Projects per year
Personal profile
Biography
Professor Constantine (Con) Tam is Head of the Lymphoma Service at Alfred Health and School of Translational Medicine.
Con received his M.B.B.S.(Hons) and M.D. degrees from the University of Melbourne. After dual training in Haematology and Haematopathology, Con completed his Leukemia Fellowship at MD Anderson Cancer Centre in Houston, Texas. Prior to moving to the Alfred, Con served as Disease Group Lead for Low Grade Lymphoma and CLL at Peter MacCallum Cancer Centre & Royal Melbourne Hospital for over 10 years. He is also past Director of Haematology at St. Vincent's Hospital.
Con is passionate about developing new treatments for blood cancers. He is the global lead for the BTK inhibitor zanubrutinib, and oversaw its development from the first-in-human dosing (in Melbourne) to successful international licensing studies worldwide. Con designed and performed the first global study to combine ibrutinib and venetoclax, publishing the results in the New England Journal of Medicine 5 years after inception. In 2015, he became the Australian lead for the pivotal study of Tisagenlecleucel in diffuse large B-cell lymphoma, leading to public funding for CAR T-cells as standard treatment in Australia.
The publication record for Con includes 240 peer-reviewed papers in New England Journal of Medicine, Lancet, Journal of Clinical Oncology, Blood and other top-tier journals. His work has been cited >17,000 times in the literature. Con is the current Lymphoma Editor for Blood Advances.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Oncology
- Haematology
- Chronic Lymphocytic Leukemia
- Hairy Cell Leukemia
- Waldenstrom’s Macroglobulinemia
- Relapsed Mantle Cell Lymphoma
- Lymphoma
- Myeloproliferative Diseases
- Genomics
Collaborations and top research areas from the last five years
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A Phase 1, First-in-human Study of JNJ-87801493 in Combination with CD3 T-Cell Engagers in Participants with Relapsed/Refractory B-cell Non-Hodgkin Lymphoid Malignancies (NHLs)
Si Lun Tam, C. & Kennedy, N.
29/01/24 → 28/01/26
Project: Research
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Australia and New Zealand consensus position statement: use of COVID-19 therapeutics in patients with haematological malignancies
Campbell, A., Teh, B., Mulligan, S., Ross, D. M., Weinkove, R., Gilroy, N., Gangatharan, S., Prince, H. M., Szer, J., Trotman, J., Lane, S., Dickinson, M., Quach, H., Enjeti, A. K., Ku, M., Gregory, G., Hapgood, G., Ho, P. J., Cochrane, T., Cheah, C., & 8 others , Feb 2024, In: Internal Medicine Journal. 54, 2, p. 328-336 9 p.Research output: Contribution to journal › Article › Other › peer-review
Open Access -
Reply to Y. Song et al
Dimopoulos, M. A., Opat, S., Treon, S. P. & Tam, C. S., 1 Feb 2024, In: Journal of Clinical Oncology. 42, 4, p. 482-484 3 p.Research output: Contribution to journal › Letter › Other › peer-review
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A phase 1 study evaluating PRT2527, a potent and highly selective CDK9 inhibitor, in patients with select relapsed/refractory B-cell malignancies
Cheson, B. D., Assouline, S., Munir, T., Langerbeins, P., Tam, C., Gregory, G. P., Morschhauser, F., Jurczak, W., Choi, M. Y., Shouse, G., Tani, M., Paris, G., Sun, W., Atwal, S. K., Hong, W. J. & Sarkozy, C., 2023, p. 19. 1 p.Research output: Contribution to conference › Poster › peer-review
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Chronic lymphocytic leukaemia Australasian consensus practice statement
Anderson, M. A., Bennett, R., Badoux, X., Best, G., Chia, N., Cochrane, T., Cull, G., Crassini, K., Harrup, R., Jackson, S., Kuss, B., Lasica, M., Lew, T. E., Marlton, P., Opat, S., Palfreyman, E., Polizzotto, M. N., Ratnasingam, S., Seymour, J. F., Soosapilla, A., & 5 others , Sept 2023, In: Internal Medicine Journal. 53, 9, p. 1678-1691 14 p.Research output: Contribution to journal › Article › Other › peer-review
Open Access1 Citation (Scopus) -
Cognition following chimeric antigen receptor T-cell therapy: A systematic review
Kazzi, C., Kuznetsova, V., Siriratnam, P., Griffith, S., Wong, S., Tam, C. S., Alpitsis, R., Spencer, A., O'Brien, T. J., Malpas, C. B. & Monif, M., Nov 2023, In: Journal of Autoimmunity. 140, 11 p., 103126.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access4 Citations (Scopus)