Projects per year
Personal profile
Research interests
- Oral drug delivery, bioavailability enhancement and lymphatic drug transport
- Lipid-based formulation design and assessment
- Intracellular drug transport pathways and nuclear targeting
- Nanomedicines, in particular dendrimer-based drug delivery
- Translation and commercialisation
Biography
Chris Porter is Director, Monash Institute of Pharmaceutical Sciences (MIPS) at Monash University, Melbourne and Professor of Pharmaceutics. He completed his undergraduate and graduate studies at the University of Nottingham before moving to Australia in 1992. Subsequently, Chris’ research program has focused on understanding and quantifying drug absorption, distribution and elimination profiles and on developing the models and techniques to probe these interactions. A major interest has been the issues and problems surrounding the absorption of poorly water soluble, highly lipophilic drugs. In particular Chris' programs have explored the use of lipid-modified drugs and lipid based delivery systems to promote drug integration into endogenous lipid transport pathways in order to enhance oral bioavailability and stimulate lymphatic transport. His interests have also expanded into the mechanisms of cellular transport of lipophilic drugs. In parallel Chris has a long standing interest in the potential utility of dendrimers as drug delivery systems. Chris has published more than 250 peer reviewed papers in these areas, attracting >28,000 citations (h-index 86, Google Scholar) and is a Thompson ISI/Clarivate Highly Cited researcher (2015, 2016, 2018). His research programs have attracted ~$30m in funding from government and commercial organisations. He is an inventor on >15 patent families, many of which are the subject of licencing/assignment deals. The most significant of these are with Starpharma (Melbourne) to develop the DEP® dendrimer based delivery system (currently in Phase 2 clinical trial) and with PureTech Health (Boston) to develop the Glyph® lymphatic targeting technology (currently in Phase 1 clinical trial). His group continues to collaborate closely with these organisations to progress the technologies. Chris is a current member of the Editorial Boards of ACS Molecular Pharmaceutics, Pharmaceutical Research, the Journal of Pharmaceutical Sciences and the Journal of Pharmacy and Pharmacology. He is a previous member of the Board of Scientific Advisors of CRS. He is a Fellow of the American Association of Pharmaceutical Scientists and the Royal Australian Chemical Institute.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Intracellular Binding Proteins
- Lipid-Based Formulation Design
- Lymphatic Drug Transport
- Nanomedicines
- Dendrimer-Based Drug Delivery
- Oral Drug Delivery
- Bioavailability Enhancement
- Polyethylene Glycol
- Dendrimer
- Poly L-Lysine
- Pharmacokinetics
- Biodistribution
Collaborations and top research areas from the last five years
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MMQPA: Monash-Moderna Quantitative Pharmacology Accelerator
Kirkpatrick, C., Landersdorfer, C. & Porter, C.
Monash University – Internal University Contribution
15/08/23 → 14/08/28
Project: Research
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Development of novel mRNA products for clinical trials
Pouton, C., Beilharz, T., Carroll, J., Porter, C., Al-Wassiti, H., Davidovich, C., Johnston, A. & Trevaskis, N.
10/05/23 → 2/10/28
Project: Research
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The Victorian Pre-clinical mRNA Innovation Incubator (VPMII)
Porter, C., Pouton, C., Carroll, J., Beilharz, T., Purcell, D. F. J., Caruso, F., Trevaskis, N., Johnston, A., Davidovich, C. & Knott, G.
23/06/22 → 22/06/25
Project: Research
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The role of hyaluronan in antigen and immune cell trafficking
Porter, C., Mintern, J. D., Johnston, A., Feeney, O. & Hays Putnam, A.
1/05/22 → 30/04/25
Project: Research
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Translating treatments for lymphatic dysfunction associated with organ failure
Phillips, A. R. J., Windsor, J. A., Tawhai, M., Trevaskis, N., Huang, W., Astle, F., Hickey, A., Campbell, D., Jiang, Y., Green, C. R., Burrowes, K., Clarke, R. B., Mirjalili, S. A., Boyd, B., Paton, J. F. R., Clark, A., Pendharkar, S., Hong, J. & Porter, C.
