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Research Output

2020

Ionic liquid forms of the antimalarial lumefantrine in combination with LFCS type IIIB lipid-based formulations preferentially increase lipid solubility, in vitro solubilization behavior and in vivo exposure

Tay, E., Nguyen, T. H., Ford, L., Williams, H. D., Benameur, H., Scammells, P. J. & Porter, C. J. H., Jan 2020, In : Pharmaceutics. 12, 1, 25 p., 17.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Quantifying In Vivo Luminal Drug Solubilization -Supersaturation-Precipitation Profiles to Explain the Performance of Lipid Based Formulations

Tanaka, Y., Tay, E., Nguyen, T. H. & Porter, C. J. H., 1 Mar 2020, In : Pharmaceutical Research. 37, 3, 17 p., 47.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Spatial Properties of Reactive Oxygen Species Govern Pathogen-Specific Immune System Responses

To, E. E., O'Leary, J. J., O'Neill, L. A. J., Vlahos, R., Bozinovski, S., Porter, C. J. H., Brooks, R. D., Brooks, D. A. & Selemidis, S., 24 Mar 2020, In : Antioxidants and Redox Signaling. 32, 13, p. 982-992 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2019

A 30 kDa polyethylene glycol-enfuvirtide complex enhances the exposure of enfuvirtide in lymphatic viral reservoirs in rats

Kaminskas, L. M., Williams, C. C., Leong, N. J., Chan, L. J., Butcher, N. J., Feeney, O. M., Porter, C. J. H., Tyssen, D., Tachedjian, G. & Ascher, D. B., 1 Apr 2019, In : European Journal of Pharmaceutics and Biopharmaceutics. 137, p. 218-226 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor α agonists

Patil, R., Mohanty, B., Liu, B., Chandrashekaran, I. R., Headey, S. J., Williams, M. L., Clements, C. S., Ilyichova, O., Doak, B. C., Genissel, P., Weaver, R., Vuillard, L., Halls, M. L., Porter, C. J. H. & Scanlon, M. J., 8 Mar 2019, In : Journal of Biological Chemistry. 294, 10, p. 3720-3734 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

A Nonionic Polyethylene Oxide (PEO) Surfactant Model: Experimental and Molecular Dynamics Studies of Kolliphor EL

Suys, E. J. A., Warren, D. B., Pham, A. C., Nowell, C. J., Clulow, A. J., Benameur, H., Porter, C. J. H., Pouton, C. W. & Chalmers, D. K., 1 Jan 2019, In : Journal of Pharmaceutical Sciences. 108, 1, p. 193-204 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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5 Citations (Scopus)

Engineering Biocoatings to Prolong Drug Release from Supraparticles

Ma, Y., Cortez-Jugo, C., Li, J., Lin, Z., Richardson, R. T., Han, Y., Zhou, J., Björnmalm, M., Feeney, O. M., Zhong, Q. Z., Porter, C. J. H., Wise, A. K. & Caruso, F., 1 Jan 2019, In : Biomacromolecules. 20, 9, p. 3425-3434 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Lymphatic Uptake of Liposomes after Intraperitoneal Administration Primarily Occurs via the Diaphragmatic Lymphatics and is Dependent on Liposome Surface Properties

Lee, G., Han, S., Inocencio, I., Cao, E., Hong, J., Phillips, A. R. J., Windsor, J. A., Porter, C. J. H. & Trevaskis, N. L., 2 Dec 2019, In : Molecular Pharmaceutics. 16, 12, p. 4987-4999 13 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Pointing in the right direction: Controlling the orientation of proteins on nanoparticles improves targeting efficiency

Yong, K. W., Yuen, D., Chen, M. Z., Porter, C. J. H. & Johnston, A. P. R., 13 Mar 2019, In : Nano Letters. 19, 3, p. 1827−1831 5 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Promoting intestinal lymphatic transport targets a liver-X receptor (LXR) agonist (WAY-252,623) to lymphocytes and enhances immunomodulation

Cao, E., Lindgren, A., Martinsson, S., Hu, L., Lindfors, L., Sigfridsson, K., Skantze, U., Michaëlsson, E., Trevaskis, N. L. & Porter, C. J. H., 28 Feb 2019, In : Journal of Controlled Release. 296, p. 29-39 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Removal of interstitial hyaluronan with recombinant human hyaluronidase improves the systemic and lymphatic uptake of cetuximab in rats

Styles, I. K., Feeney, O. M., Nguyen, T-H., Brundel, D., Kang, D. W., Clift, R., McIntosh, M. P. & Porter, C. J. H., 10 Dec 2019, In : Journal of Controlled Release. 315, p. 85-96 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The mechanisms of pharmacokinetic food-drug interactions – A perspective from the UNGAP group

