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2020

Experimental traumatic brain injury does not lead to lung infection

Sun, M., Brady, R. D., Wanrooy, B., Mychasiuk, R., Yamakawa, G. R., Casillas-Espinosa, P. M., Wong, C. H. Y., Shultz, S. R. & McDonald, S. J., 15 Jun 2020, In : Journal of Neuroimmunology. 343, 4 p., 577239.

Research output: Contribution to journalArticleResearchpeer-review

2019

Advanced age promotes colonic dysfunction and gut-derived lung infection after stroke

Wen, S. W., Shim, R., Ho, L., Wanrooy, B. J., Srikhanta, Y., Prame Kumar, K., Nicholls, A. J., Shen, S., Sepehrizadeh, T., De Veer, M., Srikanth, V., Ma, H., Phan, T., Lyras, D. & Wong, C., 1 Oct 2019, In : Aging Cell. 18, 5, 13 p., e12980.

Research output: Contribution to journalArticleResearchpeer-review

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2 Citations (Scopus)

Chronic sympathetic driven hypertension promotes atherosclerosis by enhancing hematopoiesis

Al-Sharea, A., Lee, M. K. S., Whillas, A., Michell, D. L., Shihata, W. A., Nicholls, A. J., Cooney, O. D., Kraakman, M. J., Veiga, C. B., Jefferis, A. M., Jackson, K., Nagareddy, P. R., Lambert, G., Wong, C. H. Y., Andrews, K. L., Head, G. A., Chin-Dusting, J. & Murphy, A. J., 28 Feb 2019, In : Haematologica: the hematology journal. 104, 3, p. 456-467 12 p.

Research output: Contribution to journalArticleResearchpeer-review

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7 Citations (Scopus)

Stroke Severity, and Not Cerebral Infarct Location, Increases the Risk of Infection

Shim, R., Wen, S. W., Wanrooy, B. J., Rank, M., Thirugnanachandran, T., Ho, L., Sepehrizadeh, T., de Veer, M., Srikanth, V. K., Ma, H., Phan, T. G., Sobey, C. G. & Wong, C. H. Y., 10 Nov 2019, (Accepted/In press) In : Translational Stroke Research. 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Activation of the sympathetic nervous system modulates neutrophil function

Nicholls, A. J., Wen, S. W., Hall, P., Hickey, M. J. & Wong, C. H. Y., 1 Feb 2018, In : Journal of leukocyte biology. 103, 2, p. 295-309 15 p.

Research output: Contribution to journalArticleResearchpeer-review

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12 Citations (Scopus)

An insight into intestinal mucosal microbiota disruption after stroke

Stanley, D., Moore, R. J. & Wong, C. H. Y., 1 Dec 2018, In : Scientific Reports. 8, 1, 12 p., 568.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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17 Citations (Scopus)

Distinct contributions of hyperglycemia and high-fat feeding in metabolic syndrome-induced neuroinflammation

Wanrooy, B. J., Kumar, K. P., Wen, S. W., Qin, C. X., Ritchie, R. H. & Wong, C. H. Y., 22 Oct 2018, In : Journal of Neuroinflammation. 15, 1, 13 p., 293.

Research output: Contribution to journalArticleResearchpeer-review

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4 Citations (Scopus)

IL-33 modulates inflammatory brain injury but exacerbates systemic immunosuppression following ischemic stroke

Zhang, S. R., Piepke, M., Chu, H. X., Broughton, B. R. S., Shim, R., Wong, C. H. Y., Lee, S., Evans, M. A., Vinh, A., Sakkal, S., Arumugam, T. V., Magnus, T., Huber, S., Gelderblom, M., Drummond, G. R., Sobey, C. G. & Kim, H. A., 20 Sep 2018, In : JCI Insight. 3, 18, 16 p., e121560.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Invariant natural killer T cells shape the gut microbiota and regulate neutrophil recruitment and function during intestinal inflammation

Shen, S., Kumar, K. P., Stanley, D., Moore, R. J., Hao Van, T. T., Wen, S. W., Hickey, M. J. & Wong, C. H. Y., 7 May 2018, In : Frontiers in Immunology. 9, 15 p., 999.

