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Research Output 2001 2019

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2 Citations (Scopus)

IL-37 increases in patients after ischemic stroke and protects from inflammatory brain injury, motor impairment and lung infection in mice

Zhang, S. R., Nold, M. F., Tang, S. C., Bui, C. B., Nold, C. A., Arumugam, T. V., Drummond, G. R., Sobey, C. G. & Kim, H. A., 1 Dec 2019, In : Scientific Reports. 9, 1, 12 p., 6922.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Mild closed-head injury in conscious rats causes transient neurobehavioral and glial disturbances: A novel experimental model of concussion

Pham, L., Shultz, S. R., Kim, H. A., Brady, R., Wortman, R. C., Genders, S. G., Hale, M. W., O'Shea, R., Djouma, E., van den Buuse, M., Church, J. E., Christie, B. R., Drummond, G., Sobey, C. G. & McDonald, S., 15 Jul 2019, In : Journal of Neurotrauma. 36, 14, p. 2260-2271 12 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension

Krishnan, S. M., Ling, Y. H., Huuskes, B. M., Ferens, D. M., Saini, N., Chan, C. T., Diep, H., Kett, M. M., Samuel, C. S., Kemp-Harper, B. K., Robertson, A. A. B., Cooper, M. A., Peter, K., Latz, E., Mansell, A. S., Sobey, C. G., Drummond, G. R. & Vinh, A., 15 Mar 2019, In : Cardiovascular Research. 115, 4, p. 776-787 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2018
10 Citations (Scopus)

Acute or Delayed Systemic Administration of Human Amnion Epithelial Cells Improves Outcomes in Experimental Stroke

Evans, M. A., Lim, R., Kim, H. A., Chu, H. X., Gardiner-Mann, C. V., Taylor, K. W. E., Chan, C. T., Brait, V. H., Lee, S., Dinh, Q. N., Vinh, A., Phan, T. G., Srikanth, V. K., Ma, H., Arumugam, T. V., Fann, D. Y., Poh, L., Hunt, C. P. J., Pouton, C. W., Haynes, J. M. & 12 others, Selemidis, S., Kwan, W., Teo, L., Bourne, J. A., Neumann, S., Young, S., Gowing, E. K., Drummond, G. R., Clarkson, A. N., Wallace, E. M., Sobey, C. G. & Broughton, B. R. S., 1 Mar 2018, In : Stroke. 49, 3, p. 700-709 10 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Diet-induced vitamin D deficiency has no effect on acute post-stroke outcomes in young male mice

Evans, M. A., Kim, H. A., De Silva, T. M., Arumugam, T. V., Clarkson, A. N., Drummond, G. R., Zosky, G. R., Broughton, B. R. S. & Sobey, C. G., 1 Nov 2018, In : Journal of Cerebral Blood Flow and Metabolism. 38, 11, p. 1968-1978 11 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Evidence that NF-κB and MAPK Signaling Promotes NLRP Inflammasome Activation in Neurons Following Ischemic Stroke

Fann, D. Y. W., Lim, Y. A., Cheng, Y. L., Lok, K. Z., Chunduri, P., Baik, S. H., Drummond, G. R., Dheen, S. T., Sobey, C. G., Jo, D. G., Chen, C. L. H. & Arumugam, T. V., Feb 2018, In : Molecular Neurobiology. 55, 2, p. 1082-1096 15 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

IL-33 modulates inflammatory brain injury but exacerbates systemic immunosuppression following ischemic stroke

Zhang, S. R., Piepke, M., Chu, H. X., Broughton, B. R. S., Shim, R., Wong, C. H. Y., Lee, S., Evans, M. A., Vinh, A., Sakkal, S., Arumugam, T. V., Magnus, T., Huber, S., Gelderblom, M., Drummond, G. R., Sobey, C. G. & Kim, H. A., 20 Sep 2018, In : JCI Insight. 3, 18, 16 p., e121560.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

