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Personal profile

Biography

A/Professor Claudia Nold is a pharmacist by training with broad expertise in cytokine biology, inflammation and immunology. After her graduation from pharmacy school in 2000, she was awarded a competitive three-year PhD Fellowship by the Deutsche Forschungsgemeinschaft (the German NHMRC equivalent) and started her PhD at the Pharmazentrum Frankfurt, Germany. This fellowship entailed a 6-month tenure at the Institute of Asthma and Allergy at the Karolinska Institute, Stockholm, Sweden.

From 2006 until 2009 she held a post-doctoral position in Denver, Colorado, USA in the laboratory of Professor Charles A. Dinarello, who first described the function of Interleukin 1. Some of her achievements of this productive time included the description of anti-viral, endothelial and angiogenic properties of interleukin (IL-)32, and the important paper on the functional differences between monocytes and macrophages (200+ citations).

In 2009, A/Prof Nold was recruited to The Ritchie Centre at Hudson Institute of Medical Research in Melbourne, and continued to publish at a very high level. Of outstanding importance, however, was the discovery of the function of IL-37, which has had a major impact on the interleukin field, leading to a fundamental reorganisation of the nomenclature of the IL-1 family of cytokines in 2010.

In 2011 she was awarded the Christina Fleischmann Award of the International Society of Interferon and Cytokine Research. This award recognizes young female investigators for notable contributions to basic or clinical research. The second achievement exemplifies the translational trajectory that is paramount to her laboratory: her team has almost completed the bedside-to-bench-and-back circuit with their work on interleukin 1 receptor antagonist (IL-1Ra) in bronchopulmonary dysplasia (BPD). There is an urgent medical need to find the first safe and effective treatment for BPD in the neonatal intensive care unit, and the Nold laboratory showed in a mouse model that IL-1Ra prevents the disease. The team is now planning a clinical trial to prove the concept in babies.

In 2014 A/Prof C Nold was awarded the top ranked Future Leader Fellowship and received the Paul Korner Innovation Award of the Australian Heart Foundation.

Because of these innovative programs, the Nold team has been awarded substantial grant funding, filed several patents and are collaborating with multiple partners in the pharmaceutical industry.

Education/Academic qualification

Natural Sciences, PhD, Goethe-Universität Frankfurt am Main (Goethe University Frankfurt)

Award Date: 12 Oct 2005

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Projects

Research Output

Parsing the IL-37-mediated suppression of inflammasome function

Rudloff, I., Ung, H. K., Dowling, J. K., Mansell, A., D'Andrea, L., Ellisdon, A. M., Whisstock, J., Berger, P., Nold, C. & Nold, M., Jan 2020, In : Cells. 9, 1, 19 p., 178.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

IL-37 increases in patients after ischemic stroke and protects from inflammatory brain injury, motor impairment and lung infection in mice

Zhang, S. R., Nold, M. F., Tang, S. C., Bui, C. B., Nold, C. A., Arumugam, T. V., Drummond, G. R., Sobey, C. G. & Kim, H. A., 1 Dec 2019, In : Scientific Reports. 9, 1, 12 p., 6922.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)

Interleukin-1 receptor antagonist protects newborn mice against pulmonary hypertension

Bui, C. B., Kolodziej, M., Lamanna, E., Elgass, K., Sehgal, A., Rudloff, I., Schwenke, D. O., Tsuchimochi, H., Kroon, M. A. G. M., Cho, S. X., Maksimenko, A., Cholewa, M., Berger, P. J., Young, M. J., Bourke, J. E., Pearson, J. T., Nold, M. F. & Nold-Petry, C. A., 11 Jul 2019, In : Frontiers in Immunology. 10, JULY, 15 p., 1480.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Endometrial Mesenchymal Stem/Stromal Cells Modulate the Macrophage Response to Implanted Polyamide/Gelatin Composite Mesh in Immunocompromised and Immunocompetent Mice

Darzi, S., Deane, J. A., Nold, C. A., Edwards, S. E., Gough, D. J., Mukherjee, S., Gurung, S., Tan, K. S., Vashi, A. V., Werkmeister, J. A. & Gargett, C. E., 1 Dec 2018, In : Scientific Reports. 8, 1, 15 p., 6554.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
11 Citations (Scopus)

Defining T helper cell immunity in bronchopulmonary dysplasia

Lao, J. C., Pang, M. A., Malhotra, A., Tan, K., Beker, F., Konig, K., Collins, C., Theda, C., Kamlin, C. O., Yeomans, E., Elsayed, K., Noble, E., Walsh, G., Argus, B., Twitchell, E., Berger, P., Veldman, A., Nold-Petry, C. A. & Nold, M. F., 1 May 2017, p. 125-126. 1 p.

Research output: Contribution to conferenceAbstract

Prizes

Advancing Women's Research Success

Nold, Claudia (Recipient), 2013

Prize: Prize (including medals and awards)

American Association of Immunologists Abstract Award

Nold, Claudia (Recipient), 2013

Prize: Prize (including medals and awards)

Best Publication Award 2011

Nold, Claudia (Recipient), 2011

Prize: Prize (including medals and awards)

Best Publication Award 2015

Nold, Claudia (Recipient), 2015

Prize: Prize (including medals and awards)

Activities

MRFF Priority Round Assessor

Claudia Nold (Fellow)

2020

Activity: External Academic EngagementGrant review responsibilities

American Association of Immunologists

Claudia Nold (Fellow)

2020

Activity: External Academic EngagementProfessional association or peak discipline body

National Health and Medical Research Council Research Translation Faculty

Claudia Nold (Fellow)

2020

Activity: External Academic EngagementProfessional association or peak discipline body

International Cytokine and Interferon Society

Claudia Nold (Fellow)

2020

Activity: External Academic EngagementProfessional association or peak discipline body

Australasian Society of Immunology

Claudia Nold (Fellow)

2020

Activity: External Academic EngagementProfessional association or peak discipline body

Press / Media

Goethe Institute - STEM/CLIL Science Workshops in German-

Claudia Nold

1/10/18

1 Media contribution

Press/Media: Public Engagement Activities

Bronchopulmonary Dysplasia (BPD)

Claudia Nold

2/10/17

1 item of Media coverage

Press/Media: Research

Doctor awarded for work with ill preterm babies

Claudia Nold

11/11/15

1 Media contribution

Press/Media: Research

Researchers add insights to IL-37's anti-inflammatory potential

Claudia Nold

5/10/15

1 Media contribution

Press/Media: Article/Feature