Projects per year
Personal profile
Biography
A/Professor Claudia Nold is a pharmacist by training with broad expertise in cytokine biology, inflammation and immunology. After her graduation from pharmacy school in 2000, she was awarded a competitive three-year PhD Fellowship by the Deutsche Forschungsgemeinschaft (the German NHMRC equivalent) and started her PhD at the Pharmazentrum Frankfurt, Germany. This fellowship entailed a 6-month tenure at the Institute of Asthma and Allergy at the Karolinska Institute, Stockholm, Sweden.
From 2006 until 2009 she held a post-doctoral position in Denver, Colorado, USA in the laboratory of Professor Charles A. Dinarello, who first described the function of Interleukin 1. Some of her achievements of this productive time included the description of anti-viral, endothelial and angiogenic properties of interleukin (IL-)32, and the important paper on the functional differences between monocytes and macrophages (200+ citations).
In 2009, A/Prof Nold was recruited to The Ritchie Centre at Hudson Institute of Medical Research in Melbourne, and continued to publish at a very high level. Of outstanding importance, however, was the discovery of the function of IL-37, which has had a major impact on the interleukin field, leading to a fundamental reorganisation of the nomenclature of the IL-1 family of cytokines in 2010.
In 2011 she was awarded the Christina Fleischmann Award of the International Society of Interferon and Cytokine Research. This award recognizes young female investigators for notable contributions to basic or clinical research. The second achievement exemplifies the translational trajectory that is paramount to her laboratory: her team has almost completed the bedside-to-bench-and-back circuit with their work on interleukin 1 receptor antagonist (IL-1Ra) in bronchopulmonary dysplasia (BPD). There is an urgent medical need to find the first safe and effective treatment for BPD in the neonatal intensive care unit, and the Nold laboratory showed in a mouse model that IL-1Ra prevents the disease. The team is now planning a clinical trial to prove the concept in babies.
In 2014 A/Prof C Nold was awarded the top ranked Future Leader Fellowship and received the Paul Korner Innovation Award of the Australian Heart Foundation.
Because of these innovative programs, the Nold team has been awarded substantial grant funding, filed several patents and are collaborating with multiple partners in the pharmaceutical industry.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Natural Sciences, PhD, Regulation of Eicosanoid Synthesizing Enzymes in Rat Renal Mesangial Cells and Human Cord Blood Mast Cells, Goethe-Universität Frankfurt am Main (Goethe University Frankfurt)
Award Date: 12 Oct 2005
Collaborations and top research areas from the last five years
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Developing and Repurposing Therapies: Pioneering Interventional Immunology for Early Life Diseases & Beyond
Nold, C. (Primary Chief Investigator (PCI))
1/01/25 → 31/12/29
Project: Research
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Targeting Interleukin-1 to Prevent Cardiovascular Disease in Preterm Infants
Nold, C. (Primary Chief Investigator (PCI)), Nold, M. (Chief Investigator (CI)), Sehgal, A. (Chief Investigator (CI)) & Hunt, R. (Chief Investigator (CI))
1/01/24 → 31/12/25
Project: Research
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Interventional Immunology in Early Life Diseases
Nold, C. (Primary Chief Investigator (PCI))
1/01/20 → 31/12/24
Project: Research
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Interleukin 37 – a novel cytokine therapy for Necrotizing Enterocolitis in the preterm.
Nold, C. (Primary Chief Investigator (PCI)), King, S. K. (Chief Investigator (CI)), Theda, C. (Chief Investigator (CI)) & Nold, M. (Chief Investigator (CI))
1/01/18 → 31/12/20
Project: Research
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A Cell Therapy for Necrotising Enterocolitis
Wallace, E. (Primary Chief Investigator (PCI)), Lim, R. (Chief Investigator (CI)), Nold, C. (Chief Investigator (CI)) & Clevers, H. C. (Chief Investigator (CI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/18 → 31/12/21
Project: Research
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Safety of Hepatitis B Vaccines (Monovalent or as Part of Combination) in Preterm Infants: A Systematic Review
Tee, Q. W., Odisho, R., Purcell, E., Purcell, R., Buttery, J., Nold-Petry, C. A., Nold, M. F. & Malhotra, A., Mar 2024, In: Vaccines. 12, 3, 16 p., 261.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access1 Citation (Scopus) -
The small-molecule formyl peptide receptor biased agonist, compound 17b, is a vasodilator and anti-inflammatory in mouse precision-cut lung slices
Studley, W. R., Lamanna, E., Martin, K. A., Nold-Petry, C. A., Royce, S. G., Woodman, O. L., Ritchie, R. H., Qin, C. X. & Bourke, J. E., Jul 2024, In: British Journal of Pharmacology. 181, 14, p. 2287-2301 15 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access6 Citations (Scopus) -
Thirteen years to get from b to a: one of the neglected isoforms of IL-37 enters the stage
Cho, S. X., Rudloff, I., Ellisdon, A. M., Nold-Petry, C. A. & Nold, M. F., Feb 2024, In: Cellular & Molecular Immunology. 21, 2, p. 201-202 2 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
1 Citation (Scopus) -
A systematic review of immune-based interventions for perinatal neuroprotection: closing the gap between animal studies and human trials
Kelly, S. B., Tran, N. T., Polglase, G. R., Hunt, R. W., Nold, M. F., Nold-Petry, C. A., Olson, D. M., Chemtob, S., Lodygensky, G. A., Robertson, S. A., Gunn, A. J. & Galinsky, R., 2023, In: Journal of Neuroinflammation. 20, 32 p., 241.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access6 Citations (Scopus) -
Interleukin-1: an important target for perinatal neuroprotection?
Kelly, S. B., Green, E., Hunt, R. W., Nold-Petry, C. A., Gunn, A. J., Nold, M. F. & Galinsky, R., Jan 2023, In: Neural Regeneration Research. 18, 1, p. 47-50 4 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access11 Citations (Scopus)
Prizes
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Advancing Women's Research Success
Nold, C. (Recipient), 2013
Prize: Prize (including medals and awards)
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American Association of Immunologists Abstract Award
Nold, C. (Recipient), 2013
Prize: Prize (including medals and awards)
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Christina Fleischmann Award of the International Society of Interferon and Cytokine Research
Nold, C. (Recipient), 2011
Prize: Prize (including medals and awards)
Activities
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American Association of Immunologists
Nold, C. (Fellow)
2020Activity: External Academic Engagement › Professional association or peak discipline body
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Australasian Society of Immunology
Nold, C. (Fellow)
2020Activity: External Academic Engagement › Professional association or peak discipline body
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National Health and Medical Research Council Research Translation Faculty
Nold, C. (Fellow)
2020Activity: External Academic Engagement › Professional association or peak discipline body
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International Cytokine and Interferon Society
Nold, C. (Fellow)
2020Activity: External Academic Engagement › Professional association or peak discipline body
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Glyconet Brandenburg
Nold, C. (Fellow)
2020Activity: External Academic Engagement › Professional association or peak discipline body
Press/Media
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Helping pre-term babies avoid bronchopulmonary dysplasia by controlling immune responses
6/04/22
1 Media contribution
Press/Media: Article/Feature
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Understanding how bats resist COVID-19 could inform human treatments
27/09/21
1 Media contribution
Press/Media: Article/Feature