Personal profile
Biography
Cristina works at the Australian Regenerative Medicine Institute (ARMI) in the Faculty of Medicine, Nursing and Health Sciences at Monash University as a Research Fellow.
Biography
My current research program focuses on transcriptional regulation of myeloid development and disease.
We use zebrafish and mouse models to discover and understand molecular pathways in haematopoietic development. Within this context, we look at the role of transcription factors and mRNA splicing regulators, employing a multi-disciplinary approach integrating molecular genetics, biochemistry, genomics, and proteomics.
Research area keywords
- Haemopoiesis
- Zebrafish
- Transcriptional Regulation
- Neutrophils
- White blood cell development
- Splicing
- Biochemistry and Cell Biology
- Transcription factors
- Transgenic Animals
- Genetics
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Collaborations and top research areas from the last five years
Projects
- 5 Finished
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Fluorescent Fish: Installation of fluorescence microscopes for screening of fluorescent transgenic animals Fish/Aqua Core
Kaslin, J. (Primary Chief Investigator (PCI)), Currie, P. (Chief Investigator (CI)), Lieschke, G. (Chief Investigator (CI)), Ramialison, M. (Chief Investigator (CI)), Bryson-Richardson, R. (Chief Investigator (CI)), Keightley, C. (Chief Investigator (CI)), Peleg, A. (Chief Investigator (CI)), Abud, H. (Chief Investigator (CI)), McGlinn, E. (Chief Investigator (CI)), Merson, T. (Chief Investigator (CI)), Hobbs, R. (Chief Investigator (CI)), Anko, M.-L. (Chief Investigator (CI)) & Bird, P. (Chief Investigator (CI))
1/12/16 → 31/12/17
Project: Research
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NHMRC Equipment Grant - Water filtration upgrade for cost effective water treatment in FishCore
Kaslin, J. (Primary Chief Investigator (PCI)), Abud, H. (Chief Investigator (CI)), Anko, M.-L. (Chief Investigator (CI)), Bryson-Richardson, R. (Chief Investigator (CI)), Currie, P. (Chief Investigator (CI)), Dworkin, S. (Chief Investigator (CI)), Ferrero, R. (Chief Investigator (CI)), Hobbs, R. (Chief Investigator (CI)), Keightley, C. (Chief Investigator (CI)), Lieschke, G. (Chief Investigator (CI)), McGlinn, E. (Chief Investigator (CI)), Peleg, A. (Chief Investigator (CI)) & Ramialison, M. (Chief Investigator (CI))
NHMRC - National Health and Medical Research Council (Australia)
5/12/14 → 31/12/15
Project: Research
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Zbtb11 interactions in haematopoiesis and disease
Lieschke, G. (Primary Chief Investigator (PCI)) & Keightley, C. (Chief Investigator (CI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/14 → 31/12/16
Project: Research
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Imaris 3D/4D image analysis software and workstations
Lieschke, G. (Primary Chief Investigator (PCI)), Abud, H. (Chief Investigator (CI)), Bourne, J. (Chief Investigator (CI)), Currie, P. (Chief Investigator (CI)), Dworkin, S. (Chief Investigator (CI)), Harper, I. (Chief Investigator (CI)), Heng, J. (Chief Investigator (CI)), Hickey, M. (Chief Investigator (CI)), Kaslin, J. (Chief Investigator (CI)), Keightley, C. (Chief Investigator (CI)), Marcelle, C. (Chief Investigator (CI)), McGlinn, E. (Chief Investigator (CI)), Peleg, A. (Chief Investigator (CI)), Plachta, N. (Chief Investigator (CI)), Risbridger, G. (Chief Investigator (CI)), Rosenthal, N. (Chief Investigator (CI)) & Sloan, E. (Chief Investigator (CI))
NHMRC - National Health and Medical Research Council (Australia)
17/12/13 → 31/12/13
Project: Research
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Role of ZBTB11 in hepatocellular carcinoma
Lieschke, G. (Primary Chief Investigator (PCI)), Gong, Z. (Chief Investigator (CI)) & Keightley, C. (Chief Investigator (CI))
1/01/13 → 31/12/15
Project: Research
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Late fetal hematopoietic failure results from ZBTB11 deficiency despite abundant HSC specification
Cao, H., Naik, S. H., Amann-Zalcenstein, D., Hickey, P., Salim, A., Cao, B., Nilsson, S. K., Keightley, M. C. & Lieschke, G. J., 14 Nov 2023, In: Blood Advances. 7, 21, p. 6506-6519 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Link opens in a new tab Citations (Scopus) -
Pioneer neutrophils release chromatin within in vivo swarms
Isles, H. M., Loynes, C. A., Alasmari, S., Kon, F. C., Henry, K. M., Kadochnikova, A., Hales, J., Muir, C. F., Keightley, M. C., Kadirkamanathan, V., Hamilton, N., Lieschke, G. J., Renshaw, S. A. & Elks, P. M., Jul 2021, In: eLife. 10, 29 p., e68755.Research output: Contribution to journal › Article › Research › peer-review
Open Access44 Link opens in a new tab Citations (Scopus) -
Frontline Science: Dynamic cellular and subcellular features of migrating leukocytes revealed by in vivo lattice lightsheet microscopy
Manley, H. R., Potter, D. L., Heddleston, J. M., Chew, T.-L., Keightley, M. C. & Lieschke, G. J., Aug 2020, In: Journal of Leukocyte Biology. 108, 2, p. 455-468 14 p.Research output: Contribution to journal › Article › Research › peer-review
21 Link opens in a new tab Citations (Scopus) -
Splicing dysfunction and disease: The case of granulopoiesis
Keightley, M.-C. & Lieschke, G. J., Mar 2018, In: Seminars in Cell & Developmental Biology. 75, p. 23-39 17 p.Research output: Contribution to journal › Review Article › Other › peer-review
2 Link opens in a new tab Citations (Scopus) -
The Neutrophil Nucleus: An Important Influence on Neutrophil Migration and Function
Manley, H. R., Keightley, M. C. & Lieschke, G. J., 4 Dec 2018, In: Frontiers in Immunology. 9, 18 p., 2867.Research output: Contribution to journal › Review Article › Research › peer-review
Open AccessFile95 Link opens in a new tab Citations (Scopus)