Christopher Langmead

Servier Drug Discovery Program Head, Drug Discovery Biology

https://orcid.org/0000-0003-3483-1120

EmailChris.Langmead@monash.edu

Research activity per year

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Personal profile

Biography

Head, Servier Program in Drug Discovery
Faculty of Pharmacy and Pharmaceutical Sciences
Monash Institute of Pharmaceutical Sciences

Chris Langmead has a strong interest in drug discovery, having spent 15 years working in the pharmaceutical and biotech industry in the UK, where he led project teams to discover four pre-clinical candidate drugs and managed collaborations with academic labs and other pharmaceutical companies.

In 2012 he joined MIPS to head up a drug discovery program in collaboration with Servier Laboratories, France. He is particularly interested in GPCRs as drug targets in neurodegenerative and psychiatric disorders, but also has interest in structure-function of GPCRs and analytical receptor pharmacology, with particular reference to allosteric interactions.

Servier Program in Drug Discovery

In 2012, the Monash Institute of Pharmaceutical Sciences (MIPS) entered into a collaborative drug discovery research agreement with Les Laboratoires Servier, a leading European pharmaceutical company (http://tinyurl.com/brrztb4).

The collaboration makes use of MIPS' acknowledged world-leading capability in the identification of novel GPCR targets, in the understanding of GPCR functional biology and in the design of new chemical entities to modulate GPCR activity. MIPS has developed GPCR expertise comprising technology, research facilities and world leading scientists that enable it to conduct fundamental research, drug discovery and preclinical drug development activities on GPCR targets with therapeutic potential.

Monash teaching commitment

Lectures to 3rd year BPharmSci students in the Faculty of Pharmacy and Pharmaceutical Sciences
Supervision of Honours students in Drug Discovery Biology

Research interests

GPCR target validation, hit identification and lead optimisation
CNS drug discovery
Allosteric modulation of GPCRs
Molecular and analytical pharmacology

Research area keywords

G protein-coupled receptors
drug discovery
hit identification
high throughput screening
muscarinic receptors
neuropharmacology
analytical pharmacology
allosteric modulation
structure-function
target validation
hit-to-lead
lead optimisation
psychiatric disorders
cognitive disorders

Network

Recent external collaboration on country level. Dive into details by clicking on the dots or

1 Active
4 Finished

Discovering new drugs for epilepsy using personalised medicine
Kwan, P., Rollo, B., Langmead, C., Ayers, K. L. & Harris, A.
1/06/20 → 31/05/22
Project: Research
NHMRC Equipment Grant - Promethion High-Definition Multiplexed Respirometry System
Sexton, P., Christopoulos, A., Wootten, D. & Langmead, C.
Monash University – Internal Faculty Contribution, Monash University – Internal Department Contribution
1/01/19 → 31/12/19
Project: Research
NHMRC Equipment Grant - FLIPR Tetra high-throughput cellular screening system
Sexton, P., Christopoulos, A., Leach, K., Gregory, K., Veldhuis, N., Poole, D. & Langmead, C.
1/01/18 → 31/12/18
Project: Research
Alcohol and Striatal Adaptation
Lawrence, A., Langmead, C. & Spanswick, D.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/17 → 31/12/20
Project: Research
GPR88 as a novel target for fronto-striatal dysfunction in schizophrenia
Langmead, C. & Nithianantharajah, J.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/16 → 31/12/18
Project: Research

59 Article
5 Review Article
4 Poster
3 Editorial
More

Acetylcholine Muscarinic M₄ Receptors as a Therapeutic Target for Alcohol Use Disorder: Converging Evidence From Humans and Rodents
Walker, L. C., Berizzi, A. E., Chen, N. A., Rueda, P., Perreau, V. M., Huckstep, K., Srisontiyakul, J., Govitrapong, P., Xiaojian, J., Lindsley, C. W., Jones, C. K., Riddy, D. M., Christopoulos, A., Langmead, C. J. & Lawrence, A. J., 28 Feb 2020, (Accepted/In press) In : Biological Psychiatry. 12 p.
Research output: Contribution to journal › Article › Research › peer-review

3 Citations (Scopus)
Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists
Zhang, X., Belousoff, M. J., Zhao, P., Kooistra, A. J., Truong, T. T., Ang, S. Y., Underwood, C. R., Egebjerg, T., Šenel, P., Stewart, G. D., Liang, Y-L., Glukhova, A., Venugopal, H., Christopoulos, A., Furness, S. G. B., Miller, L. J., Reedtz-Runge, S., Langmead, C. J., Gloriam, D. E., Danev, R. & 2 others, Sexton, P. M. & Wootten, D., 5 Nov 2020, In : Molecular Cell. 80, 3, p. 485-500 16 p.
Research output: Contribution to journal › Article › Research › peer-review

7 Citations (Scopus)
Negative allosteric modulators of the human calcium-sensing receptor bind to overlapping and distinct sites within the 7-transmembrane domain
Josephs, T. M., Keller, A. N., Khajehali, E., DeBono, A., Langmead, C. J., Conigrave, A. D., Capuano, B., Kufareva, I., Gregory, K. J. & Leach, K., Apr 2020, In : British Journal of Pharmacology. 177, 8, p. 1917-1930 14 p.
Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)
New Advances in Targeting the Resolution of Inflammation: Implications for Specialized Pro-Resolving Mediator GPCR Drug Discovery
Park, J., Langmead, C. & Riddy, D., 20 Jan 2020, In : ACS Pharmacology & Translational Science. 3, 1, p. 88-106 19 p.
Research output: Contribution to journal › Review Article › Research › peer-review
Preface
Langmead, C. J., 2020, Advances in Pharmacology. Langmead, C. J. (ed.). Apple Academic Press, Inc., p. xiii-xvii 5 p.
Research output: Chapter in Book/Report/Conference proceeding › Foreword / Postscript › Other › peer-review