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Research Output 2001 2019

  • 41 Article
  • 3 Review Article
  • 1 Chapter (Book)
  • 1 Comment / Debate
2019

Identification of the Binding Site of Apical Membrane Antigen 1 (AMA1) Inhibitors Using a Paramagnetic Probe

Akter, M., Drinkwater, N., Devine, S. M., Drew, S. C., Krishnarjuna, B., Debono, C. O., Wang, G., Scanlon, M. J., Scammells, P. J., McGowan, S., MacRaild, C. A. & Norton, R. S., 5 Mar 2019, In : ChemMedChem. 14, 5, p. 603-612 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Interaction of merozoite surface protein 2 with lipid membranes

Lu, C., Zheng, X., Zhang, W., Zhao, H., MacRaild, C. A., Norton, R. S., Zhuang, Y., Wang, J. & Zhang, X., Feb 2019, In : FEBS Letters. 593, 3, p. 288-295 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Modulation of the aggregation of an amyloidogenic sequence by flanking-disordered region in the intrinsically disordered antigen merozoite surface protein 2

Zhang, W., Zhang, J., MacRaild, C. A., Norton, R. S., Anders, R. F. & Zhang, X., 2019, In : European Biophysics Journal. 48, 1, p. 99-110 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural and functional characterisation of a novel peptide from the Australian sea anemone Actinia tenebrosa

Elnahriry, K. A., Wai, D. C. C., Krishnarjuna, B., Badawy, N. N., Chittoor, B., MacRaild, C. A., Williams-Noonan, B. J., Surm, J. M., Chalmers, D. K., Zhang, A. H., Peigneur, S., Mobli, M., Tytgat, J., Prentis, P. & Norton, R. S., 1 Oct 2019, In : Toxicon. 168, p. 104-112 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Corrigendum to “Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK” [Peptides 99 (2018) 169–178](S0196978117303054)(10.1016/j.peptides.2017.10.001)

Krishnarjuna, B., MacRaild, C. A., Sunanda, P., Morales, R. A. V., Peigneur, S., Macrander, J., Yu, H. H., Daly, M., Raghothama, S., Dhawan, V., Chauhan, S., Tytgat, J., Pennington, M. W. & Norton, R. S., 1 Mar 2018, In : Peptides. 101, 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Disordered epitopes as peptide vaccines

MacRaild, C. A., Seow, J., Das, S. C. & Norton, R. S., May 2018, In : Peptide Science. 110, 3, 11 p., e24067.

Research output: Contribution to journalReview ArticleResearchpeer-review

Probing the correlation between insulin activity and structural stability through introduction of the rigid A6 –A11 bond

Ong, S. C., Belgi, A., Van Lierop, B., Delaine, C., Andrikopoulos, S., MacRaild, C. A., Norton, R. S., Haworth, N. L., Robinson, A. J. & Forbes, B. E., 27 Jul 2018, In : Journal of Biological Chemistry. 293, 30, p. 11928-11943 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure, folding and stability of a minimal homologue from Anemonia sulcata of the sea anemone potassium channel blocker ShK

Krishnarjuna, B., MacRaild, C. A., Sunanda, P., Morales, R. A. V., Peigneur, S., Macrander, J., Yu, H. H., Daly, M., Raghothama, S., Dhawan, V., Chauhan, S., Tytgat, J., Pennington, M. W. & Norton, R. S., Jan 2018, In : Peptides. 99, p. 169–178 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2017

Antimalarial drug discovery targeting apical membrane antigen 1

Devine, S. M., MacRaild, C. A., Norton, R. S. & Scammells, P. J., 2017, In : MedChemComm. 8, 1, p. 13-20 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Lipid interactions modulate the structural and antigenic properties of the C-terminal domain of the malaria antigen merozoite surface protein 2

Das, S. C., Morales, R. A. V., Seow, J., Krishnarjuna, B., Dissanayake, R., Anders, R. F., Macraild, C. A. & Norton, R. S., 2017, In : FEBS Journal. 284, 16, p. 649–2662 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure and activity of contryphan-Vc2: importance of the D-amino acid residue

