Claude Bernard

Emeritus Prof

1970 …2019
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Research Output 1970 2018

2018

Redirecting adult mesenchymal stromal cells to the brain: a new approach for treating CNS autoimmunity and neuroinflammation?

Wilson, J. J., Foyle, K. L., Foeng, J., Norton, T., McKenzie, D. R., Payne, N., Bernard, C. C., McColl, S. R. & Comerford, I., 1 Apr 2018, In : Immunology and Cell Biology. 96, 4, p. 347-357 11 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

2017

Altered expression of IGF-I system in neurons of the inflamed spinal cord during acute experimental autoimmune encephalomyelitis

Parvaneh Tafreshi, A., Talebi, F., Ghorbani, S., Bernard, C. & Noorbakhsh, F., 1 Oct 2017, In : Journal of Comparative Neurology. 525, 14, p. 3072-3082 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Essential role for CCR6 in certain inflammatory diseases demonstrated using specific antagonist and knockin mice

Robert, R., Ang, C., Sun, G., Juglair, L., Lim, E. X., Mason, L. J., Payne, N. L., Bernard, C. C. A. & Mackay, C. R., 3 Aug 2017, In : JCI Insight. 2, 15, 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016

B cell-derived transforming growth factor-β1 expression limits the induction phase of autoimmune neuroinflammation

Bjarnadóttir, K., Benkhoucha, M., Merkler, D., Weber, M. S., Payne, N. L., Bernard, C. C. A., Molnarfi, N. & Lalive, P. H., 6 Oct 2016, In : Scientific Reports. 6, 14 p., 34594.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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CNS accumulation of regulatory B cells is VLA-4-dependent

Lehmann-Horn, K., Sagan, S. A., Winger, R. C., Spencer, C. M., Bernard, C. C. A., Sobel, R. A. & Zamvil, S. S., 2016, In : Neurology: Neuroimmunology & Neuroinflammation. 3, 2, p. 1-7 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Graphene functionalized scaffolds reduce the inflammatory response and supports endogenous neuroblast migration when implanted in the Adult Brain

Zhou, K., Motamed, S., Thouas, G. A., Bernard, C. C., Li, D., Parkington, H. C., Coleman, H. A., Finkelstein, D. I. & Forsythe, J. S., 15 Mar 2016, In : PLoS ONE. 11, 3, 15 p., e0151589.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Implantable amyloid hydrogels for promoting stem cell differentiation to neurons

Das, S., Zhou, K., Ghosh, D., Jha, N. N., Singh, P. K., Jacob, R. S., Bernard, C. C., Finkelstein, D. I., Forsythe, J. S. & Maji, S., 2016, In : NPG Asia Materials. 8, p. 1-14 14 p., e304.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Myelin-reactive antibodies initiate T cell-mediated CNS autoimmune disease by opsonization of endogenous antigen

Kinzel, S., Lehmann-Horn, K., Torke, S., Hausler, D., Winkler, A., Stadelmann, C., Payne, N., Feldmann, L., Saiz, A., Reindl, M., Lalive, P. H., Bernard, C. C., Bruck, W. & Weber, M. S., 1 Jul 2016, In : Acta Neuropathologica. 132, 1, p. 43-58 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Treatment of spontaneous EAE by laquinimod reduces Tfh, B cell aggregates, and disease progression

Varrin-Doyer, M., Pekarek, K. L., Spencer, C. M., Bernard, C. C. A., Sobel, R. A., Cree, B. A. C., Schulze-Topphoff, U. & Zamvil, S. S., 2016, In : Neurology: Neuroimmunology & Neuroinflammation. 3, 5, e272.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2015

Amnion cell-mediated immune modulation following bleomycin challenge: controlling the regulatory T cell response

Tan, J., Chan, S. T., Lo, C. Y-W., Deane, J. A., McDonald, C., Bernard, C. C. A., Wallace, E. M. & Lim, R. S. W., 2015, In : Stem Cell Research and Therapy. 6, 1, p. 1 - 12 12 p., 8.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

APP intracellular domain acts as a transcriptional regulator of miR-663 suppressing neuronal differentiation

Shu, R., Wong, W. S. F., Ma, Q-H., Yang, Z. Z., Zhu, H., Liu, F. J., Wang, P., Ma, J., Yan, S., Polo, J. M., Bernard, C. C. A., Stanton, L. W., Dawe, G. S. & Xiao, Z., 1 Jan 2015, In : Cell Death and Disease. 6, 2, 12 p., e1651.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Application of human induced pluripotent stem cells for modeling and treating neurodegenerative diseases

Payne, N. L., Sylvain, A., O'Brien, C., Herszfeld, D., Sun, G. & Bernard, C. C. A., 2015, In : New Biotechnology. 32, 1, p. 212 - 228 17 p.

