Christoph Hagemeyer

Assoc Professor

  • 99 Commercial Road, Monash AMREP building Level 1, Walkway, via The Alfred Centre

    3004 Melbourne

    Australia

Accepting PhD Students

19992023
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Research Output 1999 2019

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Article
1999
48 Citations (Scopus)

Testosterone metabolism in rat brain is differentially enhanced by phenytoin-inducible cytochrome P450 isoforms

Rosenbrock, H., Hagemeyer, C. E., Singec, I., Knoth, R. & Volk, B., 1999, In : Journal of Neuroendocrinology. 11, 8, p. 597 - 604 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2000
8 Citations (Scopus)

Different testosterone metabolism by immortalized embryonic and postnatal hippocampal neurons from C57BL/6 mice: A crucial role for androstenedione

Hagemeyer, C. E., Knoth, R., Volk, B., Rosenbrock, H. & Singec, I., 2000, In : Journal of Neuroscience Research. 60, 1, p. 106 - 115 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2001
16 Citations (Scopus)

Expression and localization of the CYP2B subfamily predominantly in neurones of rat brain

Hagemeyer, C. E., Knoth, R., Volk, B., Rosenbrock, H. & Ditter, M., 2001, In : Journal of Neurochemistry. 76, 2, p. 332 - 340 9 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Identification, induction and localization of cytochrome P450s of the 3A-subfamily in mouse brain

Rosenbrock, H., Hagemeyer, C. E., Ditter, M., Knoth, R. & Volk, B., 2001, In : Neurotoxicity Research. 3, 4, p. 339 - 349 11 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Oxidative hydrolysis of scoparone by cytochrome p450 cyp2c29 reveals a novel metabolite

Meyer, R. P., Hagemeyer, C. E., Knoth, R., Kurz, G. & Volk, B., 2001, In : Biochemical and Biophysical Research Communications. 285, 1, p. 32 - 39 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2002
33 Citations (Scopus)

Synaptic vesicle protein synaptoporin is differently expressed by subpopulations of mouse hippocampal neurons

Singec, I., Knoth, R., Ditter, M., Hagemeyer, C. E., Rosenbrock, H., Frotscher, M. & Volk, B., 2002, In : Neuroscience. 452, 2, p. 139 - 153 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2003
39 Citations (Scopus)

Predominantly neuronal expression of cytochrome P450 isoforms CYP3A11 and CYP3A13 in mouse brain

Hagemeyer, C. E., Rosenbrock, H., Ditter, M., Knoth, R. & Volk, B., 2003, In : Neuroscience. 117, 3, p. 521 - 529 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2004
21 Citations (Scopus)

Construction and characterization of a recombinant plasminogen activator composed of an anti-fibrin single-chain antibody and low-molecular-weight urokinase

Hagemeyer, C. E., Tomic, I., Weirich, U., Graeber, J., Nordt, T. K., Runge, M. S., Bode, C. & Peter, K., 2004, In : Journal of Thrombosis and Haemostasis. 2, 5, p. 797 - 803 7 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Fibrin-targeted direct factor Xa inhibition: Construction and characterization of a recombinant factor Xa inhibitor composed of an anti-fibrin single-chain antibody and tick anticoagulant peptide

Hagemeyer, C. E., Tomic, I., Jaminet, P., Weirich, U., Bassler, N., Schwarz, M., Runge, M. S., Bode, C. & Peter, K., 2004, In : Thrombosis and Haemostasis. 92, 1, p. 47 - 53 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2006
24 Citations (Scopus)

Anti-epileptic drug phenytoin enhances androgen metabolism and androgen receptor expression in murine hippocampus

Meyer, R. P., Hagemeyer, C. E., Knoth, R., Kaufmann, M. R. & Volk, B., Jan 2006, In : Journal of Neurochemistry. 96, 2, p. 460 - 472 13 p.

Research output: Contribution to journalArticleResearchpeer-review

112 Citations (Scopus)

Conformation-specific blockade of the integrin GPIIb/IIIa: A novel antiplatelet strategy that selectively targets activated platelets

Schwarz, M., Meade, G., Stoll, P., Ylanne, J., Bassler, N., Chen, Y. C., Hagemeyer, C. E., Ahrens, I., Moran, N., Kenny, D., Fitzgerald, D. J., Bode, C. & Peter, K., 6 Jul 2006, In : Circulation Research. 99, 1, p. 25 - 33 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2007
62 Citations (Scopus)

A mechanistic model for paradoxical platelet activation by ligand-mimetic alphaIIbbeta3 (GPIIb/IIIa) antagonists

Bassler, N., Loeffler, C., Mangin, P., Yuan, Y-P., Schwarz, M., Hagemeyer, C. E., Eisenhardt, S. U., Ahrens, I., Bode, C., Jackson, S. & Peter, K., 2007, In : Arteriosclerosis, Thrombosis and Vascular Biology. 27, 3, p. 9 - 15 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Antibodies as helpers: Targeted antithrombotic and fibrinolytic therapy

Schwarz, M., Hagemeyer, C. E., Peter, K. & Bode, C., 2007, In : Hamostaseologie. 27, 5, p. 360 - 362 3 p.

Research output: Contribution to journalArticleResearchpeer-review

61 Citations (Scopus)

Targeting ligand-induced binding sites on GPIIb/IIIa via single-chain antibody allows effective anticoagulation without bleeding time prolongation

Stoll, P., Bassler, N., Hagemeyer, C. E., Eisenhardt, S. U., Chen, Y-C., Schmidt, R., Schwarz, M., Ahrens, I., Katagiri, Y., Pannen, B., Bode, C. & Peter, K., 2007, In : Arteriosclerosis, Thrombosis and Vascular Biology. 27, 5, p. 1206 - 1212 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2008
113 Citations (Scopus)

Magnetic resonance imaging contrast agent targeted toward activated platelets allows in vivo detection of thrombosis and monitoring of thrombolysis

Von Zur Muhlen, C., von Elverfeldt, D., Moeller, J. A., Choudhury, R. P., Paul, D., Hagemeyer, C. E., Olschewski, M., Becker, A-K., Neudorfer, I., Bassler, N., Schwarz, M., Bode, C. & Peter, K., 2008, In : Circulation. 118, 3, p. 258 - 267 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2009
16 Citations (Scopus)

Concordant up-regulation of cytochrome P450 Cyp3a11, testosterone oxidation and androgen receptor expression in mouse brain after xenobiotic treatment

Meyer, R. P., Gehlhaus, M., Schwab, R., Burck, C., Knoth, R. & Hagemeyer, C. E., 2009, In : Journal of Neurochemistry. 109, 2, p. 670 - 681 12 p.

Research output: Contribution to journalArticleResearchpeer-review

152 Citations (Scopus)

Dissociation of pentameric to monomeric C-reactive protein on activated platelets localizes inflammation to atherosclerotic plaques

Eisenhardt, S. U., Habersberger, J., Murphy, A., Chen, Y-C., Woollard, K. J., Bassler, N., Qian, H., von zur Muhlen, C., Hagemeyer, C. E., Ahrens, I., Chin-Dusting, J., Bobik, A. & Peter, K., 17 Jul 2009, In : Circulation Research. 105, 2, p. 128-137 10 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)
67 Citations (Scopus)

Single-chain antibodies as diagnostic tools and therapeutic agents

Hagemeyer, C. E., Von Zur Muhlen, C., von Elverfeldt, D. & Peter, K., 2009, In : Thrombosis and Haemostasis. 101, 6, p. 1012 - 1019 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2010
19 Citations (Scopus)

7-Benzyloxyresorufin-O-dealkylase activity as a marker for measuring cytochrome P450 CYP3A induction in mouse liver

Hagemeyer, C. E., Burck, C., Schwab, R., Knoth, R. & Meyer, R. P., 2010, In : Analytical Biochemistry. 398, 1, p. 104 - 111 8 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Genetic transfer of fusion proteins effectively inhibits VCAM-1-mediated cell adhesion and transmigration via inhibition of cytoskeletal anchorage

Hagemeyer, C. E., Ahrens, I., Bassler, N., Dschachutaschwili, N., Chen, Y-C., Eisenhardt, S. U., Bode, C. & Peter, K., 2010, In : Journal of Cellular and Molecular Medicine. 14, 1-2, p. 290 - 302 13 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Targeting the platelet integrin GPIIb/IIIa

Hagemeyer, C. E. & Peter, K., 2010, In : Current Pharmaceutical Design. 16, 37, p. 4119 - 4133 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2011
17 Citations (Scopus)

