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Research Output 1982 2019

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2019

A 30 kDa polyethylene glycol-enfuvirtide complex enhances the exposure of enfuvirtide in lymphatic viral reservoirs in rats

Kaminskas, L. M., Williams, C. C., Leong, N. J., Chan, L. J., Butcher, N. J., Feeney, O. M., Porter, C. J. H., Tyssen, D., Tachedjian, G. & Ascher, D. B., 1 Apr 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 137, p. 218-226 9 p.

Research output: Contribution to journalArticleResearchpeer-review

A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor α agonists

Patil, R., Mohanty, B., Liu, B., Chandrashekaran, I. R., Headey, S. J., Williams, M. L., Clements, C. S., Ilyichova, O., Doak, B. C., Genissel, P., Weaver, R., Vuillard, L., Halls, M. L., Porter, C. J. H. & Scanlon, M. J., 8 Mar 2019, In : Journal of Biological Chemistry. 294, 10, p. 3720-3734 15 p.

Research output: Contribution to journalArticleResearchpeer-review

A Nonionic Polyethylene Oxide (PEO) Surfactant Model: Experimental and Molecular Dynamics Studies of Kolliphor EL

Suys, E. J. A., Warren, D. B., Pham, A. C., Nowell, C. J., Clulow, A. J., Benameur, H., Porter, C. J. H., Pouton, C. W. & Chalmers, D. K., 1 Jan 2019, In : Journal of Pharmaceutical Sciences. 108, 1, p. 193-204 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Pointing in the right direction: Controlling the orientation of proteins on nanoparticles improves targeting efficiency

Yong, K. W., Yuen, D., Chen, M. Z., Porter, C. J. H. & Johnston, A. P. R., 13 Mar 2019, In : Nano Letters. 19, 3, p. 1827−1831 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Promoting intestinal lymphatic transport targets a liver-X receptor (LXR) agonist (WAY-252,623) to lymphocytes and enhances immunomodulation

Cao, E., Lindgren, A., Martinsson, S., Hu, L., Lindfors, L., Sigfridsson, K., Skantze, U., Michaëlsson, E., Trevaskis, N. L. & Porter, C. J. H., 28 Feb 2019, In : Journal of Controlled Release. 296, p. 29-39 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The mechanisms of pharmacokinetic food-drug interactions – A perspective from the UNGAP group

Koziolek, M., Alcaro, S., Augustijns, P., Basit, A. W., Grimm, M., Hens, B., Hoad, C. L., Jedamzik, P., Madla, C. M., Maliepaard, M., Marciani, L., Maruca, A., Parrott, N., Pávek, P., Porter, C. J. H., Reppas, C., van Riet-Nales, D., Rubbens, J., Statelova, M., Trevaskis, N. L. & 4 othersValentová, K., Vertzoni, M., Čepo, D. V. & Corsetti, M., 15 Jun 2019, In : European Journal of Pharmaceutical Sciences. 134, p. 31-59 29 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Unlocking the full potential of lipid-based formulations using lipophilic salt/ionic liquid forms

Williams, H. D., Ford, L., Igonin, A., Shan, Z., Botti, P., Morgen, M. M., Hu, G., Pouton, C. W., Scammells, P. J., Porter, C. J. H. & Benameur, H., 29 May 2019, (Accepted/In press) In : Advanced Drug Delivery Reviews. 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Cyclic peptide-poly(HPMA) nanotubes as drug delivery vectors: In vitro assessment, pharmacokinetics and biodistribution

Larnaudie, S. C., Sanchis, J., Nguyen, T. H., Peltier, R., Catrouillet, S., Brendel, J. C., Porter, C. J. H., Jolliffe, K. A. & Perrier, S., 1 Sep 2018, In : Biomaterials. 178, p. 570-582 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Doxorubicin Conjugation and Drug Linker Chemistry Alter the Intravenous and Pulmonary Pharmacokinetics of a PEGylated Generation 4 Polylysine Dendrimer in Rats

Leong, N. J., Mehta, D., McLeod, V. M., Kelly, B. D., Pathak, R., Owen, D. J., Porter, C. J. H. & Kaminskas, L. M., 1 Sep 2018, In : Journal of Pharmaceutical Sciences. 107, 9, p. 2509-2513 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Enhancing the Oral Absorption of Kinase Inhibitors Using Lipophilic Salts and Lipid-Based Formulations

Williams, H. D., Ford, L., Han, S., Tangso, K. J., Lim, S., Shackleford, D. M., Vodak, D. T., Benameur, H., Pouton, C. W., Scammells, P. J. & Porter, C. J. H., 1 Jan 2018, In : Molecular Pharmaceutics. 15, 12, p. 5678−5696 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Fatty Acid-Binding Protein 5 Mediates the Uptake of Fatty Acids, but not Drugs, Into Human Brain Endothelial Cells