Koziolek, M., Alcaro, S., Augustijns, P., Basit, A. W., Grimm, M., Hens, B., Hoad, C. L., Jedamzik, P., Madla, C. M., Maliepaard, M., Marciani, L., Maruca, A., Parrott, N., Pávek, P., Porter, C. J. H., Reppas, C., van Riet-Nales, D., Rubbens, J., Statelova, M., Trevaskis, N. L. & 4 others, Valentová, K., Vertzoni, M., Čepo, D. V. & Corsetti, M., 15 Jun 2019, In : European Journal of Pharmaceutical Sciences. 134, p. 31-59 29 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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15 Citations (Scopus)

Unlocking the full potential of lipid-based formulations using lipophilic salt/ionic liquid forms

Williams, H. D., Ford, L., Igonin, A., Shan, Z., Botti, P., Morgen, M. M., Hu, G., Pouton, C. W., Scammells, P. J., Porter, C. J. H. & Benameur, H., 2019, In : Advanced Drug Delivery Reviews. 142, 16 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)
2018

Cyclic peptide-poly(HPMA) nanotubes as drug delivery vectors: In vitro assessment, pharmacokinetics and biodistribution

Larnaudie, S. C., Sanchis, J., Nguyen, T. H., Peltier, R., Catrouillet, S., Brendel, J. C., Porter, C. J. H., Jolliffe, K. A. & Perrier, S., 1 Sep 2018, In : Biomaterials. 178, p. 570-582 13 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Doxorubicin Conjugation and Drug Linker Chemistry Alter the Intravenous and Pulmonary Pharmacokinetics of a PEGylated Generation 4 Polylysine Dendrimer in Rats

Leong, N. J., Mehta, D., McLeod, V. M., Kelly, B. D., Pathak, R., Owen, D. J., Porter, C. J. H. & Kaminskas, L. M., 1 Sep 2018, In : Journal of Pharmaceutical Sciences. 107, 9, p. 2509-2513 5 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Enhancing the Oral Absorption of Kinase Inhibitors Using Lipophilic Salts and Lipid-Based Formulations

Williams, H. D., Ford, L., Han, S., Tangso, K. J., Lim, S., Shackleford, D. M., Vodak, D. T., Benameur, H., Pouton, C. W., Scammells, P. J. & Porter, C. J. H., 1 Jan 2018, In : Molecular Pharmaceutics. 15, 12, p. 5678−5696 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

Fatty Acid-Binding Protein 5 Mediates the Uptake of Fatty Acids, but not Drugs, Into Human Brain Endothelial Cells

Lee, G. S., Pan, Y., Scanlon, M. J., Porter, C. J. H. & Nicolazzo, J. A., Apr 2018, In : Journal of Pharmaceutical Sciences. 107, 4, p. 1185-1193 9 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Gel-Mediated Electrospray Assembly of Silica Supraparticles for Sustained Drug Delivery

Ma, Y., Björnmalm, M., Wise, A. K., Cortez-Jugo, C., Revalor, E., Ju, Y., Feeney, O. M., Richardson, R. T., Hanssen, E., Shepherd, R. K., Porter, C. J. H. & Caruso, F., 19 Sep 2018, In : ACS Applied Materials & Interfaces. 10, 37, p. 31019-31031 13 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Impact of Drug Physicochemical Properties on Lipolysis-Triggered Drug Supersaturation and Precipitation from Lipid-Based Formulations

Alskär, L. C., Keemink, J., Johannesson, J., Porter, C. J. H. & Bergström, C. A. S., 1 Oct 2018, In : Molecular Pharmaceutics. 15, 10, p. 4733-4744 12 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Lipids in the Stomach – Implications for the Evaluation of Food Effects on Oral Drug Absorption

Koziolek, M., Carrière, F. & Porter, C. J. H., 1 Mar 2018, In : Pharmaceutical Research. 35, 3, 26 p., 55.

Research output: Contribution to journalReview ArticleResearchpeer-review

18 Citations (Scopus)

Minimum information reporting in bio–nano experimental literature

Faria, M., Björnmalm, M., Thurecht, K. J., Kent, S. J., Parton, R. G., Kavallaris, M., Johnston, A. P. R., Gooding, J. J., Corrie, S. R., Boyd, B. J., Thordarson, P., Whittaker, A. K., Stevens, M. M., Prestidge, C. A., Porter, C. J. H., Parak, W. J., Davis, T. P., Crampin, E. J. & Caruso, F., 1 Sep 2018, In : Nature Nanotechnology. 13, 9, p. 777-785 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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107 Citations (Scopus)
15 Citations (Scopus)