NOX2 oxidase expressed in endosomes promotes cell proliferation and prostate tumour development

Harrison, I. P., Vinh, A., Johnson, I. R. D., Luong, R., Drummond, G. R., Sobey, C. G., Tiganis, T., Williams, E. D., O'Leary, J., Brooks, D. A. & Selemidis, S., 23 Oct 2018, In : Oncotarget. 9, 83, p. 35378-35393 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Phase 1 trial of amnion cell therapy for ischemic stroke

Phan, T. G., Ma, H., Lim, R., Sobey, C. G. & Wallace, E. M., 7 Jun 2018, In : Frontiers in Neurology. 9, JUN, 7 p., 198.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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6 Citations (Scopus)

Vitamin D3 Supplementation Reduces Subsequent Brain Injury and Inflammation Associated with Ischemic Stroke

Evans, M. A., Kim, H. A., Ling, Y. H., Uong, S., Vinh, A., De Silva, T. M., Arumugam, T. V., Clarkson, A. N., Zosky, G. R., Drummond, G. R., Broughton, B. R. S. & Sobey, C. G., 1 Mar 2018, In : NeuroMolecular Medicine. 20, 1, p. 147-159 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017
8 Citations (Scopus)

Advanced atherosclerosis is associated with inflammation, vascular dysfunction and oxidative stress, but not hypertension

Dinh, Q. N., Chrissobolis, S., Diep, H., Chan, C. T., Ferens, D., Drummond, G. R. & Sobey, C. G., Feb 2017, In : Pharmacological Research. p. 70-76 7 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Anakinra reduces blood pressure and renal fibrosis in one kidney/DOCA/salt-induced hypertension

Ling, Y. H., Krishnan, S. M., Chan, C. T., Diep, H., Ferens, D., Chin-Dusting, J., Kemp-Harper, B. K., Samuel, C. S., Hewitson, T. D., Latz, E., Mansell, A., Sobey, C. G. & Drummond, G. R., Feb 2017, In : Pharmacological Research. 116, p. 77-86 10 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy

To, E. E., Vlahos, R., Luong, R., Halls, M. L., Reading, P. C., King, P. T., Chan, C., Drummond, G. R., Sobey, C. G., Broughton, B. R. S., Starkey, M. R., van der Sluis, R., Lewin, S. R., Bozinovski, S., O'Neill, L. A. J., Quach, T., Porter, C. J. H., Brooks, D. A., O'Leary, J. & Selemidis, S., 1 Dec 2017, In : Nature Communications. 8, 1, 17 p., 69.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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13 Citations (Scopus)

Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress

Dinh, Q. N., Drummond, G. R., Kemp-Harper, B. K., Diep, H., De Silva, T. M., Kim, H. A., Vinh, A., Robertson, A. A. B., Cooper, M. A., Mansell, A., Chrissobolis, S. & Sobey, C. G., 28 Jun 2017, In : Aging. 9, 6, p. 1595-1605 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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114 Citations (Scopus)

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview

Alexander, S. P. H., Kelly, E., Marrion, N. V., Peters, J. A., Faccenda, E., Harding, S. D., Pawson, A. J., Sharman, J. L., Southan, C., Buneman, O. P., Cidlowski, J. A., Christopoulos, A., Davenport, A. P., Fabbro, D., Spedding, M., Striessnig, J., Davies, J. A. & CGTP Collaborators, 1 Dec 2017, In : British Journal of Pharmacology. 174, S1, p. S1-S16 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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21 Citations (Scopus)

Treatment with an interleukin-1 receptor antagonist mitigates neuroinflammation and brain damage after polytrauma

Sun, M., Brady, R. D., Wright, D. K., Kim, H. A., Zhang, S. R., Sobey, C. G., Johnstone, M. R., O'Brien, T. J., Semple, B. D., McDonald, S. J. & Shultz, S. R., Nov 2017, In : Brain, Behavior, and Immunity. 66, p. 359-371 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Vasoactive actions of nitroxyl (HNO) are preserved in resistance arteries in diabetes

