Christopher Langmead

Dr

20012020

Research output per year

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Personal profile

Biography

  • Head, Servier Program in Drug Discovery
  • Faculty of Pharmacy and Pharmaceutical Sciences
  • Monash Institute of Pharmaceutical Sciences

Chris Langmead has a strong interest in drug discovery, having spent 15 years working in the pharmaceutical and biotech industry in the UK, where he led project teams to discover four pre-clinical candidate drugs and managed collaborations with academic labs and other pharmaceutical companies.

In 2012 he joined MIPS to head up a drug discovery program in collaboration with Servier Laboratories, France. He is particularly interested in GPCRs as drug targets in neurodegenerative and psychiatric disorders, but also has interest in structure-function of GPCRs and analytical receptor pharmacology, with particular reference to allosteric interactions.

In 2012 he joined MIPS to head up a drug discovery program in collaboration with Servier Laboratories, France. He is particularly interested in GPCRs as drug targets in neurodegenerative and psychiatric disorders, but also has interest in structure-function of GPCRs and analytical receptor pharmacology, with particular reference to allosteric interactions.

Servier Program in Drug Discovery

In 2012, the Monash Institute of Pharmaceutical Sciences (MIPS) entered into a collaborative drug discovery research agreement with Les Laboratoires Servier, a leading European pharmaceutical company (http://tinyurl.com/brrztb4).

The collaboration makes use of MIPS' acknowledged world-leading capability in the identification of novel GPCR targets, in the understanding of GPCR functional biology and in the design of new chemical entities to modulate GPCR activity. MIPS has developed GPCR expertise comprising technology, research facilities and world leading scientists that enable it to conduct fundamental research, drug discovery and preclinical drug development activities on GPCR targets with therapeutic potential.

Monash teaching commitment

  • Lectures to 3rd year BPharmSci students in the Faculty of Pharmacy and Pharmaceutical Sciences
  • Supervision of Honours students in Drug Discovery Biology

Research interests

  • GPCR target validation, hit identification and lead optimisation
  • CNS drug discovery
  • Allosteric modulation of GPCRs
  • Molecular and analytical pharmacology

Research area keywords

  • G protein-coupled receptors
  • drug discovery
  • hit identification
  • high throughput screening
  • muscarinic receptors
  • neuropharmacology
  • analytical pharmacology
  • allosteric modulation
  • structure-function
  • target validation
  • hit-to-lead
  • lead optimisation
  • psychiatric disorders
  • cognitive disorders

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Projects

Research Output

Acetylcholine Muscarinic M4 Receptors as a Therapeutic Target for Alcohol Use Disorder: Converging Evidence From Humans and Rodents

Walker, L. C., Berizzi, A. E., Chen, N. A., Rueda, P., Perreau, V. M., Huckstep, K., Srisontiyakul, J., Govitrapong, P., Xiaojian, J., Lindsley, C. W., Jones, C. K., Riddy, D. M., Christopoulos, A., Langmead, C. J. & Lawrence, A. J., 28 Feb 2020, (Accepted/In press) In : Biological Psychiatry. 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Negative allosteric modulators of the human calcium-sensing receptor bind to overlapping and distinct sites within the 7-transmembrane domain

Josephs, T. M., Keller, A. N., Khajehali, E., DeBono, A., Langmead, C. J., Conigrave, A. D., Capuano, B., Kufareva, I., Gregory, K. J. & Leach, K., Apr 2020, In : British Journal of Pharmacology. 177, 8, p. 1917-1930 14 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

New Advances in Targeting the Resolution of Inflammation: Implications for Specialized Pro-Resolving Mediator GPCR Drug Discovery

Park, J., Langmead, C. & Riddy, D., 20 Jan 2020, In : ACS Pharmacology & Translational Science. 3, 1, p. 88-106 19 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Crystal structure of the M5 muscarinic acetylcholine receptor

Vuckovic, Z., Gentry, P. R., Berizzi, A. E., Hirata, K., Varghese, S., Thompson, G., van der Westhuizen, E. T., Burger, W. A. C., Rahmani, R., Valant, C., Langmead, C. J., Lindsley, C. W., Baell, J. B., Tobin, A. B., Sexton, P. M., Christopoulos, A. & Thal, D. M., 17 Dec 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 51, p. 26001-26007 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)