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Research Output 1986 2019

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2019

AKT signaling promotes DNA damage accumulation and proliferation in polycystic kidney disease

Conduit, S. E., Davies, E. M., Ooms, L. M., Gurung, R., Mcgrath, M. J., Hakim, S., Cottle, D. L., Smyth, I. M., Dyson, J. M. & Mitchell, C. A., 18 Oct 2019, (Accepted/In press) In : Human Molecular Genetics.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation

Ma, X., Zhang, L., Song, J., Nguyen, E., Lee, R. S., Rodgers, S. J., Li, F., Huang, C., Schittenhelm, R. B., Chan, H., Chheang, C., Wu, J., Brown, K. K., Mitchell, C. A., Simpson, K. J. & Daly, R. J., 17 Jan 2019, In : Nature Communications. 10, 1, 16 p., 296.

Research output: Contribution to journalArticleResearchpeer-review

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1 Citation (Scopus)

Effective angiogenesis requires regulation of phosphoinositide signaling

Davies, E. M., Gurung, R., Le, K. Q. & Mitchell, C. A., Jan 2019, In : Advances in Biological Regulation. 71, p. 69-78 10 p.

Research output: Contribution to journalArticleResearchpeer-review

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1 Citation (Scopus)
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The myotubularin MTMR4 regulates phagosomal phosphatidylinositol 3-phosphate turnover and phagocytosis

Sheffield, D. A., Jepsen, M. R., Feeney, S. J., Bertucci, M. C., Sriratana, A., Naughtin, M. J., Dyson, J. M., Coppel, R. L. & Mitchell, C. A., 8 Nov 2019, In : Journal of Biological Chemistry. 294, 45, p. 16684-16697 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

β-catenin ablation exacerbates polycystic kidney disease progression

Conduit, S. E., Hakim, S., Feeney, S. J., Ooms, L. M., Dyson, J. M., Abud, H. E. & Mitchell, C. A., 15 Jan 2019, In : Human Molecular Genetics. 28, 2, p. 230-244 15 p.

Research output: Contribution to journalArticleResearchpeer-review

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2017
15 Citations (Scopus)

A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma

Conduit, SE., Ramaswamy, V., Remke, M., Watkins, DN., Wainwright, BJ., Taylor, MD., Mitchell, CA. & Dyson, JM., 26 Oct 2017, In : Oncogene. 36, 43, p. 5969-5984 16 p.

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26 Citations (Scopus)

INPP5E regulates phosphoinositide-dependent cilia transition zone function

Dyson, J. M., Conduit, S. E., Feeney, S. J., Hakim, S., DiTommaso, T., Fulcher, A. J., Sriratana, A., Ramm, G., Horan, K. A., Gurung, R., Wicking, C., Smyth, I. & Mitchell, C. A., 2 Jan 2017, In : Journal of Cell Biology. 216, 1, p. 247-263 17 p.

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24 Citations (Scopus)

Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing

Carroll, B., Nelson, G., Rabanal-Ruiz, Y., Kucheryavenko, O., Dunhill-Turner, N. A., Chesterman, C. C., Zahari, Q., Zhang, T-T., Conduit, S. E., Mitchell, C. A., Maddocks, O. D. K., Lovat, P., Von Zglinicki, T. & Korolchuk, V. I., 31 May 2017, In : Journal of Cell Biology. 216, 7, p. 1949-1957 9 p.

Research output: Contribution to journalArticleResearchpeer-review

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2016
15 Citations (Scopus)

Inpp5e suppresses polycystic kidney disease via inhibition of PI3K/Akt-dependent mTORC1 signaling

Hakim, S., Dyson, J. M., Feeney, S. J., Davies, E. M., Sriratana, A., Koenig, M. N., Plotnikova, O., Smyth, I. M., Ricardo, S. D., Hobbs, R. M. & Mitchell, C. A., 2016, In : Human Molecular Genetics. 25, 11, p. 2295-2313 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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8 Citations (Scopus)

PtdIns(3,4,5)P3 -dependent rac exchanger 1 (PREX1) rac-guanine nucleotide exchange factor (GEF) activity promotes breast cancer cell proliferation and tumor growth via activation of extracellular signal-regulated kinase 1/2 (ERK1/2) signaling

Liu, H-J., Ooms, L. M., Srijakotre, N., Man, J., Vieusseux, J., Waters, J. E., Feng, Y., Bailey, C. G., Rasko, J. E. J., Price, J. T. & Mitchell, C. A., 12 Aug 2016, In : Journal of Biological Chemistry. 291, 33, p. 17258-17270 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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20 Citations (Scopus)

Regulation of PtdIns(3,4,5)P3/Akt signalling by inositol polyphosphate 5-phosphatases

Eramo, M. J. & Mitchell, C. A., 9 Feb 2016, In : Biochemical Society Transactions. 44, 1, p. 240-252 13 p.