Tare, M., Kalidindi, R. S. R., Bubb, K. J., Parkington, H. C., Boon, W-M., Li, X., Sobey, C. G., Drummond, G. R., Ritchie, R. H. & Kemp-Harper, B. K., Apr 2017, In : Naunyn-Schmiedeberg's Archives of Pharmacology. 390, 4, p. 397-408 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2016
23 Citations (Scopus)

Aldosterone-induced oxidative stress and inflammation in the brain are mediated by the endothelial cell mineralocorticoid receptor

Dinh, Q. N., Young, M. J., Evans, M. A., Drummond, G. R., Sobey, C. G. & Chrissobolis, S., 2016, In : Brain Research. 1637, p. 146 - 153 8 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Evidence of CCR2-independent transmigration of Ly6Chi monocytes into the brain after permanent cerebral ischemia in mice

Chu, H. X., Kim, H. A., Lee, S., Broughton, B. R. S., Drummond, G. R. & Sobey, C. G., 15 Apr 2016, In : Brain Research. 1637, p. 118-127 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Ghrelin-related peptides do not modulate vasodilator nitric oxide production or superoxide levels in mouse systemic arteries

Ku, J. M., Sleeman, M. W., Sobey, C. G., Andrews, Z. B. & Miller, A. A., Apr 2016, In : Clinical and Experimental Pharmacology and Physiology. 43, 4, p. 468-475 8 p.

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)

Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induced hypertension in mice

Krishnan, S. M., Dowling, J. K., Ling, Y. H., Diep, H., Chan, C. T., Ferens, D., Kett, M. M., Pinar, A., Samuel, C. S., Vinh, A., Arumugam, T. V., Hewitson, T. D., Kemp-Harper, B. K., Robertson, A. A. B., Cooper, M. A., Latz, E., Mansell, A., Sobey, C. G. & Drummond, G. R., 1 Feb 2016, In : British Journal of Pharmacology. 173, 4, p. 752-765 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2015
32 Citations (Scopus)

Activin and NADPH-oxidase in preeclampsia: insights from in vitro and murine studies

Lim, R., Acharya, R., Delpachitra, P., Hobson, S., Sobey, C. G., Drummond, G. R. & Wallace, E. M., 1 Jan 2015, In : American Journal of Obstetrics and Gynecology. 212, 1, p. 86.e1 - 86.e12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Danger signals in stroke

Gelderblom, M., Sobey, C. G., Kleinschnitz, C. & Magnus, T., 2015, In : Ageing Research Reviews. 24, Pt. A, p. 77 - 82 6 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Effect of a broad-specificity chemokine-binding protein on brain leukocyte infiltration and infarct development

Lee, S. S., Chu, H. X., Kim, H. A. H., Real, N. C., Sharif, S., Fleming, S. B., Mercer, A. A., Wise, L., Drummond, G. R. & Sobey, C. G., 2015, In : Stroke. 46, 2, p. 537 - 544 8 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Effect of a selective mas receptor agonist in cerebral ischemia in vitro and in vivo

Lee, S. S., Evans, M. A., Chu, H. X., Kim, H. H. A., Widdop, R. E., Drummond, G. R. & Sobey, C. G., 2015, In : PLoS ONE. 10, 11, 11 p., e0142087.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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11 Citations (Scopus)

Emerging roles of the {gamma}-secretase-notch axis in inflammation

Cheng, Y-L., Choi, Y., Sobey, C. G., Arumugam, T. V. & Jo, D-G., 2015, In : Pharmacology and Therapeutics. 147, p. 80 - 90 11 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Evidence that Ly6C(hi) monocytes are protective in acute ischemic stroke by promoting M2 macrophage polarization

Chu, H. X., Broughton, B. R. S., Kim, H. H. A., Lee, S. S., Drummond, G. R. & Sobey, C. G., 2015, In : Stroke. 46, 7, p. 1929 - 1937 9 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Ghrelin-related peptides exert protective effects in the cerebral circulation of male mice through a nonclassical ghrelin receptor(s)

