20012019
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Research Output 2001 2019

2019

Correction to: Variation in neurosurgical management of traumatic brain injury: a survey in 68 centers participating in the CENTER-TBI study (Acta Neurochirurgica, (2018), 10.1007/s00701-018-3761-z)

van Essen, T. A., den Boogert, H. F., Cnossen, M., de Ruiter, G. C. W., Haitsma, I., Polinder, S., Steyerberg, E. W., Menon, D., Maas, A. I. R., Lingsma, H. F., Peul, W. C. & on behalf of the CENTER-TBI Investigators and Participants, Mar 2019, In : Acta Neurochirurgica. 161, 3, p. 451-455 5 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

2018

Erythropoietin does not alter serum profiles of neuronal and axonal biomarkers after traumatic brain injury: Findings from the Australian EPO-TBI clinical trial

Hellewell, S. C., Mondello, S., Conquest, A., Shaw, G., Madorsky, I., Deng, J. V., Little, L., Kobeissy, F., Bye, N., Bellomo, R., Cooper, D. J., Vallance, S., Board, J. & Morganti-Kossmann, M. C., 1 Apr 2018, In : Critical Care Medicine. 46, 4, p. 554-561 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Interferons in traumatic brain and spinal cord injury: Current evidence for translational application

Roselli, F., Chandrasekar, A. & Morganti-Kossmann, M. C., 19 Jun 2018, In : Frontiers in Neurology. 9, JUN, 11 p., 458.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File

Reflections on 35 Years of Journal of Neurotrauma

Morganti-Kossmann, M. C., 1 Jan 2018, In : Journal of Neurotrauma. 35, 1, p. 14-15 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments

Morganti-Kossmann, M. C., Semple, B. D., Hellewell, S. C., Bye, N. & Ziebell, J. M., 1 May 2018, In : Acta Neuropathologica. 137, 5, p. 731-755 25 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2017

Dual-modality NIRF-MRI cubosomes and hexosomes: High throughput formulation and in vivo biodistribution

Tran, N., Bye, N., Moffat, B. A., Wright, D. K., Cuddihy, A., Hinton, T. M., Hawley, A. M., Reynolds, N. P., Waddington, L. J., Mulet, X., Turnley, A. M., Morganti-Kossmann, M. C. & Muir, B. W., 1 Feb 2017, In : Materials Science and Engineering C: Materials for Biological Applications. 71, p. 584-593 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Monitoring the neuroinflammatory response following acute brain injury

Thelin, E. P., Tajsic, T., Zeiler, F. A., Menon, D. K., Hutchinson, P. J. A., Carpenter, K. L. H., Morganti-Kossmann, M. C. & Helmy, A., 20 Jul 2017, In : Frontiers in Neurology. 8, JUL, p. 1-14 14 p., 351.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File

The scavenging chemokine receptor ACKR2 has a significant impact on acute mortality rate and early lesion development after traumatic brain injury

Woodcock, T. M., Frugier, T., Nguyen, T. T., Semple, B. D., Bye, N., Massara, M., Savino, B., Besio, R., Sobacchi, C., Locati, M. & Morganti-Kossmann, M. C., 1 Nov 2017, In : PLoS ONE. 12, 11, 21 p., e0188305.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2016

Environmental enrichment attenuates traumatic brain injury: Induced neuronal hyperexcitability in supragranular layers of sensory cortex

Alwis, D. S., Yan, E. B., Johnstone, V., Carron, S., Hellewell, S., Morganti-Kossmann, M. C. & Rajan, R., 1 Jun 2016, In : Journal of Neurotrauma. 33, 11, p. 1084-1101 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Impact acceleration model of diffuse traumatic brain injury

Hellewell, S. C., Ziebell, J. M., Lifshitz, J. & Morganti-Kossmann, M. C., 2016, Methods in Molecular Biology. Humana Press, Vol. 1462. p. 253-266 14 p. (Methods in Molecular Biology; vol. 1462).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Lesion size is exacerbated in hypoxic rats whereas hypoxia-inducible factor-1 alpha and vascular endothelial growth factor increase in injured normoxic rats: A prospective cohort study of secondary hypoxia in focal traumatic brain injury

Thelin, E. P., Frostell, A., Mulder, J., Mitsios, N., Damberg, P., Aski, S. N., Risling, M., Svensson, K. M., Morganti-Kossmann, M. C. & Bellander, B-M., 7 Mar 2016, In : Frontiers in Neurology. 7, MAR, 17 p., 23.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Targeted therapeutic mild hypercapnia after cardiac arrest: A phase II multi-centre randomised controlled trial (the CCC trial)

