• 26 Innovation Walk

    3800 Clayton

1994 …2021
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Research Output 1994 2019

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2019

Cumulin and FSH cooperate to regulate inhibin B and activin B production by human granulosa-lutein cells in vitro

Richani, D., Constance, K., Lien, S., Agapiou, D., Stocker, W. A., Hedger, M. P., Ledger, W., Thompson, J. G., Robertson, D. M., Mottershead, D. G., Walton, K. L., Harrison, C. A. & Gilchrist, R., 1 Apr 2019, In : Endocrinology. 160, 4, p. 853-862 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Non-canonical cyclic AMP SMAD1/5/8 signalling in human granulosa cells

Bertoldo, M. J., Cheung, M. Y., Sia, Z. K., Agapiou, D., Corley, S. M., Wilkins, M. R., Richani, D., Harrison, C. A. & Gilchrist, R. B., 15 Jun 2019, In : Molecular and Cellular Endocrinology. 490, p. 37-46 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy

Marini, K., Croucher, D. R., McCloy, R. A., Vaghjiani, V., Gonzalez-Rajal, A., Hastings, J. F., Chin, V. T., Szczepny, A., Kostyrko, K., Marquez, C., Jayasekara, W. S. N., Alamgeer, M., Boolell, V., Han, J. Z. R., Waugh, T., Lee, H. C., Oakes, S. R., Kumar, B., Harrison, C. A., Hedger, M. P. & 13 othersLorensuhewa, N., Kita, B., arrow, R. B., Robinson, B. W. S., de Kretser, D. M., Wu, J., Ganju, V., Sweet-Cordero, E. A., Burgess, A., Martelotto, L. G., Rossello, F. J., Cain, J. & Watkins, D. N., 25 Jul 2018, In : Science Translational Medicine. 10, 451, 13 p., eaat3504.

Research output: Contribution to journalArticleResearchpeer-review

Molecular characterization of latent GDF8 reveals mechanisms of activation

Walker, R. G., McCoy, J. C., Czepnik, M., Mills, M. J., Hagg, A., Walton, K. L., Cotton, T. R., Hyvönen, M., Lee, R. T., Gregorevic, P., Harrison, C. A. & Thompson, T. B., 30 Jan 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 5, p. E866-E875 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

BMP15 mutations associated with primary ovarian insufficiency reduce expression, activity, or synergy with gdf9

Patino, L. C., Walton, K. L., Mueller, T. D., Johnson, K. E., Stocker, W., Richani, D., Agapiou, D., Gilchrist, R. B., Laissue, P. & Harrison, C. A., 1 Mar 2017, In : Journal of Clinical Endocrinology and Metabolism. 102, 3, p. 1009-1019 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Multiple soluble TGF-β receptors in addition to soluble endoglin are elevated in preeclamptic serum and they synergistically inhibit TGF-β signaling

Wang, Y., Chen, Q., Zhao, M., Walton, K., Harrison, C. & Nie, G., 1 Aug 2017, In : Journal of Clinical Endocrinology and Metablism. 102, 8, p. 3065-3074 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease

Chen, J., Walton, K. L., Hagg, A. G., Colgan, T. D., Johnson, K. E., Qian, H., Gregorevic, P. & Harrison, C. A., 27 Jun 2017, In : Proceedings of the National Academy of Sciences. 114, 26, p. E5266-E5275 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural basis for potency differences between GDF8 and GDF11

Walker, R. G., Czepnik, M., Goebel, E. J., McCoy, J. C., Vujic, A., Cho, M., Oh, J., Aykul, S., Walton, K. L., Schang, G., Bernard, D. J., Hinck, A. P., Harrison, C. A., Martinez-Hackert, E., Wagers, A. J., Lee, R. T. & Thompson, T. B., 3 Mar 2017, In : BMC Biology. 15, 1, 22 p., 19.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma

Coulson, R., Liew, S. H., Connelly, A. A., Yee, N. S., Deb, S., Kumar, B., Vargas, A. C., O'Toole, S. A., Parslow, A. C., Poh, A., Putoczki, T., Morrow, R. J., Alorro, M., Lazarus, K. A., Yeap, E. F. W., Walton, K. L., Harrison, C. A., Hannan, N. J., George, A. J., Clyne, C. D. & 3 othersErnst, M., Allen, A. M. & Chand, A. L., 20 Feb 2017, In : Oncotarget. 8, 12, p. 18640-18656 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2016

