Craig Morton

Dr

1990 …2018
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Research Output 1990 2018

2018
2 Citations (Scopus)

Bone marrow transplantation corrects haemolytic anaemia in a novel ENU mutagenesis mouse model of TPI deficiency

Conway, A., Brown, F. C., Hortle, E. J., Burgio, G., Foote, S. J., Morton, C. J., Jane, S. M. & Curtis, D. J., 21 May 2018, In : Disease Models and Mechanisms. 11, 5, 8 p., dmm034678.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Characterization of Tfrc-mutant mice with microcytic phenotypes

Conway, A. J., Brown, F. C., Rank, G., Kile, B. T., Morton, C. J., Jane, S. M. & Curtis, D. J., 14 Aug 2018, In : Blood Advances. 2, 15, p. 1914-1922 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017
4 Citations (Scopus)

Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1

Mohanty, B., Rimmer, K., McMahon, R. M., Headey, S. J., Vazirani, M., Shouldice, S. R., Coinçon, M., Tay, S., Morton, C. J., Simpson, J. S., Martin, J. L. & Scanlon, M. J., 1 Mar 2017, In : PLoS ONE. 12, 3, 20 p., e0173436.

Research output: Contribution to journalArticleResearchpeer-review

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40 Citations (Scopus)

Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites

Braig, D., Nero, T. L., Koch, H. G., Kaiser, B., Wang, X., Thiele, J. R., Morton, C. J., Zeller, J., Kiefer, J., Potempa, L. A., Mellett, N. A., Miles, L. A., Du, X. J., Meikle, P. J., Huber-Lang, M., Stark, G. B., Parker, M. W., Peter, K. & Eisenhardt, S. U., 23 Jan 2017, In : Nature Communications. 8, 19 p., 14188.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2015
24 Citations (Scopus)

Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides

Hermans, S. J., Ascher, D. B., Hancock, N. C., Holien, J. K., Michell, B. J., Chai, S. Y. Y., Morton, C. J. & Parker, M. W., 2015, In : Protein Science. 24, 2, p. 190 - 199 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Sent packing: protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility

McMahon, R. M., Coincon, M., Tay, S., Heras, B., Morton, C. J., Scanlon, M. J. & Martin, J. L., 2015, In : Acta Crystallographica Section D: Biological Crystallography. 71, 12, p. 2386-2395 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2014
8 Citations (Scopus)

Discovery and in vivo evaluation of alcohol-containing benzothiazoles as potent dual-targeting bacterial DNA supercoiling inhibitors

Palmer, J. T., Axford, L. C., Barker, S., Bennett, J. M., Blair, M., Collins, I., Davies, D. T., Ford, L., Gannon, C. T., Lancett, P., Logan, A., Lunniss, C. J., Morton, C. J., Offermann, D. A., Pitt, G. R. W., Rao, B. N., Singh, A. K., Shukla, T., Srivastava, A., Stokes, N. R. & 3 others, Thomaides-Brears, H. B., Yadav, A. & Haydon, D. J., 1 Sep 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 17, p. 4215-4222 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Discovery of phosphodiesterase-4 inhibitors: Serendipity and rational drug design

Feil, S. C., Holien, J. K., Morton, C. J., Hancock, N. C., Thompson, P. & Parker, M. W., 2014, In : Australian Journal of Chemistry. 67, 12, p. 1780 - 1785 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2013
23 Citations (Scopus)

Design and evaluation of the performance of an NMR screening fragment library

Doak, B. C., Morton, C. J., Simpson, J. S. & Scanlon, M., 2013, In : Australian Journal of Chemistry. 66, 12, p. 1465-1472 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2011
19 Citations (Scopus)

Regulation of insulin-regulated membrane aminopeptidase activity by its C-terminal domain

Ascher, D., Cromer, B., Morton, C., Volitakis, I., Cherny, R., Albiston, A., Chai, S. & Parker, M., 2011, In : Biochemistry. 50, 13, p. 2611 - 2622 12 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Thiophene inhibitors of PDE4: crystal structures show a second binding mode at the catalytic domain of PDE4D2

Nankervis, J., Feil, S., Hancock, N., Zheng, Z., Ng, H., Morton, C., Holien, J., Ho, P., Frazzetto, M., Jennings, I., Manallack, D., Martin, T. J., Thompson, P. & Parker, M., 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 23, p. 7089 - 7093 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2010
14 Citations (Scopus)

Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of insulin-regulated aminopeptidase

Albiston, A., Pham, V., Ye, S., Ng, L., Lew, R., Thompson, P., Butler, J., Morton, C., Parker, M. & Chai, S., 2010, In : Molecular Pharmacology. 78, 4, p. 600 - 607 8 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Recognition and detoxification of the insecticide DDT by Drosophila melanogaster glutathione S-transferase D1

Low, W. Y., Feil, S. C., Ng, H. L., Gorman, M. A., Morton, C. J., Pyke, J., McConville, M. J., Bieri, M., Mok, Y. F., Robin, C., Gooley, P. R., Parker, M. W. & Batterham, P., 2010, In : Journal of Molecular Biology. 399, 3, p. 358 - 366 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2008
73 Citations (Scopus)

Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase

Albiston, A. L., Morton, C. J., Ng, H. L., Pham, V., Yeatman, H. R., Ye, S., Fernando, R. N., De Bundel, D., Ascher, D. B., Mendelsohn, F. AO., Parker, M. W. & Chai, S. Y., 2008, In : FASEB Journal. 22, 12, p. 4209 - 4217 9 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Identification of modulating residues defining the catalytic cleft of insulin-regulated aminopeptidase

Ye, S., Chai, S. Y., Lew, R. A., Ascher, D. B., Morton, C. J., Parker, M. W. & Albiston, A. L., 2008, In : Biochemistry and Cell Biology. 86, 3, p. 251 - 261 11 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding

Pearce, M. C., Morton, C. J., Feil, S. C., Hansen, G., Adams, J. J., Parker, M. W. & Bottomley, S. P., 2008, In : Protein Science. 17, 12, p. 2127 - 2133 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2007
120 Citations (Scopus)

Critical role for the second extracellular loop in the binding of both orthosteric and allosteric G protein-coupled receptor ligands

Avlani, V. A., Gregory, K. J., Morton, C. J., Parker, M. W., Sexton, P. & Christopoulos, A., 2007, In : Journal of Biological Chemistry. 282, 35, p. 25677 - 25686 10 p.

Research output: Contribution to journalArticleResearchpeer-review

67 Citations (Scopus)

Molecular evolution of glutathione S-transferases in the genus Drosophila

Low, W. Y., Ng, H. L., Morton, C. J., Parker, M. J., Batterham, P. & Robin, C., 2007, In : Genetics. 177, 3, p. 1363 - 1375 13 p.

Research output: Contribution to journalArticleResearchpeer-review

61 Citations (Scopus)

Structures of perfringolysin O suggest a pathway for activation of cholesterol-dependent cytolysins

Rossjohn, J., Polekhina, G., Feil, S. C., Morton, C. J., Tweten, R. K. & Parker, M. W., 2007, In : Journal of Molecular Biology. 367, 5, p. 1227 - 1236 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

Hsp90 increases LIM kinase activity by promoting its homo-dimerization.

Li, R., Soosairajah, J., Harari, D., Citri, A., Price, J. T., Ng, H. L., Morton, C. J., Parker, M. W., Yarden, Y. & Bernard, O., 2006, In : FASEB Journal. 20, 8, p. 1218 - 1220 2 p.

Research output: Contribution to journalArticleResearchpeer-review

2005
25 Citations (Scopus)

Insights into interactions between the alpha-helical region of the salmon calcitonin antagonists and the human calcitonin receptor using photoaffinity labeling

Pham, V., Dong, M., Wade, J. D., Miller, L. J., Morton, C. J., Ng, H., Parker, M. W. & Sexton, P. M., 2005, In : Journal of Biological Chemistry. 280, 31, p. 28610 - 28622 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2003
220 Citations (Scopus)

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain

Barnham, K. J., McKinstry, W. J., Multhaup, G., Galatis, D., Morton, C. J., Curtain, C. C., Williamson, N. A., White, A. R., Hinds, M. G., Norton, R. S., Beyreuther, K., Masters, C. L., Parker, M. W. & Cappai, R., 2003, In : Journal of Biological Chemistry. 278, 19, p. 17401 - 17407 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2002

Electrostatic and Hydrophobic Forces Tether the Proximal Region of the Angiotnsin II Receptor (AT1A) Carboxyl Terminus to Anionic Lipids

Mozsolits, H., Unabia, S., Ahmad, A., Morton, C. J., Thomas, W. G. & Aguilar, M. I., 2002, In : Biochemistry. 41, 24, p. 7830 - 7840 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1995
8 Citations (Scopus)

NMR studies of the solution properties of recombinant murine interleukin-6

Morton, C. J., Bai, H., Hammacher, A., Norton, R. S., Simpson, R. J. & Mabbutt, B. C., 12 Jun 1995, In : Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular. 1249, 2, p. 189-203 15 p.

Research output: Contribution to journalArticleResearchpeer-review

1994
13 Citations (Scopus)

Solution structure of synthetic peptides corresponding to the C‐terminal helix of interleukin‐6

MORTON, C. J., SIMPSON, R. J. & NORTON, R. S., 1994, In : European Journal of Biochemistry. 219, 1-2, p. 97-107 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1993
27 Citations (Scopus)

Role of the C‐terminus in the activity, conformation, and stability of interleukin‐6

Ward, L. D., Hammacher, A., Zhang, JG. G., Morton, C. J., Simpson, R. J., Weinstock, J., Yasukawa, K. & Norton, R. S., 1993, In : Protein Science. 2, 9, p. 1472-1481 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1990
63 Citations (Scopus)

Complete amino acid sequence of tenebrosin‐C, a cardiac stimulatory and haemolytic protein from the sea anemone Actinia tenebrosa

Simpson, R. J., Reid, G. E., Moritz, R. L., Morton, C. & Norton, R. S., 1990, In : European Journal of Biochemistry. 190, 2, p. 319-328 10 p.

Research output: Contribution to journalArticleResearchpeer-review