Ku, J., Andrews, Z. B., Barsby, T., Reichenbach, A., Lemus, M. B., Drummond, G. R., Sleeman, M., Spencer, S. J., Sobey, C. G. & Miller, A. A., 2015, In : Endocrinology. 156, 1, p. 280 - 290 11 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)
16 Citations (Scopus)

MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents

Samson, A. L., Ju, L., Kim, H. A., Zhang, S., Lee, J. A. A., Sturgeon, S. A., Sobey, C. G., Jackson, S. & Schoenwaelder, S. M., 2015, In : Scientific Reports. 5, (Art. No: 16171), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
18 Citations (Scopus)
68 Citations (Scopus)

Obligatory role for B cells in the development of angiotensin II-dependent hypertension

Chan, C. T-L., Sobey, C. G., Lieu, M., Ferens, D. M., Kett, M. M., Diep, H., Kim, H. H. A., Krishnan, S. M., Lewis, C. V., Salimova, E., Tipping, P. G., Vinh, A., Samuel, C. S., Peter, K., Guzik, T. J., Kyaw, T. S., Toh, B-H., Bobik, A. & Drummond, G. R., 2015, In : Hypertension. 66, 5, p. 1023 - 1033 11 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Pin1 promotes neuronal death in stroke by stabilizing Notch intracellular domain

Baik, S-H., Fane, M., Park, J. H., Cheng, Y-L., Fann, D. Y-W., Yun, U. J., Choi, Y., Park, J-S., Chai, B. H., Park, J. S., Back, S. H., Jeong, J. I., Jang, Y. J., Bahn, G., Lee, J-Y., Li, Y., Sobey, C. G., Uchida, T., Park, J. H., Kim, H. T. & 3 others, Tang, S-C., Arumugam, T. V. & Jo, D-G., 2015, In : Annals of Neurology. 77, 3, p. 504 - 516 13 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Risk of major cardiovascular events in people with down syndrome

Sobey, C. G., Judkins, C. P., Sundararajan, V., Phan, T. G., Drummond, G. R. & Srikanth, V. K., 2015, In : PLoS ONE. 10, 9, 11 p., e0137093.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2014
14 Citations (Scopus)

Antibodies in the pathogenesis of hypertension

Chan, C., Lieu, M., Toh, B-H., Kyaw, T. S., Bobik, A., Sobey, C. G. & Drummond, G. R., 2014, In : BioMed Research International. 2014, (Art. No: 504045), p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Brain immune cell composition and functional outcome after cerebral ischemia: comparison of two mouse strains

Kim, H. A., Whittle, S., Lee, S. S., Chu, H., Zhang, S., Wei, Z., Arumugam, T., Vinh, A., Drummond, G. R. & Sobey, C. G., 2014, In : Frontiers in Cellular Neuroscience. 8, 365, 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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16 Citations (Scopus)

Chronic aldosterone administration causes Nox2-mediated increases in reactive oxygen species production and endothelial dysfunction in the cerebral circulation

Chrissobolis, S., Drummond, G. R., Faraci, F. M. & Sobey, C. G., 2014, In : Journal of Hypertension. 32, 9, p. 1815 - 1821 7 p.

Research output: Contribution to journalArticleResearchpeer-review

66 Citations (Scopus)

Endothelial cell mineralocorticoid receptors regulate deoxycorticosterone/salt-mediated cardiac remodeling and vascular reactivity but not blood pressure

Rickard, A., Morgan, J., Chrissobolis, S., Miller, A. A., Sobey, C. G. & Young, M. J., 2014, In : Hypertension. 63, 5, p. 1033 - 1040 8 p.

Research output: Contribution to journalArticleResearchpeer-review

135 Citations (Scopus)

Endothelial NADPH oxidases: which NOX to target in vascular disease?