A novel, more efficient approach to generate bioactive inhibins

Walton, K. L., Kelly, E. K., Johnson, K. E., Robertson, D. M., Stanton, P. G. & Harrison, C. A., 1 Jul 2016, In : Endocrinology. 157, 7, p. 2799-2809 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Biological activity and in vivo half-life of pro-activin A in male rats

Johnson, K. E., Makanji, Y., Temple-Smith, P., Kelly, E. K., Barton, P. A., Al-Musawi, S. L., Mueller, T. D., Walton, K. L. & Harrison, C. A., 15 Feb 2016, In : Molecular and Cellular Endocrinology. 422, p. 84 - 92 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Differential effects of IL6 and activin A in the development of cancer-associated cachexia

Chen, J. L., Walton, K. L., Qian, H., Colgan, T. D., Hagg, A., Watt, M. J., Harrison, C. A. & Gregorevic, P., 15 Sep 2016, In : Cancer Research. 76, 18, p. 5372-5382 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice

Winbanks, C. E., Murphy, K. T., Bernardo, B. C., Qian, H., Liu, Y., Sepulveda, P. V., Beyer, C., Hagg, A., Thomson, R. E., Chen, J. L., Walton, K. L., Loveland, K. L., McMullen, J. R., Rodgers, B. D., Harrison, C. A., Lynch, G. S. & Gregorevic, P., 20 Jul 2016, In : Science Translational Medicine. 8, 348, 12 p., 348ra98.

Research output: Contribution to journalArticleResearchpeer-review

2015

Cumulin, an oocyte-secreted heterodimer of the transforming growth factor-beta family, is a potent activator of granulosa cells and improves oocyte quality

Mottershead, D. G., Sugimura, S., Al-Musawi, S., Li, J-J., Richani, D., White, M. A., Martin, G. A., Trotta, A., Ritter, L. J., Shi, J., Mueller, T. D., Harrison, C. A. & Gilchrist, R., 2015, In : Journal of Biological Chemistry. 290, 39, p. 24007 - 24020 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Development of novel activin-targeted therapeutics

Chen, J., Walton, K., Al-Musawi, S., Kelly, E. M., Qian, H., La, M., Lu, L., Lovrecz, G. O., Ziemann, M., Lazarus, R., El-Osta, A., Gregorevic, P. & Harrison, C. A., 2015, In : Molecular Therapy. 23, 3, p. 434-444 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibin biosynthesis and activity are limited by a prodomain-derived peptide

Walton, K., Kelly, E. M., Chan, K. L., Harrison, C. A. & Robertson, D., 2015, In : Endocrinology. 156, 8, p. 3047 - 3057 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Aberrant GDF9 expression and activation are associated with common human ovarian disorders

Simpson, C. M., Robertson, D. M., Al-Musawi, S. L., Heath, D., McNatty, K., Ritter, L. J., Mottershead, D. G., Gilchrist, R., Harrison, C. A. & Stanton, P. G., 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 4, p. 615 - 624 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Elevated expression of activins promotes muscle wasting and cachexia

Chen, J. L., Walton, K., Winbanks, C. E., Murphy, K. T., Thomson, R. E., Makanji, Y., Qian, H., Lynch, G. S., Harrison, C. A. & Gregorevic, P., 2014, In : FASEB Journal. 28, 4, p. 1711 - 1723 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Germline mutations of inhibins in early-onset ovarian epithelial tumors

Tournier, I., Marlin, R., Walton, K., Charbonnier, F., Coutant, S., Théry, J-C., Charbonnier, C., Spurrell, C., Vezain, M., Ippolito, L., Bougeard, G., Roman, H., Tinat, J., Sabourin, J-C., Stoppa-Lyonnet, D., Caron, O., Paillerets, B. B., Vaur, D., King, M-C., Harrison, C. & 1 othersFrebourg, T., Mar 2014, In : Human Mutation. 35, 3, p. 294-297 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2013

Activin-beta(c) reduces reproductive tumour progression and abolishes cancer-associated cachexia in inhibin-deficient mice

Gold, E., Marino, F. E., Harrison, C., Makanji, Y. & Risbridger, G. P., 2013, In : Journal of Pathology. 229, 4, p. 599 - 607 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Htra3 is downregulated in cancer cell lines and significantly reduced in primary serous and granulosa cell ovarian tumors

Singh, H., Li, Y., Fuller, P. J., Harrison, C., Rao, J., Stephens, A. N. & Nie, G-Y., 2013, In : Journal of Cancer. 4, 2, p. 152-164 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Identification of protein binding partners of ALK-5 kinase inhibitors

