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Personal profile


Colby Zaph is Professor and Head of the Laboratory of Mucosal Immunity and Inflammation in the Department of Biochemistry and Molecular Biology and is a member of the Infetion and Immunity Program of the Biomedicine Discovery Institute.

Professor Zaph obtained a B.Sc. (Honours) in Biochemistry from the University of Saskatchewan in Saskatoon, Canada in 1995. He obtained his Ph.D. in 2004 from the University of Pennsylvania in Philadelphia, USA working with Phillip Scott on memory T cell responses that develop follwing infection with the protozoan parasite Leishmania major. He carried out his postdoctoral studies at the University of Pennsylvania with David Artis where he focused on the cellular and molecular mechanisms that regulate immunity and inflammation at mucosal sites, which continues to be the overall focus of his laboratory.

Professor Zaph has made several important contributions such as defining the role of parasite persistence in memory T cell development (Zaph et al. (2004) Nat. Med. 10:1104) and identifying a critical role for intestinal epithelial cells in licensing innate and adaptive immune responses during intestinal infection (Zaph et al. (2007) Nature 446:552). More recently, his reserach has focused on the role of lysine methylation in epigenetic regulation of gene expression (Lehnertz et al. (2010) J. Exp. Med. 207:915; Antignano et al. (2014) J. Clin. Invest. 124:1945), as well as a novel signaling mechanism that controls subcellular localization of proteins (Oudhoff et al. (2013) Dev. Cell 26:188).

Research area keywords

  • Immunology
  • Inflammation
  • Infection
  • Epigenetics
  • IBDs

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Projects 2015 2020

Research Output 2003 2019

2 Citations (Scopus)

HIC1 links retinoic acid signalling to group 3 innate lymphoid cell-dependent regulation of intestinal immunity and homeostasis

Burrows, K., Antignano, F., Chenery, A., Bramhall, M., Korinek, V., Underhill, T. M. & Zaph, C., 22 Feb 2018, In : PLoS Pathogens. 14, 2, 15 p., e1006869.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
5 Citations (Scopus)

The transcriptional repressor HIC1 regulates intestinal immune homeostasis

Burrows, K., Antignano, F., Bramhall, M., Chenery, A., Scheer, S., Korinek, V., Underhill, T. M. & Zaph, C., 1 Nov 2017, In : Mucosal Immunology. 10, 6, p. 1518-1528 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
6 Citations (Scopus)

The lysine methyltransferase G9a in immune cell differentiation and function

Scheer, S. & Zaph, C., 11 Apr 2017, In : Frontiers in Immunology. 8, 11 p., 429.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
8 Citations (Scopus)

Early-life antibiotic treatment enhances the pathogenicity of CD4+ T cells during intestinal inflammation

Scheer, S., Medina, T. S., Murison, A., Taves, M. D., Antignano, F., Chenery, A. L., Soma, K. K., Perona-Wright, G., Lupien, M., Arrowsmith, C. H., Carvalho, D. R. & Zaph, C., 1 Apr 2017, In : Journal of leukocyte biology. 101, 4, p. 893-900 8 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program

Antignano, F., Braam, M., Hughes, M. R., Chenery, A. L., Burrows, K., Gold, M. J., Oudhoff, M. J., Rattray, D., Halim, T. Y., Cait, A., Takei, F., Rossi, F. M., McNagny, K. M. & Zaph, C., 13 Jun 2016, In : Journal of Experimental Medicine. 213, 7, p. 1153-1162 10 p.

Research output: Contribution to journalArticleResearchpeer-review