Activated platelets in carotid artery thrombosis in mice can be selectively targeted with a radiolabeled single-chain antibody

Heidt, T., Braun, F., Peter, K., Goldschmidt, J., Pethe, A., Hagemeyer, C. E., Neudorfer, I., Zirlik, A., Weber, W. A., Bode, C., Meyer, P. T., Behe, M. & Von Zur Muhlen, C., 2011, In : PLoS ONE. 6, 3, 9 p., e18446.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
10 Citations (Scopus)

An activation-specific platelet inhibitor that can be turned on/off by medically used hypothermia

Topcic, D., Kim, W., Holien, J. K., Jia, F., Armstrong, P., Hohmann, J. D., Straub, A., Krippner, G. Y., Haller, C. A., Domeij, H., Hagemeyer, C. E., Parker, M. W., Chaikof, E. L. & Peter, K., 2011, In : Arteriosclerosis, Thrombosis and Vascular Biology. 31, 9, p. 2015 - 2023 9 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Enzymatic single-chain antibody tagging: A universal approach to targeted molecular imaging and cell homing in cardiovascular disease

Ta, H. T., Prabhu, S., Leitner, E., Jia, F., von Elverfeldt, D., Jackson, K. E., Heidt, T., Nair, A. K. N., Pearce, H., Von Zur Muhlen, C., Wang, X., Peter, K. & Hagemeyer, C. E., 2011, In : Circulation Research. 109, 4, p. 365 - 373 9 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

GPVI and GPIb alpha mediate staphylococcal superantigen-like protein 5 (SSL5) induced platelet activation and direct toward glycans as potential inhibitors

Hu, H., Armstrong, P., Khalil, E., Chen, Y-C., Straub, A., Li, M., Soosairajah, J., Hagemeyer, C., Bassler, N., Huang, D., Ahrens, I., Krippner, G., Gardiner, E. & Peter, K., 2011, In : PLoS ONE. 6, 4, 9 p., e19190.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
34 Citations (Scopus)

MRI of inducible P-selectin expression in human activated platelets involved in the early stages of atherosclerosis

Jacobin-Valat, M-J., Deramchia, K., Mornet, S., Hagemeyer, C. E., Bonetto, S., Robert, R., Biran, M., Massot, P., Miraux, S., Clofent-Sanchez, G., Bouzier-Sore, A-K., Franconi, J-M., Duguet, E. & Sanchez, S., 2011, In : NMR in Biomedicine. 24, 4, p. 413 - 424 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2012
51 Citations (Scopus)

Bio-click chemistry: enzymatic functionalization of PEGylated capsules for targeting applications

Leung, M. K. M., Hagemeyer, C. E., Johnston, A. P. R., Gonzales, C., Kamphuis, M. MJ., Ardipradja, K., Such, G. K., Peter, K. & Caruso, F., 2012, In : Angewandte Chemie - International Edition. 51, 29, p. 7132 - 7136 5 p.

Research output: Contribution to journalArticleResearchpeer-review

96 Citations (Scopus)

Novel single-chain antibody-targeted microbubbles for molecular ultrasound imaging of thrombosis: Validation of a unique noninvasive method for rapid and sensitive detection of thrombi and monitoring of success or failure of thrombolysis in mice

Wang, X., Hagemeyer, C. E., Hohmann, J. D., Leitner, E., Armstrong, P. CJ., Jia, F., Olschewski, M., Needles, A., Peter, K. & Ahrens, I., 2012, In : Circulation. 125, 25, p. 3117 - 3126 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2013
86 Citations (Scopus)

A novel mouse model of atherosclerotic plaque instability for drug testing and mechanistic/therapeutic discoveries using gene and microRNA expression profiling

Chen, Y-C., Bui, A. V., Diesch, J., Manasseh, R., Hausding, C., Rivera, J., Haviv, I., Agrotis, A., Htun, N. M., Jowett, J. B. M., Hagemeyer, C. E., Hannan, R. D., Bobik, A. & Peter, K., 2013, In : Circulation Research. 113, 3, p. 252 - 265 14 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Delayed targeting of CD39 to activated platelet GPIIb/IIIa via a single-chain antibody: breaking the link between antithrombotic potency and bleeding?