Drane, S. B., Robinson, S. D., MacRaild, C., Chhabra, S., Chittoor, B., A V Morales, R., Leung, E. W. W., Belgi, A., Espino, S. S., Olivera, B. M., Robinson, A. J., Chalmers, D. K. & Norton, R. S., 1 Apr 2017, In : Toxicon : official journal of the International Society on Toxinology. 129, p. 113-122 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure and Characterisation of a Key Epitope in the Conserved C-Terminal Domain of the Malaria Vaccine Candidate MSP2

Seow, J., A V Morales, R., MacRaild, C. A., Bankala, K., McGowan, S., Dingjan, T., Jaipuria, G., Rouet, R., Wilde, K., Atreya, H. S., Richards, J. S., Anders, R. F., Christ, D., Drinkwater, N. & Norton, R. S., 24 Mar 2017, In : Journal of Molecular Biology. 429, 6, p. 836-846 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The Single Disulfide-Directed β-Hairpin Fold. Dynamics, Stability, and Engineering

Chittoor, B., Krishnarjuna, B., Morales, R. A. V., Macraild, C. A., Sadek, M. M., Leung, E. W. W., Robinson, S. D., Pennington, M. W. & Norton, R. S., 16 May 2017, In : Biochemistry. 56, 19, p. 2455-2466 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin

Menting, J. G., Gajewiak, J., MacRaild, C., Chou, D. H. C., Disotuar, M. M., Smith, N. A., Miller, C., Erchegyi, J., Rivier, J. E., Olivera, B. M., Forbes, B. E., Smith, B. J., Norton, R., Safavi-Hemami, H. & Lawrence, M. C., 1 Oct 2016, In : Nature Structural and Molecular Biology. 23, 10, p. 916-920 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Antibody recognition of disordered antigens

Macraild, C. A., Richards, J. S., Anders, R. F. & Norton, R. S., 5 Jan 2016, In : Structure. 24, 1, p. 148-157 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Applications of 19F-NMR in fragment-based drug discovery

Norton, R. S., Leung, E. W. W., Chandrashekaran, I. R. & MacRaild, C. A., 1 Jul 2016, In : Molecules. 21, 7, 13 p., 860.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File

Solution NMR characterization of apical membrane antigen 1 and small molecule interactions as a basis for designing new antimalarials

Krishnarjuna, B., Lim, S. S., Devine, S. M., Debono, C. O., Lam, R., Chandrashekaran, I. R., Jaipuria, G., Yagi, H., Atreya, H. S., Scanlon, M. J., MacRaild, C. A., Scammells, P. J. & Norton, R. S., 1 Jun 2016, In : Journal of Molecular Recognition. 29, 6, p. 281-291 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Stereoselective synthesis and structural elucidation of dicarba peptides

Gleeson, E. C., Wang, Z. J., Robinson, S. D., Chhabra, S., MacRaild, C. A., Jackson, W. R., Norton, R. S. & Robinson, A. J., 2016, In : Chemical Communications. 52, 24, p. 4446-4449 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Strain-transcending immune response generated by chimeras of the malaria vaccine candidate merozoite surface protein 2

Krishnarjuna, B., Andrew, D., MacRaild, C. A., Morales, R. A. V., Beeson, J. G., Anders, R. F., Richards, J. S. & Norton, R. S., 11 Feb 2016, In : Scientific Reports. 6, 12 p., 20613.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Structure–activity studies of β-hairpin peptide inhibitors of the Plasmodium falciparum AMA1–RON2 interaction

Wang, G., Drinkwater, N., Drew, D. R., MacRaild, C. A., Chalmers, D. K., Mohanty, B., Lim, S. S., Anders, R. F., Beeson, J. G., Thompson, P. E., McGowan, S., Simpson, J. S., Norton, R. S. & Scanlon, M. J., 9 Oct 2016, In : Journal of Molecular Biology. 428, 20, p. 3986-3998 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Conformational dynamics and antigenicity in the disordered malaria antigen merozoite surface protein 2

MacRaild, C. A., Zachrdla, M., Andrew, D. W., Krishnarjuna, B., Novacek, J., Zidek, L., Sklenar, V., Richards, J. S., Beeson, J. G., Anders, R. F. & Norton, R. S., 2015, In : PLoS ONE. 10, 3, 18 p., e0119899.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Insights into the immunological properties of intrinsically disordered malaria proteins using proteome scale predictions

Guy, A. J., Irani, V. R., MacRaild, C. A., Anders, R. F., Norton, R. S., Beeson, J. G., Richards, J. S. & Ramsland, P. A., 2015, In : PLoS ONE. 10, 10, 22 p., e0141729.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Structural basis for epitope masking and strain specificity of a conserved epitope in an intrinsically disordered malaria vaccine candidate

De Almeida Vilela Morales, R., MacRaild, C. A., Seow, J. T-J., Krishnarjuna, B., Drinkwater, N., Rouet, R., Anders, R. F., Christ, D., McGowan, S. & Norton, R. S., 2015, In : Scientific Reports. 5, 10 p., 10103 .

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2014

A critical evaluation of pyrrolo[2,3-d]pyrimidine-4-amines as Plasmodium falciparum apical membrane antigen 1 (AMA1) inhibitors

Devine, S., Lim, S. S., Chandrashekaran, I. R., MacRaild, C. A., Drew, D. R., Debono, C., Lam, R., Anders, R. F., Beeson, J. G., Scanlon, M., Scammells, P. J. & Norton, R. S., 2014, In : MedChemComm. 5, 10, p. 1500 - 1506 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Ligand-induced conformational change of Plasmodium falciparum AMA1 detected using 19F NMR

Ge, X., MacRaild, C. A., Devine, S., Debono, C., Wang, G., Scammells, P. J., Scanlon, M., Anders, R. F., Foley, M. & Norton, R. S., 2014, In : Journal of Medicinal Chemistry. 57, 15, p. 6419 - 6427 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular insights into the interaction between Plasmodium falciparum apical membrane antigen 1 and an invasion-inhibitory peptide

Wang, G., MacRaild, C. A., Mohanty, B., Mobli, M., Cowieson, N. P., Anders, R. F., Simpson, J. S., McGowan, S., Norton, R. S. & Scanlon, M., 2014, In : PLoS ONE. 9, 10, p. 1-12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

RASP: Rapid and robust backbone chemical shift assignments from protein structure

MacRaild, C. A. & Norton, R. S., 2014, In : Journal of Biomolecular NMR. 58, 3, p. 155 - 163 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure and dynamics of apical membrane antigen 1 from Plasmodium falciparum FVO

Lim, S. S., Yang, W. W., Krishnarjuna, B., Kannan Sivaraman, K., Chandrashekaran, I. R., Kass, I., MacRaild, C. A., Devine, S., Debono, C., Anders, R. F., Scanlon, M., Scammells, P. J., Norton, R. S. & McGowan, S., 2014, In : Biochemistry. 53, 46, p. 7310 - 7320 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

Development of inhibitors of Plasmodium falciparum apical membrane antigen 1 based on fragment screening

Lim, S. S., Debono, C., MacRaild, C. A., Chandrashekaran, I. R., Dolezal, O., Anders, R. F., Simpson, J. S., Scanlon, M., Devine, S., Scammells, P. J. & Norton, R. S., 2013, In : Australian Journal of Chemistry. 66, 12, p. 1530 - 1536 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Dicarba alpha-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABA(B) receptors

Van Lierop, B. J., Robinson, S., Kompella, S. N., Belgi, A., McArthur, J. R., Hung, A., MacRaild, C. A., Adams, D. J., Norton, R. S. & Robinson, A. J., 2013, In : ACS Chemical Biology. 8, 8, p. 1815 - 1821 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Antigenic characterization of an intrinsically unstructured protein, plasmodium falciparum merozoite surface protein 2

Adda, C. G., MacRaild, C. A., Reiling, L., Wycherley, K., Boyle, M. J., Kienzle, V., Masendycz, P., Foley, M., Beeson, J. G., Norton, R. S. & Anders, R., 2012, In : Infection and Immunity. 80, 12, p. 4177 - 4185 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Lipid interactions of the malaria antigen merozoite surface protein 2

MacRaild, C. A., Pedersen, M. O., Anders, R. F. & Norton, R. S., 2012, In : Biochimica et Biophysica Acta - Biomembranes. 1818, 11, p. 2572 - 2578 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Apical membrane antigen 1 as an anti-malarial drug target

MacRaild, C., Anders, R., Foley, M. & Norton, R., 2011, In : Current Topics in Medicinal Chemistry. 11, 16, p. 2039 - 2047 9 p.

