Projects per year
Personal profile
Biography
Chris Langmead is Professor, Deputy Director, and Better Medicines Theme Leader of the Neuromedicines Discovery Centre at the Monash Institute of Pharmaceutical Sciences (MIPS), a collaborative venture targeting new medicines development for poorly-treated mental health disorders. He also directs a collaborative neuroscience R&D program with Servier (France) and is the co-founder and CEO of Phrenix Therapeutics, a biotech spin-out from the Neuromedicines Discovery Centre that is developing next-generation therapeutics for schizophrenia.
Prior to these roles this he was Head of Pharmacology at Heptares Therapeutics Ltd., a UK-based biotechnology company (2009-2012), where he was responsible all of the company’s discovery biology. He is an acknowledged expert in drug discovery, particularly in the field of psychiatry, where he has led multiple projects into late stage preclinical development, many of which have progressed into clinical trials. These successes enabled the US$400M sale of Heptares Therapeutics Ltd. to the Sosei Group Corporation in 2015. Prior to joining Heptares, Chris was a neuroscience researcher at GlaxoSmithKline, UK (1998-2009).
He has a degree and PhD in pharmacology from Queens' College, Cambridge and University College London, respectively, was the youngest person to be elected as a Fellow of the British Pharmacological Society in 2012, and was the recipient of the British Pharmacological Society Novartis Prize in 2017. Chris serves on the editorial boards of the British Journal of Pharmacology, ACS Chemical Neuroscience, ACS Pharmacology & Translational Science and Frontiers in Pharmacology. He is also a corresponding member of NC-IUPHAR. He has published over 70 research articles, reviews and book chapters on drug discovery, which have been cited over 5000 times.
Monash teaching commitment
Supervision of Honours and HDR students in the Neuromedicines Discovery Centre
Research interests
- Drug discovery (target validation, hit identification, lead optimisation)
- Next-generation medicines for mental health and CNS disorders
- Allosteric modulation of GPCRs
- Molecular and analytical pharmacology
- Research translation and commercialisation
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- G protein-coupled receptors
- drug discovery
- hit identification
- high throughput screening
- muscarinic receptors
- neuropharmacology
- analytical pharmacology
- allosteric modulation
- structure-function
- target validation
- hit-to-lead
- lead optimisation
- psychiatric disorders
- cognitive disorders
Collaborations and top research areas from the last five years
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Drug Target Identification Platform
Creek, D., Avery, V. M., Pitson, S. M., George, A. J., Olechnowicz, S., Baell, J., Schittenhelm, R., Li, J., Langmead, C., Stupple, P., Drinkwater, C., Flynn, B., Brouwer, K., Arndt, G. M. & Newman, S.
Department of Health and Aged Care (Australia)
30/06/23 → 6/12/28
Project: Research
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Pre-clinical evaluation of selective adenosine A1 receptor positive allosteric modulators for the treatment of drug-resistant epilepsy
Kwan, P., May, L., Rollo, B., O'Brien, T., Casillas-Espinosa, P., Howden, S., Christopoulos, A., Gregory, K., Scammells, P., Baltos, J., Elliot, D., TN Nguyen, A., Langmead, C., Antonic-Baker, A., Sumer, H., Javaid, S. & Gu, J.
1/06/22 → 31/05/27
Project: Research
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Novel GPR52 agonists for schizophrenia / Phrenix Therapeutics
Stewart, G., Langmead, C., Nithianantharajah, J. & Baell, J.
1/06/22 → …
Project: Research
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To support the research and development of NHMRC guidelines on use of drugs for mental health conditions
Bell, S., Langmead, C., Lawrence, A. & Davey, C. G.
1/02/24 → 31/01/25
Project: Research
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Measuring attitudes towards using psychedelic drugs to treat mental illness
Kunstler, B., Smith, L., Wright, B., Goodwin, D., Hatty, M. & Langmead, C.
27/10/22 → 25/11/22
Project: Research
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Characterization of a putative orexin receptor in Ciona intestinalis sheds light on the evolution of the orexin/hypocretin system in chordates
Rinne, M. K., Urvas, L., Mandrika, I., Fridmanis, D., Riddy, D. M., Langmead, C. J., Kukkonen, J. P. & Xhaard, H., Dec 2024, In: Scientific Reports. 14, 1, 15 p., 7690.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Ligand-directed biased agonism at human histamine H3 receptor isoforms across Gαi/o- and β-arrestin2-mediated pathways
Rahman, S. N., Imhaouran, F., Leurs, R., Christopoulos, A., Valant, C. & Langmead, C. J., Oct 2024, In: Biochemical Pharmacology. 228, 24 p., 115988.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Molecular and structural insights into the 5-HT2C receptor as a therapeutic target for substance use disorders
Ubhayarathna, M., Langmead, C. J., Diepenhorst, N. A. & Stewart, G. D., Nov 2024, In: British Journal of Pharmacology. 181, 22, p. 4414-4429 16 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access4 Citations (Scopus) -
Molecular insights into orphan G protein-coupled receptors relevant to schizophrenia
Lu, Y., Hatzipantelis, C. J., Langmead, C. J. & Stewart, G. D., Jul 2024, In: British Journal of Pharmacology. 181, 14, p. 2095-2113 19 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access2 Citations (Scopus) -
Opportunities and challenges for the development of M1 muscarinic receptor positive allosteric modulators in the treatment for neurocognitive deficits
Nguyen, H. T. M., van der Westhuizen, E. T., Langmead, C. J., Tobin, A. B., Sexton, P. M., Christopoulos, A. & Valant, C., Jul 2024, In: British Journal of Pharmacology. 181, 14, p. 2114-2142 29 p.Research output: Contribution to journal › Review Article › Research › peer-review
8 Citations (Scopus)
Prizes
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Georgina Sweet Fellowship
Lu, Jackie (Recipient) & Langmead, Christopher (Recipient), 18 Jun 2021
Prize: Competitive Fellowships
Press/Media
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How to boost community and stakeholder support for the use of psychedelic medicines
Brea Kunstler, Melissa Hatty, Liam Smith, Breanna Wright & Christopher Langmead
14/02/23
1 Media contribution
Press/Media: Article/Feature