Lee, G. S., Pan, Y., Scanlon, M. J., Porter, C. J. H. & Nicolazzo, J. A., Apr 2018, In : Journal of Pharmaceutical Sciences. 107, 4, p. 1185-1193 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Gel-Mediated Electrospray Assembly of Silica Supraparticles for Sustained Drug Delivery

Ma, Y., Björnmalm, M., Wise, A. K., Cortez-Jugo, C., Revalor, E., Ju, Y., Feeney, O. M., Richardson, R. T., Hanssen, E., Shepherd, R. K., Porter, C. J. H. & Caruso, F., 19 Sep 2018, In : ACS Applied Materials and Interfaces. 10, 37, p. 31019-31031 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Impact of Drug Physicochemical Properties on Lipolysis-Triggered Drug Supersaturation and Precipitation from Lipid-Based Formulations

Alskär, L. C., Keemink, J., Johannesson, J., Porter, C. J. H. & Bergström, C. A. S., 1 Oct 2018, In : Molecular Pharmaceutics. 15, 10, p. 4733-4744 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Minimum information reporting in bio–nano experimental literature

Faria, M., Björnmalm, M., Thurecht, K. J., Kent, S. J., Parton, R. G., Kavallaris, M., Johnston, A. P. R., Gooding, J. J., Corrie, S. R., Boyd, B. J., Thordarson, P., Whittaker, A. K., Stevens, M. M., Prestidge, C. A., Porter, C. J. H., Parak, W. J., Davis, T. P., Crampin, E. J. & Caruso, F., 1 Sep 2018, In : Nature Nanotechnology. 13, 9, p. 777-785 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

Jimenez-Vargas, N. N., Pattison, L. A., Zhao, P., Lieu, T., Latorre, R., Jensen, D. D., Castro, J., Aurelio, L., Le, G. T., Flynn, B., Herenbrink, C. K., Yeatman, H. R., Edgington-Mitchell, L., Porter, C. J. H., Halls, M. L., Canals, M., Veldhuis, N. A., Poole, D. P., McLean, P., Hicks, G. A. & 7 othersScheff, N., Chen, E., Bhattacharya, A., Schmidt, B. L., Brierley, S. M., Vanner, S. J. & Bunnett, N. W., 31 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 31, p. E7438-E7447 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Reducing Dendrimer Generation and PEG Chain Length Increases Drug Release and Promotes Anticancer Activity of PEGylated Polylysine Dendrimers Conjugated with Doxorubicin via a Cathepsin-Cleavable Peptide Linker

Mehta, D., Leong, N., McLeod, V. M., Kelly, B. D., Pathak, R., Owen, D. J., Porter, C. J. H. & Kaminskas, L. M., 1 Oct 2018, In : Molecular Pharmaceutics. 15, 10, p. 4568-4576 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Transformation of Biopharmaceutical Classification System Class I and III Drugs Into Ionic Liquids and Lipophilic Salts for Enhanced Developability Using Lipid Formulations

Williams, H. D., Ford, L., Lim, S., Han, S., Baumann, J., Sullivan, H., Vodak, D., Igonin, A., Benameur, H., Pouton, C. W., Scammells, P. J. & Porter, C. J. H., 2018, In : Journal of Pharmaceutical Sciences. 107, 1, p. 203–216 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

An Evaluation of Optimal PEGylation Strategies for Maximizing the Lymphatic Exposure and Antiviral Activity of Interferon after Subcutaneous Administration

Chan, L. J., Feeney, O. M., Leong, N. J., McLeod, V. M., Porter, C. J. H., Williams, C. C. & Kaminskas, L. M., 11 Sep 2017, In : Biomacromolecules. 18, 9, p. 2866-2875 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Computational Models of the Gastrointestinal Environment. 1. The Effect of Digestion on the Phase Behavior of Intestinal Fluids

Birru, W. A., Warren, D., Headey, S. J., Benameur, H., Porter, C., Pouton, C. W. & Chalmers, D. K., 6 Mar 2017, In : Molecular Pharmaceutics. 14, 3, p. 566-579 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Computational Models of the Intestinal Environment. 3. The Impact of Cholesterol Content and pH on Mixed Micelle Colloids

Suys, E. J. A., Warren, D. B., Porter, C. J. H., Benameur, H., Pouton, C. W. & Chalmers, D. K., 6 Nov 2017, In : Molecular Pharmaceutics. 14, 11, p. 3684-3697 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Correlating in Vitro Solubilization and Supersaturation Profiles with in Vivo Exposure for Lipid Based Formulations of the CETP Inhibitor CP-532,623