Research output: Contribution to journalArticleResearchpeer-review

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2015
14 Citations (Scopus)

Differential SKIP expression in PTEN-deficient glioblastoma regulates cellular proliferation and migration

Davies, E. M., Kong, A. M., Tan, A. Y. L., Gurung, R., Sriratana, A., Bukczynska, P. E., Ooms, L. M., McLean, C. A., Tiganis, T. & Mitchell, C. A., 2015, In : Oncogene. 34, 28, p. 3711-3727 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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5 Citations (Scopus)

FHL1 reduces dystrophy in transgenic mice overexpressing FSHD muscular dystrophy region gene 1 (FRG1)

Feeney, S. J., Mcgrath, M. J., Sriratana, A., Gehrig, S. M., Lynch, G. S., D'Arcy, C. E., Price, J. T., McLean, C. A., Tupler, R. & Mitchell, C. A., 19 Feb 2015, In : PLoS ONE. 10, 2, 29 p., e0117665.

Research output: Contribution to journalArticleResearchpeer-review

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13 Citations (Scopus)

Heterozygous expression of the oncogenic Pik3ca (H1047R) mutation during murine development results in fatal embryonic and extraembryonic defects

Hare, L. M., Schwarz, Q. P., Wiszniak, S., Gurung, R., Montgomery, K. G., Mitchell, C. A. & Phillips, W. A., 1 Aug 2015, In : Developmental Biology. 404, 1, p. 14-26 13 p.

Research output: Contribution to journalArticleResearchpeer-review

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26 Citations (Scopus)

Inositol polyphosphate 4-phosphatase II (INPP4B) is associated with chemoresistance and poor outcome in AML

Rijal, S., Fleming, S., Cummings, N., Rynkiewicz, N., Ooms, L. M., Nguyen, N-Y. N., Teh, T-C., Avery, S., McManus, J., Papenfuss, A. T., McLean, C. A., Guthridge, M. A., Mitchell, C. A. & Wei, A., 30 Apr 2015, In : Blood. 125, 18, p. 2815-2824 10 p.

Research output: Contribution to journalArticleResearchpeer-review

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12 Citations (Scopus)

INPP4B is highly expressed in prostate intermediate cells and its loss of expression in prostate carcinoma predicts for recurrence and poor long term survival

Rynkiewicz, N. K., Fedele, C. G., Chiam, K. H., Gupta, R., Kench, J. G., Ooms, L. M., McLean, C. A., Giles, G. G., Horvath, L. G. & Mitchell, C. A., 2015, In : Prostate. 75, 1, p. 92-102 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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33 Citations (Scopus)

INPP5E interacts with AURKA, linking phosphoinositide signaling to primary cilium stability

Plotnikova, O., Seo, S., Cottle, D. L., Conduit, S. E., Hakim, S., Dyson, J. M., Mitchell, C. A. & Smyth, I. M., 2015, In : Journal of Cell Science. 128, 2, p. 364-372 9 p.

Research output: Contribution to journalArticleResearchpeer-review

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14 Citations (Scopus)

Prognostic value of INPP4B protein immunohistochemistry in ovarian cancer

Salmena, L., Shaw, P. A., Fan, I., McLaughlin, J. R., Rosen, B., Risch, H. A., Mitchell, C. A., Sun, P., Narod, S. A. & Kotsopoulos, J., 2015, In : European Journal of Gynaecological Oncology. 36, 3, p. 260 - 267 8 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

The inositol polyphosphate 5-Phosphatase PIPP regulates AKT1-Dependent breast cancer growth and metastasis

