Christopher Langmead

Dr

20012020

Research output per year

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Research Output

2010

N-desmethylclozapine (NDMC) is an antagonist at the human native muscarinic M1 receptor

Thomas, D. R., Dada, A., Jones, G. A., Deisz, R. A., Gigout, S., Langmead, C. J., Werry, T. D., Hendry, N., Hagan, J. J., Davies, C. H. & Watson, J. M., 1 Jun 2010, In : Neuropharmacology. 58, 8, p. 1206-1214 9 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Novel N-substituted benzimidazolones as potent, selective, CNS-penetrant, and orally active M1 mAChR agonists

Budzik, B., Garzya, V., Shi, D., Walker, G., Woolley-Roberts, M., Pardoe, J., Lucas, A., Tehan, B., Rivero, R. A., Langmead, C. J., Watson, J. M., Wu, Z., Forbes, I. T. & Jin, JI., 9 Sep 2010, In : ACS Medicinal Chemistry Letters. 1, 6, p. 244-248 5 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Orthosteric and allosteric modes of interaction of novel selective agonists of the M1 muscarinic acetylcholine receptor

Avlani, V. A., Langmead, C. J., Guida, E., Wood, M. D., Tehan, B. G., Herdon, H. J., Watson, J. M., Sexton, P. & Christopoulos, A., 2010, In : Molecular Pharmacology. 78, 1, p. 94 - 104 11 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Performance of mouse neural stem cells as a screening reagent: Characterization of PAC1 activity in medium-throughput functional assays

Lodge, A. P., Langmead, C. J., Daniel, G., Anderson, G. W. & Werry, T. D., 2010, In : Journal of Biomolecular Screening. 15, 2, p. 159-168 10 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Screening for Allosteric Modulators of G Protein-Coupled Receptors

Langmead, C., 15 Jul 2010, GPCR Molecular Pharmacology and Drug Targeting: Shifting Paradigms and New Directions. John Wiley & Sons, p. 276-299 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

2009

Contrasting effects of allosteric and orthosteric agonists on M1 muscarinic acetylcholine receptor internalization and down-regulation

Thomas, R. L., Langmead, C. J., Wood, M. D. & Challiss, R. A. J., Dec 2009, In : Journal of Pharmacology and Experimental Therapeutics. 331, 3, p. 1086-1095 10 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Evaluation of expression and function of the H+/myo-inositol transporter HMIT

Di Daniel, E., Mok, M. H. S., Mead, E., Mutinelli, C., Zambello, E., Caberlotto, L., Pell, T. J., Langmead, C. J., Shah, A. J., Duddy, G., Kew, J. N. C. & Maycox, P. R., 16 Jul 2009, In : BMC Cell Biology. 10, 54.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Growth hormone secretagogues and growth hormone releasing peptides act as orthosteric super-agonists but not allosteric regulators for activation of the G protein Gαo1 by the ghrelin receptor

Bennett, K. A., Langmead, C. J., Wise, A. & Milligan, G., Oct 2009, In : Molecular Pharmacology. 76, 4, p. 802-811 10 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Mutagenic mapping suggests a novel binding mode for selective agonists of M1 muscarinic acetylcholine receptors

Lebon, G., Langmead, C. J., Tehan, B. G. & Hulme, E. C., 2009, In : Molecular Pharmacology. 75, 2, p. 331 - 341 11 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)
2008

Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1

Langmead, C. J., Austin, N. E., Branch, C. L., Brown, J. T., Buchanan, K. A., Davies, C. H., Forbes, I. T., Fry, V. A. H., Hagan, J. J., Herdon, H. J., Jones, G. A., Jeggo, R. D., Kew, J. N. C., Mazzali, A., Melarange, R. A., Patel, N., Pardoe, J., Randall, A. D., Roberts, C. J., Roopun, A. K. & 6 others, Starr, K. R., Teriakidis, A., Wood, M. D., Whittington, M. A., Wu, Z. & Watson, J. M., 2008, In : British Journal of Pharmacology. 154, 5, p. 1104 - 1115 12 p.

Research output: Contribution to journalArticleResearchpeer-review

96 Citations (Scopus)

G protein coupling and signaling pathway activation by M1 muscarinic acetylcholine receptor orthosteric and allosteric agonists

Thomas, R. L., Mistry, R., Langmead, C. J., Wood, M. D. & Challiss, R. A. J., 2008, In : Journal of Pharmacology and Experimental Therapeutics. 327, 2, p. 365 - 374 10 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

Muscarinic acetylcholine receptors as CNS drug targets

Langmead, C. J., Watson, J. M. & Reavill, C., 2008, In : Pharmacology and Therapeutics. 117, 2, p. 232 - 243 12 p.