Eastwood, G. M., Schneider, A. G., Suzuki, S., Peck, L., Young, H., Tanaka, A., Mårtensson, J., Warrillow, S., McGuinness, S., Parke, R., Gilder, E., Mccarthy, L., Galt, P., Taori, G., Eliott, S., Lamac, T., Bailey, M., Harley, N., Barge, D., Hodgson, C. L. & 8 others, Morganti-Kossmann, M. C., Pebay, A., Conquest, A., Archer, J. S., Bernard, S., Stub, D., Hart, G. K. & Bellomo, R., 1 Jul 2016, In : Resuscitation. 104, p. 83-90 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Therapies negating neuroinflammation after brain trauma

Hellewell, S., Semple, B. D. & Morganti-Kossmann, M. C., 2016, In : Brain Research. 1640, p. 36-56 21 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Variation in structure and process of care in traumatic brain injury: Provider profiles of European Neurotrauma Centers participating in the CENTER-TBI study

Cnossen, M. C., Polinder, S., Lingsma, H. F., Maas, A. I. R., Menon, D., Steyerberg, E. W. & CENTER-TBI Investigators and Participants, 1 Aug 2016, In : PLoS ONE. 11, 8, e0161367.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2015

Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans

Yan, E. B., Frugier, T. J., Lim, C. K., Heng, B., Sundaram, G., Tan, M., Rosenfeld, J. V., Walker, D. W., Guillemin, G. J. & Morganti-Kossmann, M. C., 12 Dec 2015, In : Journal of Neuroinflammation. 12, 1, 17 p., 110.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Collaborative European neurotrauma effectiveness research in traumatic brain injury (CENTER-TBI): a prospective longitudinal observational study

Maas, A. I. R., Menon, D. K., Steyerberg, E. W., Citerio, G., Lecky, F. E., Manley, G. T., Hill, S., Legrand, V., Sorgner, A., Cameron, P., Gruen, R. L., Morganti-Kossmann, M. C. & Rosenfeld, J. V., 2015, In : Neurosurgery. 76, 1, p. 67 - 80 14 p.

Research output: Contribution to journalArticleOther

Traumatic brain injury induces elevation of Co in the human brain

Roberts, B. R., Hare, D. J., McLean, C. A., Conquest, A., Lind, M., Li, Q-X., Bush, A. I., Masters, C. L., Morganti-Kossmann, M-C. & Frugier, T. J., 1 Jan 2015, In : Metallomics. 7, 1, p. 66-70 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2014

Anti-lysophosphatidic acid antibodies improve traumatic brain injury outcomes

Crack, P. J., Zhang, M., Morganti-Kossmann, M. C., Morris, A., Wojciak, J. M., Fleming, J. K., Karve, I., Wright, D. K., Sashindranath, M., Goldshmit, Y., Conquest, A., Daglas, M., Johnston, L. A., Medcalf, R. L., Sabbadini, R. A. & Pebay, A., 2014, In : Journal of Neuroinflammation. 11, (Art. No: 37), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Measurement of serum melatonin in intensive care unit patients: changes in traumatic brain injury, trauma, and medical conditions

Seifman, M. A., Gomes, K., Nguyen, P. N., Bailey, M. J., Rosenfeld, J. V., Cooper, D. J. & Morganti-Kossmann, M. C., 2014, In : Frontiers in Neurology. 5, Art. No.: 237, p. 1 - 7 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Nuclear trafficking of Pten after brain injury leads to neuron survival not death

Goh, C., Putz, U., Howitt, J., Hian, L. L., Gunnersen, J., Bye, N., Morganti-Kossmann, M. C. & Tan, S-S., 2014, In : Experimental Neurology. 252, p. 37 - 46 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Post-traumatic hypoxia is associated with prolonged cerebral cytokine production, higher serum biomarker levels, and poor outcome in patients with severe traumatic brain injury

Yan, E. B., Satgunaseelan, L., Paul, E., Bye, N., Nguyen, P., Agyapomaa, D., Kossmann, T. K., Rosenfeld, J. V. & Morganti-Kossmann, M. C., 2014, In : Journal of Neurotrauma. 31, 7, p. 618 - 629 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Rod microglia: A morphological definition

Taylor, S. E., Morganti-Kossmann, C., Lifshitz, J. & Ziebell, J. M., 2014, In : PLoS ONE. 9, 5, 9 p., e97096.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2013

Characterising effects of impact velocity on brain and behaviour in a model of diffuse traumatic axonal injury

Yan, E. B., Johnstone, V., Alwis, D. D. S., Morganti-Kossmann, M. C. & Rajan, R., 2013, In : Neuroscience. 248, p. 17 - 29 13 p.