Ciayadi, R., Kelso, G., Potdar, M. K., Harris, S. J., Walton, K., Harrison, C. A. & Hearn, M. T. W., 2013, In : Bioorganic & Medicinal Chemistry. 21, 21, p. 6496 - 6500 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Retinoic acid promotes Sertoli cell differentiation and antagonises activin-induced proliferation

Nicholls, P., Harrison, C. A., Rainczuk, K. E. K., Vogl, A. W. & Stanton, P. G., 2013, In : Molecular and Cellular Endocrinology. 377, 1-2, p. 33 - 43 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Species differences in the expression and activity of bone morphogenetic protein 15

Al-Musawi, S., Walton, K. L., Heath, D., Simpson, C. M. & Harrison, C. A., 2013, In : Endocrinology. 154, 2, p. 888 - 899 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The activin A antagonist follistatin inhibits asthmatic airway remodelling

Hardy, C. L., Nguyen, H-A. T., Mohamud, R., Yao, J. J., Oh, D. Y., Plebanski, M., Loveland, K. A. L., Harrison, C., Rolland, J. M. & O'Hehir, R. E., 2013, In : Thorax. 68, 1, p. 9 - 18 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass

Winbanks, C. E., Chen, J., Qian, H., Liu, Y., Bernardo, B. C., Beyer, C., Watt, K. I., Thomson, R. E., Connor, T., Turner, B. J., McMullen, J. R., Larsson, L., McGee, S. L., Harrison, C. A. & Gregorevic, P., 2013, In : Journal of Cell Biology. 203, 2, p. 345 - 357 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Use of detergent-based buffers allows detection of precursor inhibin forms in an immunoassay format

Walton, K. L., Chan, K. L., Pruysers, E., Kelly, E. K., Harris, G., Harrison, C. A. & Robertson, D. M., 5 Dec 2013, In : Molecular and Cellular Endocrinology. 381, 1-2, p. 106-114 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Activation of latent human GDF9 by a single residue change (Gly 391 Arg) in the mature domain

Simpson, C., Stanton, P. G., Walton, K. L., Chan, K., Ritter, L. J., Gilchrist, R. B. & Harrison, C. A., 2012, In : Endocrinology. 153, 3, p. 1301 - 1310 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Activin signaling regulates sertoli cell differentiation and function

Nicholls, P. K., Stanton, P. G., Chen, J. L., Olcorn, J. S., Haverfield, J. T., Qian, H., Walton, K. L., Gregorevic, P. & Harrison, C. A., 2012, In : Endocrinology. 153, 12, p. 6065 - 6077 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin

Winbanks, C. E., Weeks, K. L., Thomson, R. E., Sepulveda, P. V., Beyer, C., Qian, H., Chen, J. L., Allen, J. M., Lancaster, G. I., Febbraio, M. A., Harrison, C. A., McMullen, J. R., Chamberlain, J. S. & Gregorevic, P., 28 Jun 2012, In : Journal of Cell Biology. 197, 7, p. 997-1008 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Lentiviral transduction of rat Sertoli cells as a means to modify gene expression

Nicholls, P. K., Stanton, P. G., Rainczuk, K. K. E., Qian, H., Gregorevic, P. & Harrison, C. A., 2012, In : Spermatogenesis. 2, 4, p. 279 - 284 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Feedback Regulation by Inhibins A and B of the Pituitary Secretion of Follicle-Stimulating Hormone

Makanji, Y., Harrison, C. A. & Robertson, D. M., 2011, In : Vitamins and Hormones-Advances in Research and Applications. 85, p. 299-321 23 p.

Research output: Contribution to journalArticleResearchpeer-review

Generation of a specific activin antagonist by modification of the activin A propeptide

Makanji, Y., Walton, K. L., Chan, K. L., Gregorevic, P., Robertson, D. M. & Harrison, C. A., Oct 2011, In : Endocrinology. 152, 10, p. 3758-3768 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Hormonal regulation of sertoli cell micro-RNAs at spermiation

Nicholls, P. K., Harrison, C. A., Walton, K. L., McLachlan, R. I., O'Donnell, L. & Stanton, P., 2011, In : Endocrinology. 152, 4, p. 1670 - 1683 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Prodomains regulate the synthesis, extracellular localisation and activity of TGF-β superfamily ligands

Harrison, C. A., Al-Musawi, S. L. & Walton, K. L., Oct 2011, In : Growth Factors. 29, 5, p. 174-186 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

Interleukin 11 and activin A synergise to regulate progesterone-induced but not cAMP-induced decidualization

