20022023

Research output per year

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Research Output

2020

Aerosol Pirfenidone Pharmacokinetics after Inhaled Delivery in Sheep: a Viable Approach to Treating Idiopathic Pulmonary Fibrosis

Kaminskas, L. M., Landersdorfer, C. B., Bischof, R. J., Leong, N., Ibrahim, J., Davies, A. N., Pham, S., Beck, S., Montgomery, A. B. & Surber, M. W., 1 Jan 2020, In : Pharmaceutical Research. 37, 1, 11 p., 3.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Meropenem-Tobramycin Combination Regimens Combat Carbapenem-Resistant Pseudomonas aeruginosa in the Hollow-Fiber Infection Model Simulating Augmented Renal Clearance in Critically Ill Patients

Yadav, R., Bergen, P. J., Rogers, K. E., Kirkpatrick, C. M. J., Wallis, S. C., Huang, Y., Bulitta, J. B., Paterson, D. L., Lipman, J., Nation, R. L., Roberts, J. A. & Landersdorfer, C. B., Jan 2020, In : Antimicrobial Agents and Chemotherapy. 64, 1, 14 p., e01679-19.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Nanosilver Mitigates Biofilm Formation via FapC Amyloidosis Inhibition

Huma, Z., Javed, I., Zhang, Z., Bilal, H., Sun, Y., Hussain, S. Z., Davis, T. P., Otzen, D. E., Landersdorfer, C. B., Ding, F., Hussain, I. & Ke, P. C., 1 Jan 2020, (Accepted/In press) In : Small. 10 p., 1906674.

Research output: Contribution to journalArticleResearchpeer-review

Using machine learning to optimize antibiotic combinations: dosing strategies for meropenem and polymyxin B against carbapenem-resistant Acinetobacter baumannii

Smith, N. M., Lenhard, J. R., Boissonneault, K. R., Landersdorfer, C. B., Bulitta, J. B., Holden, P. N., Forrest, A., Nation, R. L., Li, J. & Tsuji, B. T., 12 Feb 2020, (Accepted/In press) In : Clinical Microbiology and Infection. 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2019

An optimised Cu(0)-RDRP approach for the synthesis of lipidated oligomeric vinyl azlactone: toward a versatile antimicrobial materials screening platform

Grace, J. L., Amado, M., Reid, J. C., Elliott, A. G., Landersdorfer, C. B., Truong, N. P., Kempe, K., Cooper, M. A., Davis, T. P., Montembault, V., Pascual, S., Fontaine, L., Velkov, T., Quinn, J. F. & Whittaker, M. R., 21 Nov 2019, In : Journal of Materials Chemistry B. 7, 43, p. 6796-6809 14 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Characterization of Hypermutator Pseudomonas aeruginosa Isolates from Patients with Cystic Fibrosis in Australia

Rees, V. E., Deveson Lucas, D. S., López-Causapé, C., Huang, Y., Kotsimbos, T., Bulitta, J. B., Rees, M. C., Barugahare, A., Peleg, A. Y., Nation, R. L., Oliver, A., Boyce, J. D. & Landersdorfer, C. B., 1 Apr 2019, In : Antimicrobial Agents and Chemotherapy. 63, 4, 11 p., e02538-18.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Evaluation of Tobramycin and Ciprofloxacin as a Synergistic Combination Against Hypermutable Pseudomonas Aeruginosa Strains via Mechanism-Based Modelling

Rees, V. E., Bulitta, J. B., Oliver, A., Nation, R. L. & Landersdorfer, C. B., 1 Sep 2019, In : Pharmaceutics. 11, 9, 17 p., 470.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Four Decades of β-Lactam Antibiotic Pharmacokinetics in Cystic Fibrosis

Bulitta, J. B., Jiao, Y., Drescher, S. K., Oliver, A., Louie, A., Moya, B., Tao, X., Wittau, M., Tsuji, B. T., Zavascki, A. P., Shin, B. S., Drusano, G. L., Sörgel, F. & Landersdorfer, C. B., 6 Feb 2019, In : Clinical Pharmacokinetics. 58, 2, p. 143-156 14 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Optimization of dosing regimens of intravenous colistin in patients with cystic fibrosis: What data are required?

Nation, R. L. & Landersdorfer, C. B., 2019, In : Pediatric Pulmonology. 54, 10, p. 1497-1498 3 p.

