Projects per year
Personal profile
Biography
Christina is an Infectious Diseases physician-scientist and is internationally recognised for her clinical and research expertise in cryptococcal meningitis (CM) and cryptococcosis-associated immune reconstitution inflammatory syndrome (C-IRIS). She completed her medical degree and physician training in Melbourne, and has extensive international clinical trial experience, particularly in resource-limited settings. As part of her PhD on C-IRIS immunopathogenesis, she established a cohort of 130 HIV-CM co-infected persons in Durban, South Africa. She held an NHMRC Early career fellowship on HIV prevention and cure (2015-2020) and extended her international clinical trial experience working on investigational new agents for the treatment of COVID-19 (2020-2022). She is an infectious diseases physician at The Alfred Hospital, Melbourne and principal investigator of early phase and first-in-human studies at Nucleus Network, Melbourne.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Principal Investigator, Nucleus Network Ltd
3 Apr 2023 → …
Senior Research Fellow for Clinical Trials and Cohorts, Kirby Institute
Mar 2020 → 31 Dec 2021
Honorary research associate, Centre for the AIDS Programme of Research in South Africa
2018 → …
Honorary Lecturer, University of KwaZulu-Natal
Apr 2012 → Apr 2015
Infectious Diseases Physician, Alfred Hospital
2011 → …
Research area keywords
- Cryptococcosis
- Immune reconstitution inflammatory Syndrome
- HIV/AIDS
- Fungal infections
- Opportunistic infections
- Cryptococcal meningitis
- Infection and immunity
- infections in immunocompromised hosts
- Infectious Disease
- COVID-19
- SARS-CoV-2
Collaborations and top research areas from the last five years
Projects
- 3 Finished
-
Immunopathogenesis of cryptococcal meningitis and paradoxical cryptococcal meningitis immune restoration disease in persons living with HIV: Comparisons of immune responses in the central nervous syst
Chang, C., French, M. A. & Lewin, S.
Pfizer (Australia) (trading as Pfizer Australia Pty Limited)
1/06/11 → 31/05/12
Project: Research
-
Cryptococcal Meningitis Immune Restoration Disease
Kidd, S., Chang, C. & Lewin, S.
1/11/09 → 31/10/10
Project: Research
Research output
-
Antiretroviral Initiation at ≥800 CD4+ Cells/mm3 Associated With Lower Human Immunodeficiency Virus Reservoir Size
Rasmussen, T. A., Ahuja, S. K., Kuwanda, L., Vjecha, M. J., Hudson, F., Lal, L., Rhodes, A., Chang, J., Palmer, S., Auberson-Munderi, P., Mugerwa, H., Wood, R., Badal-Faesen, S., Pillay, S., Mngqibisa, R., LaRosa, A., Hildago, J., Petoumenos, K., Chiu, C., Lutaakome, J., & 8 others , 14 Nov 2022, In: Clinical Infectious Diseases. 75, 10, p. 1781-1791 11 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Comparative Immunogenicity and Effectiveness of mRNA-1273, BNT162b2, and Ad26.COV2.S COVID-19 Vaccines
Naranbhai, V., Garcia-Beltran, W. F., Chang, C. C., Berrios Mairena, C., Thierauf, J. C., Kirkpatrick, G., Onozato, M. L., Cheng, J., St Denis, K. J., Lam, E. C., Kaseke, C., Tano-Menka, R., Yang, D., Pavlovic, M., Yang, W., Kui, A., Miller, T. E., Astudillo, M. G., Cahill, J. E., Dighe, A. S., & 5 others , 1 Apr 2022, In: Journal of Infectious Diseases. 225, 7, p. 1141-1150 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access66 Citations (Scopus) -
Design and implementation of an international, multi-arm, multi-stage platform master protocol for trials of novel SARS-CoV-2 antiviral agents: Therapeutics for Inpatients with COVID-19 (TICO/ACTIV-3)
Murray, D. D., Babiker, A. G., Baker, J. V., Barkauskas, C. E., Brown, S. M., Chang, C. C., Davey, V. J., Gelijns, A. C., Ginde, A. A., Grund, B., Higgs, E., Hudson, F., Kan, V. L., Lane, H. C., Murray, T. A., Paredes, R., Parmar, M. K. B., Pett, S., Phillips, A. N., Polizzotto, M. N., & 9 others , Feb 2022, In: Clinical Trials. 19, 1, p. 52-61 10 p.Research output: Contribution to journal › Article › Research › peer-review
10 Citations (Scopus) -
Efficacy and safety of two neutralising monoclonal antibody therapies, sotrovimab and BRII-196 plus BRII-198, for adults hospitalised with COVID-19 (TICO): a randomised controlled trial
ACTIV-3/Therapeutics for Inpatients with COVID-19 (TICO) Study Group, 1 May 2022, In: The Lancet Infectious Diseases. 22, 5, p. 622-635 14 p.Research output: Contribution to journal › Article › Research › peer-review
105 Citations (Scopus) -
Hyperimmune immunoglobulin for hospitalised patients with COVID-19 (ITAC): a double-blind, placebo-controlled, phase 3, randomised trial
The ITAC (INSIGHT 013) Study Group, 5 Feb 2022, In: The Lancet. 399, 10324, p. 530-540 11 p.Research output: Contribution to journal › Article › Research › peer-review
27 Citations (Scopus)
Press/Media
-
3RRR 102.7 radio interview – Zika virus and travel medicine, 24 July 2016
24/07/16
1 item of Media coverage
Press/Media: Public Engagement Activities
-
JoyFM 94.9 radio interview – Sexually transmitted illnesses and the syphilis epidemic 18 August 2015
18/08/15
1 item of Media coverage
Press/Media: Public Engagement Activities
-
JoyFM 94.9 radio interview - Treatment as prevention 17 February 2015
17/02/15
1 item of Media coverage
Press/Media: Public Engagement Activities
-
Victorian AIDS council, Midsumma Hypothetical "MJ Loves Tina, Charlie's Chasing Harry", Melbourne Town Hall, 20 Jan 2015
20/01/15
1 item of Media coverage
Press/Media: Public Engagement Activities