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Personal profile

Biography

A/Professor Claudia Nold is a pharmacist by training with broad expertise in cytokine biology, inflammation and immunology. After her graduation from pharmacy school in 2000, she was awarded a competitive three-year PhD Fellowship by the Deutsche Forschungsgemeinschaft (the German NHMRC equivalent) and started her PhD at the Pharmazentrum Frankfurt, Germany. This fellowship entailed a 6-month tenure at the Institute of Asthma and Allergy at the Karolinska Institute, Stockholm, Sweden.

From 2006 until 2009 she held a post-doctoral position in Denver, Colorado, USA in the laboratory of Professor Charles A. Dinarello, who first described the function of Interleukin 1. Some of her achievements of this productive time included the description of anti-viral, endothelial and angiogenic properties of interleukin (IL-)32, and the important paper on the functional differences between monocytes and macrophages (200+ citations).

In 2009, A/Prof Nold was recruited to The Ritchie Centre at Hudson Institute of Medical Research in Melbourne, and continued to publish at a very high level. Of outstanding importance, however, was the discovery of the function of IL-37, which has had a major impact on the interleukin field, leading to a fundamental reorganisation of the nomenclature of the IL-1 family of cytokines in 2010.

In 2011 she was awarded the Christina Fleischmann Award of the International Society of Interferon and Cytokine Research. This award recognizes young female investigators for notable contributions to basic or clinical research. The second achievement exemplifies the translational trajectory that is paramount to her laboratory: her team has almost completed the bedside-to-bench-and-back circuit with their work on interleukin 1 receptor antagonist (IL-1Ra) in bronchopulmonary dysplasia (BPD). There is an urgent medical need to find the first safe and effective treatment for BPD in the neonatal intensive care unit, and the Nold laboratory showed in a mouse model that IL-1Ra prevents the disease. The team is now planning a clinical trial to prove the concept in babies.

In 2014 A/Prof C Nold was awarded the top ranked Future Leader Fellowship and received the Paul Korner Innovation Award of the Australian Heart Foundation.

Because of these innovative programs, the Nold team has been awarded substantial grant funding, filed several patents and are collaborating with multiple partners in the pharmaceutical industry.

Education/Academic qualification

Natural Sciences, PhD, Goethe-Universitat Frankfurt am Main (Goethe University Frankfurt)

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Projects 2010 2020

Research Output 2004 2019

IL-37 increases in patients after ischemic stroke and protects from inflammatory brain injury, motor impairment and lung infection in mice

Zhang, S. R., Nold, M. F., Tang, S. C., Bui, C. B., Nold, C. A., Arumugam, T. V., Drummond, G. R., Sobey, C. G. & Kim, H. A., 1 Dec 2019, In : Scientific Reports. 9, 1, 12 p., 6922.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Endometrial Mesenchymal Stem/Stromal Cells Modulate the Macrophage Response to Implanted Polyamide/Gelatin Composite Mesh in Immunocompromised and Immunocompetent Mice

Darzi, S., Deane, J. A., Nold, C. A., Edwards, S. E., Gough, D. J., Mukherjee, S., Gurung, S., Tan, K. S., Vashi, A. V., Werkmeister, J. A. & Gargett, C. E., 1 Dec 2018, In : Scientific Reports. 8, 1, 15 p., 6554.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Defining T helper cell immunity in bronchopulmonary dysplasia

Lao, J. C., Pang, M. A., Malhotra, A., Tan, K., Beker, F., Konig, K., Collins, C., Theda, C., Kamlin, C. O., Yeomans, E., Elsayed, K., Noble, E., Walsh, G., Argus, B., Twitchell, E., Berger, P., Veldman, A., Nold-Petry, C. A. & Nold, M. F., 1 May 2017, p. 125-126. 1 p.

Research output: Contribution to conferenceAbstractOtherpeer-review

Gp96 peptide antagonist gp96-II confers therapeutic effects in murine intestinal inflammation

Nold-Petry, C. A., Nold, M. F., Levy, O., Kliger, Y., Oren, A., Borukhov, I., Becker, C., Wirtz, S., Sandhu, M. K., Neurath, M. & Dinarello, C. A., 11 Dec 2017, In : Frontiers in Immunology. 8, DEC, 13 p., 1531.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Homodimerization attenuates the anti-inflammatory activity of interleukin-37

Ellisdon, A. M., Nold-Petry, C. A., D'Andrea, L., Cho, S. X., Lao, J. C., Rudloff, I., Ngo, D., Lo, C. Y., Soares da Costa, T. P., Perugini, M. A., Conroy, P. J., Whisstock, J. C. & Nold, M. F., 10 Feb 2017, In : Science Immunology. 2, 8, 12 p., eaaj1548.

Research output: Contribution to journalArticleResearchpeer-review

Prizes

Advancing Women's Research Success

Claudia Nold (Recipient), 2013

Prize: Prize (including medals and awards)

American Association of Immunologists Abstract Award

Claudia Nold (Recipient), 2013

Prize: Prize (including medals and awards)

Best Publication Award 2010

Claudia Nold (Recipient), 2010

Prize: Prize (including medals and awards)

Best Publication Award 2015

Claudia Nold (Recipient), 2015

Prize: Prize (including medals and awards)

Activities 2013 2017

  • 7 Peer review responsibility

Archives of Disease in Childhood (Journal)

Claudia Nold (Peer reviewer)
5 Mar 2017

Activity: Publication peer-review and editorial work typesPeer review responsibility

Journal of Cellular Biochemistry (Journal)

Claudia Nold (Peer reviewer)
6 Jul 2016

Activity: Publication peer-review and editorial work typesPeer review responsibility

Scandinavian Journal of Rheumatology (Journal)

Claudia Nold (Peer reviewer)
15 Oct 2016

Activity: Publication peer-review and editorial work typesPeer review responsibility

Oxford University Press (Publisher)

Claudia Nold (Peer reviewer)
3 Dec 2015

Activity: Publication peer-review and editorial work typesPeer review responsibility

Cellular Physiology and Biochemistry (Journal)

Claudia Nold (Peer reviewer)
3 Mar 2015

Activity: Publication peer-review and editorial work typesPeer review responsibility

Press / Media

Goethe Institute - STEM/CLIL Science Workshops in German-

Claudia Nold

1/10/18

1 media contribution

Press/Media: Public Engagement Activities

Bronchopulmonary Dysplasia (BPD)

Claudia Nold

2/10/17

1 item of media coverage

Press/Media: Research

Doctor awarded for work with ill preterm babies

Claudia Nold

11/11/15

1 media contribution

Press/Media: Research

Understand your body.

Claudia Nold

5/10/15

1 media contribution

Press/Media: Public Engagement Activities

Scientists override the body’s inflammatory response

Claudia Nold

5/10/15

1 media contribution

Press/Media: Public Engagement Activities