Research output: Contribution to journalLetterOtherpeer-review

1 Citation (Scopus)

Population Pharmacokinetics of Intravenous Colistin in Pediatric Patients: Implications for the Selection of Dosage Regimens

Ooi, M. H., Ngu, S. J., Chor, Y. K., Li, J., Landersdorfer, C. B. & Nation, R. L., 13 Nov 2019, In : Clinical Infectious Diseases. 69, 11, p. 1962-1969 8 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)
2018

Combating Carbapenem-Resistant Acinetobacter baumannii by an Optimized Imipenem-plus-Tobramycin Dosage Regimen: Prospective Validation via Hollow-Fiber Infection and Mathematical Modeling

Landersdorfer, C. B., Yadav, R., Rogers, K. E., Kim, T. H., Shin, B. S., Boyce, J. D., Nation, R. L. & Bulitta, J. B., 1 Apr 2018, In : Antimicrobial Agents and Chemotherapy. 62, 4, 8 p., e02053-17.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)

Differences in suppression of regrowth and resistance despite similar initial bacterial killing for meropenem and piperacillin/tazobactam against Pseudomonas aeruginosa and Escherichia coli

Bergen, P. J., Bulitta, J. B., Sime, F. B., Lipman, J., McGregor, M. J., Millen, N., Paterson, D. L., Kirkpatrick, C. M. J., Roberts, J. A. & Landersdorfer, C. B., 1 May 2018, In : Diagnostic Microbiology and Infectious Disease. 91, 1, p. 69-76 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)
4 Citations (Scopus)

Erratum: Correction to: Lessons learned in the development of sustained release penicillin drug delivery systems for the prophylactic treatment of rheumatic heart disease (RHD) (Drug delivery and translational research (2018) 8 3 (729-739))

Montagnat, O. D., Webster, G. R., Bulitta, J. B., Landersdorfer, C., Wyber, R., Sheel, M., Carapetis, J. R. & Boyd, B. J., 1 Jun 2018, In : Drug Delivery and Translational Research. 8, 3, p. 863-863 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access

First population pharmacokinetic analysis showing increased quinolone metabolite formation and clearance in patients with cystic fibrosis compared to healthy volunteers

Jiao, Y., Kim, T. H., Tao, X., Kinzig, M., Landersdorfer, C. B., Drescher, S. K., Sutaria, D. S., Moya, B., Holzgrabe, U., Sörgel, F. & Bulitta, J. B., 15 Oct 2018, In : European Journal of Pharmaceutical Sciences. 123, p. 416-428 13 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

In reply

Wong, A., Landersdorfer, C. B. & Graudins, A., 1 Feb 2018, In : European Journal of Clinical Pharmacology. 74, 2, p. 253-253 1 p.

Research output: Contribution to journalLetterOtherpeer-review

Open Access
File

Lessons learned in the development of sustained release penicillin drug delivery systems for the prophylactic treatment of rheumatic heart disease (RHD)

Montagnat, O. D., Webster, G. R., Bulitta, J. B., Landersdorfer, C., Wyber, R., Sheel, M., Carapetis, J. R. & Boyd, B. J., 5 Feb 2018, In : Drug Delivery and Translational Research. 8, 3, p. 729-739 11 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Meropenem Combined with Ciprofloxacin Combats Hypermutable Pseudomonas aeruginosa from Respiratory Infections of Cystic Fibrosis Patients

Rees, V. E., Yadav, R., Rogers, K. E., Bulitta, J. B., Wirth, V., Oliver, A., Boyce, J. D., Peleg, A. Y., Nation, R. L. & Landersdorfer, C. B., 1 Nov 2018, In : Antimicrobial Agents and Chemotherapy. 62, 11, 12 p., e01150-18.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Optimization and evaluation of piperacillin-tobramycin combination dosage regimens against Pseudomonas aeruginosa for patients with altered pharmacokinetics via the hollow-fiber infection model and mechanism-based modeling

Yadav, R., Rogers, K. E., Bergen, P. J., Bulitta, J. B., Kirkpatrick, C. M. J., Wallis, S. C., Paterson, D. L., Nation, R. L., Lipman, J., Roberts, J. A. & Landersdorfer, C. B., 1 May 2018, In : Antimicrobial Agents and Chemotherapy. 62, 5, 12 p., e00078.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Optimization of a meropenem-tobramycin combination dosage regimen against hypermutable and nonhypermutable pseudomonas aeruginosa via mechanism-based modeling and the hollow-fiber infection model

Landersdorfer, C. B., Rees, V. E., Yadav, R., Rogers, K. E., Kim, T. H., Bergen, P. J., Cheah, S-E., Boyce, J. D., Peleg, A. Y., Oliver, A., Shin, B. S., Nation, R. L. & Bulitta, J. B., 1 Apr 2018, In : Antimicrobial Agents and Chemotherapy. 62, 4, 13 p., e02055-17.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
7 Citations (Scopus)

