Projects per year
Personal profile
Biography
Professor Constantine (Con) Tam is Head of the Lymphoma Service at Alfred Health and School of Translational Medicine.
Con received his M.B.B.S.(Hons) and M.D. degrees from the University of Melbourne. After dual training in Haematology and Haematopathology, Con completed his Leukemia Fellowship at MD Anderson Cancer Centre in Houston, Texas. Prior to moving to the Alfred, Con served as Disease Group Lead for Low Grade Lymphoma and CLL at Peter MacCallum Cancer Centre & Royal Melbourne Hospital for over 10 years. He is also past Director of Haematology at St. Vincent's Hospital.
Con is passionate about developing new treatments for blood cancers. He is the global lead for the BTK inhibitor zanubrutinib, and oversaw its development from the first-in-human dosing (in Melbourne) to successful international licensing studies worldwide. Con designed and performed the first global study to combine ibrutinib and venetoclax, publishing the results in the New England Journal of Medicine 5 years after inception. In 2015, he became the Australian lead for the pivotal study of Tisagenlecleucel in diffuse large B-cell lymphoma, leading to public funding for CAR T-cells as standard treatment in Australia.
The publication record for Con includes 240 peer-reviewed papers in New England Journal of Medicine, Lancet, Journal of Clinical Oncology, Blood and other top-tier journals. His work has been cited >17,000 times in the literature. Con is the current Lymphoma Editor for Blood Advances.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Oncology
- Haematology
- Chronic Lymphocytic Leukemia
- Hairy Cell Leukemia
- Waldenstrom’s Macroglobulinemia
- Relapsed Mantle Cell Lymphoma
- Lymphoma
- Myeloproliferative Diseases
- Genomics
Collaborations and top research areas from the last five years
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A Phase 3, Open-Label, Randomized Study to Evaluate the Safety and Efficacy of BGB-16673 Compared to Pirtobrutinib in Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Si Lun Tam, C. (Primary Chief Investigator (PCI))
7/08/25 → 6/08/27
Project: Research
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Clonal dynamics of chronic lymphocytic leukemia treated with Pirtobrutinib after previous treatment with Zanubrutinib (PiPoZa)
Si Lun Tam, C. (Primary Chief Investigator (PCI))
30/07/25 → 29/07/27
Project: Research
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A Phase 3 Randomized, Open-Label, Multicenter Study of Sonrotoclax Plus Anti-CD20 Antibody Therapies Versus Venetoclax Plus Rituximab in Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Si Lun Tam, C. (Primary Chief Investigator (PCI))
18/07/25 → 17/07/27
Project: Research
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The ACRF Centre for Dynamic Immuno-Oncology (CDIO)
Shackleton, M. (Primary Chief Investigator (PCI)), Cherk, M. (Chief Investigator (CI)), Naranbhai, V. (Chief Investigator (CI)), McLean, C. (Chief Investigator (CI)), Monif, M. (Chief Investigator (CI)), Si Lun Tam, C. (Chief Investigator (CI)), Kalff, A. (Chief Investigator (CI)), Fleming, S. (Chief Investigator (CI)), Mar, V. (Chief Investigator (CI)), Ge, Z. (Chief Investigator (CI)) & Cheung, J. (Project Manager)
7/04/25 → 7/01/30
Project: Research
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A Phase 3, Open-Label, Randomized Study of BGB-16673 Compared to Investigator’s Choice (Idelalisib Plus Rituximab or Bendamustine Plus Rituximab or Venetoclax Plus Rituximab Retreatment) in Patients With Chronic Lymphocytic Leukemia Previously Exposed to Both BTK and BCL2 Inhibitors
Si Lun Tam, C. (Primary Chief Investigator (PCI))
27/03/25 → 26/03/27
Project: Research
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CLOX and neurotox: Utility of the clock drawing task in monitoring for immune effector cell-associated neurotoxicity syndrome following chimeric antigen receptor T-cell therapy
Kazzi, C., Simpson, T., Wronski, M., Seery, N., Wesselingh, R., Tan, T. H., Ko, K. Y., Pearce, D. J., Abbott, C., Li, J., Griffith, S. P., Wong, S. M., Westworth, M., Inam, S., Tam, C. S., Fleming, S., Van Der Walt, A., O'Brien, T. J., Alpitsis, R. & Spencer, A. & 3 others, , Oct 2025, In: British Journal of Haematology. 207, 4, p. 1495-1503 9 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Monitoring the neurological complications of chimeric antigen receptor (CAR) T-cell therapy in patients with sensory and physical impairments and non-native-speaking backgrounds using modified immune effector cell-associated encephalopathy (ICE) scores: a case series
Kazzi, C., Simpson, T., Abbott, C., Wronski, M., Seery, N., Tan, T. H. L., Wesselingh, R., Ko, K., Wong, S. M., Inam, S., Tam, C., Fleming, S., O’Brien, T. J., Alpitsis, R., Spencer, A., Malpas, C. & Monif, M., 12 Feb 2025, In: BMJ Neurology Open. 7, 1, 9 p., e000927.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Neurotoxicity associated with chimeric antigen receptor T-cell therapy
Wronski, M., Wesselingh, R., Kazzi, C., Seery, N., Ko, K., Li, J., Tan, T. H., Simpson, T., Abbott, C., Fleming, S., Inam, S., Tam, C. S., Wong, S. M., O'Brien, T., van der Walt, A., Spencer, A., Butzkueven, H. & Monif, M., 15 Oct 2025, In: Journal of Neuroimmunology. 407, 25 p., 578717.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Tranexamic acid versus placebo to prevent bleeding in patients with haematological malignancies and severe thrombocytopenia (TREATT): a randomised, double-blind, parallel, phase 3 superiority trial
TREATT Trial Investigators, Jan 2025, In: The Lancet Haematology. 12, 1, p. e14-e22 9 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile6 Citations (Scopus) -
Australia and New Zealand consensus position statement: use of COVID-19 therapeutics in patients with haematological malignancies
Campbell, A., Teh, B., Mulligan, S., Ross, D. M., Weinkove, R., Gilroy, N., Gangatharan, S., Prince, H. M., Szer, J., Trotman, J., Lane, S., Dickinson, M., Quach, H., Enjeti, A. K., Ku, M., Gregory, G., Hapgood, G., Ho, P. J., Cochrane, T. & Cheah, C. & 8 others, , Feb 2024, In: Internal Medicine Journal. 54, 2, p. 328-336 9 p.Research output: Contribution to journal › Article › Other › peer-review
Open Access