Research output: Contribution to journalArticleResearchpeer-review

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7 Citations (Scopus)

Sex-hormone-driven innate antibodies protect females and infants against EPEC infection

Zeng, Z., Surewaard, B. G. J., Wong, C. H. Y., Guettler, C., Petri, B., Burkhard, R., Wyss, M., Le Moual, H., Devinney, R., Thompson, G. C., Blackwood, J., Joffe, A. R., McCoy, K. D., Jenne, C. N. & Kubes, P., 1 Oct 2018, In : Nature Immunology. 19, 10, p. 1100-1111 12 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)
2017

An unexplored brain-gut microbiota axis in stroke

Wen, S. W. & Wong, C. H. Y., 2017, In : Gut Microbes. 8, 6, p. 601-606 6 p.

Research output: Contribution to journalArticleOtherpeer-review

20 Citations (Scopus)

Prolonged activation of invariant natural killer T cells and TH2-skewed immunity in stroke patients

Wong, C. H. Y., Jenne, C. N., Tam, P., Léger, C., Venegas, A., Ryckborst, K., Hill, M. D. & Kubes, P., 19 Jan 2017, In : Frontiers in Neurology. 8, JAN, 9 p., 6.

Research output: Contribution to journalArticleResearchpeer-review

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10 Citations (Scopus)

Type-I interferon signalling through IFNAR1 plays a deleterious role in the outcome after stroke

Zhang, M., Downes, C. E., Wong, C., Brody, K. M., Guio-Agulair, P. L., Gould, J., Ates, R., Hertzog, P. J., Taylor, J. M. & Crack, P. J., 1 Sep 2017, In : Neurochemistry International. 108, p. 472-480 9 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)
2016

Avenues to autoimmune arthritis triggered by diverse remote inflammatory challenges

Chevalier, N., Tan, J. K., Mason, L. J., Robert, R., McKenzie, C. I., Lim, F., Wong, C. H., Macia, L., Thorburn, A. N., Russ, B. E., Masters, S. L. & Mackay, C. R., 1 Sep 2016, In : Journal of Autoimmunity. 73, p. 120-129 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

CRIg Functions as a Macrophage Pattern Recognition Receptor to Directly Bind and Capture Blood-Borne Gram-Positive Bacteria

Zeng, Z., Surewaard, B. G. J., Wong, C. H. Y., Geoghegan, J. A., Jenne, C. N. & Kubes, P., 13 Jul 2016, In : Cell Host and Microbe. 20, 1, p. 99-106 8 p.

Research output: Contribution to journalArticleResearchpeer-review

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48 Citations (Scopus)

G protein-coupled receptor 43 modulates neutrophil recruitment during acute inflammation

Kamp, M. E., Shim, R., Nicholls, A. J., Oliveira, A. C., Mason, L. J., Binge, L., Mackay, C. R. & Wong, C. H. Y., 22 Sep 2016, In : PLoS ONE. 11, 9, 15 p., e0163750.

Research output: Contribution to journalArticleResearchpeer-review

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22 Citations (Scopus)

Protective actions of des-Acylated ghrelin on brain injury and blood-Brain barrier disruption after stroke in mice

Ku, J. M., Taher, M., Chin, K. Y., Barsby, T., Austin, V., Wong, C. H. Y., Andrews, Z. B., Spencer, S. J. & Miller, A. A., 26 Jul 2016, In : Clinical Science. 130, 17, p. 1545-1558 14 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

The role of follicular helper T cell molecules and environmental influences in autoantibody production and progression to inflammatory arthritis in mice

Chevalier, N., Macia, L., Tan, J. K., Mason, L. J., Robert, R., Thorburn, A. N., Wong, C. H. Y., Tsai, L. M., Bourne, K., Brink, R., Yu, D. & Mackay, C. R., 4 Apr 2016, In : Arthritis & Rheumatology. 68, 4, p. 1026-1038 13 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Translocation and dissemination of commensal bacteria in post-stroke infection

Stanley, D., Mason, L. J., MacKin, K. E., Srikhanta, Y. N., Lyras, D., Prakash, M. D., Nurgali, K., Venegas, A., Hill, M. D., Moore, R. J. & Wong, C. H. Y., 1 Nov 2016, In : Nature Medicine. 22, 11, p. 1277-1284 8 p.

