Christopher Porter

Personal profile

Research interests

Oral drug delivery, bioavailability enhancement and lymphatic drug transport
Lipid-based formulation design and assessment
Intracellular drug transport pathways and nuclear targeting
Nanomedicines, in particular dendrimer-based drug delivery
Translation and commercialisation

Monash teaching commitment

Biopharmaceutical principles of drug delivery (PAC 4261)
Drug delivery system design (PSC 3081)
Research project (PAC 3522)

Biography

Chris Porter is Director, Monash Institute of Pharmaceutical Sciences (MIPS) at Monash University, Melbourne and Professor of Pharmaceutics. He completed his undergraduate and graduate studies at the University of Nottingham before moving to Australia in 1992. Subsequently, Chris’ research program has focused on understanding and quantifying drug absorption, distribution and elimination profiles and on developing the models and techniques to probe these interactions. A major interest has been the issues and problems surrounding the absorption of poorly water soluble, highly lipophilic drugs. In particular Chris' programs have explored the use of lipid-modified drugs and lipid based delivery systems to promote drug integration into endogenous lipid transport pathways in order to enhance oral bioavailability and stimulate lymphatic transport. His interests have also expanded into the mechanisms of cellular transport of lipophilic drugs. In parallel Chris has a long standing interest in the potential utility of dendrimers as drug delivery systems. Chris has published more than 220 peer reviewed papers in these areas, attracting >16,000 citations (h-index 70, Google Scholar) and is a Thompson ISI/Clarivate Highly Cited researcher (2015, 2016, 2018). His research programs have attracted ~$17m in funding from government and commercial organisations. He is an inventor on >15 patent families and this IP has been commercialised through three major licencing/assignment deals with Starpharma, PureTech and Lonza. His group continues to collaborate closely with all three organisations to progress the technologies. Chris is a current member of the Editorial Boards of ACS Molecular Pharmaceutics, Pharmaceutical Research, the Journal of Pharmaceutical Sciences and the Journal of Pharmacy and Pharmacology. He is a previous member of the Board of Scientific Advisors of CRS. He is a fellow of the American Association of Pharmaceutical Scientists and the Royal Australian Chemical Institute.

Keywords

Intracellular Binding Proteins
Lipid-Based Formulation Design
Lymphatic Drug Transport
Nanomedicines
Dendrimer-Based Drug Delivery
Oral Drug Delivery
Bioavailability Enhancement
Polyethylene Glycol
Dendrimer
Poly L-Lysine
Pharmacokinetics
Biodistribution

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Projects 2003 2021

1 Curtailed
1 Not started
10 Active
22 Finished

ARC Centre of Excellence in Convergent Bio-Nano Science and Technology

Davis, T., Boyd, B., Bunnett, N., Caruso, F., Corrie, S. R., Crampin, E., Gooding, J., Johnston, A., Kavallaris, M., Kearnes, M., Kent, S., McGhee, J., Nann, T., Parton, R., Porter, C., Thordarson, P., Thurecht, K., Voelcker, N. H., Whittaker, A., Abbott, N., Alexander, C., Dawson, K., Greguric, I., Haddleton, D., Hawker, C., Lee, D. S., Lewis, J., McLean, K., Stevens, M., Jones-Jayasinghe, N., Thierry, B. & Prestidge, C. A.

Australian Research Council (ARC), Memorial Sloan Kettering Cancer Center, The University of Nottingham (UK), University College Dublin, University of California , University of Warwick, University of Wisconsin-Madison, SungKyunKwan University, Monash University, The University of Melbourne, The University of New South Wales, The University of Queensland , University of South Australia, Australian Nuclear Science and Technology Organisation , CSIRO Materials Science and Engineering (CMSE), Imperial College London

30/06/14 → 29/06/21

Project: Research

Drug targeting to sites of lymph-adipose interaction to transform the treatment of disease

Trevaskis, N., Porter, C., Watt, M. & Creek, D.

National Health & Medical Research Council (NHMRC)

1/01/16 → 31/12/18

Project: Research

Understanding the Cellular Pathways of Nuclear Receptor Activation

Porter, C., Bunnett, N., Halls, M. & Scanlon, M.

Australian Research Council (ARC), Monash University

1/01/15 → 1/12/19

Project: Research

Molecular Dynamics Studies of Lipid-Based Delivery Systems

Pouton, C., Chalmers, D. & Porter, C.

1/08/18 → 1/08/21

Project: Research

Oral Peptides Research Program

Pouton, C., Thompson, P. & Porter, C.

Lonza (Belgium)

20/06/18 → 20/06/21

Project: Research