Ooms, L. M., Binge, L. C., Davies, E. M., Rahman, P., Conway, J. R. W., Gurung, R., Ferguson, D. T., Papa, A., Fedele, C. G., Vieusseux, J. L., Chai, R. C. C., Koentgen, F., Price, J. T., Tiganis, T., Timpson, P., McLean, C. A. & Mitchell, C. A., 10 Aug 2015, In : Cancer Cell. 28, 2, p. 155-169 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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29 Citations (Scopus)
Open Access
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2014
6 Citations (Scopus)

199th ENMC international workshop: FHL1 related myopathies, June 7-9, 2013, Naarden, The Netherlands

Bertrand, A. T., Bonnemann, C. G., Bonne, G., Mitchell, C. A. & Mcgrath, M. J., 2014, In : Neuromuscular Disorders. 24, 5, p. 453 - 462 10 p.

Research output: Contribution to journalArticleOther

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Assessing the subcellular distribution of oncogenic phosphoinositide 3-kinase using microinjection into live cells

Layton, M. J., Rynkiewicz, N. K., Ivetac, I., Horan, K. A., Mitchell, C. A. & Phillips, W. A., 2014, In : Bioscience Reports. 34, 2 (Art. ID: e00104), p. 165 - 180 16 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

FHL1 mutants that cause clinically distinct human myopathies form protein aggregates and impair myoblast differentiation

Wilding, B. R., Mcgrath, M. J., Bonne, G. & Mitchell, C. A., 2014, In : Journal of Cell Science. 127, 10, p. 2269 - 2281 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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8 Citations (Scopus)

Identification of FHL1 as a therapeutic target for Duchenne muscular dystrophy

D'Arcy, C. E., Feeney, S. J., McLean, C. A., Gehrig, S. M., Lynch, G. S., Smith, J. E., Cowling, B. S., Mitchell, C. A. & Mcgrath, M. J., 2014, In : Human Molecular Genetics. 23, 3, p. 618 - 636 19 p.

Research output: Contribution to journalArticleResearchpeer-review

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2013
33 Citations (Scopus)

Phosphoinositide 3-kinase and INPP4B in human breast cancer

Bertucci, M. C. & Mitchell, C. A., 2013, In : Annals of the New York Academy of Sciences. 1280, 1, p. 1 - 5 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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38 Citations (Scopus)

Regulation of the transcriptional coactivator FHL2 licenses activation of the androgen receptor in castrate-resistant prostate cancer

Mcgrath, M. J., Binge, L. C., Sriratana, A., Wang, H., Robinson, P. A., Pook, D. W., Fedele, C. G., Brown, S., Dyson, J. M., Cottle, D. L., Cowling, B. S., Niranjan, B., Risbridger, G. P. & Mitchell, C. A., 2013, In : Cancer Research. 73, 16, p. 5066 - 5079 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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51 Citations (Scopus)

TCPTP regulates SFK and STAT3 signaling and is lost in triple-negative breast cancers

Shields, B., Wiede, F., Gurzov, E., Wee, K. T. B., Hauser, C., Zhu, H-J., Molloy, T. J., O'Toole, S. A., Daly, R. J., Sutherland, R. L., Mitchell, C. A., McLean, C. A. & Tiganis, T., 2013, In : Molecular and Cellular Biology. 33, 3, p. 557 - 570 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2012
7 Citations (Scopus)

Autophosphorylation of serine 608 in the p85 regulatory subunit of wild type or cancer-associated mutants of phosphoinositide 3-kinase does not affect its lipid kinase activity

Layton, M. J., Saad, M., Church, N., Pearson, R. B., Mitchell, C. A. & Phillips, W. A., 2012, In : BMC Biochemistry. 13, 1, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
77 Citations (Scopus)

Evidence for FHL1 as a novel disease gene for isolated hypertrophic cardiomyopathy

Friedrich, F. W., Wilding, B. R., Reischmann, S., Crocini, C., Lang, P., Charron, P., Muller, O. J., Mcgrath, M. J., Vollert, I., Hansen, A., Linke, W. A., Hengstenberg, C., Bonne, G., Morner, S., Wichter, T., Madeira, H., Arbustini, E., Eschenhagen, T., Mitchell, C. A., Isnard, R. & 1 others, Carrier, L., 2012, In : Human Molecular Genetics. 21, 14, p. 3237 - 3254 18 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Inositol polyphosphate 5-phosphatases; new players in the regulation of cilia and ciliopathies

Conduit, S. E., Dyson, J. M. & Mitchell, C. A., 2012, In : FEBS Letters. 586, 18, p. 2846 - 2857 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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13 Citations (Scopus)

INPP4A/INPP4B and P-Rex proteins: Related but different?