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)
2015

A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury

Dal-Secco, D., Wang, J., Zeng, Z., Kolaczkowska, E., Wong, C. H. Y., Petri, B., Ransohoff, R. M., Charo, I. F., Jenne, C. N. & Kubes, P., 2015, In : Journal of Experimental Medicine. 212, 4, p. 447 - 456 10 p.

Research output: Contribution to journalArticleResearchpeer-review

167 Citations (Scopus)

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

Thorburn, A. N., McKenzie, C., Shen, S. S., Stanley, D., Macia, L., Mason, L. J., Roberts, L. K., Wong, C. H. Y., Shim, R., Robert, R., Chevalier, N., Tan, J. K., Marino, E. M., Moore, R. J., Wong, L. H. H., McConville, M. J., Tull, D. L., Wood, L., Murphy, V., Mattes, J. & 3 others, Gibson, P. G., Wood, L. G. & Mackay, C. R., 2015, In : Nature Communications. 6, 7320, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
282 Citations (Scopus)

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

Macia, L., Tan, J., Vieira, A. T., Leach, K., Stanley, D., Luong, S., Maruya, M., McKenzie, C., Hijikata, A., Wong, C. H. Y., Binge, L. C., Thorburn, A. N., Chevalier, N., Ang Kim Lian, C., Marino Moreno, E., Robert, R., Offermanns, S., Teixeira, M. M., Moore, R. J., Flavell, R. A. & 2 others, Fagarasan, S. & Mackay, C. R., 2015, In : Nature Communications. 6, (Art. No: 7734), p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
323 Citations (Scopus)
2014

Invariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia

Lee, W-Y., Sanz, M-J., Wong, C. H. Y., Hardy, P-O., Salman-Dilgimen, A., Moriarty, T. J., Chaconas, G., Marques, A., Krawetz, R., Mody, C. H. & Kubes, P., 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 38, p. 13936 - 13941 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
30 Citations (Scopus)
2013

Characterization of migration parameters on peripheral and central nervous system T cells following treatment of experimental allergic encephalomyelitis with CRYAB

Oyebamiji, A. I., Finlay, T. M., Hough, R. M., Hoghooghi, V., Lim, E-M. F., Wong, C. H. Y. & Ousman, S. S., 2013, In : Journal of Neuroimmunology. 259, 1-2, p. 66 - 74 9 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Imaging natural killer T cells in action

Wong, C. H. Y. & Kubes, P., 2013, In : Immunology and Cell Biology. 91, 4, p. 304 - 310 7 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

MyD88 is a critical regulator of hematopoietic cell-mediated neuroprotection seen after stroke

Downes, C. E., Wong, C. H. Y., Henley, K. J., Guio-Aguilar, P. L., Zhang, M., Ates, R., Mansell, A. S., Kile, B. T. & Crack, P. J., 2013, In : PLoS ONE. 8, 3, 8 p., e57948.

Research output: Contribution to journalArticleResearchpeer-review

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16 Citations (Scopus)

Neutrophils recruited to sites of infection protect from virus challenge by releasing neutrophil extracellular traps

Jenne, C. N., Wong, C. H. Y., Zemp, F. J., McDonald, B., Rahman, M. M., Forsyth, P. A., McFadden, G. & Kubes, P., 2013, In : Cell Host and Microbe. 13, 2, p. 169 - 180 12 p.

Research output: Contribution to journalArticleResearchpeer-review

183 Citations (Scopus)

Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance

Wong, C. H. Y., Jenne, C. N., Petri, B., Chrobok, N. L. & Kubes, P., 2013, In : Nature Immunology. 14, 8, p. 785 - 792 8 p.

Research output: Contribution to journalArticleResearchpeer-review

163 Citations (Scopus)
2012

Insulin-regulated aminopeptidase deficiency provides protection against ischemic stroke in mice

Pham, V., Albiston, A., Downes, C., Wong, C. H. Y., Diwakarla, L. P., Ng, L., Lee, S., Crack, P. & Chai, S., 2012, In : Journal of Neurotrauma. 29, 6, p. 1243 - 1248 6 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis

Langer, H. F., Choi, E. Y., Zhou, H., Schleicher, R., Chung, K-J., Tang, Z., Gobel, K., Bdeir, K., Chatzigeorgiou, A., Wong, C. H. Y., Bhatia, S., Kruhlak, M. J., Rose, J. W., Burns, J. B. Y., Hill, K. E., Qu, H., Zhang, Y., Lehrmann, E., Becker, K. G., Wang, Y. & 7 others, Simon, D. I., Nieswandt, B., Lambris, J. D., Li, X., Meuth, S. G., Kubes, P. & Chavakis, T., 2012, In : Circulation Research. 110, 9, p. 1202 - 1210 9 p.

