Projects per year
Personal profile
Biography
After a brief stint in the pharmaceutical industry, Claudia has returned to Monash to take up a Post Doctorate research position in the Intergrative Cardiovascular Pharmacology group, led by Prof. Robert Widdop. Continuing on from research completed for her PhD at Monash University, her main research focus is in the area of stroke and the role of the Renin Angiotensin System (RAS) in determining stroke outcome.
More recently, Claudia's research has taken on a more clinical focus as she explores whether the AT-2 receptor could be a potential target for stroke therapy and investigates the neuroprotective properties of various modulators of the RAS. Her current research utilizes an integrated perspective and encompasses both in vivo and in vitro techniques to elucidate the complex cascade that contributes to the neuronal damage resulting from stroke.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Projects
- 2 Finished
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Targeting insulin regulated aminopeptidase (IRAP) as a novel treatment for stroke
1/03/21 → 28/02/22
Project: Research
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Optimising the photothrombotic model of stroke in the C57BI/6 and FVB/N strains of mouse
Knezic, A., Broughton, B. R. S., Widdop, R. E. & McCarthy, C. A., Dec 2022, In: Scientific Reports. 12, 1, 11 p., 7598.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a
Chassagnon, I. R., McCarthy, C. A., Chin, Y. K. Y., Pineda, S. S., Keramidas, A., Mobli, M., Pham, V., De Silva, T. M., Lynch, J. W., Widdop, R. E., Rash, L. D. & King, G. F., 4 Apr 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 14, p. 3750-3755 6 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile123 Citations (Scopus) -
AT2R, vascular effects, and blood pressure
Dias Baraldi, D., Jones, E. S., Hilliard, L. M., Del Borgo, M. P., Gaspari, T. A., McCarthy, C. A., Vinh, A., Weungoda, I., Aguilar, M-I. I., Denton, K. M. & Widdop, R. E., 2015, The Protective Arm of the Renin-Angiotensin System: Functional Aspects and Therapeutic Implications. Unger, T., Steckelings, U. M. & dos Santos, R. A. S. (eds.). 1st ed. London UK: Elsevier, p. 49 - 55 7 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review
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PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a
McCarthy, C. A., Rash, L. D., Chassagnon, I. R., King, G. F. & Widdop, R. E., 2015, In: Neuropharmacology. 99, (Art. No: 5986), p. 650 - 657 8 p.Research output: Contribution to journal › Article › Research › peer-review
37 Citations (Scopus) -
Direct angiotensin AT2 receptor stimulation using a novel AT2 receptor agonist, compound 21, evokes neuroprotection in conscious hypertensive rats
McCarthy, C. A., Vinh, A., Miller, A. A., Hallberg, A., Alterman, M., Callaway, J. K. & Widdop, R. E., 2014, In: PLoS ONE. 9, 4 (Art. No: e95762), p. 1 - 10 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access67 Citations (Scopus)