Research output: Contribution to journalArticleResearchpeer-review

B-cell very late antigen-4 deficiency reduces leukocyte recruitment and susceptibility to central nervous system autoimmunity

Lehmann-Horn, K., Sagan, S. A., Bernard, C. C. A., Sobel, R. A. & Zamvil, S. S., 2015, In : Annals of Neurology. 77, 5, p. 902 - 908 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Immunosuppressive potential of human amnion epithelial cells in the treatment of experimental autoimmune encephalomyelitis

McDonald, C. A., Payne, N. L., Sun, G., Moussa, L., Siatskas, C., Lim, R. S. W., Wallace, E. M., Jenkin, G. & Bernard, C. C. A., 12 Dec 2015, In : Journal of Neuroinflammation. 12, 1, 112.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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In vivo multi-modal imaging of experimental autoimmune uveoretinitis in transgenic reporter mice reveals the dynamic nature of inflammatory changes during disease progression

Chen, X., Kezic, J., Forrester, J. V., Goldberg, G. L., Wicks, I. P., Bernard, C. C. A. & McMenamin, P. G., 12 Dec 2015, In : Journal of Neuroinflammation. 12, 1, 12 p., 17.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Lithium chloride improves the efficiency of induced pluripotent stem cell-derived neurospheres

Tafreshi, A. P., Sylvain, A., Sun, G., Herszfeld, D., Schulze, K. E. & Bernard, C. C. A., 2015, In : Biological Chemistry. 396, 8, p. 923 - 928 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

3D presentation of a neurotrophic factor for the regulation of neural progenitor cells

Zhou, K., Thouas, G., Bernard, C. C. A. & Forsythe, J. S., 2014, In : Nanomedicine. 9, 8, p. 1239 - 1251 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Fine structure of neurally differentiated iPS cells generated from a multiple sclerosis (MS) patient: a case study

Herszfeld, D., Payne, N. L., Sylvain, A., Sun, G., Bernard, C. C. A., Clark, J. M. & Sathananthan, A. H., 2014, In : Microscopy and Microanalysis. 20, 6, p. 1869 - 1875 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Gene therapy delivery of myelin oligodendrocyte glycoprotein (MOG) via hematopoietic stem cell transfer induces MOG-specific B cell deletion

Chung, J., Figgett, W. A., Fairfax, K., Bernard, C. C. A., Chan, C. J., Toh, B-H., Mackay-Fisson, F. & Alderuccio, F. P., 2014, In : Journal of Immunology. 192, 6, p. 2593 - 2601 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Immunodominant T-cell epitopes of MOG reside in its transmembrane and cytoplasmic domains in EAE

Shetty, A., Gupta, S. G., Varrin-Doyer, M., Weber, M. S., Prod'Homme, T., Molnarfi, N., Ji, N., Nelson, P. A., Patarroyo, J. C., Schulze-Topphoff, U., Fogal, S. E., Forsthuber, T., Sobel, R. A., Bernard, C. C. A., Slavin, A. J. & Zamvil, S. S., 14 Aug 2014, In : Neurology: Neuroimmunology & Neuroinflammation. 1, 2, 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Inactive GSK3b is disturbed in the spinal cord during experimental autoimmune encephalomyelitis, but rescued by stem cell therapy

Tafreshi, A. P., Payne, N. L., Sun, G., Sylvain, A., Schulze, K. E. & Bernard, C. C. A., 2014, In : Neuroscience. 277, p. 498 - 505 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Intrathecal anti-CD20 efficiently depletes meningeal B cells in CNS autoimmunity

Lehmann-Horn, K., Kinzel, S., Feldmann, L., Radelfahr, F., Hemmer, B., Traffehn, S., Bernard, C. C. A., Stadelmann, C., Brück, W. & Weber, M. S., 1 Jul 2014, In : Annals of Clinical and Translational Neurology. 1, 7, p. 490-496 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Mesenchymal stem cells and conditioned medium avert enteric neuropathy and colon dysfunction in guinea pig TNBS-induced colitis

Robinson, A. M., Sakkal, S., Park, A., Jovanovska, V., Payne, N. L., Carbone, S., Miller, S., Bornstein, J. C., Bernard, C. C. A., Boyd, R. L. & Nurgali, K., 2014, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 307, 11, p. 1115 - 1129 15 p.

