1985 …2023

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2020

Ultrafast star-shaped acoustic micromixer for high throughput nanoparticle synthesis

An Le, N. H., Deng, H., Devendran, C., Akhtar, N., Ma, X., Pouton, C., Chan, H-K., Neild, A. & Alan, T., 7 Feb 2020, In : Lab on a Chip. 20, 3, p. 582-591 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2019

A Nonionic Polyethylene Oxide (PEO) Surfactant Model: Experimental and Molecular Dynamics Studies of Kolliphor EL

Suys, E. J. A., Warren, D. B., Pham, A. C., Nowell, C. J., Clulow, A. J., Benameur, H., Porter, C. J. H., Pouton, C. W. & Chalmers, D. K., 1 Jan 2019, In : Journal of Pharmaceutical Sciences. 108, 1, p. 193-204 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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5 Citations (Scopus)

Colloidal aspects of dispersion and digestion of self-dispersing lipid-based formulations for poorly water-soluble drugs

Vithani, K., Jannin, V., Pouton, C. W. & Boyd, B. J., 2019, In : Advanced Drug Delivery Reviews. 142, p. 16-34 19 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Improvement in the Predicted Partitioning of Alcohol and Polyethylene Oxide Groups Between Water and Octanol (logP) in Molecular Dynamics Simulations

Warren, D. B., McPhee, E., Birru, W. A., Benameur, H., Chalmers, D. K. & Pouton, C. W., 1 Jan 2019, In : Journal of Pharmaceutical Sciences. 108, 1, p. 214-222 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Isolation of LMX1a Ventral Midbrain Progenitors Improves the Safety and Predictability of Human Pluripotent Stem Cell-Derived Neural Transplants in Parkinsonian Disease

de Luzy, I. R., Niclis, J. C., Gantner, C. W., Kauhausen, J. A., Hunt, C. P. J., Ermine, C., Pouton, C. W., Thompson, L. H. & Parish, C. L., 27 Nov 2019, In : Journal of Neuroscience. 39, 48, p. 9521-9531 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Local inflammation alters the lung disposition of a drug loaded pegylated liposome after pulmonary dosing to rats

Haque, S., Feeney, O., Meeusen, E., Boyd, B. J., McIntosh, M. P., Pouton, C. W., Whittaker, M. & Kaminskas, L. M., 10 Aug 2019, In : Journal of Controlled Release. 307, p. 32-43 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Location of Solvated Probe Molecules Within Nonionic Surfactant Micelles Using Molecular Dynamics

Warren, D. B., McPhee, E., Birru, W. A., Benameur, H., Chalmers, D. K. & Pouton, C. W., 1 Jan 2019, In : Journal of Pharmaceutical Sciences. 108, 1, p. 205-213 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Unlocking the full potential of lipid-based formulations using lipophilic salt/ionic liquid forms

Williams, H. D., Ford, L., Igonin, A., Shan, Z., Botti, P., Morgen, M. M., Hu, G., Pouton, C. W., Scammells, P. J., Porter, C. J. H. & Benameur, H., 2019, In : Advanced Drug Delivery Reviews. 142, 16 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Acute or Delayed Systemic Administration of Human Amnion Epithelial Cells Improves Outcomes in Experimental Stroke

Evans, M. A., Lim, R., Kim, H. A., Chu, H. X., Gardiner-Mann, C. V., Taylor, K. W. E., Chan, C. T., Brait, V. H., Lee, S., Dinh, Q. N., Vinh, A., Phan, T. G., Srikanth, V. K., Ma, H., Arumugam, T. V., Fann, D. Y., Poh, L., Hunt, C. P. J., Pouton, C. W., Haynes, J. M. & 12 others, Selemidis, S., Kwan, W., Teo, L., Bourne, J. A., Neumann, S., Young, S., Gowing, E. K., Drummond, G. R., Clarkson, A. N., Wallace, E. M., Sobey, C. G. & Broughton, B. R. S., 1 Mar 2018, In : Stroke. 49, 3, p. 700-709 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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15 Citations (Scopus)

Enhancing the Oral Absorption of Kinase Inhibitors Using Lipophilic Salts and Lipid-Based Formulations

Williams, H. D., Ford, L., Han, S., Tangso, K. J., Lim, S., Shackleford, D. M., Vodak, D. T., Benameur, H., Pouton, C. W., Scammells, P. J. & Porter, C. J. H., 1 Jan 2018, In : Molecular Pharmaceutics. 15, 12, p. 5678−5696 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)

Optimization transgene expression of short fully synthesized lipopeptide-based transfection agent for non-viral gene delivery vehicle

Tarwadi, Restiani, D. E., Pambudi, S., Jazayeri, J. J., Pouton, C. W., Rachmawati, H., Kartasasmita, R. E. & Asyarie, S., Nov 2018, In : Journal of Pharmaceutical Sciences and Research. 10, 11, p. 41-54 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding protein

Daniel, P. M., Filiz, G., Brown, D. V., Christie, M., Waring, P. M., Zhang, Y., Haynes, J. M., Pouton, C., Flanagan, D., Vincan, E., Johns, T. G., Montgomery, K., Phillips, W. A. & Mantamadiotis, T., 1 Jan 2018, In : Neuro-Oncology. 20, 10, p. 1344-1355 12 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)
12 Citations (Scopus)

Self-Crosslinking Lipopeptide/DNA/PEGylated Particles: A New Platform for DNA Vaccination Designed for Assembly in Aqueous Solution

Ho, J. K., White, P. J. & Pouton, C. W., 7 Sep 2018, In : Molecular Therapy: Nucleic Acids. 12, p. 504-517 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Solubilisation behaviour of poorly water-soluble drugs during digestion of solid SMEDDS

Vithani, K., Hawley, A., Jannin, V., Pouton, C. & Boyd, B. J., 1 Sep 2018, In : European Journal of Pharmaceutics and Biopharmaceutics. 130, p. 236-246 11 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)
3 Citations (Scopus)

Synthesis and Pharmacological Evaluation of Noscapine-Inspired 5-Substituted Tetrahydroisoquinolines as Cytotoxic Agents

Devine, S. M., Yong, C., Amenuvegbe, D., Aurelio, L., Muthiah, D., Pouton, C., Callaghan, R., Capuano, B. & Scammells, P. J., 27 Sep 2018, In : Journal of Medicinal Chemistry. 61, 18, p. 8444-8456 13 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Transformation of Biopharmaceutical Classification System Class I and III Drugs Into Ionic Liquids and Lipophilic Salts for Enhanced Developability Using Lipid Formulations

Williams, H. D., Ford, L., Lim, S., Han, S., Baumann, J., Sullivan, H., Vodak, D., Igonin, A., Benameur, H., Pouton, C. W., Scammells, P. J. & Porter, C. J. H., 2018, In : Journal of Pharmaceutical Sciences. 107, 1, p. 203–216 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
10 Citations (Scopus)
2017

A PITX3-EGFP Reporter Line Reveals Connectivity of Dopamine and Non-dopamine Neuronal Subtypes in Grafts Generated from Human Embryonic Stem Cells

Niclis, J. C., Gantner, C. W., Hunt, C. P. J., Kauhausen, J. A., Durnall, J. C., Haynes, J. M., Pouton, C. W., Parish, C. L. & Thompson, L. H., 12 Sep 2017, In : Stem Cell Reports. 9, 3, p. 868-882 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
9 Citations (Scopus)

A suicidal strain of Listeria monocytogenes is effective as a DNA vaccine delivery system for oral administration

Sinha, S., Kuo, C. Y., Ho, J. K., White, P. J., Jazayeri, J. A. & Pouton, C. W., 2017, In : Vaccine. 35, 38, 8 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Computational Models of the Gastrointestinal Environment. 1. The Effect of Digestion on the Phase Behavior of Intestinal Fluids

Birru, W. A., Warren, D., Headey, S. J., Benameur, H., Porter, C., Pouton, C. W. & Chalmers, D. K., 6 Mar 2017, In : Molecular Pharmaceutics. 14, 3, p. 566-579 14 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)
12 Citations (Scopus)

Computational Models of the Intestinal Environment. 3. The Impact of Cholesterol Content and pH on Mixed Micelle Colloids

Suys, E. J. A., Warren, D. B., Porter, C. J. H., Benameur, H., Pouton, C. W. & Chalmers, D. K., 6 Nov 2017, In : Molecular Pharmaceutics. 14, 11, p. 3684-3697 14 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Effect of increased surface hydrophobicity via drug conjugation on the clearance of inhaled PEGylated polylysine dendrimers