Menkhorst, E., Salamonsen, L. A., Zhang, J., Harrison, C. A., Gu, J. & Dimitriadis, E., Mar 2010, In : Journal of Reproductive Immunology. 84, 2, p. 124-132 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Two distinct regions of latency-associated peptide coordinate stability of the latent transforming growth factor-beta1 complex

Walton, K. L., Makanji, Y., Chen, J., Wilce, M. C. J., Chan, K. L., Robertson, D. M. & Harrison, C. A., 2010, In : Journal of Biological Chemistry. 285, 22, p. 17029 - 17037 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

A common biosynthetic pathway governs the dimerization and secretion of inhibin and related transforming growth factor beta (TGFbeta) ligands

Walton, K., Makanji, Y., Wilce, M. C. J., Chan, K. L., Robertson, D. M. & Harrison, C. A., 2009, In : Journal of Biological Chemistry. 284, 14, p. 9311 - 9320 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Expression of nodal signalling components in cycling human endometrium and in endometrial cancer

Papageorgiou, I., Nicholls, P. K., Wang, F., Lackmann, M., Makanji, Y., Salamonsen, L. A., Robertson, D. M. & Harrison, C. A., 29 Oct 2009, In : Reproductive Biology and Endocrinology. 7, 122, 11 p., 122.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Extra-ovarian expression and activity of growth differentiation factor 9

Wang, Y., Nicholls, P. K., Stanton, P. G., Harrison, C. A., Sarraj, M., Gilchrist, R. B., Findlay, J. K. & Farnworth, P. G., 2009, In : Journal of Endocrinology. 202, 3, p. 419 - 430 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Growth differentiation factor 9 is a germ cell regulator of sertoli cell function

Nicholls, P. K., Harrison, C. A., Gilchrist, R., Farnworth, P. G. & Stanton, P. G., 2009, In : Endocrinology. 150, p. 2481 - 2490 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibin B is a more potent suppressor of rat follicle-stimulating hormone release than inhibin a in vitro and in vivo

Makanji, Y., Temple-Smith, P. D. M., Walton, K. L., Harrison, C. A. & Robertson, D., 2009, In : Endocrinology. 150, 10, p. 4784 - 4793 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Loss of betaglycan contributes to the malignant properties of human granulosa tumor cells

Bilandzic, M., Chu, S., Farnworth, P. G., Harrison, C., Nicholls, P., Wang, Y., Escalona, R. M., Fuller, P. J., Findlay, J. K. & Stenvers, K. L., Apr 2009, In : Molecular Endocrinology. 23, 4, p. 539-548 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis, purification and bioactivity of recombinant human activin A expressed in the yeast pichia pastoris

Papakonstantinou, T., Harris, S. J., Fredericks, D. P., Harrison, C. A., Wallace, E. M. & Hearn, M. T. W., 2009, In : Protein Expression and Purification. 64, p. 131 - 138 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

A distinct cohort of the TGFbeta superfamily members expressed in human endometrium regulate decidualization

Stoikos, C. J., Harrison, C. A., Salamonsen, L. A. & Dimitriadis, E., 2008, In : Human Reproduction. 23, 6, p. 1447 - 1456 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Suppression of inhibin A biological activity by alterations in the binding site for betaglycan

Makanji, Y., Walton, K., Wilce, M. C. J., Chan, K. L., Robertson, D. M. & Harrison, C. A., 2008, In : Journal of Biological Chemistry. 283, 24, p. 16743 - 16751 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

Functional analysis of the human inhibin α subunit variant A257T and its potential role in premature ovarian failure

Chand, A. L., Ooi, G. T., Harrison, C. A., Shelling, A. N. & Robertson, D. M., Dec 2007, In : Human Reproduction. 22, 12, p. 3241-3248 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibin A and B in vitro bioactivities are modified by their degree of glycosylation and their affinities to betaglycan

Makanji, Y., Harrison, C. A., Stanton, P. G., Krishna, R. & Robertson, D., 2007, In : Endocrinology. 148, 5, p. 2309 - 2316 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Mutational analysis of betaglycan/TGF-βRIII in premature ovarian failure

Chand, A. L., Robertson, D. M., Shelling, A. N. & Harrison, C. A., Jan 2007, In : Fertility and Sterility. 87, 1, p. 210-212 3 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

Activin-A binds follistatin and type II receptors through overlapping binding sites: Generation of mutants with isolated binding activities

Harrison, C. A., Chan, K. L. & Robertson, D. M., Jun 2006, In : Endocrinology. 147, 6, p. 2744-2753 10 p.

Research output: Contribution to journalArticleResearchpeer-review