Research output: Contribution to journalArticleResearchpeer-review

EGCG disaggregates amyloid-like fibrils formed by Plasmodium falciparum merozoite surface protein 2

Chandrashekaran, I., Adda, C., MacRaild, C., Anders, R. & Norton, R., 2011, In : Archives of Biochemistry and Biophysics. 513, 2, p. 153 - 157 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

Identification of key residues involved in fibril formation by the conserved N-terminal region of plasmodium falciparum merozoite surface protein 2 (MSP2)

Yang, X., Adda, C. G., MacRaild, C. A., Low, A., Zhang, X., Zeng, W., Jackson, D. C., Anders, R. F. & Norton, R. S., 2010, In : Biochimie. 92, 10, p. 1287 - 1295 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition by flavonoids of amyloid-like fibril formation by plasmodium falciparum merozoite surface protein 2

Chandrashekaran, I. R., Adda, C. G., MacRaild, C. A., Anders, R. F. & Norton, R. S., 2010, In : Biochemistry. 49, 28, p. 5899 - 5908 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Interaction between Plasmodium falciparum apical membrane antigen 1 and the rhoptry neck protein complex defines a key step in the erythrocyte invasion process of malaria parasites

Richard, D., MacRaild, C. A., Riglar, D. T., Chan, J-A., Foley, M., Baum, J., Ralph, S. A., Norton, R. S. & Cowman, A. F., 2010, In : Journal of Biological Chemistry. 285, 19, p. 14815 - 14822 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Structure and activity of (2,8)-dicarba-(3,12)-cystino alpha-ImI, an a-conotoxin containing a nonreducible cystine analogue

MacRaild, C. A., Illesinghe, J., Van Lierop, B. J., Townsend, A. L., Chebib, M., Livett, B. G., Robinson, A. J. & Norton, R. S., 2009, In : Journal of Medicinal Chemistry. 52, 3, p. 755 - 762 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Lipid Modulators of Protein Misfolding and Aggregation

MacRaild, C. A. & Howlett, G. J., 23 Jan 2008, Amyloid Proteins: The Beta Sheet Conformation and Disease. Wiley-VCH Verlag GmbH & Co. KGaA, Vol. 1. p. 111-129 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

2007

Global Changes in Local Protein Dynamics Reduce the Entropic Cost of Carbohydrate Binding in the Arabinose-binding Protein

MacRaild, C. A., Daranas, A. H., Bronowska, A. & Homans, S. W., 4 May 2007, In : Journal of Molecular Biology. 368, 3, p. 822-832 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2004

Non-fibrillar components of amyloid deposits mediate the self-association and tangling of amyloid fibrils

MacRaild, C. A., Stewart, C. R., Mok, Y. F., Gunzburg, M. J., Perugini, M. A., Lawrence, L. J., Tirtaatmadja, V., Cooper-White, J. J. & Howlett, G. J., 14 May 2004, In : Journal of Biological Chemistry. 279, 20, p. 21038-21045 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The structure and interactions of human apolipoprotein C-II in dodecyl phosphocholine

MacRaild, C. A., Howlett, G. J. & Gooley, P. R., 29 Jun 2004, In : Biochemistry. 43, 25, p. 8084-8093 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2003

Sedimentation velocity analysis of flexible macromolecules: Self-association and tangling of amyloid fibrils

MacRaild, C. A., Hatters, D. M., Lawrence, L. J. & Howlett, G. J., 1 Apr 2003, In : Biophysical Journal. 84, 4, p. 2562-2569 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The Circularization of Amyloid Fibrils Formed by Apolipoprotein C-II

Hatters, D. M., MacRaild, C. A., Daniels, R., Gosal, W. S., Thomson, N. H., Jones, J. A., Davis, J. J., MacPhee, C. E., Dobson, C. M. & Howlett, G. J., 1 Jan 2003, In : Biophysical Journal. 85, 6, p. 3979-3990 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2001

NMR structure of human apolipoprotein C-II in the presence of sodium dodecyl sulfate

MacRaild, C. A., Hatters, D. M., Howlett, G. J. & Gooley, P. R., 8 May 2001, In : Biochemistry. 40, 18, p. 5414-5421 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The interaction of human apolipoprotein C-I with sub-micellar phospholipid

Atcliffe, B. W., MacRaild, C. A., Gooley, P. R. & Howlett, G. J., 27 Sep 2001, In : European Journal of Biochemistry. 268, 10, p. 2838-2846 9 p.

Research output: Contribution to journalArticleResearchpeer-review