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Christopher Langmead

Dr

 https://orcid.org/0000-0003-3483-1120
20012020
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Personal profile

Biography

  • Head, Servier Program in Drug Discovery
  • Faculty of Pharmacy and Pharmaceutical Sciences
  • Monash Institute of Pharmaceutical Sciences

Chris Langmead has a strong interest in drug discovery, having spent 15 years working in the pharmaceutical and biotech industry in the UK, where he led project teams to discover four pre-clinical candidate drugs and managed collaborations with academic labs and other pharmaceutical companies.

In 2012 he joined MIPS to head up a drug discovery program in collaboration with Servier Laboratories, France. He is particularly interested in GPCRs as drug targets in neurodegenerative and psychiatric disorders, but also has interest in structure-function of GPCRs and analytical receptor pharmacology, with particular reference to allosteric interactions.

In 2012 he joined MIPS to head up a drug discovery program in collaboration with Servier Laboratories, France. He is particularly interested in GPCRs as drug targets in neurodegenerative and psychiatric disorders, but also has interest in structure-function of GPCRs and analytical receptor pharmacology, with particular reference to allosteric interactions.

Servier Program in Drug Discovery

In 2012, the Monash Institute of Pharmaceutical Sciences (MIPS) entered into a collaborative drug discovery research agreement with Les Laboratoires Servier, a leading European pharmaceutical company (http://tinyurl.com/brrztb4).

The collaboration makes use of MIPS' acknowledged world-leading capability in the identification of novel GPCR targets, in the understanding of GPCR functional biology and in the design of new chemical entities to modulate GPCR activity. MIPS has developed GPCR expertise comprising technology, research facilities and world leading scientists that enable it to conduct fundamental research, drug discovery and preclinical drug development activities on GPCR targets with therapeutic potential.

Monash teaching commitment

  • Lectures to 3rd year BPharmSci students in the Faculty of Pharmacy and Pharmaceutical Sciences
  • Supervision of Honours students in Drug Discovery Biology

Research interests

  • GPCR target validation, hit identification and lead optimisation
  • CNS drug discovery
  • Allosteric modulation of GPCRs
  • Molecular and analytical pharmacology

Keywords

  • G protein-coupled receptors
  • drug discovery
  • hit identification
  • high throughput screening
  • muscarinic receptors
  • neuropharmacology
  • analytical pharmacology
  • allosteric modulation
  • structure-function
  • target validation
  • hit-to-lead
  • lead optimisation
  • psychiatric disorders
  • cognitive disorders

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Projects 2016 2020

NHMRC Equipment Grant - Promethion High-Definition Multiplexed Respirometry System

Sexton, P., Christopoulos, A., Wootten, D. L. & Langmead, C. J.

Monash University – Internal Faculty Contribution, Monash University – Internal Department Contribution

1/01/19 → 31/12/19

Project: Research

Alcohol and Striatal Adaptation

Lawrence, A., Langmead, C. J. & Spanswick, D. C.

National Health & Medical Research Council (NHMRC)

1/01/17 → 31/12/20

Project: Research

NHMRC Equipment Grant - FLIPR Tetra high-throughput cellular screening system

Sexton, P., Christopoulos, A., Leach, K., Gregory, K. J., Veldhuis, N. A., Poole, D. P. & Langmead, C. J.

1/01/18 → 31/12/18

Project: Research

GPR88 as a novel target for fronto-striatal dysfunction in schizophrenia

Langmead, C. J. & Nithianantharajah, J.

National Health & Medical Research Council (NHMRC)

1/01/16 → 31/12/18

Project: Research

Research Output 2001 2018

Comparative genotypic and phenotypic analysis of human peripheral blood monocytes and surrogate monocyte-like cell lines commonly used in metabolic disease research

Riddy, D. M., Goy, E., Delerive, P., Summers, R. J. & Langmead, C. J., 1 May 2018, In : PLoS ONE. 13, 5, 19 p., e0197177.

Research output: Contribution to journal › Article › Research › peer-review

Open Access
File

G protein–coupled receptors targeting insulin resistance, obesity, and type 2 diabetes mellitus

Riddy, D. M., Delerive, P., Summers, R. J., Sexton, P. & Langmead, C. J., 1 Jan 2018, In : Pharmacological Reviews. 70, 1, p. 39-67 29 p.

Research output: Contribution to journal › Review Article › Research › peer-review

Molecular pharmacology of GPCRs

Langmead, C. J. & Summers, R. J., 1 Nov 2018, In : British Journal of Pharmacology. 175, 21, p. 4005-4008 4 p.

Research output: Contribution to journal › Editorial › Other

Open Access
File

Muscarinic M5 receptors modulate ethanol seeking in rats

Berizzi, A. E., Perry, C. J., Shackleford, D. M., Lindsley, C. W., Jones, C. K., Chen, N. A., Sexton, P. M., Christopoulos, A., Langmead, C. J. & Lawrence, A. J., 1 Jun 2018, In : Neuropsychopharmacology. 43, 7, p. 1510-1517 8 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access
File

High throughput, quantitative analysis of human osteoclast differentiation and activity

Diepenhorst, N., Nowell, C., Rueda, P., Henriksen, K., Pierce, T., Cook, A., Pastoureau, P., Sabatini, M., Charman, W., Christopoulos, A., Summers, R., Sexton, P. & Langmead, C., 15 Feb 2017, In : Analytical Biochemistry. 519, p. 51-56 6 p.

Research output: Contribution to journal › Article › Research › peer-review