36, 10, p. 1404-1416 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Emerging roles for epigenetic programming in the control of inflammatory signaling integration in heath and disease

Hu, Y., Yan, F., Ying, L. & Xu, D., 2017, Regulation of Inflammatory Signaling in Health and Disease. Xu, D. (ed.). Singapore: Springer, p. 63-90 28 p. (Advances in Experimental Medicine and Biology; vol. 1024).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

6 Citations (Scopus)

Identification of a histone family gene signature for predicting the prognosis of cervical cancer patients

Li, X., Tian, R., Gao, H., Yang, Y., Williams, B. R. G., Gantier, M. P., McMillan, N. A. J., Xu, D., Hu, Y. & Gao, YE., 1 Dec 2017, In : Scientific Reports. 7, 1, 13 p., 16495.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
27 Citations (Scopus)

MIR-127 promotes EMT and stem-like traits in lung cancer through a feed-forward regulatory loop

Shi, L., Wang, Y., Lu, Z., Zhang, H., Zhuang, N., Wang, B., Song, Z., Chen, G., Huang, C., Xu, D., Zhang, Y., Zhang, W. & Gao, Y., 23 Mar 2017, In : Oncogene. 36, 12, p. 1631-1643 13 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Overexpression of the transcription factor ATF3 with a regulatory molecular signature associates with the pathogenic development of colorectal cancer

Yan, F., Ying, L., Li, X., Qiao, B., Meng, Q., Yu, L., Yuan, X., Ren, S. T., Chan, D. W., Shi, L., Ni, P., Wang, X., Xu, D. & Hu, Y., 2017, In : Oncotarget. 8, 29, p. 47020-47036 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)

Understanding immune phenotypes in human gastric disease tissues by multiplexed immunohistochemistry

Ying, L., Yan, F., Meng, Q., Yuan, X., Yu, L., Williams, B. R. G., Chan, D. W., Shi, L., Tu, Y., Ni, P., Wang, X., Xu, D. & Hu, Y., 12 Oct 2017, In : Journal of Translational Medicine. 15, 1, 11 p., 206.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2016
4 Citations (Scopus)

Activating transcription factor 3 expression as a marker of response to the histone deacetylase inhibitor pracinostat

Sooraj, D., Xu, D., Cain, J. E., Gold, D. P. & Williams, B. R. G., 1 Jul 2016, In : Molecular Cancer Therapeutics. 15, 7, p. 1726-1739 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)

Bcl6 Sets a Threshold for Antiviral Signaling by Restraining IRF7 Transcriptional Program

Xu, F., Kang, Y., Zhuang, N., Lu, Z., Zhang, H., Xu, D., Ding, Y., Yin, H. & Shi, L., 5 Jan 2016, In : Scientific Reports. 6, 13 p., 18778.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
5 Citations (Scopus)

Gelsolin suppresses gastric cancer metastasis through inhibition of PKR-p38 signaling

Yuan, X., Wang, W., Li, J., Zheng, P., Dong, P., Chen, L., Zhou, Y., Xie, G., Xu, D., Liu, Y. & Shen, L., 13 Jul 2016, In : Oncotarget. 7, 33, p. 53459-53470 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2015
33 Citations (Scopus)

BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs

Sadler, A. J., Rossello, F. J., Yu, L., Deane, J. A., Yuan, X-L., Wang, D., Irving, A. T., Liaskos, M., Gantier, M. P. M., Ying, H., Yim, H. C. H., Hartland, E. L., Notini, A. J., De Boer, C. M., White, S., Mansell, A. S., Liu, J-P., Watkins, D. N., Gerondakis, S. D., Williams, B. R. G. & 1 others, Xu, D., 2015, In : Proceedings of the National Academy of Sciences. 112, 5, p. 1535 - 1540 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
58 Citations (Scopus)

Regulatory T cells in rheumatoid arthritis showed increased plasticity toward Th17 but retained suppressive function in peripheral blood

Wang, T., Sun, X., Zhao, J., Zhang, J., Zhu, H., Li, C., Gao, N., Jia, Y., Xu, D., Huang, F-P., Li, N., Lu, L. & Li, Z. G., 2015, In : Annals of the Rheumatic Diseases. 74, 6, p. 1293 - 1301 9 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Telomerase deficiency causes alveolar stem cell senescence-associated low-grade inflammation in lungs