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

Jimenez-Vargas, N. N., Pattison, L. A., Zhao, P., Lieu, T., Latorre, R., Jensen, D. D., Castro, J., Aurelio, L., Le, G. T., Flynn, B., Herenbrink, C. K., Yeatman, H. R., Edgington-Mitchell, L., Porter, C. J. H., Halls, M. L., Canals, M., Veldhuis, N. A., Poole, D. P., McLean, P., Hicks, G. A. & 7 others, Scheff, N., Chen, E., Bhattacharya, A., Schmidt, B. L., Brierley, S. M., Vanner, S. J. & Bunnett, N. W., 31 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 31, p. E7438-E7447 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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23 Citations (Scopus)

Reducing Dendrimer Generation and PEG Chain Length Increases Drug Release and Promotes Anticancer Activity of PEGylated Polylysine Dendrimers Conjugated with Doxorubicin via a Cathepsin-Cleavable Peptide Linker

Mehta, D., Leong, N., McLeod, V. M., Kelly, B. D., Pathak, R., Owen, D. J., Porter, C. J. H. & Kaminskas, L. M., 1 Oct 2018, In : Molecular Pharmaceutics. 15, 10, p. 4568-4576 9 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Transformation of Biopharmaceutical Classification System Class I and III Drugs Into Ionic Liquids and Lipophilic Salts for Enhanced Developability Using Lipid Formulations

Williams, H. D., Ford, L., Lim, S., Han, S., Baumann, J., Sullivan, H., Vodak, D., Igonin, A., Benameur, H., Pouton, C. W., Scammells, P. J. & Porter, C. J. H., 2018, In : Journal of Pharmaceutical Sciences. 107, 1, p. 203–216 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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11 Citations (Scopus)
2017

An Evaluation of Optimal PEGylation Strategies for Maximizing the Lymphatic Exposure and Antiviral Activity of Interferon after Subcutaneous Administration

Chan, L. J., Feeney, O. M., Leong, N. J., McLeod, V. M., Porter, C. J. H., Williams, C. C. & Kaminskas, L. M., 11 Sep 2017, In : Biomacromolecules. 18, 9, p. 2866-2875 10 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Computational Models of the Gastrointestinal Environment. 1. The Effect of Digestion on the Phase Behavior of Intestinal Fluids

Birru, W. A., Warren, D., Headey, S. J., Benameur, H., Porter, C., Pouton, C. W. & Chalmers, D. K., 6 Mar 2017, In : Molecular Pharmaceutics. 14, 3, p. 566-579 14 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)
14 Citations (Scopus)

Computational Models of the Intestinal Environment. 3. The Impact of Cholesterol Content and pH on Mixed Micelle Colloids

Suys, E. J. A., Warren, D. B., Porter, C. J. H., Benameur, H., Pouton, C. W. & Chalmers, D. K., 6 Nov 2017, In : Molecular Pharmaceutics. 14, 11, p. 3684-3697 14 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Correlating in Vitro Solubilization and Supersaturation Profiles with in Vivo Exposure for Lipid Based Formulations of the CETP Inhibitor CP-532,623

McEvoy, C. L., Trevaskis, N. L., Feeney, O. M., Edwards, G. A., Perlman, M. E., Ambler, C. M. & Porter, C. J. H., 4 Dec 2017, In : Molecular Pharmaceutics. 14, 12, p. 4525-4538 14 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Effect of increased surface hydrophobicity via drug conjugation on the clearance of inhaled PEGylated polylysine dendrimers

Haque, S., McLeod, V. M., Jones, S., Fung, S., Whittaker, M., McIntosh, M., Pouton, C., Owen, D. J., Porter, C. J. H. & Kaminskas, L. M., 1 Oct 2017, In : European Journal of Pharmaceutics and Biopharmaceutics. 119, p. 408-418 11 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy

To, E. E., Vlahos, R., Luong, R., Halls, M. L., Reading, P. C., King, P. T., Chan, C., Drummond, G. R., Sobey, C. G., Broughton, B. R. S., Starkey, M. R., van der Sluis, R., Lewin, S. R., Bozinovski, S., O'Neill, L. A. J., Quach, T., Porter, C. J. H., Brooks, D. A., O'Leary, J. & Selemidis, S., 1 Dec 2017, In : Nature Communications. 8, 1, 17 p., 69.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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30 Citations (Scopus)

Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission

Yarwood, R. E., Imlach, W. L., Lieu, T., Veldhuis, N. A., Jensen, D. D., Herenbrink, C. K., Aurelio, L., Cai, Z., Christie, M. J., Poole, D. P., Porter, C. J. H., McLean, P., Hicks, G. A., Geppetti, P., Halls, M. L., Canals, M. & Bunnett, N. W., 14 Nov 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 46, p. 12309-12314 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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40 Citations (Scopus)