Research output: Contribution to journalArticleResearchpeer-review

The role of markers of inflammation in traumatic brain injury

Woodcock, T. & Morganti-Kossmann, M. C., 2013, In : Frontiers in Neurology. 4, Article 18, p. 1 - 18 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2012

Attenuation of microglial activation with minocycline is not associated with changes in neurogenesis after focal traumatic brain injury in adult mice

Ng, S. Y., Semple, B. D., Morganti-Kossmann, M. C. & Bye, N., 2012, In : Journal of Neurotrauma. 29, 7, p. 1410 - 1425 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Cerebral inflammation after traumatic injury: regulation of secondary damage, repair or both?

Semple, B. D. & Morganti-Kossmann, M. C., 2012, Traumatic Brain and Spinal Cord Injury: Challenges and Developments. Morganti-Kossmann, C., Raghupathi, R. & Maas, A. (eds.). New York, USA: Cambridge University Press, p. 155 - 168 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Early management of severe traumatic brain injury

Rosenfeld, J. V., Maas, A. I., Bragge, P., Morganti-Kossmann, M. C., Manley, G. T. & Gruen, R. L., 2012, In : The Lancet. 380, 9847, p. 1088 - 1098 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Guilty molecules, guilty minds? The conflicting roles of the innate immune response to traumatic brain injury

Hellewell, S. & Morganti-Kossmann, M. C., 2012, In : Mediators of Inflammation. 2012, Art. ID: 356494, p. 1 - 18 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Inflammatory regulators of redirected neural migration in the injured brain

Bye, N., Turnley, A. M. & Morganti-Kossmann, M. C., 2012, In : Neurosignals. 20, 3, p. 132 - 146 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Sensory cortex underpinnings of traumatic brain injury deficits

Alwis, D. D. S., Yan, E. B., Morganti-Kossmann, M. C. & Rajan, R., 2012, In : PLoS ONE. 7, 12, 19 p., e52169.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans

Sashindranath, M., Sales, E., Daglas, M., Freeman, R., Samson, A. L., Cops, E., Beckham, S. A., Galle, A. A., McLean, C. A., Morganti-Kossmann, M. C., Rosenfeld, J. V., Madani, R., Vassalli, J-D., Su, E. J., Lawrence, D. A. & Medcalf, R. L., 2012, In : Brain. 135, 11, p. 3251 - 3264 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Attenuated neurological deficit, cell death and lesion volume in Fas-mutant mice is associated with altered neuroinflammation following traumatic brain injury

Ziebell, J., Bye, N., Semple, B. D., Kossmann, T. K. & Morganti-Kossmann, M., 2011, In : Brain Research. 1414, p. 94 - 105 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Neurogenesis and glial proliferation are stimulated following diffuse traumatic brain injury in adult rats

Bye, N., Carron, S., Han, X., Agyapomaa, D., Ng, S., Yan, E., Rosenfeld, J. & Morganti-Kossmann, M., 2011, In : Journal of Neuroscience Research. 89, 7, p. 986 - 1000 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Post-traumatic hypoxia exacerbates neurological deficit, neuroinflammation and cerebral metabolism in rats with diffuse traumatic brain injury

Yan, E., Hellewell, S., Bellander, B-M., Agyapomaa, D. & Morganti-Kossmann, M., 2011, In : Journal of Neuroinflammation. 8, 147, p. 1 - 16 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2010

Animal models of traumatic brain injury: Is there an optimal model to reproduce human brain injury in the laboratory?

Morganti-Kossmann, M. C., Yan, E. B. & Bye, N., 2010, In : Injury. 41, Suppl 1, p. 10 - 13 4 p.

Research output: Contribution to journalArticleResearchpeer-review

CCL2 modulates cytokine production in cultured mouse astrocytes

Semple, B., Frugier, T. J. & Morganti-Kossmann, M. C., 2010, In : Journal of Neuroinflammation. 7, 67, p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Deficiency of the chemokine receptor CXCR2 attenuates neutrophil infiltration and cortical damage following closed head injury

Semple, B. D., Bye, N., Ziebell, J. M. & Morganti-Kossmann, M. C., 2010, In : Neurobiology of Disease. 40, 2, p. 394 - 403 10 p.