Chen, R., Zhang, K., Chen, H., Zhao, X., Wang, J., Li, L., Cong, Y-S., Ju, Z., Xu, D., Williams, B. R. G., Jia, J. & Liu, J-P., 2015, In : Journal of Biological Chemistry. 290, 52, p. 30813 - 30829 17 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

The acetyltransferase HAT1 moderates the NF-?B response by regulating the transcription factor PLZF

Sadler, A. J., Suliman, B. A., Yu, L., Yuan, X-L., Wang, D., Irving, A. T., Sarvestani, S., Banerjee, A., Mansell, A. S., Liu, J-P., Gerondakis, S. D., Williams, B. R. G. & Xu, D., 2015, In : Nature Communications. 6, 13 (Art. ID: 6795), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
13 Citations (Scopus)

The polycomb group protein enhancer of zeste 2 is a novel therapeutic target for cervical cancer

Ding, M., Zhang, H., Li, Z., Wang, C., Chen, J. J., Shi, L., Xu, D. & Gao, Y., 2015, In : Clinical and Experimental Pharmacology and Physiology. 42, 5, p. 458 - 464 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2014
172 Citations (Scopus)

High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3

De Nardo, D. F., Labzin, L. I., Kono, H., Seki, R., Schmidt, S. V., Beyer, M., Xu, D., Zimmer, S., Lahrmann, C., Schildberg, F. A., Vogelhuber, J., Kraut, M., Ulas, T., Kerksiek, A., Krebs, W., Bode, N., Grebe, A., Fitzgerald, M. L., Hernandez, N. J., Williams, B. R. G. & 7 others, Knolle, P. A., Kneilling, M., Rocken, M., Lutjohann, D., Wright, S. D., Schultze, J. L. & Latz, E., 2014, In : Nature Immunology. 15, 2, p. 152 - 160 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2013
5 Citations (Scopus)

Activating transcription factor 3 contributes to Toll-like receptor-mediated macrophage survival via repression of Bax and Bak

Thompson, M., Xu, D. & Williams, B. R. G., 2013, In : Journal of Interferon and Cytokine Research. 33, 11, p. 682 - 693 12 p.

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)

Activation of TLR4 signaling promotes gastric cancer progression by inducing mitochondrial ROS production

Yuan, X-L., Zhou, Y-L., Wang, W., Li, J., Xie, G., Zhao, Y., Xu, D. & Shen, L., 2013, In : Cell Death and Disease. 4, 9 (Article # e794), p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
58 Citations (Scopus)

ATF3 suppresses metastasis of bladder cancer by regulating gelsolin-mediated remodeling of the actin cytoskeleton

Yuan, X., Yu, L., Li, J., Xie, G., Rong, T., Zhang, L., Chen, J., Meng, Q., Irving, A. T., Wang, D., Williams, E., Liu, J-P., Sadler, A. J., Williams, B. R. G., Shen, L. & Xu, D., 2013, In : Cancer Research. 73, 12, p. 3625 - 3637 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
13 Citations (Scopus)

Imbalanced frequencies of Th17 and Treg cells in acute coronary syndromes are mediated by IL-6-STAT3 signaling

Ma, Y., Yuan, X., Deng, L., Xu, W., Zheng, Y., Yue, C., Zhang, G., Xie, F., Yang, Y. H., Gantier, M. P. M., Liu, J-P., Xu, D. & Shen, L., 2013, In : PLoS ONE. 8, 8 (art. no. e72804), p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
8 Citations (Scopus)

MAVS-mediated host cell defense is inhibited by Borna disease virus

Li, Y., Song, W., Wu, J., Zhang, Q., He, J., Li, A., Qian, J., Zhai, A., Hu, Y., Kao, W., Wei, L., Zhang, F-M. & Xu, D., 2013, In : International Journal of Biochemistry and Cell Biology. 45, 8, p. 1546 - 1555 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2012
111 Citations (Scopus)

A miR-19 regulon that controls NF-{kappa}B signaling

Gantier, M. P. M., Stunden, H. J., McCoy, C., Behlke, M. A., Wang, D., Liaskos, M., Sarvestani, S., Yang, Y. H., Xu, D., Corr, S. C., Morand, E. F. & Williams, B. R. G., 2012, In : Nucleic Acids Research. 40, 16, p. 8048 - 8058 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
29 Citations (Scopus)

