Projects per year
Personal profile
Biography
Professor Christina Mitchell AO is the Executive Dean of the Faculty of Medicine, Nursing and Health Sciences. She graduated with a degree in Medicine from Melbourne University and undertook general physician and haematology training fellowships. She obtained a PhD from Monash University on the anticoagulant activity of protein S.
Professor Mitchell practiced as a general physician from 1990 to 2000 and as a specialist haematologist from 1990 to 2011 in the Department of Haematology at Box Hill Hospital. In 2000, she was appointed as Head of the Department of Biochemistry and Molecular Biology in the School of Biomedical Sciences at Monash University, a role she held until she was promoted to Head of the School of Biomedical Sciences in 2006. In 2011, she was appointed as Executive Dean of the Faculty of Medicine, Nursing and Health Sciences. During her tenure, she has overseen unprecedented growth in research and education activity, revenue and impact. She has a long-standing commitment to the development and integration of the medical curriculum at Monash University.
Professor Mitchell’s research focuses on the characterisation of the metabolic pathways that regulate phosphoinositide signalling in human cancer. She leads one of the top phosphoinositide research groups world-wide, and is the top researcher in her field in Australia. She was instrumental in pioneering a field that impacts all aspects of a cell’s life, an area that has expanded to >185,000 papers. Professor Mitchell has published 175 papers to date, including in prestigious journals such as Nature, Nature Communications, New England Journal of Medicine and PNAS. She has been awarded over $30 million as Lead CI from funding bodies such as NHMRC, ARC, National Breast Cancer Foundation, and mRNA Victoria. In 2023, she was awarded an NHMRC L3 Investigator Grant.
Professor Mitchell has received numerous accolades, including the Sir John Monash Distinguished Professorship at Monash University in 2010. In 2014, she was named a Fellow of the Australian Academy of Health and Medical Sciences. In 2015, she was inducted to the Victorian Honour Roll of Women and received the Lemberg Medal for Excellence in Biochemistry from the Australian Society of Biochemistry and Molecular Biology. She was bestowed with the Order of Australia (AO) in 2019 for her services to health and medical research and education.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Cancer
- Cancer Biology
- Gene Knockout
- Muscular Dystrophy
- Phosphoinositide Signalling
- Signal Transduction
Collaborations and top research areas from the last five years
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Cilia biology: an emerging frontier.
Mitchell, C. (Primary Chief Investigator (PCI)), Smyth, I. (Chief Investigator (CI)) & Davies, M. (Chief Investigator (CI))
1/03/25 → 29/02/28
Project: Research
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Cellular recycling, a route to productivity in ageing.
Mitchell, C. (Primary Chief Investigator (PCI)) & Mcgrath, M. (Chief Investigator (CI))
ARC - Australian Research Council, Monash University – Internal Department Contribution
1/01/25 → 31/12/28
Project: Research
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Phosphoinositide signalling in disease
Mitchell, C. (Primary Chief Investigator (PCI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/23 → 31/12/27
Project: Research
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A national functional diagnostic program for therapy development in congenital muscle disease
Currie, P. (Primary Chief Investigator (PCI)), McLean, C. (Chief Investigator (CI)), Mitchell, C. (Chief Investigator (CI)), Lynch, G. (Chief Investigator (CI)), Houweling, P. J. (Chief Investigator (CI)), Mcgrath, M. (Chief Investigator (CI)), Ruparelia, A. (Chief Investigator (CI)), Fahey, M. (Chief Investigator (CI)), Yiu, E. M. (Chief Investigator (CI)), Cairns, A. (Chief Investigator (CI)), Forbes, R. (Chief Investigator (CI)), Farrar, M. (Chief Investigator (CI)), Porrello, E. R. (Chief Investigator (CI)) & Gregorevic, P. (Chief Investigator (CI))
1/07/22 → 30/06/27
Project: Research
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The Meydan Family Foundation Diabetes Complications Research Hub
Cooper, M. (Primary Chief Investigator (PCI)), Jane, S. (Chief Investigator (CI)) & Mitchell, C. (Chief Investigator (CI))
31/12/16 → 31/12/25
Project: Research
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Deletion of Aurora kinase A prevents the development of polycystic kidney disease in mice
Tham, M. S. (Leading Author), Cottle, D. L. (Leading Author), Zylberberg, A. K. (Leading Author), Short, K. M., Jones, L. K., Chan, P., Conduit, S. E., Dyson, J. M., Mitchell, C. A. & Smyth, I. M. (Leading Author), 2024, In: Nature Communications. 15, 1, 18 p., 371.Research output: Contribution to journal › Article › Research › peer-review
Open Access11 Citations (Scopus) -
Autophagic lysosome reformation in health and disease
Nanayakkara, R., Gurung, R., Rodgers, S. J., Eramo, M. J., Ramm, G., Mitchell, C. A. & McGrath, M. J., 4 May 2023, In: Autophagy. 19, 5, p. 1378-1395 18 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access71 Citations (Scopus) -
Deterministic early endosomal maturations emerge from a stochastic trigger-and-convert mechanism
York, H. M., Joshi, K., Wright, C. S., Kreplin, L. Z., Rodgers, S. J., Moorthi, U. K., Gandhi, H., Patil, A., Mitchell, C. A., Iyer-Biswas, S. & Arumugam, S., 2 Aug 2023, In: Nature Communications. 14, 1, 15 p., 4652.Research output: Contribution to journal › Article › Research › peer-review
Open Access13 Citations (Scopus) -
Functional and Phenotypic Characterisations of Common Syngeneic Tumour Cell Lines as Estrogen Receptor-Positive Breast Cancer Models
Lambouras, M., Roelofs, C., Pereira, M., Gruber, E., Vieusseux, J. L., Lanteri, P., Johnstone, C. N., Muntz, F., O’Toole, S., Ooms, L. M., Mitchell, C. A., Anderson, R. L. & Britt, K. L., Mar 2023, In: International Journal of Molecular Sciences. 24, 6, 12 p., 5666.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
Sequential conversion of PtdIns3P to PtdIns(3,5)P2 via endosome maturation couples nutrient signaling to lysosome reformation and basal autophagy
Rodgers, S. J., Jones, E. I., Mitchell, C. A. & McGrath, M. J., 3 Apr 2023, In: Autophagy. 19, 4, p. 1365-1367 3 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus)
Prizes
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Buschell Travelling Fellowship
Mitchell, C. (Recipient), 1988
Prize: Prize (including medals and awards)
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Carl de Gruchy Medal, St. Vincent's Hospital
Mitchell, C. (Recipient), 2015
Prize: Prize (including medals and awards)
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Dean's Prize for Excellence in Research in the Medical Faculty
Mitchell, C. (Recipient), 2003
Prize: National/international honour
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Fellow of the Australian Academy of Health and Medical Sciences
Mitchell, C. (Recipient), 2014
Prize: Election to learned society
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Activities
- 2 Submissions to industry or govt committees, commissions and inquiries
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Scientific Advisory Board
Mitchell, C. (Member)
1 Jan 2011Activity: External Academic Engagement › Submissions to industry or govt committees, commissions and inquiries
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Organising Committee
Mitchell, C. (Member)
1 Jan 2010Activity: External Academic Engagement › Submissions to industry or govt committees, commissions and inquiries