McEvoy, C. L., Trevaskis, N. L., Feeney, O. M., Edwards, G. A., Perlman, M. E., Ambler, C. M. & Porter, C. J. H., 4 Dec 2017, In : Molecular Pharmaceutics. 14, 12, p. 4525-4538 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Effect of increased surface hydrophobicity via drug conjugation on the clearance of inhaled PEGylated polylysine dendrimers

Haque, S., McLeod, V. M., Jones, S., Fung, S., Whittaker, M., McIntosh, M., Pouton, C., Owen, D. J., Porter, C. J. H. & Kaminskas, L. M., 1 Oct 2017, In : European Journal of Pharmaceutics and Biopharmaceutics. 119, p. 408-418 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy

To, E. E., Vlahos, R., Luong, R., Halls, M. L., Reading, P. C., King, P. T., Chan, C., Drummond, G. R., Sobey, C. G., Broughton, B. R. S., Starkey, M. R., van der Sluis, R., Lewin, S. R., Bozinovski, S., O'Neill, L. A. J., Quach, T., Porter, C. J. H., Brooks, D. A., O'Leary, J. & Selemidis, S., 1 Dec 2017, In : Nature Communications. 8, 1, 17 p., 69.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission

Yarwood, R. E., Imlach, W. L., Lieu, T., Veldhuis, N. A., Jensen, D. D., Herenbrink, C. K., Aurelio, L., Cai, Z., Christie, M. J., Poole, D. P., Porter, C. J. H., McLean, P., Hicks, G. A., Geppetti, P., Halls, M. L., Canals, M. & Bunnett, N. W., 14 Nov 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 46, p. 12309-12314 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Ionic Liquid Forms of Weakly Acidic Drugs in Oral Lipid Formulations: Preparation, Characterization, in Vitro Digestion, and in Vivo Absorption Studies

Sahbaz, Y., Nguyen, T. H., Ford, L., McEvoy, C. L., Williams, H. D., Scammells, P. J. & Porter, C. J. H., 6 Nov 2017, In : Molecular Pharmaceutics. 14, 11, p. 3669-3683 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Lymphatic transport and lymph node targeting of methotrexate-conjugated PEGylated dendrimers are enhanced by reducing the length of the drug linker or masking interactions with the injection site

Ryan, G. M., McLeod, V. M., Mehta, D., Kelly, B. D., Stanislawski, P. C., Owen, D. J., Kaminskas, L. M. & Porter, C. J. H., 1 Nov 2017, In : Nanomedicine-Nanotechnology Biology and Medicine. 13, 8, p. 2485-2494 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

Jensen, D. D., Lieu, T., Halls, M. L., Veldhuis, N. A., Imlach, W. L., Mai, Q. N., Poole, D. P., Quach, T., Aurelio, L., Conner, J., Klein Herenbrink, C., Barlow, N., Simpson, J. S., Scanlon, M. J., Graham, B., McCluskey, A., Robinson, P. J., Escriou, V., Nassini, R., Materazzi, S. & 6 othersGeppetti, P., Hicks, G. A., Christie, M. J., Porter, C. J. H., Canals, M. & Bunnett, N. W., 31 May 2017, In : Science Translational Medicine. 9, 392, 15 p., aal3447.

Research output: Contribution to journalArticleResearchpeer-review

Templated polymer replica nanoparticles to facilitate assessment of material-dependent pharmacokinetics and biodistribution

Song, D., Cui, J., Sun, H., Nguyen, T. H., Alcantara, S., De Rose, R., Kent, S. J., Porter, C. J. H. & Caruso, F., 1 Jan 2017, In : ACS Applied Materials and Interfaces. 9, 39, p. 33683-33694 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

50 years of oral lipid-based formulations: provenance, progress and future perspectives

Feeney, O. M., Crum, M. F., McEvoy, C., Trevaskis, N., Williams, H., Pouton, C., Charman, W. N., Bergstrom, C. & Porter, C. J. H., 1 Jun 2016, In : Advanced Drug Delivery Reviews. 101, p. 167-194 27 p.

Research output: Contribution to journalArticleResearchpeer-review

A comparison of the pharmacokinetics and pulmonary lymphatic exposure of a generation 4 PEGylated dendrimer following intravenous and aerosol administration to rats and sheep

Ryan, G., Bischof, R., Enkhbaatar, P., McLeod, V. M., Chan, L. J., Jones, S. A., Owen, D. J., Porter, C. J. & Kaminskas, L. M., 2016, In : Pharmaceutical Research. 33, 2, p. 510-525 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Addition of 20-kDa PEG to insulin lispro alters absorption and decreases clearance in animals

Knadler, M. P., Nguyen, T. H., Campanale, K., de Veer, M. J., Beals, J. M., Li, S., Hansen, R., Siesky, A., Michael, M. D. & Porter, C. J. H., Dec 2016, In : Pharmaceutical Research. 33, 12, p. 2920-2929 10 p.