Rynkiewicz, N., Liu, T., Balamatsias, D. & Mitchell, C. A., 2012, In : Advances in Enzyme Regulation. 52, 1, p. 265 - 279 15 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Scube activity is necessary for Hedgehog signal transduction in vivo

Johnson, J-L. FA., Hall, T. E., Dyson, J. M., Sonntag, C., Ayers, K. L., Berger, S., Gautier, P., Mitchell, C. A., Hollway, G. E. & Currie, P. D., 2012, In : Developmental Biology. 368, 2, p. 193 - 202 10 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

The in vitro preconditioning of myoblasts to enhance subsequent survival in an in vivo tissue engineering chamber model

Tilkorn, D. J., Davies, E., Keramidaris, E., Dingle, A. M., Gerrand, Y-W., Taylor, C. J., Han, X. L., Palmer, J. A., Penington, A. J., Mitchell, C. A., Morrison, W. A., Dusting, G. J. & Mitchell, G. M., 2012, In : Biomaterials. 33, 15, p. 3868 - 3879 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2011
24 Citations (Scopus)

A mutation in synaptojanin 2 causes progressive hearing loss in the ENU-mutagenised mouse strain Mozart

Manji, S. S. M., Williams, L. L., Miller, K. A., Ooms, L. M., Bahlo, M., Mitchell, C. A. & Dahl, H-H. M., 2011, In : PLoS ONE. 6, 3, 11 p., e17607.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
14 Citations (Scopus)

An ENU-induced mouse mutant of SHIP1 reveals a critical role of the stem cell isoform for suppression of macrophage activation

Nguyen, N-Y. N., Maxwell, M. J., Ooms, L., Davies, E. M., Hilton, A. A., Collinge, J. E., Hilton, D. J., Kile, B. T., Mitchell, C. A., Hibbs, M. L., Jane, S. M. & Curtis, D. J., 2011, In : Blood. 117, 20, p. 5362-5371 10 p., 20.

Research output: Contribution to journalArticleResearchpeer-review

61 Citations (Scopus)

Four and a half LIM protein 1 gene mutations cause four distinct human myopathies: A comprehensive review of the clinical, histological and pathological features

Cowling, B., Cottle, D. L., Wilding, B., D'Arcy, C. E., Mitchell, C. A. & Mcgrath, M. J., 2011, In : Neuromuscular Disorders. 21, 4, p. 237 - 251 15 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Hypertrophy and dietary tyrosine ameliorate the phenotypes of a mouse model of severe nemaline myopathy

Nguyen, M-A. T., Joya, J., Kee, A. J., Domazetovska, A., Yang, N., Hook, J. W., Lemckert, F. A., Kettle, E., Valova, V. A., Robinson, P. J., North, K., Gunning, P. W., Mitchell, C. A. & Hardeman, E. C., 2011, In : Brain. 134, 12, p. 3516 - 3529 14 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Identification of a proline-rich inositol polyphosphate 5-phosphatase (PIPP) collapsin response mediator protein 2 (CRMP2) complex that regulates neurite elongation

Astle, M., Ooms, L., Cole, A., Binge, L., Dyson, J., Layton, M., Petratos, S., Sutherland, C. & Mitchell, C. A., 2011, In : Journal of Biological Chemistry. 286, 26, p. 23407 - 23418 12 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Identification of P-Rex1 as a novel Rac1-guanine nucleotide exchange factor (GEF) that promotes actin remodeling and GLUT4 protein trafficking in adipocytes

Balamatsias, D., Kong, A., Waters, J. E., Sriratana, A., Gurung, R., Bailey, C. G., Rasko, J. E. J., Tiganis, T., Macaulay, S. L. & Mitchell, C. A., 2011, In : Journal of Biological Chemistry. 286, 50, p. 43229 - 43240 12 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton

Rahman, P., Huysmans, R., Wiradjaja, F., Gurung, R., Ooms, L., Sheffield, D., Dyson, J., Layton, M., Sriratana, A., Takada, H., Tiganis, T. & Mitchell, C. A., 2011, In : Journal of Biological Chemistry. 286, 34, p. 29758 - 29770 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2010
169 Citations (Scopus)

Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers

Fedele, C. G., Ooms, L. M., Ho, M., Vieusseux, J. L., O'Toole, S. A., Millar, E. K., Lopez-Knowles, E., Sriratana, A., Gurung, R., Baglietto, L., Giles, G., Bailey, C. G., Rasko, J. EJ., Shields, B. J., Price, J. T., Majerus, P. W., Sutherland, R. L., Tiganis, T., McLean, C. A. & Mitchell, C. A., 2010, In : Proceedings of the National Academy of Sciences. 107, 51, p. 22231 - 22236 6 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

The myotubularin phosphatase MTMR4 regulates sorting from early endosomes

Naughtin, M. J., Sheffield, D. A., Rahman, P., Hughes, W. E., Gurung, R., Stow, J., Nandurkar, H., Dyson, J. M. & Mitchell, C. A., 2010, In : Journal of Cell Science. 123, Pt 18, p. 3071 - 3083 13 p.

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)

The PtdIns(3,4)P 2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death

Sasaki, J., Kofuji, S., Itoh, R., Momiyama, T., Takayama, K., Murakami, H., Chida, S., Tsuya, Y., Takasuga, S., Eguchi, S., Asanuma, K., Horie, Y., Miura, K., Davies, E. M., Mitchell, C. A., Yamazaki, M., Hirai, H., Takenawa, T., Suzuki, A. & Sasaki, T., 2010, In : Nature. 465, 7297, p. 497 - 501 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2009
67 Citations (Scopus)

Clinical, histological and genetic characterization of reducing body myopathy caused by mutations in FHL1

Schessl, J., Taratuto, A. L., Sewry, C., Battini, R., Chin, S. S., Maiti, B., Dubrovsky, A. L., Erro, M. G., Espada, G., Robertella, M., Saccoliti, M., Olmos, P., Bridges, L. R., Standring, P., Hu, Y., Zou, Y., Swoboda, K. J., Scavina, M., Goebel, H-H., Mitchell, C. A. & 3 others, Flanigan, K. M., Muntoni, F. & Bonnemann, C. G., 2009, In : Brain. 132, 2, p. 452 - 464 13 p.

Research output: Contribution to journalArticleResearchpeer-review

362 Citations (Scopus)

Reactive oxygen species enhance insulin sensitivity

Loh, K. Y., Deng, H., Fukushima, A., Cai, X., Boivin, B., Galic, S., Bruce, C., Shields, B. J., Skiba, B., Ooms, L. M., Stepto, N. K., Wu, B. J., Mitchell, C. A., Tonks, N. K., Watt, M. J., Febbraio, M. A., Crack, P. J., Andrikopoulos, S. & Tiganis, T., 2009, In : Cell Metabolism. 10, 4, p. 260 - 272 13 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)

Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1

Ivetac, I., Gurung, R., Hakim, S., Horan, K. A., Sheffield, D. A., Binge, L. C., Majerus, P. W., Tiganis, T. & Mitchell, C. A., 2009, In : EMBO Reports. 10, 5, p. 487 - 493 7 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Requirement of phosphatidylinositol(3,4,5)trisphosphate in phosphatidylinositol 3-kinase-induced oncogenic transformation

Denley, A., Gymnopoulos, M., Kang, S., Mitchell, C. A. & Vogt, P. K., 2009, In : Molecular Cancer Research. 7, 7, p. 1132 - 1138 7 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

SLIMMER (FHL1B/KyoT3) interacts with the proapoptotic protein Siva-1 (CD27BP) and delays skeletal myoblast apoptosis

Cottle, D. L., Mcgrath, M. J., Wilding, B. R., Cowling, B. S., Kane, J. M., D'Arcy, C. E., Holdsworth, M., Hatzinisiriou, I., Prescott, M., Brown, S. & Mitchell, C. A., 2009, In : Journal of Biological Chemistry. 284, 39, p. 26964 - 26977 14 p.

Research output: Contribution to journalArticleResearchpeer-review

158 Citations (Scopus)

The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease

Ooms, L. M., Horan, K. A., Rahman, P., Seaton, G., Gurung, R., Kethesparan, D. S. & Mitchell, C. A., 2009, In : Biochemical Journal. 419, 1, p. 29 - 49 21 p.

Research output: Contribution to journalArticleResearchpeer-review