Projects per year
Personal profile
Biography
Professor of Pharmaceutical Biology, Theme Leader: Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences.
Faculty of Pharmacy and Pharmaceutical Sciences, Monash University (based at Monash Parkville Campus)
Research interests
- Use of stem cells, and cells derived by differentiation of stem cells, in drug discovery.
- Differentiation of pluripotent stem cells to derive brain cells (particularly neurons and microglia)
- Stem cell derived models of neurodegenerative diseases (Parkinsosn's and Alzheimer's diseases)
- Design and performance of delivery systems for nucleic acid therapeutics (DNA and RNA).
- Lipid-based delivery systems for oral delivery of poorly water-soluble drugs and oral peptides.
Monash teaching commitment
I have responsibility for teaching programs in our BPharm, new MPharm, and BPharm SCi degree programs. As a member of the Faculty Executive I assist in allocation of staff workload across various units.
I teach into units involving virology, biotechnology, formulations of small molecule drugs and biotech products, cancer biology and general methods in molecular biology.
I teach postgraduate students throughout the academic calendar year - currently I co-supervise 16 PhD students
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Developing an mRNA vaccine for the treatment of Alzheimer's disease
Nisbet, R. & Pouton, C.
21/07/23 → 31/12/25
Project: Research
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Development of novel mRNA products for clinical trials
Pouton, C., Beilharz, T., Carroll, J., Porter, C., Al-Wassiti, H., Davidovich, C., Johnston, A. & Trevaskis, N.
10/05/23 → 2/10/28
Project: Research
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RaRtech: a novel and rapid mRNA manufacturing technology for pandemics preparedness and therapeutics
Al-Wassiti, H., Pouton, C., Ho, J. & Teo, S.
mRNA Victoria, Monash University – Internal Faculty Contribution
21/10/22 → 20/01/25
Project: Research
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Improved glucose control, with lower insulin doses, for the treatment of type 1 diabetes
Cowley, M., Simonds, S., Thompson, P., Pouton, C. & Greenough, C.
MTP-IIGC Ltd (trading as MTP Connect)
1/08/22 → 15/02/25
Project: Research
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Tailored Monoacyl Poly(2-oxazoline)- and Poly(2-oxazine)-Lipids as PEG-Lipid Alternatives for Stabilization and Delivery of mRNA-Lipid Nanoparticles
He, X., Payne, T. J., Takanashi, A., Fang, Y., Kerai, S. D., Morrow, J. P., Al-Wassiti, H., Pouton, C. W. & Kempe, K., 25 Jun 2024, In: Biomacromolecules. 25, 7, p. 4591–4603 13 p.Research output: Contribution to journal › Article › Research › peer-review
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Delivery and Expression of mRNA in the Secondary Lymphoid Organs Drive Immune Responses to Lipid Nanoparticle-mRNA Vaccines after Intramuscular Injection
Takanashi, A., Pouton, C. W. & Al-Wassiti, H., 7 Aug 2023, In: Molecular Pharmaceutics. 20, 8, p. 3876-3885 10 p.Research output: Contribution to journal › Article › Research › peer-review
9 Citations (Scopus) -
Interim results from a phase I randomized, placebo-controlled trial of novel SARS-CoV-2 beta variant receptor-binding domain recombinant protein and mRNA vaccines as a 4th dose booster
Nolan, T. M., Deliyannis, G., Griffith, M., Braat, S., Allen, L. F., Audsley, J., Chung, A. W., Ciula, M., Gherardin, N. A., Giles, M. L., Gordon, T. P., Grimley, S. L., Horng, L., Jackson, D. C., Juno, J. A., Kedzierska, K., Kent, S. J., Lewin, S. R., Littlejohn, M., McQuilten, H. A., & 24 others, Dec 2023, In: EBioMedicine. 98, 17 p., 104878.Research output: Contribution to journal › Article › Research › peer-review
Open Access6 Citations (Scopus) -
Molecular Dynamics Simulation Studies of Bile, Bile Salts, Lipid-Based Drug Formulations, and mRNA-Lipid Nanoparticles: A Review
Guruge, A. G., Warren, D. B., Pouton, C. W. & Chalmers, D. K., 17 May 2023, In: Molecular Pharmaceutics. 20, 6, p. 2781-2800 20 p.Research output: Contribution to journal › Review Article › Research › peer-review
4 Citations (Scopus) -
mRNA vaccines encoding membrane-anchored receptor-binding domains of SARS-CoV-2 mutants induce strong humoral responses and can overcome immune imprinting
Al-Wassiti, H., Fabb, S. A., Grimley, S. L., Panakkal Kochappan, R., Ho, J., Wong, C. Y., Tan, C. W., Payne, T. J., Takanashi, A., Sicilia, H., Teo, S., McAuley, J. L., Ellenberg, P., Cooney, J. P., Davidson, K., Bowen, R. A., Pellegrini, M., Rockman, S., Godfrey, D. I., Nolan, T. M., & 4 others, 4 Oct 2023, 35 p. bioRxiv.Research output: Other contribution › Research
Open Access
Activities
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Executive
Colin Pouton (Member)
2 Jan 2012Activity: External Academic Engagement › Grant review responsibilities
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Member
Colin Pouton (Member)
22 Sept 2011Activity: External Academic Engagement › Submissions to industry or govt committees, commissions and inquiries