Projects per year
Personal profile
Biography
- Head, Servier Program in Drug Discovery
- Faculty of Pharmacy and Pharmaceutical Sciences
- Monash Institute of Pharmaceutical Sciences
Chris Langmead has a strong interest in drug discovery, having spent 15 years working in the pharmaceutical and biotech industry in the UK, where he led project teams to discover four pre-clinical candidate drugs and managed collaborations with academic labs and other pharmaceutical companies.
In 2012 he joined MIPS to head up a drug discovery program in collaboration with Servier Laboratories, France. He is particularly interested in GPCRs as drug targets in neurodegenerative and psychiatric disorders, but also has interest in structure-function of GPCRs and analytical receptor pharmacology, with particular reference to allosteric interactions.
In 2012 he joined MIPS to head up a drug discovery program in collaboration with Servier Laboratories, France. He is particularly interested in GPCRs as drug targets in neurodegenerative and psychiatric disorders, but also has interest in structure-function of GPCRs and analytical receptor pharmacology, with particular reference to allosteric interactions.
Servier Program in Drug Discovery
In 2012, the Monash Institute of Pharmaceutical Sciences (MIPS) entered into a collaborative drug discovery research agreement with Les Laboratoires Servier, a leading European pharmaceutical company (http://tinyurl.com/brrztb4).
The collaboration makes use of MIPS' acknowledged world-leading capability in the identification of novel GPCR targets, in the understanding of GPCR functional biology and in the design of new chemical entities to modulate GPCR activity. MIPS has developed GPCR expertise comprising technology, research facilities and world leading scientists that enable it to conduct fundamental research, drug discovery and preclinical drug development activities on GPCR targets with therapeutic potential.
Monash teaching commitment
- Lectures to 3rd year BPharmSci students in the Faculty of Pharmacy and Pharmaceutical Sciences
- Supervision of Honours students in Drug Discovery Biology
Research interests
- GPCR target validation, hit identification and lead optimisation
- CNS drug discovery
- Allosteric modulation of GPCRs
- Molecular and analytical pharmacology
Research area keywords
- G protein-coupled receptors
- drug discovery
- hit identification
- high throughput screening
- muscarinic receptors
- neuropharmacology
- analytical pharmacology
- allosteric modulation
- structure-function
- target validation
- hit-to-lead
- lead optimisation
- psychiatric disorders
- cognitive disorders
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Discovering new drugs for epilepsy using personalised medicine
Kwan, P., Rollo, B., Langmead, C., Ayers, K. L. & Harris, A.
1/06/20 → 31/05/22
Project: Research
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Human high-throughput in-vitro phenotypic screening for new epilepsy drugs
Rollo, B., Kwan, P., O'Brien, T., Langmead, C., Baell, J., Casillas-Espinosa, P., May, L., Ayers, K. L. & Sumer, H.
1/06/22 → 1/01/23
Project: Research
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NHMRC Equipment Grant - FLIPR Tetra high-throughput cellular screening system
Sexton, P., Christopoulos, A., Leach, K., Gregory, K., Veldhuis, N., Poole, D. & Langmead, C.
1/01/18 → 31/12/18
Project: Research
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Cryo-EM structure of the dual incretin receptor agonist, peptide-19, in complex with the glucagon-like peptide-1 receptor
Johnson, R. M., Zhang, X., Piper, S. J., Nettleton, T. J., Vandekolk, T. H., Langmead, C. J., Danev, R., Sexton, P. M. & Wootten, D., 12 Nov 2021, In: Biochemical and Biophysical Research Communications. 578, p. 84-90 7 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
Pharmacological Insights Into Safety and Efficacy Determinants for the Development of Adenosine Receptor Biased Agonists in the Treatment of Heart Failure
Rueda, P., Merlin, J., Chimenti, S., Feletou, M., Paysant, J., White, P. J., Christopoulos, A., Sexton, P. M., Summers, R. J., Charman, W. N., May, L. T. & Langmead, C. J., 11 Mar 2021, In: Frontiers in Pharmacology. 12, 15 p., 628060.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Acetylcholine Muscarinic M4 Receptors as a Therapeutic Target for Alcohol Use Disorder: Converging Evidence From Humans and Rodents
Walker, L. C., Berizzi, A. E., Chen, N. A., Rueda, P., Perreau, V. M., Huckstep, K., Srisontiyakul, J., Govitrapong, P., Xiaojian, J., Lindsley, C. W., Jones, C. K., Riddy, D. M., Christopoulos, A., Langmead, C. J. & Lawrence, A. J., 15 Dec 2020, In: Biological Psychiatry. 88, 12, p. 898-909 12 p.Research output: Contribution to journal › Article › Research › peer-review
11 Citations (Scopus) -
Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists
Zhang, X., Belousoff, M. J., Zhao, P., Kooistra, A. J., Truong, T. T., Ang, S. Y., Underwood, C. R., Egebjerg, T., Šenel, P., Stewart, G. D., Liang, Y-L., Glukhova, A., Venugopal, H., Christopoulos, A., Furness, S. G. B., Miller, L. J., Reedtz-Runge, S., Langmead, C. J., Gloriam, D. E., Danev, R. & 2 others, , 5 Nov 2020, In: Molecular Cell. 80, 3, p. 485-500 16 p.Research output: Contribution to journal › Article › Research › peer-review
36 Citations (Scopus) -
In the Loop: Extrastriatal Regulation of Spiny Projection Neurons by GPR52
Spark, D. L., Mao, M., Ma, S., Sarwar, M., Nowell, C. J., Shackleford, D. M., Sexton, P. M., Nithianantharajah, J., Stewart, G. D. & Langmead, C. J., 15 Jul 2020, In: ACS Chemical Neuroscience. 11, 14, p. 2066-2076 11 p.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus)