Projects per year
Personal profile
Biography
Professor of Pharmaceutical Biology, Theme Leader: Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences.
Faculty of Pharmacy and Pharmaceutical Sciences, Monash University (based at Monash Parkville Campus)
Research interests
- Use of stem cells, and cells derived by differentiation of stem cells, in drug discovery.
- Differentiation of pluripotent stem cells to derive brain cells (particularly neurons and microglia)
- Stem cell derived models of neurodegenerative diseases (Parkinsosn's and Alzheimer's diseases)
- Design and performance of delivery systems for nucleic acid therapeutics (DNA and RNA).
- Lipid-based delivery systems for oral delivery of poorly water-soluble drugs and oral peptides.
Monash teaching commitment
I have responsibility for teaching programs in our BPharm, new MPharm, and BPharm SCi degree programs. As a member of the Faculty Executive I assist in allocation of staff workload across various units.
I teach into units involving virology, biotechnology, formulations of small molecule drugs and biotech products, cancer biology and general methods in molecular biology.
I teach postgraduate students throughout the academic calendar year - currently I co-supervise 16 PhD students
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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CGCPT: Cumming Global Centre for Pandemic Therapeutics Round 2
McIntosh, M. (Primary Chief Investigator (PCI)), Tang, J. (Chief Investigator (CI)), Pouton, C. (Chief Investigator (CI)), Haque, S. (Chief Investigator (CI)) & Bischof, R. (Chief Investigator (CI))
6/01/25 → 6/01/28
Project: Research
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Identifying and overcoming mechanisms of immune evasion in cancer
Asselin-Labat, M.-L. (Primary Chief Investigator (PCI)), Kallies, A. (Chief Investigator (CI)), Phipson, B. (Chief Investigator (CI)), Vasanthakumar, A. (Chief Investigator (CI)), Gebhardt, T. (Chief Investigator (CI)), Klein, O. (Chief Investigator (CI)), Pilkington, E. (Chief Investigator (CI)), Fox, A. (Associate Investigator (AI)), Carlino, M. S. (Associate Investigator (AI)), Oshlack, A. (Associate Investigator (AI)), Wimmer, V. (Associate Investigator (AI)) & Pouton, C. (Associate Investigator (AI))
1/01/25 → 31/12/29
Project: Research
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mRNA CORE NCRIS funding
Pouton, C. (Primary Chief Investigator (PCI))
19/02/24 → 31/12/25
Project: Research
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Developing an mRNA vaccine for the treatment of Alzheimer's disease
Nisbet, R. (Chief Investigator (CI)) & Pouton, C. (Primary Chief Investigator (PCI))
21/07/23 → 31/12/25
Project: Research
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Development of novel mRNA products for clinical trials
Pouton, C. (Primary Chief Investigator (PCI)), Beilharz, T. (Chief Investigator (CI)), Carroll, J. (Chief Investigator (CI)), Porter, C. (Chief Investigator (CI)), Al-Wassiti, H. (Chief Investigator (CI)), Davidovich, C. (Chief Investigator (CI)), Johnston, A. (Chief Investigator (CI)) & Trevaskis, N. (Chief Investigator (CI))
10/05/23 → 2/10/28
Project: Research
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A versatile antibody capture system drives specific in vivo delivery of mRNA-loaded lipid nanoparticles
Chen, M. Z., Yuen, D., McLeod, V. M., Yong, K. W., Smyth, C. H., Herling, B. R., Payne, T. J., Fabb, S. A., Belousoff, M. J., Algarni, A., Sexton, P. M., Porter, C. J. H., Pouton, C. W. & Johnston, A. P. R., 4 Aug 2025, In: Nature Nanotechnology. 20, p. 1273–1284 21 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
Efficient mRNA delivery to resting T cells to reverse HIV latency
Cevaal, P. M., Kan, S., Fisher, B. M., Moso, M. A., Tan, A., Liu, H., Ali, A., Tanaka, K., Shepherd, R. A., Kim, Y., Ong, J., Furtado, D. L., Holz, M., Purcell, D. F. J., Casan, J. M. L., Payne, T., Zhao, W., Fareh, M., McMahon, J. H. & Deeks, S. G. & 8 others, , 29 May 2025, In: Nature Communications. 16, 1, 12 p., 4979.Research output: Contribution to journal › Article › Research › peer-review
Open Access6 Citations (Scopus) -
Impact of ionizable lipid type on the pharmacokinetics and biodistribution of mRNA-lipid nanoparticles after intravenous and subcutaneous injection
Ren, Y., Lin, L., Abdallah, M., Zhu, X., Liu, H., Fabb, S. A., Payne, T. J., Pouton, C. W., Johnston, A. P. R. & Trevaskis, N. L., 10 Aug 2025, In: Journal of Controlled Release. 384, 14 p., 113945.Research output: Contribution to journal › Article › Research › peer-review
10 Citations (Scopus) -
Morphological changes induced by buffer exchange during preparation of mRNA-lipid nanoparticles occur in a stepwise manner as pH is elevated
He, Y., Pilkington, E. H., Kang, H. J., Fong, W. K., Clulow, A. J., Johnston, A. P. R. & Pouton, C. W., 11 Dec 2025, In: Molecular Therapy - Methods & Clinical Development. 33, 4, 12 p., 101578.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Therapeutic applications of cell engineering using mRNA technology
He, Y., Johnston, A. P. R. & Pouton, C. W., Jan 2025, In: Trends in Biotechnology. 43, 1, p. 83-97 15 p.Research output: Contribution to journal › Review Article › Research › peer-review
2 Citations (Scopus)
Activities
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Executive
Pouton, C. (Member)
2 Jan 2012Activity: External Academic Engagement › Grant review responsibilities
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Member
Pouton, C. (Member)
22 Sept 2011Activity: External Academic Engagement › Submissions to industry or govt committees, commissions and inquiries