Health Research Council of New Zealand
1/09/21 → 31/08/26
Project: Research
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Glyceride-mimetic prodrugs incorporating self-immolative spacers promote lymphatic transport, avoid first-pass metabolism, and enhance oral bioavailability
Hu, L., Quach, T., Han, S., Lim, S. F., Yadav, P., Senyschyn, D., Trevaskis, N. L., Simpson, J. S. & Porter, C. J. H., 2016, In: Angewandte Chemie - International Edition. 55, 44, p. 13700 –13705 6 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access53 Citations (Scopus) -
Mesenteric lymphatic dysfunction promotes insulin resistance and represents a potential treatment target in obesity
Cao, E., Watt, M. J., Nowell, C. J., Quach, T., Simpson, J. S., De Melo Ferreira, V., Agarwal, S., Chu, H., Srivastava, A., Anderson, D., Gracia, G., Lam, A., Segal, G., Hong, J., Hu, L., Phang, K. L., Escott, A. B. J., Windsor, J. A., Phillips, A. R. J., Creek, D. J., & 3 others , 20 Sept 2021, In: Nature Metabolism. 3, 9, p. 1175-1188 14 p.Research output: Contribution to journal › Article › Research › peer-review
68 Citations (Scopus) -
Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief
Jensen, D. D., Lieu, T., Halls, M. L., Veldhuis, N. A., Imlach, W. L., Mai, Q. N., Poole, D. P., Quach, T., Aurelio, L., Conner, J., Klein Herenbrink, C., Barlow, N., Simpson, J. S., Scanlon, M. J., Graham, B., McCluskey, A., Robinson, P. J., Escriou, V., Nassini, R., Materazzi, S., & 6 others , 31 May 2017, In: Science Translational Medicine. 9, 392, 15 p., aal3447.Research output: Contribution to journal › Article › Research › peer-review
154 Citations (Scopus) -
From sewer to saviour - targeting the lymphatic system to promote drug exposure and activity
Trevaskis, N., Kaminskas, L. M. & Porter, C. J., 2015, In: Nature Reviews Drug Discovery. 14, 11, p. 781-803 23 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile496 Citations (Scopus) -
Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs
Porter, C. J., Trevaskis, N. & Charman, W. N., 2007, In: Nature Reviews Drug Discovery. 6, 14, p. 231 - 248 18 p.Research output: Contribution to journal › Article › Research › peer-review
1566 Citations (Scopus)
Prizes
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Clarivate Analytics Highly Cited
Porter, Christopher (Recipient), 2018
Prize: Prize (including medals and awards)
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Clarivate Analytics Highly Cited
Porter, Christopher (Recipient), 2016
Prize: National/international honour
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Fellow of the American Association of Pharmaceutical Scientists
Christopher Porter (Fellow)
2014 → …Activity: External Academic Engagement › Professional association or peak discipline body
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Fellow of the Royal Australian Chemical Institute
Christopher Porter (Fellow)
2009 → …Activity: External Academic Engagement › Professional association or peak discipline body
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Starpharma Pty Ltd (External organisation)
Benjamin James Boyd (Inventor), Lisa Michelle Kaminskas (Inventor) & Christopher John Porter (Inventor)
7 Sept 2016Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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Starpharma Pty Ltd (External organisation)
Benjamin James Boyd (Inventor), Lisa Michelle Kaminskas (Inventor) & Christopher John Porter (Inventor)
11 Nov 2016Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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Starpharma Pty Ltd (External organisation)
Benjamin James Boyd (Inventor), Lisa Michelle Kaminskas (Inventor) & Christopher John Porter (Inventor)
22 Apr 2014Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
Press/Media
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Relief in sight: Pain researchers announce breakthrough
Michelle Halls, Christopher Porter & Meritxell Canals
1/06/17
1 item of Media coverage
Press/Media: Article/Feature
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Monash pain treatment a 'game changer'
Michelle Halls, Christopher Porter, Meritxell Canals & Nigel Bunnett
1/06/17
1 item of Media coverage
Press/Media: Article/Feature