Drummond, G. R. & Sobey, C. G., 2014, In : Trends in Endocrinology and Metabolism. 25, 9, p. 452 - 463 12 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Evidence that collaboration between HIF-1a and Notch-1 promotes neuronal cell death in ischemic stroke

Cheng, Y-L., Park, J-S., Manzanero, S., Choi, Y., Baik, S-H., Okun, E., Gelderblom, M., Fann, D. Y-W., Magnus, T., Launikonis, B. S., Mattson, M. P., Sobey, C. G., Jo, D-G. & Arumugam, T., 2014, In : Neurobiology of Disease. 62, p. 286 - 295 10 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Evidence that neuronal Notch-1 promotes JNK/c-Jun activation and cell death following ischemic stress

Cheng, Y-L., Choi, Y., Seow, W. L., Manzanero, S., Sobey, C. G., Jo, D-G. & Arumugam, T. V., 2014, In : Brain Research. 1586, p. 193 - 202 10 p.

Research output: Contribution to journalArticleResearchpeer-review

60 Citations (Scopus)

IL-1beta and IL-18: inflammatory markers or mediators of hypertension?

Murali Krishnan, S., Sobey, C. G., Latz, E., Mansell, A. S. & Drummond, G. R., 2014, In : British Journal of Pharmacology. 171, 24, p. 5589 - 5602 14 p.

Research output: Contribution to journalArticleResearchpeer-review

80 Citations (Scopus)

Immune cell infiltration in malignant middle cerebral artery infarction: comparison with transient cerebral ischemia

Chu, H. X., Huynh, K., Lee, S. S., Moore, J. P., Chan, C. T. L., Vinh, A., Gelderblom, M., Arumugam, T., Broughton, B. R. S., Drummond, G. R. & Sobey, C. G., 2014, In : Journal of Cerebral Blood Flow and Metabolism. 34, 3, p. 450 - 459 10 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Intravenous immunoglobulin (IVIg) provides protection against endothelial cell dysfunction and death in ischemic stroke

Widiapradja, A., Santro, T., Basta, M., Sobey, C. G., Manzanero, S. & Arumugam, T., 2014, In : Experimental & Translational Stroke Medicine. 6, 1 (Art. No.: 7), p. 1 - 6 6 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

PI3Kdelta inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model

Low, P. C., Manzanero, S., Mohannak, N., Narayana, V. K., Nguyen, T. H., Kvaskoff, D., Brennan, F. H., Ruitenberg, M. J., Gelderblom, M., Magnus, T., Kim, H. H. A., Broughton, B. R. S., Sobey, C. G., Vanhaesebroeck, B., Stow, J. L., Arumugam, T. & Meunier, F. A., 2014, In : Nature Communications. 5, 3450, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
46 Citations (Scopus)

Role of CCR2 in inflammatory conditions of the central nervous system

Chu, H., Arumugam, T., Gelderblom, M., Magnus, T., Drummond, G. R. & Sobey, C. G., 2014, In : Journal of Cerebral Blood Flow and Metabolism. 34, 9, p. 1425 - 1429 5 p.

Research output: Contribution to journalArticleResearchpeer-review

150 Citations (Scopus)

Roles of inflammation, oxidative stress, and vascular dysfunction in hypertension

Dinh, Q. N., Drummond, G. R., Sobey, C. G. & Chrissobolis, S., 2014, In : BioMed Research International. 2014, 406960, p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
50 Citations (Scopus)

Sex-dependent effects of G protein-coupled estrogen receptor activity on outcome after ischemic stroke

Broughton, B. R. S., Brait, V. H., Kim, H. H. A., Lee, S. S., Chu, H. X., Gardiner-Mann, C. V., Guida, E., Evans, M. A., Miller, A. A., Arumugam, T., Drummond, G. R. & Sobey, C. G., 2014, In : Stroke. 45, 3, p. 835 - 841 7 p.

Research output: Contribution to journalArticleResearchpeer-review