Christina Gertrude Yap

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Christina Gertrude Yap

Dr

 https://orcid.org/0000-0001-9070-755X

Accepting PhD Students

PhD projects

Investigation of the molecular mechanisms responsible for the ameliorative effects of tocotrienol-rich vitamin E (Tocovid) on HFD and streptozotozin induced diabetic nephropathy.
Contact person: Dr Christina GY - christina.yap@monash.edu

1996 …2022

Research activity per year

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Personal profile

Biography

Dr. Christina GY has obtained her PhD from Monash University in 2012. In her PhD research project she explored candidate early predictors for diabetic nephropathy. Her hypothetical candidate early predictor for diabetic nephropathy risk is CYP2E1. In her post-doctoral projects she developed a targeted proteomic approach to quantitate CYP2E1 from human blood samples and assessed the applicability of this analytical method in clinical practice.

Her research interests are early biomolecules in the development of metabolic syndromes, drug metabolizing enzymes and obesity.

Dr. Christina's research expertise skills are HPLC, LCMS-MS, Genomics (Microarray analysis using Genespring and Partek softwares), Proteomics, Metabolomics, Bioinformatics and animal experimental models and cell culture models.

Currently she is a Senior Lecturer (Metabolic Medicine) at the School of Medicine, Monash University Malaysia in Kuala Lumpur Malaysia. She teaches Problem Based Learning (PBL), Histology, Physiology and Pharmacology into the MD and Bachelor of Pharmacy courses.

 

Research interests

  • Pharmacokinetics and xenobiotic interaction with drug metabolizing enzymes.
  • Development of early biomarkers in diabetic nephropathy.
  • Translational studies of diabetic nephropathy.
  • Teaching & Learning methods in medical education.

 

Research projects completed:    

  1. 1997-1998            Drug abuse screening among psychotic patients (from wad 5UHUM).
  2. 1997-1998            Screening for drug abuse among Immigrant workers.
  3. 1997                     I was a member of UNU (United Nations University) Project:  “Environmental Monitoring in the Asian Region”. Activity for 1997: Detection for Organotins in fish and VOC (Volatile organic compounds) in coastal waters.
  4. 1997                     Investigation of Cathinone as compliance studies in Psychotic patients.
  5. 1997                     Involved in bioavailability and bioequivalence studies of nifedipine.
  6. 2001                     Molecular cloning of p22 antigenic surface protein of Toxoplasma gondii.
  7. 2003                     Effects of Citrus grandis crude extracts on CYP2C19 and CYP3A4 activities.
  8. 2005                     Effects of “Ulams” on drug metabolizing enzymes.
  9. 2007-2013             Early Predictors of Diabetic Nephropathy. (PhD Thesis Project)
  10. 2014 – to-date       Research projects on Pre diabetes, Diabetes, Obesity and Metabolic Syndrome

 

Research Awards/Prizes won

2009    Best Mention Award

             Evaluation of CYP2E1 Gene Expression in Diabetic Nephropathy using  Quantitative Real Time PCR.

             14th Biological Science Congress,

             Chulalongkorn University, Bangkok, Thailand, 10th-12th Dec.2009.

2014    Best Presentation Award

             Targeted CYP2E1 quantification: Research to Clinical Application.

             5th World Congress on Diabetes and Metabolism, 3rd – 5th Nov 2014, Las Vegas, USA.

2017   1. First prize: Presentation Title: “The anthropometrics, cardio-metabolic health and oral microbiomes of an Indigenous tribe”.

              Monash CSJB research week 2017

          2. Second runner-up: Presentation Title: “Endogenous molecules as candidate early indicator for type 2 diabetes”

              Monash CSJB research week 2017

          3. Best Presentation Award:  Title of Presentation: “Endogenous molecules as candidate early indicator for Pre-diabetes”

              2nd World Congress on Clinical Trials in Diabetes, Berlin, Germany; 27-28th Nov 2017

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Monash teaching commitment

2011 to date

  • Physiology Lecturer: Year 1 and Year 2 MBBS/MD course.
  • Coordinator & Facilitator: PBL sessions for Year 1 and 2 MD course
  • Histology Tutor: Year 1 and Year 2 MBBS course
  • Student Project Cases (SPC) Tutor: Year 2
  • Pharmacology & Pharmacology Lecturer: Years 1, 2, 3 and 4;B. Pharmacy course
  • Facilitator: IPE session Year 2 Pharmacy and MBBS students
  • MD Year 5 - SIP Supervisions
  • HDR supervision (PhD)

1993 – 2006

  • Preparation and demonstration in practical classes for MBBS, BDS, pharmacy courses.
  • Physiology and Pharmacology lectures for BPharm students.
  • PBL Facilitator for BPharm students.

 

Leadersip duties in Education

2005      Coordinator for Cancer chemotherapy unit, School of Pharmacy, IMU, PJ

2017 - Present     Coordinator for Physiology, MBBS course, JCSMHS, MUM

2018 - Present     Coordinator for Physiology, MBBS course, JCSMHS, MUM

2018 - Present     Coordinator for Hematology, MBBS course, JCSMHS, MUM

2019 - Present     MED1100 Year 1 PBL coordinator, MD course, JCSMHS, MUM

2019 - Present     MED1100 Coordinator for Case Commentary Assignment, JCSMHS, MUM

2019 - Present     Member of Student Support Committee, JCSMHS, MUM

 

 

 

 

 

 

 

 

 

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 13 - Climate Action

Education/Academic qualification

Graduate Certificate in Higher Education, GCHE, MONASH UNIVERSITY

Award Date: 18 Apr 2015

Biomedical Sciences, PhD, MONASH UNIVERSITY

Award Date: 24 May 2012

External positions

Member, Malaysian Scientific Association

Member, Malaysian Society of Pharmacology & Physiology

Research area keywords

  • Diabetic Nephropathy
  • Obesity
  • Diagnostic test
  • Metabolic disorders
  • Medical education

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