Research output: Contribution to journalArticleResearchpeer-review

A new in vitro lipid digestion - in vivo absorption model to evaluate the mechanisms of drug absorption from lipid-based formulations

Crum, M., Trevaskis, N., Williams, H. D., Pouton, C. W. & Porter, C. J., 2016, In : Pharmaceutical Research. 33, 4, p. 970-982 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Computational prediction of formulation strategies for beyond-rule-of-5 compounds

Bergstrom, C., Charman, W. N. & Porter, C. J. H., 1 Jun 2016, In : Advanced Drug Delivery Reviews. 101, p. 6-21 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Conjugation of 10 kDa linear PEG onto trastuzumab Fab′ is sufficient to significantly enhance lymphatic exposure while preserving in vitro biological activity

Chan, L., Ascher, D. B., Yadav, R., Bulitta, J., Williams, C. C., Porter, C., Landersdorfer, C. & Kaminskas, L., 2016, In : Molecular Pharmaceutics. 13, 4, p. 1229-1241 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Fatty acid-binding protein 5 at the blood–brain barrier regulates endogenous brain docosahexaenoic acid levels and cognitive function

Pan, Y., Short, J. L., Choy, K. H. C., Zeng, A. X., Marriott, P. J., Owada, Y., Scanlon, M. J., Porter, C. J. H. & Nicolazzo, J. A., 16 Nov 2016, In : Journal of Neuroscience. 36, 46, p. 11755-11767 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Glyceride-mimetic prodrugs incorporating self-immolative spacers promote lymphatic transport, avoid first-pass metabolism, and enhance oral bioavailability

Hu, L., Quach, T., Han, S., Lim, S. F., Yadav, P., Senyschyn, D., Trevaskis, N. L., Simpson, J. S. & Porter, C. J. H., 2016, In : Angewandte Chemie - International Edition. 55, 44, p. 13700 –13705 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Hyaluronic acid molecular weight determines lung clearance and biodistribution after instillation

Kuehl, C., Zhang, T., Kaminskas, L. M., Porter, C. J. H., Davies, N. M., Forrest, L. & Berkland, C., 6 Jun 2016, In : Molecular Pharmaceutics. 13, 6, p. 1904-1914 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Lymphatic transport and lymphocyte targeting of a triglyceride mimetic prodrug is enhanced in a large animal model: studies in greyhound dogs

Han, S., Hu, L., Gracia, G., Quach, T., Simpson, J. S., Edwards, G. A., Trevaskis, N. L. & Porter, C. J. H., 3 Oct 2016, In : Molecular Pharmaceutics. 13, 10, p. 3351-3361 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Passive tumour targeting and extravasation of cylindrical polymer brushes in mouse xenografts

Mullner, M., Mehta, D., Nowell, C. & Porter, C. J., Mar 2016, In : Chemical Communications. 52, 58, p. 9121-9124 4 p.

Research output: Contribution to journalArticleOtherpeer-review

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The pharmacokinetics and biodistribution of a 64 kDa PolyPEG star polymer after subcutaneous and pulmonary administration to rats

Khor, S. Y., Hu, J., McLeod, V., Quinn, J., Porter, C. J. H., Whittaker, M., Kaminskas, L. & Davis, T., 2016, In : Journal of Pharmaceutical Sciences. 105, 1, p. 293-300 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Tools for early prediction of drug loading in lipid-based formulations

Alskär, L. C., Porter, C. & Bergstrom, C., 4 Jan 2016, In : Molecular Pharmaceutics. 13, 1, p. 251-261 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Fatty acid-binding protein 5 facilitates the blood-brain barrier transport of docosahexaenoic acid

Pan, Y., Scanlon, M., Owada, Y., Yamamoto, Y., Porter, C. J. & Nicolazzo, J., 2015, In : Molecular Pharmaceutics. 12, 12, p. 4375 - 4385 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Fatty acid-binding proteins 1 and 2 differentially modulate the activation of peroxisome proliferator-activated receptor alpha in a ligand-selective manner

Hughes, M. L. R., Liu, B., Halls, M. L., Wagstaff, K. M., Patil, R., Velkov, T., Jans, D. A., Bunnett, N. W., Scanlon, M. & Porter, C. J., 2015, In : Journal of Biological Chemistry. 290, 22, p. 13895 - 13906 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Fatty acid binding proteins expressed at the human blood-brain barrier bind drugs in an isoform-specific manner

Lee, G. S. Y., Kappler, K., Porter, C. J., Scanlon, M. & Nicolazzo, J., 2015, In : Pharmaceutical Research. 32, 10, p. 3432 - 3446 15 p.

Research output: Contribution to journalArticleResearchpeer-review