HDACi: molecular mechanisms and therapeutic implications in the innate immune system

Suliman, B., Xu, D. & Williams, B., 2012, In : Immunology and Cell Biology. 90, 1, p. 23 - 32 10 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Increased CD45RA{+} FoxP3{low} regulatory T cells with impaired suppressive function in patients with systemic lupus erythematosus

Pan, X., Yuan, X., Zheng, Y., Wang, W-W., Shan, J., Lin, F., Jiang, G., Yang, Y. H., Wang, D., Xu, D. & Shen, L., 2012, In : PLoS ONE. 7, 4, 11 p., e34662.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
18 Citations (Scopus)

Osteopontin promotes inflammation in patients with acute coronary syndrome through its activity on IL-17 producing cells

Zheng, Y., Wang, Z., Deng, L., Yuan, X-L., Ma, Y-H., Zhang, G., Gantier, M. P. M., Liu, J-P., Shen, L-S. & Xu, D., 2012, In : European Journal of Immunology. 42, 10, p. 2803 - 2814 12 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defense

Irving, A., Wang, D., Vasilevski, O., Latchoumanin, O., Kozer, N., Clayton, A., Szczepny, A., Morimoto, H., Xu, D., Williams, B. & Sadler, A., 2012, In : Immunity. 36, 5, p. 795 - 806 12 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)

The promyelocytic leukemia zinc finger protein: two decades of molecular oncology

Suliman, B. A., Xu, D. & Williams, B. R. G., 2012, In : Frontiers in Oncology. 2, 74, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2011
236 Citations (Scopus)

Analysis of microRNA turnover in mammalian cells following Dicer1 ablation

Gantier, M., McCoy, C., Rusinova, I., Saulep, D., Wang, D., Xu, D., Irving, A., Behlke, M., Hertzog, P., Mackay-Fisson, F. & Williams, B., 2011, In : Nucleic Acids Research. 39, 13, p. 5692 - 5703 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Regulatory T cells and tumor immunity in the tumor microenvironment

Shen, L-S., Thompson, M. & Xu, D., 2011, Regulatory T Cells. Hayashi, R. S. (ed.). New York, United States: Nova Science Publishers, p. 153 - 168 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Other

2010
92 Citations (Scopus)

Elevated expression of Foxp3 in tumor-infiltrating Treg cells suppresses T-cell proliferation and contributes to gastric cancer progression in a COX-2-dependent manner

Yuan, X-L., Chen, L., Li, M-X., Dong, P., Xue, J., Wang, J., Zhang, T-T., Wang, X., Zhang, F-M., Ge, H-L., Shen, L-S. & Xu, D., 2010, In : Clinical Immunology. 134, 3, p. 277 - 288 12 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Genetic modulation of TLR8 response following bacterial phagocytosis

Gantier, M. P. M., Irving, A. T., Liaskos, M., Xu, D., Evans, V., Cameron, P. U., Bourne, J. A., Ferrero, R. L., John, M., Behlke, M. A. & Williams, B. R. G., 2010, In : Human Mutation. 31, 9, p. 1069 - 1079 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2009
183 Citations (Scopus)

ATF3 transcription factor and its emerging roles in immunity and cancer

Thompson, M. R., Xu, D. & Williams, B. R. G., 2009, In : Journal of Molecular Medicine. 87, 11, p. 1053 - 1060 8 p.

Research output: Contribution to journalArticleResearchpeer-review

96 Citations (Scopus)

CD4+CD25+CD127low/- regulatory T cells express Foxp3 and suppress effector T cell proliferation and contribute to gastric cancers progression

Shen, L-S., Wang, J., Shen, D-F., Yuan, X-L., Dong, P., Li, M-X., Xue, J., Zhang, F-M., Ge, H-L. & Xu, D., 2009, In : Clinical Immunology. 131, 1, p. 109 - 118 10 p.

Research output: Contribution to journalArticleResearchpeer-review

65 Citations (Scopus)

Promyelocytic leukemia zinc finger protein regulates interferon-mediated innate immunity

Xu, D., Holko, M., Sadler, A. J., Scott, B. M., Higashiyama, S., Berkofsky-Fessler, W., McConnell, M. J., Pandolfi, P. P., Licht, J. D. & Williams, B. R. G., 2009, In : Immunity. 30, 6, p. 802 - 816 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2008
92 Citations (Scopus)

Ets2 maintains hTERT gene expression and breast cancer cell proliferation by interacting with c-Myc

Xu, D., Dwyer, J. M., Li, H., Duan, W. & Liu, J-P., 2008, In : Journal of Biological Chemistry. 283, 35, p. 23567 - 23580 14 p.