Personalizing Polymyxin B dosing using an adaptive feedback control algorithm

Lakota, E. A., Landersdorfer, C. B., Nation, R. L., Li, J., Kaye, K. S., Rao, G. G. & Forrest, A., 1 Jul 2018, In : Antimicrobial Agents and Chemotherapy. 62, 7, 9 p., e00483-18.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
5 Citations (Scopus)

Pharmacokinetics/pharmacodynamics of systemically administered polymyxin B against Klebsiella pneumoniae in mouse thigh and lung infection models

Landersdorfer, C. B., Wang, J., Wirth, V., Chen, K., Kaye, K. S., Tsuji, B., Li, J. & Nation, R. L., 1 Feb 2018, In : Journal of Antimicrobial Chemotherapy. 73, 2, p. 462-468 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
21 Citations (Scopus)

Population pharmacokinetic analyses for ertapenem in subjects with a wide range of body sizes

Lakota, E. A., Landersdorfer, C. B., Zhang, L., Nafziger, A. N., Bertino, J. S., Bhavnani, S. M. & Forrest, A., 1 Oct 2018, In : Antimicrobial Agents and Chemotherapy. 62, 10, 11 p., e00784.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Prolonged and continuous antibacterial and anti-biofilm activities of thin films embedded with gentamicin-loaded mesoporous silica nanoparticles

Tamanna, T., Landersdorfer, C. B., Ng, H. J., Bulitta, J., Wood, P. & Yu, A., 1 Aug 2018, In : Applied Nanoscience. 8, 6, p. 1471-1482 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

The pharmacokinetics of intranasal droperidol in volunteers characterised via population modelling

Cooper, I., Landersdorfer, C. B., St John, A. G. & Graudins, A., 1 Jan 2018, In : SAGE Open Medicine. 6, 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2017

Aminoglycoside concentrations required for synergy with carbapenems against Pseudomonas aeruginosa determined via mechanistic studies and modeling

Yadav, R., Bulitta, J. B., Schneider, E. K., Shin, B. S., Velkov, T., Nation, R. L. & Landersdorfer, C. B., 1 Dec 2017, In : Antimicrobial Agents and Chemotherapy. 61, 12, 16 p., e00722.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
14 Citations (Scopus)

Characterizing the time-course of antihypertensive activity and optimal dose range of fimasartan via mechanism-based population modeling

Bulitta, J. B., Paik, S. H., Chi, Y. H., Kim, T. H., Shin, S., Landersdorfer, C. B., Jiao, Y., Yadav, R. & Shin, B. S., 30 Sep 2017, In : European Journal of Pharmaceutical Sciences. 107, p. 32-44 13 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

High-intensity meropenem combinations with polymyxin B: new strategies to overcome carbapenem resistance in Acinetobacter baumannii

Lenhard, J. R., Bulitta, J. B., Connell, T. D., King-Lyons, N., Landersdorfer, C., Cheah, S-E., Thamlikitkul, V., Shin, B. S., Rao, G., Holden, P. N., Walsh, T. J., Forrest, A., Nation, R. L., Li, J. & Tsuji, B. T., 2017, In : Journal of Antimicrobial Chemotherapy. 72, 1, p. 153-165 13 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

In reply

Wong, A., Landersdorfer, C. B. & Graudins, A., 19 Nov 2017, In : European Journal of Clinical Pharmacology.

Research output: Contribution to journalLetterOtherpeer-review

Lithium in paediatric patients with bipolar disorder: implications for selection of dosage regimens via population pharmacokinetics/pharmacodynamics

Landersdorfer, C. B., Findling, R. L., Frazier, J. A., Kafantaris, V. & Kirkpatrick, C. M. J., Jan 2017, In : Clinical Pharmacokinetics. 56, 1, p. 77-90 14 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)
8 Citations (Scopus)

Pharmakokinetik und Pharmakodynamik von Antibiotika in der Intensivmedizin

Translated title of the contribution: Pharmacokinetics and pharmacodynamics of antibiotics in intensive careSorgel, F., Höhl, R., Glaser, R., Stelzer, C., Munz, M., Vormittag, M., Kinzig, M., Bulitta, J., Landersdorfer, C., Junger, A., Christ, M., Wilhelm, M. & Holzgrabe, U., Feb 2017, In : Medizinische Klinik - Intensivmedizin und Notfallmedizin. 112, 1, p. 11-22 12 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Substantial impact of altered pharmacokinetics in critically Ill patients on the antibacterial effects of meropenem evaluated via the dynamic hollow-fiber infection model