Hohmann, J. D., Wang, X., Krajewski, S., Selan, C., Haller, C. A., Straub, A., Chaikof, E. L., Nandurkar, H. H., Hagemeyer, C. E. & Peter, K., 2013, In : Blood. 121, 16, p. 3067 - 3075 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2014
9 Citations (Scopus)

Detection of activated platelets in a mouse model of carotid artery thrombosis with {18} F-labeled single-chain antibodies

Ardipradja, K., Yeoh, S. D., Alt, K., O'Keefe, G. J., Rigopoulos, A., Howells, D. W., Scott, A. M., Peter, K., Ackermann, U. & Hagemeyer, C. E., 2014, In : Nuclear Medicine and Biology. 41, 3, p. 229 - 237 9 p.

Research output: Contribution to journalArticleResearchpeer-review

264 Citations (Scopus)

Engineering multifunctional capsules through the assembly of metal-phenolic networks

Guo, J., Ejima, H., Alt, K. M., Meissner, M. V., Richardson, J. J., Yan, Y., Peter, K., von Elverfeldt, D., Hagemeyer, C. E. & Caruso, F., 2014, In : Angewandte Chemie - International Edition. 53, 22, p. 5546 - 5551 6 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Enzyme-mediated site-specific bioconjugation of metal complexes to proteins: Sortase-mediated coupling of copper-64 to a single-chain antibody

Paterson, B. M., Alt, K. M., Jeffery, C. M., Price, R. I., Jagdale, S., Williams, C. C., Rigby, S., Peter, K., Hagemeyer, C. E. & Donnelly, P. S., 2014, In : Angewandte Chemie - International Edition. 53, 24, p. 6115-6119 5 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Single-Chain antibody conjugated to a cage amine chelator and labeled with positron-emitting copper-64 for diagnostic imaging of activated platelets

Alt, K. M., Paterson, B. M., Ardipradja, K., Schieber, C., Buncic, G., Lim, B., Poniger, S., Jakoby, B., Wang, X., O'Keefe, G. J., Tochon-Danguy, H., Scott, A. M., Ackermann, U., Peter, K., Donnelly, P. S. & Hagemeyer, C. E., 2014, In : Molecular Pharmaceutics. 11, 8, p. 2855-2863 9 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Towards effective and safe thrombolysis and thromboprophylaxis: preclinical testing of a novel antibody-targeted recombinant plasminogen activator directed against activated platelets

Wang, X., Palasubramaniam, J., Gkanatsas, Y., Hohmann, J. D., Westein, E., Kanojia, R., Alt, K., Huang, D., Jia, F., Ahrens, I., Medcalf, R. L., Peter, K. & Hagemeyer, C. E., 2014, In : Circulation Research. 114, 7, p. 1083 - 1093 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2015
24 Citations (Scopus)

A versatile approach for the site-specific modification of recombinant antibodies using a combination of enzyme-mediated bioconjugation and click chemistry

Alt, K. M., Paterson, B. M., Westein, E., Rudd, S., Poniger, S., Jagdale, S., Ardipradja, K., Connell, T. U., Krippner, G. Y., Nair, A. K. N., Wang, X., Tochon-Danguy, H., Donnelly, P. S., Peter, K. & Hagemeyer, C. E., 2015, In : Angewandte Chemie - International Edition. 54, 26, p. 7515 - 7519 5 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Boronate-Phenolic Network Capsules with Dual Response to Acidic pH and cis-Diols

Guo, J., Alt, K. M., Sun, H., Tardy, B. L., Richardson, J. J., Suma, T., Ejima, H., Cui, J., Hagemeyer, C. E. & Caruso, F., 2015, In : Advanced Healthcare Materials. 4, 12, p. 1796 - 1801 6 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)

Engineering poly(ethylene glycol) particles for improved biodistribution

Cui, J., De Rose, R., Alt, K. M., Alcantara, S., Paterson, B. M., Liang, K., Hu, M., Richardson, J. J., Yan, Y., Jeffery, C. M., Price, R. I., Peter, K., Hagemeyer, C. E., Donnelly, P. S., Kent, S. J. & Caruso, F., 2015, In : ACS Nano. 9, 2, p. 1571 - 1580 10 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Ferric chloride-induced thrombosis mouse model on carotid artery and mesentery vessel

Bonnard, T. M. E. & Hagemeyer, C. E., 2015, In : Journal of Visualized Experiments. 2015, 100, p. 1 - 6 6 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