Research output: Contribution to journalArticleResearchpeer-review

303 Citations (Scopus)
2007

Roof and floor of the muscarinic binding pocket: Variations in the binding modes of orthosteric ligands

Goodwin, J. A., Hulme, E. C., Langmead, C. J. & Tehan, B. G., 1 Dec 2007, In : Molecular Pharmacology. 72, 6, p. 1484-1496 13 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Screening for positive allosteric modulators: Assessment of modulator concentration-response curves as a screening paradigm

Langmead, C. J., 1 Aug 2007, In : Journal of Biomolecular Screening. 12, 5, p. 668-676 9 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Structure-function studies of allosteric agonism at M2 muscarinic acetylcholine receptors

May, L. T., Avlani, V. A., Langmead, C. J., Herdon, H. J., Wood, M. D., Sexton, P. & Christopoulos, A., 2007, In : Molecular Pharmacology. 72, 2, p. 463 - 476 14 p.

Research output: Contribution to journalArticleResearchpeer-review

95 Citations (Scopus)
2006

Allosteric agonists of 7TM receptors: expanding the pharmacological toolbox

Langmead, C. J. & Christopoulos, A., 2006, In : Trends in Pharmacological Sciences. 27, 9, p. 475 - 481 7 p.

Research output: Contribution to journalArticleResearchpeer-review

104 Citations (Scopus)

Probing the molecular mechanism of interaction between 4-n-butyl-1-[4-(2- methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M1 receptor: Direct pharmacological evidence that AC-42 is an allosteric agonist

Langmead, C. J., Fry, V. A., Forbes, I. T., Branch, C. L., Christopoulos, A., Wood, M. D. & Herdon, H. J., 2006, In : Molecular Pharmacology. 69, 1, p. 236 - 246 11 p.

Research output: Contribution to journalArticleResearchpeer-review

91 Citations (Scopus)

SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1-[2′methyl-4′-(5-methyl-1,2,3-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): A novel, potent and selective 5-HT1B receptor antagonist

Scott, C., Langmead, C. J., Clarke, K. L., Wyman, P., Smith, P. W., Starr, K. R., Dawson, L. A., Price, G. W., Hagan, J. J. & Watson, J., 1 Jun 2006, In : Neuropharmacology. 50, 8, p. 984-990 7 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

SB-649915, a novel, potent 5-HT1A and 5-HT1B autoreceptor antagonist and 5-HT re-uptake inhibitor in native tissue

Scott, C., Soffin, E. M., Hill, M., Atkinson, P. J., Langmead, C. J., Wren, P. B., Faedo, S., Gordon, L. J., Price, G. W., Bromidge, S., Johnson, C. N., Hagan, J. J. & Watson, J., 24 Apr 2006, In : European Journal of Pharmacology. 536, 1-2, p. 54-61 8 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)
2005

Neurochemical changes in LPA1 receptor deficient mice - A putative model of schizophrenia

Roberts, C., Winter, P., Shilliam, C. S., Hughes, Z. A., Langmead, C., Maycox, P. R. & Dawson, L. A., 1 Mar 2005, In : Neurochemical Research. 30, 3, p. 371-377 7 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Neurochemical evaluation of the novel 5-HT1A receptor partial agonist/serotonin reuptake inhibitor, vilazodone

Hughes, Z. A., Starr, K. R., Langmead, C. J., Hill, M., Bartoszyk, G. D., Hagan, J. J., Middlemiss, D. N. & Dawson, L. A., 7 Mar 2005, In : European Journal of Pharmacology. 510, 1-2, p. 49-57 9 p.

Research output: Contribution to journalArticleResearchpeer-review

94 Citations (Scopus)
2004

Characterisation of the binding of [ 3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor

Langmead, C. J., Jerman, J. C., Brough, S. J., Scott, C., Porter, R. A. & Herdon, H. J., 1 Jan 2004, In : British Journal of Pharmacology. 141, 2, p. 340-346 7 p.

Research output: Contribution to journalArticleResearchpeer-review

117 Citations (Scopus)

Regulation of calcitonin gene-related peptide release from rat trigeminal nucleus caudalis slices in vitro

Jenkins, D. W., Langmead, C. J., Parsons, A. A. & Strijbos, P. J., 19 Aug 2004, In : Neuroscience Letters. 366, 3, p. 241-244 4 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)
2001

Characterization of the binding of [ 125I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor

Langmead, C. J., Szekeres, P. G., Chambers, J. K., Ratcliffe, S. J., Jones, D. N. C., Hirst, W. D., Price, G. W. & Herdon, H. J., 1 Jan 2001, In : British Journal of Pharmacology. 131, 4, p. 683-688 6 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

The effect of SB-269970, a 5-HT7 receptor antagonist, on 5-HT release from serotonergic terminals and cell bodies

Roberts, C., Allen, L., Langmead, C. J., Hagan, J. J., Middlemiss, D. N. & Price, G. W., 1 Jan 2001, In : British Journal of Pharmacology. 132, 7, p. 1574-1580 7 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)