Research output: Contribution to journalArticleResearchpeer-review

110 Citations (Scopus)
2011

A global transcriptomic view of the multifaceted role of glutathione peroxidase-1 in cerebral ischemic-reperfusion injury

Chen, M. J., Wong, C. H. Y., Peng, Z. F., Manikandan, J., Melendez, A. J., Tan, T. M., Crack, P. J. & Sang Cheung, N., 2011, In : Free Radical Biology and Medicine. 50, 6, p. 736 - 748 13 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Divergent roles of Glutathione Peroxidase-1 (Gpx1) in regulation of leukocyte-endothelial cell interactions in the inflamed cerebral microvasculature

Wong, C. H. Y., Abeynaike, L., Crack, P. & Hickey, M., 2011, In : Microcirculation. 18, 1, p. 12 - 23 12 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Functional innervation of hepatic iNKT cells is immunosuppressive following stroke

Wong, C. H. Y., Jenne, C. N., Lee, W-Y., Leger, C. & Kubes, P., 2011, In : Science. 334, 6052, p. 101 - 105 5 p.

Research output: Contribution to journalArticleResearchpeer-review

229 Citations (Scopus)

The role of CD14 in neutrophil recruitment within the liver microcirculation during endotoxemia

McAvoy, E. F., McDonald, B., Parsons, S. A., Wong, C. H. Y., Landmann, R. & Kubes, P., 2011, In : Journal of Immunology. 186, 4, p. 2592 - 2601 10 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

The use of spinning-disk confocal microscopy for the intravital analysis of platelet dynamics in response to systemic and local inflammation

Jenne, C. N., Wong, C. H. Y., Petri, B. & Kubes, P., 2011, In : PLoS ONE. 6, 9, 13 p., e25109.

Research output: Contribution to journalArticleResearchpeer-review

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59 Citations (Scopus)
2010

An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells

Lee, W-Y., Moriarty, T., Wong, C. H. Y., Zhou, H., Strieter, R. M., van Rooijen, N., Chaconas, G. & Kubes, P., 2010, In : Nature Immunology. 11, 4, p. 295 - 302 8 p.

Research output: Contribution to journalArticleResearchpeer-review

197 Citations (Scopus)

Molecular regulators of leucocyte chemotaxis during inflammation

Wong, C. H. Y., Heit, B. & Kubes, P., 2010, In : Cardiovascular Research. 86, 2, p. 183 - 191 9 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)
2009

A nonfibrin macromolecular cofactor for tPA-mediated plasmin generation following cellular injury

Samson, A. L., Borg, R. J., Niego, B., Wong, C. H. Y., Crack, P. J., Yongqing, T. & Medcalf, R. L., 2009, In : Blood. 114, 9, p. 1937 - 1946 10 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Role of endothelial TLR4 for neutrophil recruitment into central nervous system microvessels in systemic inflammation

Zhou, H., Andonegui, G., Wong, C. H. Y. & Kubes, P., 2009, In : Journal of Immunology. 183, 8, p. 5244 - 5250 7 p.

Research output: Contribution to journalArticleResearchpeer-review

93 Citations (Scopus)
2008

Absence of glutathione peroxidase-1 exacerbates cerebral ischemia-reperfusion injury by reducing post-ischemic microvascular perfusion

Wong, C. H. Y., Bozinovski, S., Hertzog, P. J., Hickey, M. J. & Crack, P. J., 2008, In : Journal of Neurochemistry. 107, 1, p. 241 - 252 12 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)

Modulation of neuro-inflammation and vascular response by oxidative stress following cerebral ischemia-reperfusion injury

Wong, C. H. Y. & Crack, P. J., 2008, In : Current Medicinal Chemistry. 15, 1, p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

137 Citations (Scopus)