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Personal profile

Biography

Cristina works at the Australian Regenerative Medicine Institute (ARMI) in the Faculty of Medicine, Nursing and Health Sciences at Monash University as a Research Fellow.

Biography

My current research program focuses on transcriptional regulation of myeloid development and disease.

We use zebrafish and mouse models to discover and understand molecular pathways in haematopoietic development. Within this context, we look at the role of transcription factors and mRNA splicing regulators, employing a multi-disciplinary approach integrating molecular genetics, biochemistry, genomics, and proteomics. 

Keywords

  • Haemopoiesis
  • Zebrafish
  • Transcriptional Regulation
  • Neutrophils
  • White blood cell development
  • Splicing
  • Biochemistry and Cell Biology
  • Transcription factors
  • Transgenic Animals
  • Genetics

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Projects 2013 2017

Research Output 1991 2018

  • 20 Article
  • 5 Review Article
  • 2 Chapter (Book)
  • 1 Comment / Debate

Splicing dysfunction and disease: The case of granulopoiesis

Keightley, M-C. & Lieschke, G. J., Mar 2018, In : Seminars in Cell and Developmental Biology. 75, p. 23-39 17 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

The Neutrophil Nucleus: An Important Influence on Neutrophil Migration and Function

Manley, H. R., Keightley, M. C. & Lieschke, G. J., 4 Dec 2018, In : Frontiers in Immunology. 9, 18 p., 2867.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File
Open Access
File

A GCSFR/CSF3R zebrafish mutant models the persistent basal neutrophil deficiency of severe congenital neutropenia

Pazhakh, V., Clark, S., Keightley, M. C. & Lieschke, G. J., 10 Mar 2017, In : Scientific Reports. 7, 11 p., 44455.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Intron retention enhances gene regulatory complexity in vertebrates

Schmitz, U., Pinello, N., Jia, F., Alasmari, S., Ritchie, W., Keightley, M-C., Shini, S., Lieschke, G. J., Wong, J. J. L. & Rasko, J. E. J., 16 Nov 2017, In : Genome Biology. 18, 1, 15 p., 216.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File