High affinity binders to EphA2 isolated from Abdurin Scaffold libraries; Characterization, binding and tumor targeting

Ullman, C., Mathonet, P., Oleksy, A., Diamamdakis, A., Tomei, L., Demartis, A., Nardi, M. C., Sambucini, S., Missineo, A., Alt, K. M., Hagemeyer, C. E., Harris, M., Hedt, A., Weis, R. & Gehlsen, K. R., 2015, In : PLoS ONE. 10, 8, 25 p., e0135278.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
25 Citations (Scopus)

HMGB1 binds to activated platelets via the receptor for advanced glycation end products and is present in platelet rich human coronary artery thrombi

Ahrens, I., Chen, Y-C., Topcic, D., Bode, M., Haenel, D., Hagemeyer, C. E., Seeba, H., Duerschmied, D., Bassler, N., Jandeleit-Dahm, K., Sweet, M. J., Agrotis, A., Bobik, A. & Peter, K., 2015, In : Thrombosis and Haemostasis. 114, 5, p. 994 - 1003 10 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Immuno-magnetoliposomes targeting activated platelets as a potentially human-compatible MRI contrast agent for targeting atherothrombosis

Meier, S., Pütz, G., Massing, U., Hagemeyer, C. E., von Elverfeldt, D., Meissner, M., Ardipradja, K., Barnert, S., Peter, K., Bode, C., Schubert, R. & Von Zur Muhlen, C., 2015, In : Biomaterials. 53, 1, p. 137 - 148 12 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Multifunctional Thrombin-Activatable Polymer Capsules for Specific Targeting to Activated Platelets

Gunawan, S. T., Kempe, K., Bonnard, T. M. E., Cui, J., Alt, K. M., Law, L. S., Wang, X., Westein, E., Such, G. K., Peter, K., Hagemeyer, C. E. & Caruso, F., 2015, In : Advanced Materials. 27, 35, p. 5153-5157 5 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Nanoporous metal-phenolic particles as ultrasound imaging probes for hydrogen peroxide

Guo, J., Wang, X., Henstridge, D. C., Richardson, J. J., Cui, J., Sharma, A., Febbraio, M. A., Peter, K., De Haan-Klein, J. B., Hagemeyer, C. E. & Caruso, F., 2015, In : Advanced Healthcare Materials. 4, 14, p. 2170 - 2175 6 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Particle generation, functionalization and sortase A-mediated modification with targeting of single-chain antibodies for diagnostic and therapeutic use

Hagemeyer, C. E., Alt, K. M., Johnston, A., Such, G. K., Ta, H. T., Leung, M. K. M., Prabhu, S., Wang, X., Caruso, F. & Peter, K., 2015, In : Nature Protocols. 10, 1, p. 90 - 105 16 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Targeted antithrombotic protein micelles

Kim, W., Haller, C. A., Dai, E., Wang, X., Hagemeyer, C. E., Liu, D. R., Peter, K. & Chaikof, E. L., 2015, In : Angewandte Chemie - International Edition. 54, 5, p. 1461 - 1465 5 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Versatile loading of diverse cargo into functional polymer capsules

Richardson, J. J., Maina, J. W., Ejima, H., Hu, M., Guo, J., Choy, M. Y., Gunawan, S. T., Lybaert, L., Hagemeyer, C. E., De Geest, B. G. & Caruso, F., Feb 2015, In : Advanced Science. 2, 1-2, 7 p., 1400007.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2016
16 Citations (Scopus)

Highly sensitive detection of minimal cardiac ischemia using positron emission tomography imaging of activated platelets

Ziegler, M., Alt, K., Paterson, B. M., Kanellakis, P., Bobik, A., Donnelly, P. S., Hagemeyer, C. E. & Peter, K., 2 Dec 2016, In : Scientific Reports. 6, p. 1-10 10 p., 38161.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
8 Citations (Scopus)

Molecular imaging of activated platelets allows the detection of pulmonary embolism with magnetic resonance imaging

Heidt, T., Ehrismann, S., Hovener, J. B., Neudorfer, I., Hilgendorf, I., Reisert, M., Hagemeyer, C. E., Zirlik, A., Reinohl, J. O., Bode, C., Peter, K., von Elverfeldt, D. & Von Zur Muhlen, C., 2016, In : Scientific Reports. 6, 9 p., 25044.

Research output: Contribution to journalArticleResearchpeer-review

Open Access