Research output: Contribution to journalArticleResearchpeer-review

In situ detection of inflammatory mediators in post mortem human brain tissue after traumatic injury

Frugier, T. J., Morganti-Kossmann, M., O'Reilly, D. & McLean, C. A., 2010, In : Journal of Neurotrauma. 27, 3, p. 497 - 507 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Involvement of pro- and anti-inflammatory cytokines and chemokines in the pathophysiology of traumatic brain injury

Ziebell, J. & Morganti-Kossmann, M., 2010, In : Neurotherapeutics. 7, 1, p. 22 - 30 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Modulation of immune response by head injury

Morganti-Kossmann, M. C., Semple, B. D., Ziebell, J. M., Yan, E. B., Bye, N. & Kossmann, T. K., 2010, New Insights to Neuroimmune Biology. Berczi, I. (ed.). First ed. USA: Elsevier, p. 193 - 220 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Neuroimmune Biology: The Brain and host defense.

Morganti-Kossmann, M., Semple, B., Yan, E., Ziebell, J., Bye, N. & Kossmann, T. K., 2010, 1 ed. Manitoba, Canada: Elsevier. 18 p.

Research output: Book/ReportBookResearchpeer-review

Post-traumatic hypoxia exacerbates brain tissue damage: analysis of axonal injury and glial responses

Hellewell, S., Yan, E. B., Agyapomaa, D., Bye, N. & Morganti-Kossmann, M., 2010, In : Journal of Neurotrauma. 27, 11, p. 1997 - 2010 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Role of CCL2 (MCP-1) in traumatic brain injury (TBI): Evidence from severe TBI patients and CCL2-/- mice

Semple, B., Bye, N., Rancan, M., Ziebell, J. M. & Morganti-Kossmann, M. C., 2010, In : Journal of Cerebral Blood Flow and Metabolism. 30, 4, p. 769 - 782 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Role of chemokines in CNS health and pathology: A focus on the CCL2/CCR2 and CXCL8/CXCR2 networks

Semple, B. D., Kossmann, T. K. & Morganti-Kossmann, M. C., 2010, In : Journal of Cerebral Blood Flow and Metabolism. 30, 3, p. 459 - 473 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Role of the inflammatory process in traumatic brain damage

Morganti-Kossmann, M. C., Satgunaseelan, L., Bye, N., Nguyen, P. & Kossmann, T. K., 2009, Inflammatory Diseases of the Central Nervous System. Kilpatrick, T., Ransohoff, R. M. & Wesselingh, S. L. (eds.). USA: Cambridge University Press, p. 185 - 200 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Other

The genomic profile of the cerebral cortex after closed head injury in mice: Effects of minocycline

Crack, P. J., Gould, J. A., Bye, N., Ross, S., Ali, U., Habgood, M., Morganti-Kossmann, M. C., Saunders, N. R. & Hertzog, P. J., 2009, In : Journal of Neural Transmission. 116, 1, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Endogenous melatonin increases in cerebrospinal fluid of patients after severe traumatic brain injury and correlates with oxidative stress and metabolic disarray

Seifman, M. A., Adamides, A., Nguyen, P., Vallance, S., Cooper, D. J., Kossmann, T. K., Rosenfeld, J. V. & Morganti-Kossmann, M. C., 2008, In : Journal of Cerebral Blood Flow and Metabolism. 28, 4, p. 684 - 696 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

Ablation of D1 dopamine receptor-expressing cells generates mice with seizures, dystonia, hyperactivity, and impaired oral behavior

Gantois, I., Fang, K., Jiang, L., Babovic, D., Lawrence, A. J., Ferreri, V., Teper, Y., Jupp, B., Ziebell, J. M., Morganti-Kossmann, M. C., O'Brien, T. J., Nally, R., Schutz, G., Waddington, J., Egan, G. F. & Drago, J., 2007, In : Proceedings of the National Academy of Sciences. 104, 10, p. 4182 - 4187 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Changes in blood-brain barrier permeability to large and small molecules following traumatic brain injury in mice

Habgood, M., Bye, N., Dziegielewska, K. M., Ek, C. J., Lane, M. A., Potter, A., Morganti-Kossmann, M. C. & Saunders, N. R., 2007, In : European Journal of Neuroscience. 25, 1, p. 231 - 238 8 p.

Research output: Contribution to journalArticleResearchpeer-review