Research output: Contribution to journalArticleResearchpeer-review

89 Citations (Scopus)

TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages

Gantier, M. P. M., Tong, S., Behlke, M. A., Xu, D., Phipps, S., Foster, P. S. & Williams, B. R. G., 2008, In : Journal of Immunology. 180, 4, p. 2117 - 2124 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2007
2 Citations (Scopus)

Identifying cis-regulatory elements by statistical analysis and phylogenetic footprinting and analyzing their coexistence and related gene ontology

Shi, W., Zhou, W. & Xu, D., 2007, In : Physiological Genomics. 31, 3, p. 374 - 384 11 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Inhibition of telomerase by targeting MAP kinase signaling

Xu, D., Li, H. & Liu, J-P., 2007, Telomerase Inhibition Strategies and Protocols. Andrews, L. G. & Tollefsbol, T. O. (eds.). 405 ed. USA: Humana Press, p. 147 - 165 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

64 Citations (Scopus)

Transcriptional regulation of telomerase activity: Roles of the the ets transcription factor family

Dwyer, J. M., Li, H., Xu, D. & Liu, J-P., 2007, In : Annals of the New York Academy of Sciences. 1114, p. 36 - 47 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2006
30 Citations (Scopus)

TGF-beta and cancer: Is Smad3 a repressor of hTERT gene?

Li, H., Xu, D., Toh, B-H. & Liu, J-P., 2006, In : Cell Research. 16, 2, p. 169 - 173 5 p.

Research output: Contribution to journalArticleResearchpeer-review

91 Citations (Scopus)

Transforming growth factor beta suppresses human telomerase reverse transcriptase (hTERT) by Smad3 interactions with c-Myc and the hTERT gene

Li, H., Xu, D., Li, J., Berndt, M. C. & Liu, J-P., 2006, In : Journal of Biological Chemistry. 281, 35, p. 25588 - 25600 13 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Ultraviolet-induced apoptosis in embryonic stem cells in vitro

Xu, D., Wilson, T. J. & Hertzog, P. J., 2006, Embryonic Stem Cell Protocols. Volume 1: Isolation and Characterization. Turksen, K. & Walker, J. M. (eds.). 2nd Edition ed. Totowa NJ USA: Humana Press, p. 327 - 338 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Other

2005
89 Citations (Scopus)

Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation

Zhou, J., Chehab, R., Tkalcevic, J., Naylor, M. J., Harris, J., Wilson, T. J., Tsao, S. E., Tellis, I., Zavarsek, S., Xu, D., Lapinskas, E. J., Visvader, J., Lindeman, G. J., Thomas, R. S., Ormandy, C. J., Hertzog, P. J., Kola, I. & Pritchard, M. A., 2005, In : EMBO Journal. 24, 3, p. 635 - 644 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2004

Tissue-specific overexpression of the HSA21 gene GABP Implications for DS

O'leary, D., Pritchard, M. A., Xu, D., Kola, I., Hertzog, P. J. & Ristevski, S., 2004, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1739, p. 81 - 87 7 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Tissue-specific overexpression of the HSA21 gene GABPα: Implications for DS

O'Leary, D. A., Pritchard, M. A., Xu, D., Kola, I., Hertzog, P. J. & Ristevski, S., 24 Dec 2004, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1739, 1, p. 81-87 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2003
1 Citation (Scopus)

Characterization of monoclonal antibodies specific to the transcription factor ETS-2 protein

Sanij, E., Scott, B. M., Wilson, T. J., Xu, D., Hertzog, P. J. & Wolvetang, E. J., 2003, In : Immunology Letters. 86, 1, p. 63 - 70 8 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Ets1 as a marker of malignant potential in gastric carcinoma

Yong, Y., Zhang, Y-C., Zhang, W-Z., Shen, L-S., Hertzog, P. J., Wilson, T. J. & Xu, D-K., 2003, In : World Journal of Gastroenterology. 9, 10, p. 2154 - 2159 6 p.

Research output: Contribution to journalArticleResearchpeer-review