Claudia Ireland

Mrs

20082017
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Personal profile

Biography

After a brief stint in the pharmaceutical industry, Claudia has returned to Monash to take up a Post Doctorate research position in the Intergrative Cardiovascular Pharmacology group, led by Prof. Robert Widdop. Continuing on from research completed for her PhD at Monash University, her main research focus is in the area of stroke and the role of the Renin Angiotensin System (RAS) in determining stroke outcome.

More recently, Claudia's research has taken on a more clinical focus as she explores whether the AT-2 receptor could be a potential target for stroke therapy and investigates the neuroprotective properties of various modulators of the RAS. Her current research utilizes an integrated perspective and encompasses both in vivo and in vitro techniques to elucidate the complex cascade that contributes to the neuronal damage resulting from stroke.

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Research Output 2008 2017

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a

Chassagnon, I. R., McCarthy, C. A., Chin, Y. K. Y., Pineda, S. S., Keramidas, A., Mobli, M., Pham, V., De Silva, T. M., Lynch, J. W., Widdop, R. E., Rash, L. D. & King, G. F., 4 Apr 2017, In : Proceedings of the National Academy of Sciences. 114, 14, p. 3750-3755 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

AT2R, vascular effects, and blood pressure

Dias Baraldi, D., Jones, E. S., Hilliard, L. M., Del Borgo, M. P., Gaspari, T. A., McCarthy, C. A., Vinh, A., Weungoda, I., Aguilar, M-I. I., Denton, K. M. & Widdop, R. E., 2015, The Protective Arm of the Renin-Angiotensin System: Functional Aspects and Therapeutic Implications. Unger, T., Steckelings, U. M. & dos Santos, R. A. S. (eds.). 1st ed. London UK: Elsevier, p. 49 - 55 7 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a

McCarthy, C. A., Rash, L. D., Chassagnon, I. R., King, G. F. & Widdop, R. E., 2015, In : Neuropharmacology. 99, (Art. No: 5986), p. 650 - 657 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Direct angiotensin AT2 receptor stimulation using a novel AT2 receptor agonist, compound 21, evokes neuroprotection in conscious hypertensive rats

McCarthy, C. A., Vinh, A., Miller, A. A., Hallberg, A., Alterman, M., Callaway, J. K. & Widdop, R. E., 2014, In : PLoS ONE. 9, 4 (Art. No: e95762), p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The protective arms of the renin-angiontensin system in stroke

McCarthy, C. A., Facey, L. J. & Widdop, R. E., 2014, In : Current Hypertension Reports. 16, 7 (Art. No: 440), p. 1 - 8 8 p.

Research output: Contribution to journalArticleResearchpeer-review