Projects per year
Personal profile
Biography
Professor Constantine (Con) Tam is Head of the Lymphoma Service at Alfred Health and Central Clinical School.
Con received his M.B.B.S.(Hons) and M.D. degrees from the University of Melbourne. After dual training in Haematology and Haematopathology, Con completed his Leukemia Fellowship at MD Anderson Cancer Centre in Houston, Texas. Prior to moving to the Alfred, Con served as Disease Group Lead for Low Grade Lymphoma and CLL at Peter MacCallum Cancer Centre & Royal Melbourne Hospital for over 10 years. He is also past Director of Haematology at St. Vincent's Hospital.
Con is passionate about developing new treatments for blood cancers. He is the global lead for the BTK inhibitor zanubrutinib, and oversaw its development from the first-in-human dosing (in Melbourne) to successful international licensing studies worldwide. Con designed and performed the first global study to combine ibrutinib and venetoclax, publishing the results in the New England Journal of Medicine 5 years after inception. In 2015, he became the Australian lead for the pivotal study of Tisagenlecleucel in diffuse large B-cell lymphoma, leading to public funding for CAR T-cells as standard treatment in Australia.
The publication record for Con includes 240 peer-reviewed papers in New England Journal of Medicine, Lancet, Journal of Clinical Oncology, Blood and other top-tier journals. His work has been cited >17,000 times in the literature. Con is the current Lymphoma Editor for Blood Advances.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Oncology
- Haematology
- Chronic Lymphocytic Leukemia
- Hairy Cell Leukemia
- Waldenstrom’s Macroglobulinemia
- Relapsed Mantle Cell Lymphoma
- Lymphoma
- Myeloproliferative Diseases
- Genomics
Network
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A Phase 3 Open-Label, Randomized Study of LOXO-305 versus Investigator’s Choice of Idelalisib plus Rituximab or Bendamustine plus Rituximab in BTK Inhibitor Pretreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (BRUIN CLL-321)
Si Lun Tam, C. & Kennedy, N.
9/11/22 → 9/11/24
Project: Research
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A Phase 1, First-in-human Study of JNJ-80948543, a T-cell Redirecting Antibody, in Participants with NHL and CLL.
Si Lun Tam, C. & Kennedy, N.
28/09/22 → 26/02/26
Project: Research
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Real-world experience of Australian and New Zealand patients with chronic lymphocytic leukemia and mantle cell lymphoma accessing ibrutinib through a Named Patient Program
Mulligan, S. P., Opat, S., Cheah, C. Y., Kuss, B., Hertzberg, M., Marlton, P., Poplar, S., Puig, A., McGeachie, M., Weinkove, R. & Tam, C. S., 2023, In: Leukemia and Lymphoma. 64, 2, p. 312–31 7 p.Research output: Contribution to journal › Article › Research › peer-review
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Zanubrutinib, Alone and in Combination with Tislelizumab, for the Treatment of Richter Transformation of Chronic Lymphocytic Leukemia
Tam, C., Munoz, J., Cull, G., Opat, S., Allewelt, H., Zhang, X., Stern, J. C., Hilger, J., By, K., Cohen, A. & Tedeschi, A., 24 Apr 2023, In: HemaSphere. 7, 4, 3 p., e870.Research output: Contribution to journal › Letter › Other › peer-review
Open Access -
A Phase 1 Study With the Novel B-Cell Lymphoma 2 Inhibitor BGB-11417 as Monotherapy or in Combination With Zanubrutinib in Patients With B-Cell Malignancies: Preliminary Data
Soumerai, J. D., Opat, S., Cheah, C. Y., Lasica, M., Verner, E., Browett, P. J., Chan, H., Barca, E. G., Hilger, J., Fang, Y., Simpson, D. & Tam, C. S., Oct 2022, In: Clinical Lymphoma, Myeloma and Leukemia. 22, p. S267-S268 2 p., CLL-118.Research output: Contribution to journal › Meeting Abstract › peer-review
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ASPEN: Long-Term Follow-Up Results of a Phase 3 Randomized Trial of Zanubrutinib vs Ibrutinib in Patients With Waldenström Macroglobulinemia
Castillo, J. J., Tam, C. S., Garcia-Sanz, R., Opat, S., D'Sa, S., Jurczak, W., Lee, H. P., Cull, G., Owen, R. G., Marlton, P., Wahlin, B. E., Tedeschi, A., Siddiqi, T., Buske, C., Leblond, V., Chan, W. Y., Schneider, J., Cohen, A. & Dimopoulos, M., Oct 2022, In: Clinical Lymphoma, Myeloma and Leukemia. 22, p. S385 1 p., IBCL-117.Research output: Contribution to journal › Meeting Abstract › peer-review
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BRUIN CLL-322: A Phase 3 Open-Label, Randomized Study of Fixed-Duration Pirtobrutinib Plus Venetoclax and Rituximab Versus Venetoclax and Rituximab in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (Trial in Progress)
Wierda, W. G., Pagel, J. M., Davids, M. S., Zinzani, P. L., Lu, Y., Liu, H., Shahda, S., Leow, C. C., Tam, C. S., Woyach, J., Eyre, T. A. & Mato, A. R., Oct 2022, In: Clinical Lymphoma, Myeloma and Leukemia. 22, p. S267 1 p., CLL-116.Research output: Contribution to journal › Meeting Abstract › peer-review