Research output: Contribution to journalArticleResearchpeer-review

MOG transmembrane and cytoplasmic domains contain highly stimulatory T-cell epitopes in MS

Varrin-Doyer, M., Shetty, A., Spencer, C. M., Schulze-Topphoff, U., Weber, M. S., Bernard, C. C. A., Forsthuber, T., Cree, B. A. C., Slavin, A. J. & Zamvil, S. S., 1 Aug 2014, In : Neurology: Neuroimmunology & Neuroinflammation. 1, 2, p. e20

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Molecular grafting onto a stable framework yields novel cyclic peptides for the treatment of multiple sclerosis

Wang, C. K., Gruber, C. W., Cemazar, M., Siatskas, C., Tagore, P., Payne, N. L., Sun, G., Wang, S., Bernard, C. C. A. & Craik, D. J., 2014, In : ACS Chemical Biology. 9, 1, p. 156 - 163 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Quantitative proteome profiling of CNS-infiltrating autoreactive CD4+ cells reveals selective changes during experimental autoimmune encephalomyelitis

Turvey, M. E., Koudelka, T., Comerford, I., Greer, J. M., Carroll, W. M., Bernard, C. C. A., Hoffmann, P. & McColl, S. R., 2014, In : Journal of Proteome Research. 13, 8, p. 3655 - 3670 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Single Beta{3}-amino acid substitutions to MOG peptides suppress the development of experimental autoimmune encephalomyelitis

McDonald, C., Payne, N. L., Sun, G., Clayton, D. J., Del Borgo, M. P., Aguilar, M. I., Perlmutter, P. & Bernard, C. C. A., 2014, In : Journal of Neuroimmunology. 277, 1-2, p. 67 - 76 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The potential of human amnion epithelial cells as an immunodoculatory and neuroregenerative treatment for multiple sclerosis

McDonald, C., Short, M. A., Jenkin, G. & Bernard, C. C. A., 2014, Perinatal Stem Cells. Atala, A. & Murphy, S. V. (eds.). USA: Springer, p. 231 - 242 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

2013

Distinct immunomodulatory and migratory mechanisms underpin the therapeutic potential of human mesenchymal stem cells in autoimmune demyelination

Payne, N. L., Sun, G., McDonald, C., Clayton, D. J., Moussa, L., Emerson-Webber, A. C., Veron, N., Siatskas, C., Herszfeld, D., Price, J. T. & Bernard, C. C. A., 2013, In : Cell Transplantation: the regenerative medicine journal. 22, 8, p. 1409 - 1425 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Human adipose-derived mesenchymal stem cells engineered to secrete IL-10 inhibit APC function and limit CNS autoimmunity

Payne, N. L., Sun, G., McDonald, C., Moussa, L., Emerson-Webber, A. C., Loisel-Meyer, S., Medin, J., Siatskas, C. & Bernard, C. C. A., 2013, In : Brain, Behavior, and Immunity. 30, p. 103 - 114 12 p.

Research output: Contribution to journalArticleResearchpeer-review

MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies

Molnarfi, N., Schulze-Topphoff, U., Weber, M. S., Patarroyo, J. C., Prod'Homme, T., Varrin-Doyer, M., Shetty, A., Linington, C., Slavin, A. J., Hidalgo, J., Jenne, D. E., Wekerle, H., Sobel, R. A., Bernard, C. C. A., Shlomchik, M. J. & Zamvil, S. S., 2013, In : Journal of Experimental Medicine. 210, 13, p. 2921 - 2937 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Nogo-receptor 1 deficiency has no influence on immune cell repertoire or function during experimental autoimmune encephalomyelitis

Litwak, S. A., Payne, N. L., Campanale, N. V., Ozturk, E., Lee, J. Y., Petratos, S., Siatskas, C., Bakhuraysah, M. & Bernard, C. C. A., 2013, In : PLoS ONE. 8, 12, 13 p., e82101.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Transplantation of umbilical cord and bone marrow-derived mesenchymal stem cells in a patient with relapsing-remitting multiple sclerosis

Hou, Z., Liu, Y., Mao, X-H., Wei, C., Meng, M., Liu, Y., Yang, Z. Z., Zhu, H., Short, M., Bernard, C. C. A. & Xiao, Z-C., 2013, In : Cell Adhesion and Migration. 7, 5, p. 404 - 407 4 p.

Research output: Contribution to journalArticleOther

2012

Comparative study on the therapeutic potential of neurally differentiated stem cells in a mouse model of multiple sclerosis

Payne, N. L., Sun, G., Herszfeld, D., Tat-Goh, P. A., Verma, P. J., Parkington, H. C., Coleman, H. A., Tonta, M. A., Siatskas, C. & Bernard, C. C. A., 2012, In : PLoS ONE. 7, 4, 14 p., e35093.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Early intervention with gene-modified mesenchymal stem cells overexpressing interleukin-4 enhances anti-inflammatory responses and functional recovery in experimental autoimmune demyelination

Payne, N. L., Dantanarayana, A., Sun, G., Moussa, L., Caine, S., McDonald, C., Herszfeld, D., Bernard, C. CA. & Siatskas, C., 2012, In : Cell Adhesion and Migration. 6, 3, p. 179 - 189 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation

Petratos, S., Ozturk, E., Azari, M. F., Kenny, R., Lee, J. Y., Magee, K. A., Harvey, A. R., McDonald, C., Taghian, K., Moussa, L., Aui, P. M., Siatskas, C., Litwak, S. A., Fehlings, M. G., Strittmatter, S. M. & Bernard, C. CA., 2012, In : Brain. 135, Pt 6, p. 1794 - 1818 25 p.