Bergen, P. J., Bulitta, J. B., Kirkpatrick, C. M. J., Rogers, K. E., McGregor, M. J., Wallis, S. C., Paterson, D. L., Nation, R. L., Lipman, J., Roberts, J. A. & Landersdorfer, C. B., 1 May 2017, In : Antimicrobial Agents and Chemotherapy. 61, 5, 14 p., e02642.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Substantial targeting advantage achieved by pulmonary administration of colistin methanesulfonate in a large-animal model

Landersdorfer, C., Nguyen, T-H., Lieu, L. T., Nguyen, G., Bischof, R., Meeusen, E., Li, J., Nation, R. & McIntosh, M., 1 Jan 2017, In : Antimicrobial Agents and Chemotherapy. 61, 1, 15 p., e01934-16.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Comparative pharmacodynamics of four different carbapenems in combination with polymyxin B against carbapenem-resistant Acinetobacter baumannii

Lenhard, J. R., Gall, J. S., Bulitta, J. B., Thamlikitkul, V., Landersdorfer, C. B., Forrest, A., Nation, R. L., Li, J. & Tsuji, B. T., 1 Dec 2016, In : International Journal of Antimicrobial Agents. 48, 6, p. 719-724 6 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Conjugation of 10 kDa linear PEG onto trastuzumab Fab′ is sufficient to significantly enhance lymphatic exposure while preserving in vitro biological activity

Chan, L., Ascher, D. B., Yadav, R., Bulitta, J., Williams, C. C., Porter, C., Landersdorfer, C. & Kaminskas, L., 2016, In : Molecular Pharmaceutics. 13, 4, p. 1229-1241 13 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Effect of different renal function on antibacterial effects of piperacillin against Pseudomonas aeruginosa evaluated via the hollow-fibre infection model and mechanism-based modelling

Bergen, P. J., Bulitta, J. B., Kirkpatrick, C. M. J., Rogers, K. E., McGregor, M. J., Wallis, S. C., Paterson, D. L., Lipman, J., Roberts, J. A. & Landersdorfer, C. B., 1 Sep 2016, In : Journal of Antimicrobial Chemotherapy. 71, 9, p. 2509-2520 12 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

External manipulation of nanostructure in photoresponsive lipid depot matrix to control and predict drug release in vivo

Fong, W-K., Hanley, T. L., Thierry, B., Hawley, A., Boyd, B. J. & Landersdorfer, C. B., 28 Apr 2016, In : Journal of Controlled Release. 228, p. 67-73 7 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Paradoxical effect of polymyxin B: high drug exposure amplifies resistance in Acinetobacter baumannii

Tsuji, B. T., Landersdorfer, C. B., Lenhard, J. R., Cheah, S-E., Thamlikitkul, V., Rao, G. G., Holden, P. N., Forrest, A., Bulitta, J. B., Nation, R. L. & Li, J., 1 Jul 2016, In : Antimicrobial Agents and Chemotherapy. 60, 7, p. 3913-3920 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
22 Citations (Scopus)

Polymyxin B in combination with doripenem against heteroresistant Acinetobacter baumannii: pharmacodynamics of new dosing strategies

Rao, G. G., Ly, N. S., Bulitta, J. B., Soon, R. L., San Roman, M. D., Holden, P. N., Landersdorfer, C. B., Nation, R. L., Li, J., Forrest, A. & Tsuji, B. T., 1 Nov 2016, In : Journal of Antimicrobial Chemotherapy. 71, 11, p. 3148-3156 9 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Population pharmacokinetic/pharmacodynamic modelling of dipeptidyl peptidase IV inhibitors

Landersdorfer, C. B., 2016, In : Clinical Pharmacokinetics. 54, 7, p. 673 - 675 3 p.

Research output: Contribution to journalLetterOther

Resistance suppression by high-intensity, short-duration aminoglycoside exposure against hypermutable and non-hypermutable Pseudomonas aeruginosa

Rees, V. E., Bulitta, J. B., Oliver, A., Tsuji, B. T., Rayner, C. R., Nation, R. L. & Landersdorfer, C. B., 1 Nov 2016, In : Journal of Antimicrobial Chemotherapy. 71, 11, p. 3157-3167 11 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)
2015

Colistin: how should It Be dosed for the critically ill?

Landersdorfer, C. B. & Nation, R. L., 2015, In : Seminars in Respiratory and Critical Care Medicine. 36, 1, p. 126-135 10 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Colistin and doripenem combinations against Pseudomonas aeruginosa: profiling the time course of synergistic killing and prevention of resistance

Ly, N. S., Bulitta, J. B., Rao, G. G., Landersdorfer, C. B., Holden, P. N., Forrest, A., Bergen, P. J., Nation, R. L., Li, J. & Tsuji, B., 2015, In : Journal of Antimicrobial Chemotherapy. 70, 5, p. 1434 - 1442 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
39 Citations (Scopus)