Haque, S., McLeod, V. M., Jones, S., Fung, S., Whittaker, M., McIntosh, M., Pouton, C., Owen, D. J., Porter, C. J. H. & Kaminskas, L. M., 1 Oct 2017, In : European Journal of Pharmaceutics and Biopharmaceutics. 119, p. 408-418 11 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Efficiently specified ventral midbrain dopamine neurons from human pluripotent stem cells under Xeno-free conditions restore motor deficits in Parkinsonian rodents

Niclis, J. C., Gantner, C. W., Alsanie, W. F., McDougall, S. J., Bye, C. R., Elefanty, A. G., Stanley, E. G., Haynes, J. M., Pouton, C. W., Thompson, L. H. & Parish, C. L., 1 Mar 2017, In : Stem Cells Translational Medicine. 6, 3, p. 937-948 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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13 Citations (Scopus)

Inclusion of digestible surfactants in solid SMEDDS formulation removes lag time and influences the formation of structured particles during digestion

Vithani, K., Hawley, A., Jannin, V., Pouton, C. & Boyd, B. J., 1 May 2017, In : The AAPS Journal. 19, 3, p. 754-764 11 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Purification and characterization of adenovirus core protein VII: A histone-like protein that is critical for adenovirus core formation

Sharma, G., Moria, N., Williams, M., Krishnarjuna, B. & Pouton, C. W., 1 Jul 2017, In : Journal of General Virology. 98, 7, p. 1785-1794 10 p., 000817.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

Specification of murine ground state pluripotent stem cells to regional neuronal populations

Alsanie, W. F., Niclis, J. C., Hunt, C. P., De Luzy, I. R., Penna, V., Bye, C. R., Pouton, C. W., Haynes, J., Firas, J., Thompson, L. H. & Parish, C. L., 22 Nov 2017, In : Scientific Reports. 7, 1, 16 p., 16001.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)
2016

50 years of oral lipid-based formulations: provenance, progress and future perspectives

Feeney, O. M., Crum, M. F., McEvoy, C., Trevaskis, N., Williams, H., Pouton, C., Charman, W. N., Bergstrom, C. & Porter, C. J. H., 1 Jun 2016, In : Advanced Drug Delivery Reviews. 101, p. 167-194 27 p.

Research output: Contribution to journalArticleResearchpeer-review

123 Citations (Scopus)

A new in vitro lipid digestion - in vivo absorption model to evaluate the mechanisms of drug absorption from lipid-based formulations

Crum, M., Trevaskis, N., Williams, H. D., Pouton, C. W. & Porter, C. J., 2016, In : Pharmaceutical Research. 33, 4, p. 970-982 13 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Chronic stress in mice remodels lymph vasculature to promote tumour cell dissemination

Le, C. P., Nowell, C. J., Kim-Fuchs, C., Botteri, E., Hiller, J. G., Ismail, H., Pimentel, M. A., Chai, M. G., Karnezis, T., Rotmensz, N., Renne, G., Gandini, S., Pouton, C. W., Ferrari, D., Möller, A., Stacker, S. A. & Sloan, E. K., 1 Mar 2016, In : Nature Communications. 7, 14 p., 10634.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
76 Citations (Scopus)

Haplotyping the human leukocyte antigen system from single chromosomes

Murphy, N. M., Burton, M., Powell, D. R., Rossello, F. J., Cooper, D., Chopra, A., Hsieh, M. J., Sayer, D. C., Gordon, L., Pertile, M. D., Tait, B. D., Irving, H. R. & Pouton, C. W., 27 Jul 2016, In : Scientific Reports. 6, 9 p., 30381.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1 Citation (Scopus)

Tissue-specific calibration of real-time PCR facilitates absolute quantification of plasmid DNA in biodistribution studies

Ho, J. K., White, P. J. & Pouton, C. W., 4 Oct 2016, In : Molecular Therapy: Nucleic Acids. 5, 10, 9 p., e371.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1 Citation (Scopus)
2015
2 Citations (Scopus)

Human pluripotent stem cell derived midbrain PITX3eGFP/w neurons: a versatile tool for pharmacological screening and neurodegenerative modeling

Watmuff, B., Hartley, B. J., Hunt, C. P. J., Fabb, S. A., Pouton, C. W. & Haynes, J. M., 2015, In : Frontiers in Cellular Neuroscience. 9, 15 p., 104.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
7 Citations (Scopus)

