Projects per year
Personal profile
Biography
Christina is an Infectious Diseases physician-scientist and is internationally recognised for her clinical and research expertise in cryptococcal meningitis (CM) and cryptococcosis-associated immune reconstitution inflammatory syndrome (C-IRIS). She completed her medical degree and infectious diseases and general medicine physician training in Melbourne, and has extensive international clinical trial experience, particularly in resource-limited settings. As part of her PhD on C-IRIS immunopathogenesis, she established a cohort of 130 HIV-CM co-infected persons in Durban, South Africa. She held an Australian NHMRC Early career fellowship on HIV prevention and cure (2015-2020). She worked with the INSIGHT clinical trial network on US-NIH funded multi-arm, multi-stage platform studies on investigational new agents for the treatment of COVID-19 (2020-2022). She is an infectious diseases physician at The Alfred Hospital, Melbourne (2009-current) and principal investigator of early phase and first-in-human studies at Nucleus Network, Melbourne (2023-current).
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Principal Investigator, Nucleus Network Pty Limited
3 Apr 2023 → …
Senior Research Fellow for Clinical Trials and Cohorts, University of New South Wales (UNSW)
Mar 2020 → 31 Dec 2021
Honorary research associate, Centre for the AIDS Programme of Research in South Africa
2018 → …
Honorary Lecturer, University of KwaZulu-Natal
Apr 2012 → Apr 2015
Infectious Diseases Physician, Alfred Hospital
2011 → …
Research area keywords
- Cryptococcosis
- Immune reconstitution inflammatory Syndrome
- HIV/AIDS
- Fungal infections
- Opportunistic infections
- Cryptococcal meningitis
- Infection and immunity
- infections in immunocompromised hosts
- Infectious Disease
- COVID-19
- SARS-CoV-2
Collaborations and top research areas from the last five years
Projects
- 3 Finished
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Immunopathogenesis of cryptococcal meningitis and paradoxical cryptococcal meningitis immune restoration disease in persons living with HIV: Comparisons of immune responses in the central nervous syst
Chang, C., French, M. A. H. & Lewin, S.
Pfizer (Australia) (trading as Pfizer Australia Pty Limited)
1/06/11 → 31/05/12
Project: Research
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Cryptococcal Meningitis Immune Restoration Disease
Kidd, S., Chang, C. & Lewin, S.
Trustee for Equity Trustees Charitable Foundation
1/11/09 → 31/10/10
Project: Research
Research output
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A Confusing Collapse: Case of an Intracranial Mass Mimicker in a Cardiac Transplant Recipient
Lai, V. W. Y., Griffin, D., Lau, J., McLean, C., Chang, C., Bigwood, S., Hare, J. & Morrissey, O., 15 Feb 2024, In: Clinical Infectious Diseases. 78, 2, p. 484-487 4 p.Research output: Contribution to journal › Article › Other › peer-review
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Does PET-CT Have a Role in the Evaluation of Tuberculosis Treatment in Phase 2 Clinical Trials
Cross, G. B., O’ Doherty, J., Chang, C. C., Kelleher, A. D. & Paton, N. I., 15 Apr 2024, In: The Journal of Infectious Diseases. 229, 4, p. 1229-1238 10 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access2 Citations (Scopus) -
Early trajectories of virological and immunological biomarkers and clinical outcomes in patients admitted to hospital for COVID-19: an international, prospective cohort study
Jensen, T. O., Murray, T. A., Grandits, G. A., Jain, M. K., Grund, B., Shaw-Saliba, K., Matthay, M. A., Abassi, M., Ardelt, M., Baker, J. V., Chen, P., Dewar, R. L., Goodman, A. L., Hatlen, T. J., Highbarger, H. C., Holodniy, M., Lallemand, P., Laverdure, S., Leshnower, B. G., Looney, D., & 14 others , Jun 2024, In: The Lancet Microbe. 5, 6, p. e559-e569 11 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Global guideline for the diagnosis and management of cryptococcosis: an initiative of the ECMM and ISHAM in cooperation with the ASM
Chang, C. C., Harrison, T. S., Bicanic, T. A., Chayakulkeeree, M., Sorrell, T. C., Warris, A., Hagen, F., Spec, A., Oladele, R., Govender, N. P., Chen, S. C., Mody, C. H., Groll, A. H., Chen, Y. C., Lionakis, M. S., Alanio, A., Castañeda, E., Lizarazo, J., Vidal, J. E., Takazono, T., & 33 others , Aug 2024, In: The Lancet Infectious Diseases. 24, 8, p. e495-e512 18 p.Research output: Contribution to journal › Review Article › Research › peer-review
23 Citations (Scopus) -
Antimicrobial susceptibility of ceftolozane-tazobactam against multidrug-resistant Pseudomonas aeruginosa isolates from Melbourne, Australia
Kostoulias, X., Chang, C. C., Wisniewski, J., Abbott, I. J., Zisis, H., Dennison, A., Spelman, D. W. & Peleg, A. Y., Aug 2023, In: Pathology. 55, 5, p. 663-668 6 p.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus)
Press/Media
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3RRR 102.7 radio interview – Zika virus and travel medicine, 24 July 2016
24/07/16
1 item of Media coverage
Press/Media: Public Engagement Activities
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JoyFM 94.9 radio interview – Sexually transmitted illnesses and the syphilis epidemic 18 August 2015
18/08/15
1 item of Media coverage
Press/Media: Public Engagement Activities
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JoyFM 94.9 radio interview - Treatment as prevention 17 February 2015
17/02/15
1 item of Media coverage
Press/Media: Public Engagement Activities
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Victorian AIDS council, Midsumma Hypothetical "MJ Loves Tina, Charlie's Chasing Harry", Melbourne Town Hall, 20 Jan 2015
20/01/15
1 item of Media coverage
Press/Media: Public Engagement Activities