Projects per year
Personal profile
Biography
A/Professor Claudia Nold is a pharmacist by training with broad expertise in cytokine biology, inflammation and immunology. After her graduation from pharmacy school in 2000, she was awarded a competitive three-year PhD Fellowship by the Deutsche Forschungsgemeinschaft (the German NHMRC equivalent) and started her PhD at the Pharmazentrum Frankfurt, Germany. This fellowship entailed a 6-month tenure at the Institute of Asthma and Allergy at the Karolinska Institute, Stockholm, Sweden.
From 2006 until 2009 she held a post-doctoral position in Denver, Colorado, USA in the laboratory of Professor Charles A. Dinarello, who first described the function of Interleukin 1. Some of her achievements of this productive time included the description of anti-viral, endothelial and angiogenic properties of interleukin (IL-)32, and the important paper on the functional differences between monocytes and macrophages (200+ citations).
In 2009, A/Prof Nold was recruited to The Ritchie Centre at Hudson Institute of Medical Research in Melbourne, and continued to publish at a very high level. Of outstanding importance, however, was the discovery of the function of IL-37, which has had a major impact on the interleukin field, leading to a fundamental reorganisation of the nomenclature of the IL-1 family of cytokines in 2010.
In 2011 she was awarded the Christina Fleischmann Award of the International Society of Interferon and Cytokine Research. This award recognizes young female investigators for notable contributions to basic or clinical research. The second achievement exemplifies the translational trajectory that is paramount to her laboratory: her team has almost completed the bedside-to-bench-and-back circuit with their work on interleukin 1 receptor antagonist (IL-1Ra) in bronchopulmonary dysplasia (BPD). There is an urgent medical need to find the first safe and effective treatment for BPD in the neonatal intensive care unit, and the Nold laboratory showed in a mouse model that IL-1Ra prevents the disease. The team is now planning a clinical trial to prove the concept in babies.
In 2014 A/Prof C Nold was awarded the top ranked Future Leader Fellowship and received the Paul Korner Innovation Award of the Australian Heart Foundation.
Because of these innovative programs, the Nold team has been awarded substantial grant funding, filed several patents and are collaborating with multiple partners in the pharmaceutical industry.
Education/Academic qualification
Natural Sciences, PhD, Goethe-Universität Frankfurt am Main (Goethe University Frankfurt)
Award Date: 12 Oct 2005
Network
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Interleukin 37 – a novel cytokine therapy for Necrotizing Enterocolitis in the preterm.
Nold, C., King, S. K., Theda, C. & Nold, M.
1/01/18 → 31/12/20
Project: Research
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A Cell Therapy for Necrotising Enterocolitis
Wallace, E., Lim, R., Nold, C. & Clevers, H.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/18 → 31/12/21
Project: Research
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Modulating inflammation as a therapy for Harlequin Ichthyosis
Smyth, I., Cottle, D., Nold, M. & Nold, C.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/17 → 31/12/20
Project: Research
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Protein engineering of a stable and potent anti-inflammatory IL-37-Fc fusion with enhanced therapeutic potential
Bujotzek, A., Tiefenthaler, G., Lariviere, L., D'Andrea, L., Marquez, E. A., Rudloff, I., Cho, S., Deen, N., Richter, W., Regenass-Lechner, F., Poehler, A., Whisstock, J., Sydow-Anderson, J., Reiser, X., Schuster, S., Neubauer, J., Hoepfl, S., Richter, K., Nold, M., Nold-Petry, C. & 2 others, , 17 Mar 2022, In: Cell Chemical Biology. 29, p. 1-11.e1–e4 15 p.Research output: Contribution to journal › Article › Research › peer-review
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Safety of in utero exposure to maternal IBD pharmacotherapies
Prentice, R. E., Bell, S. J., Nold-Petry, C. A., Nold, M. F. & Goldberg, R., Jan 2022, (Accepted/In press) In: Nature Reviews Gastroenterology and Hepatology. 2 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
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Type 2 immune polarization is associated with cardiopulmonary disease in preterm infants
Lao, J. C., Bui, C. B., Pang, M. A., Cho, S. X., Rudloff, I., Elgass, K., Schröder, J., Maksimenko, A., Mangan, N. E., Starkey, M. R., Skuza, E. M., Sun, Y. B. Y., Beker, F., Collins, C. L., Kamlin, O. F., König, K., Malhotra, A., Tan, K., Theda, C., Young, M. J. & 10 others, , 6 Apr 2022, In: Science Translational Medicine. 14, 639, 17 p., eaaz8454.Research output: Contribution to journal › Article › Research › peer-review
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Circulating Interleukin-37 Levels in Healthy Adult Humans – Establishing a Reference Range
Santarelli, D. M., Vincent, F. B., Rudloff, I., Nold, C. A., Nold, M. F. & Russo, M., 23 Jul 2021, In: Frontiers in Immunology. 12, 11 p., 708425.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile1 Citation (Scopus) -
Interleukin-1 blockade attenuates white matter inflammation and oligodendrocyte loss after progressive systemic lipopolysaccharide exposure in near-term fetal sheep
Kelly, S. B., Stojanovska, V., Zahra, V. A., Moxham, A., Miller, S. L., Moss, T. J. M., Hooper, S. B., Nold, M. F., Nold-Petry, C. A., Dean, J. M., Bennet, L., Polglase, G. R., Gunn, A. J. & Galinsky, R., Dec 2021, In: Journal of Neuroinflammation. 18, 1, 18 p., 189.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus)
Prizes
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Advancing Women's Research Success
Nold, Claudia (Recipient), 2013
Prize: Prize (including medals and awards)
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American Association of Immunologists Abstract Award
Nold, Claudia (Recipient), 2013
Prize: Prize (including medals and awards)
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Best Publication Award 2011
Nold, Claudia (Recipient), 2011
Prize: Prize (including medals and awards)
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Best Publication Award 2015
Nold, Claudia (Recipient), 2015
Prize: Prize (including medals and awards)
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Christina Fleischmann Award of the International Society of Interferon and Cytokine Research
Nold, Claudia (Recipient), 2011
Prize: Prize (including medals and awards)
Activities
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MRFF Priority Round Assessor
Claudia Nold (Fellow)
2020Activity: External Academic Engagement › Grant review responsibilities
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National Health and Medical Research Council Research Translation Faculty
Claudia Nold (Fellow)
2020Activity: External Academic Engagement › Professional association or peak discipline body
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Australasian Society of Immunology
Claudia Nold (Fellow)
2020Activity: External Academic Engagement › Professional association or peak discipline body
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American Association of Immunologists
Claudia Nold (Fellow)
2020Activity: External Academic Engagement › Professional association or peak discipline body
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Glyconet Brandenburg
Claudia Nold (Fellow)
2020Activity: External Academic Engagement › Professional association or peak discipline body
Press / Media
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Goethe Institute - STEM/CLIL Science Workshops in German-
1/10/18
1 Media contribution
Press/Media: Public Engagement Activities
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Discovery of composition and function of the cell surface receptor of IL 37
5/10/15
1 Media contribution
Press/Media: Public Engagement Activities
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Claudia Nold Scientists Override the Body's Inflammatory Response
5/10/15
1 Media contribution
Press/Media: Profile/Interview