Research output: Contribution to journalArticleResearchpeer-review

Method to impart electro- and biofunctionality to neural scaffolds using graphene-polyelectrolyte multilayers

Zhou, K., Thouas, G. A., Bernard, C., Nisbet, D. R., Finkelstein, D. I., Li, D. & Forsythe, J. S., 2012, In : ACS Applied Materials and Interfaces. 4, 9, p. 4524 - 4531 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Neural differentiation of patient specific iPS cells as a novel approach to study the pathophysiology of multiple sclerosis

Song, B., Sun, G., Herszfeld, D., Sylvain, A., Campanale, N. V., Hirst, C. E., Caine, S., Parkington, H. C., Tonta, M. A., Coleman, H. A., Short, M. A., Ricardo, S. D., Reubinoff, B. & Bernard, C. C. A., 2012, In : Stem Cell Research. 8, 2, p. 259 - 273 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The application of Fourier transform infrared microspectroscopy for the study of diseased central nervous system tissue

Caine, S., Heraud, P. R., Tobin, M. J., McNaughton, D. & Bernard, C. C. A., 2012, In : NeuroImage. 59, 4, p. 3624 - 3640 17 p.

Research output: Contribution to journalArticleResearchpeer-review

The directed differentiation of human iPS cells into kidney podocytes

Song, B., Smink, A., Jones, C., Callaghan, J. M., Firth, S. D., Bernard, C. CA., Laslett, A. L., Kerr, P. G. & Ricardo, S. D., 2012, In : PLoS ONE. 7, 9, 9 p., e46453.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Thymic gene transfer of myelin oligodendrocyte glycoprotein ameliorates the onset but not the progression of autoimmune demyelination

Siatskas, C., Seach, N. L., Sun, G., Emerson-Webber, A. C., Sylvain, A., Toh, B-H., Alderuccio, F. P., Backstrom, B. T., Boyd, R. L. & Bernard, C. CA., 2012, In : Molecular Therapy. 20, 7, p. 1349 - 1359 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

A novel unbiased proteomic approach to detect the reactivity of cerebrospinal fluid in neurological diseases

Menon, K., Steer, D. L., Short, M., Petratos, S., Smyth, I. M. & Bernard, C. CA., 2011, In : Molecular & Cellular Proteomics. 10, 6 (Art. ID: M110.000042), p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Discovery, optimization, and pharmacological characterization of novel heteroaroylphenylureas antagonists of C-C chemokine ligand 2 function

Laborde, E., Macsata, R. W., Meng, F., Peterson, B. T., Robinson, L., Schow, S. R., Simon, R. J., Xu, H., Baba, K., Inagaki, H., Ishiwata, Y., Jomori, T., Matsumoto, Y., Miyachi, A., Nakamura, T., Okamoto, M., Handel, T. M. & Bernard, C. CA., 2011, In : Journal of Medicinal Chemistry. 54, 6, p. 1667 - 1681 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Generation of induced pluripotent stem cells from human kidney mesangial cells

Song, B., Niclis, J., Alikhan, M., Sakkal, S., Sylvain, A., Kerr, P., Laslett, A., Bernard, C. & Ricardo, S., 2011, In : Journal of the American Society of Nephrology. 22, 7, p. 1213 - 1220 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Microglial cystatin F expression is a sensitive indicator for ongoing demyelination with concurrent remyelination

Ma, J., Tanaka, K. F., Shimizu, T., Bernard, C. CA., Kakita, A., Takahashi, H., Pfeiffer, S. E. & Ikenaka, K., 2011, In : Journal of Neuroscience Research. 89, 5, p. 639 - 649 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Optimizing interfacial features to regulate neural progenitor cells using polyelectrolyte multilayers and brain derived neurotrophic factor

Zhou, K., Sun, G., Bernard, C. CA., Thouas, G. A., Nisbet, D. R. & Forsythe, J. S., 2011, In : Biointerphases. 6, 4, p. 189 - 199 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Quantitative and phenotypic analysis of bone marrow-derived cells in the intact and inflamed central nervous system

Short, M., Campanale, N., Litwak, S. & Bernard, C., Sep 2011, In : Cell Adhesion and Migration. 5, 5, p. 373 - 381 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The emergence of amnion epithelial stem cells for the treatment of Multiple Sclerosis

McDonald, C., Siatskas, C. & Bernard, C. CA., 2011, In : Inflammation and Regeneration. 31, 3, p. 256 - 271 16 p.

Research output: Contribution to journalArticleOther