Toward the establishment of standardized in vitro tests for lipid-based formulations. 5. Lipolysis of representative formulations by gastric lipase

Bakala-N'Goma, J-C., Williams, H. D., Sassene, P. J., Kleberg, K., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Mullertz, A., Pouton, C. W., Porter, C. J. & Carriere, F., 2015, In : Pharmaceutical Research. 32, 4, p. 1279-1287 9 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)
2014

An in vitro digestion test that reflects rat intestinal conditions to probe the importance of formulation digestion vs first pass metabolism in danazol bioavailability from lipid based formulations

Anby, M. U., Nguyen, T-H., Yeap, Y. Y., Feeney, O., Williams, H. D., Benameur, H., Pouton, C. W. & Porter, C. J., 2014, In : Molecular Pharmaceutics. 11, 11, p. 4069 - 4083 15 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Digestion of phospholipids after secretion of bile into the duodenum changes the phase behavior of bile components

Birru, W. A., Warren, D., Ibrahim, A. M. H., Williams, H. D., Benameur, H., Porter, C. J., Chalmers, D. K. & Pouton, C. W., 2014, In : Molecular Pharmaceutics. 11, 8, p. 2825 - 2834 10 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Human leukocyte antigen haplotype phasing by allele-specific enrichment with peptide nucleic acid probes

Murphy, N., Pouton, C. W. & Irving, H. R., 2014, In : Molecular Genetics and Genomic Medicine. 2, 3, p. 245 - 253 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Non-linear increases in danazol exposure with dose in older vs. younger Beagle dogs: The potential role of differences in bile salt concentration, thermodynamic activity, and formulation digestion

Anby, M. U., Williams, H. D., Feeney, O., Edwards, G. A., Benameur, H., Pouton, C. W. & Porter, C. J., 2014, In : Pharmaceutical Research. 31, 6, p. 1536 - 1552 17 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

SIRPA, VCAM1 and CD34 identify discrete lineages during early human cardiovascular development

Skelton, R. J. P., Costa, M., Anderson, D. J., Bruveris, F., Finnin, B. W., Koutsis, K., Arasaratnam, D., White, A. J., Rafii, A., Ng, E. S-S., Elefanty, A. G., Stanley, E. G., Pouton, C. W., Haynes, J. M., Ardehali, R., Davis, R. P., Mummery, C. L. & Elliott, D. A., 2014, In : Stem Cell Research. 13, 1, p. 172 - 179 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
35 Citations (Scopus)
37 Citations (Scopus)

The synthesis and biological evaluation of multifunctionalised derivatives of noscapine as cytotoxic agents

Debono, A. J., Mistry, S. J., Xie, A., Muthiah, D., Phillips, J. R., Ventura, S., Callaghan, R., Pouton, C. W., Capuano, B. & Scammells, P. J., 2014, In : ChemMedChem. 9, 2, p. 399 - 410 12 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Toward the establishment of standardized in vitro tests for lipid-based formulations, part 4: Proposing a new lipid formulation performance classification system

Williams, H. D., Sassene, P. J., Kleberg, K., Calderone, M., Igonin, A., Jule, E., Vertommen, J., Blundell, R., Benameur, H., Mullertz, A., Porter, C. J. & Pouton, C. W., 2014, In : Journal of Pharmaceutical Sciences. 103, 8, p. 2441 - 2455 15 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Toward the establishment of standardized in vitro tests for lipid-based formulations, part 6: Effects of varying pancreatin and calcium levels

Sassene, P. J., Kleberg, K., Williams, H. D., Bakala-N'Goma, J-C., Carriere, F., Calderone, M., Jannin, V., Igonin, A., Partheil, A., Marchaud, D., Jule, E., Vertommen, J., Maio, M., Blundell, R., Benameur, H., Porter, C. J., Pouton, C. W. & Mullertz, A., 2014, In : The AAPS Journal. 16, 6, p. 1344-1357 14 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Zinc-finger nuclease enhanced gene targeting in human embryonic stem cells

Hartley, B. J., Fabb, S. A., Finnin, B. A. L., Haynes, J. M. & Pouton, C. W., 2014, In : Journal of Visualized Experiments. 90, e51764, p. e51764 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)