Ionic Liquid Forms of Weakly Acidic Drugs in Oral Lipid Formulations: Preparation, Characterization, in Vitro Digestion, and in Vivo Absorption Studies

Sahbaz, Y., Nguyen, T. H., Ford, L., McEvoy, C. L., Williams, H. D., Scammells, P. J. & Porter, C. J. H., 6 Nov 2017, In : Molecular Pharmaceutics. 14, 11, p. 3669-3683 15 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Lymphatic transport and lymph node targeting of methotrexate-conjugated PEGylated dendrimers are enhanced by reducing the length of the drug linker or masking interactions with the injection site

Ryan, G. M., McLeod, V. M., Mehta, D., Kelly, B. D., Stanislawski, P. C., Owen, D. J., Kaminskas, L. M. & Porter, C. J. H., 1 Nov 2017, In : Nanomedicine-Nanotechnology Biology and Medicine. 13, 8, p. 2485-2494 10 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

Jensen, D. D., Lieu, T., Halls, M. L., Veldhuis, N. A., Imlach, W. L., Mai, Q. N., Poole, D. P., Quach, T., Aurelio, L., Conner, J., Klein Herenbrink, C., Barlow, N., Simpson, J. S., Scanlon, M. J., Graham, B., McCluskey, A., Robinson, P. J., Escriou, V., Nassini, R., Materazzi, S. & 6 others, Geppetti, P., Hicks, G. A., Christie, M. J., Porter, C. J. H., Canals, M. & Bunnett, N. W., 31 May 2017, In : Science Translational Medicine. 9, 392, 15 p., aal3447.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Templated polymer replica nanoparticles to facilitate assessment of material-dependent pharmacokinetics and biodistribution

Song, D., Cui, J., Sun, H., Nguyen, T. H., Alcantara, S., De Rose, R., Kent, S. J., Porter, C. J. H. & Caruso, F., 1 Jan 2017, In : ACS Applied Materials & Interfaces. 9, 39, p. 33683-33694 12 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)
2016

50 years of oral lipid-based formulations: provenance, progress and future perspectives

Feeney, O. M., Crum, M. F., McEvoy, C., Trevaskis, N., Williams, H., Pouton, C., Charman, W. N., Bergstrom, C. & Porter, C. J. H., 1 Jun 2016, In : Advanced Drug Delivery Reviews. 101, p. 167-194 27 p.

Research output: Contribution to journalArticleResearchpeer-review

135 Citations (Scopus)

A comparison of the pharmacokinetics and pulmonary lymphatic exposure of a generation 4 PEGylated dendrimer following intravenous and aerosol administration to rats and sheep

Ryan, G., Bischof, R., Enkhbaatar, P., McLeod, V. M., Chan, L. J., Jones, S. A., Owen, D. J., Porter, C. J. & Kaminskas, L. M., 2016, In : Pharmaceutical Research. 33, 2, p. 510-525 16 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Addition of 20-kDa PEG to insulin lispro alters absorption and decreases clearance in animals

Knadler, M. P., Nguyen, T. H., Campanale, K., de Veer, M. J., Beals, J. M., Li, S., Hansen, R., Siesky, A., Michael, M. D. & Porter, C. J. H., Dec 2016, In : Pharmaceutical Research. 33, 12, p. 2920-2929 10 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

A new in vitro lipid digestion - in vivo absorption model to evaluate the mechanisms of drug absorption from lipid-based formulations

Crum, M., Trevaskis, N., Williams, H. D., Pouton, C. W. & Porter, C. J., 2016, In : Pharmaceutical Research. 33, 4, p. 970-982 13 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Computational prediction of formulation strategies for beyond-rule-of-5 compounds

Bergstrom, C., Charman, W. N. & Porter, C. J. H., 1 Jun 2016, In : Advanced Drug Delivery Reviews. 101, p. 6-21 16 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)

Conjugation of 10 kDa linear PEG onto trastuzumab Fab′ is sufficient to significantly enhance lymphatic exposure while preserving in vitro biological activity

Chan, L., Ascher, D. B., Yadav, R., Bulitta, J., Williams, C. C., Porter, C., Landersdorfer, C. & Kaminskas, L., 2016, In : Molecular Pharmaceutics. 13, 4, p. 1229-1241 13 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)
4 Citations (Scopus)
23 Citations (Scopus)

Glyceride-mimetic prodrugs incorporating self-immolative spacers promote lymphatic transport, avoid first-pass metabolism, and enhance oral bioavailability

Hu, L., Quach, T., Han, S., Lim, S. F., Yadav, P., Senyschyn, D., Trevaskis, N. L., Simpson, J. S. & Porter, C. J. H., 2016, In : Angewandte Chemie - International Edition. 55, 44, p. 13700 –13705 6 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)