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Research Output 2001 2018

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2018

Characterization of Plasmodium falciparum Atypical Kinase PfPK7- Dependent Phosphoproteome

Pease, B. N., Huttlin, E. L., Jedrychowski, M. P., Dorin-Semblat, D., Sebastiani, D., Segarra, D. T., Roberts, B. F., Chakrabarti, R., Doerig, C., Gygi, S. P. & Chakrabarti, D., 1 Jun 2018, In : Journal of Proteome Research. 17, 6, p. 2112-2123 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites

Fang, H., Gomes, A. R., Klages, N., Pino, P., Maco, B., Walker, E. M., Zenonos, Z. A., Angrisano, F., Baum, J., Doerig, C., Baker, D. A., Billker, O. & Brochet, M., 12 Oct 2018, In : Nature Communications. 9, 1, 14 p., 4248.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Inducing controlled cell cycle arrest and re-entry during asexual proliferation of Plasmodium falciparum malaria parasites

van Biljon, R., Niemand, J., van Wyk, R., Clark, K., Verlinden, B., Abrie, C., von Grüning, H., Smidt, W., Smit, A., Reader, J., Painter, H., Llinás, M., Doerig, C. & Birkholtz, L. M., 1 Dec 2018, In : Scientific Reports. 8, 1, 16581.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Multispectral Atomic Force Microscopy-Infrared Nano-Imaging of Malaria Infected Red Blood Cells

Perez-Guaita, D., Kochan, K., Batty, M., Doerig, C., Garcia-Bustos, J., Espinoza, S., McNaughton, D., Heraud, P. & Wood, B. R., 6 Mar 2018, In : Analytical Chemistry. 90, 5, p. 3140-3148 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: Updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

Harding, S. D., Sharman, J. L., Faccenda, E., Southan, C., Pawson, A. J., Ireland, S., Gray, A. J. G., Bruce, L., Alexander, S. P. H., Anderton, S., Bryant, C., Davenport, A. P., Doerig, C., Fabbro, D., Levi-Schaffer, F., Spedding, M., Davies, J. A. & NC-IUPHAR, 4 Jan 2018, In : Nucleic Acids Research. 46, D1, p. D1091-D1106 16 p.

Research output: Contribution to journalArticleOtherpeer-review

The protein kinase CK2 catalytic domain from Plasmodium falciparum: Crystal structure, tyrosine kinase activity and inhibition

Ruiz-Carrillo, D., Lin, J., El Sahili, A., Wei, M., Sze, S. K., Cheung, P. C. F., Doerig, C. & Lescar, J., 9 May 2018, In : Scientific Reports. 8, 1, 12 p., 7365.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

Malaria Parasites in a Hungry Host: Kinases and Host Caloric Restriction Brought Together

Garcia-Bustos, J. F. & Doerig, C., Nov 2017, In : Trends in Parasitology. 33, 11, p. 831-832 2 p.

Research output: Contribution to journalArticleOtherpeer-review

Signalome-wide assessment of host cell response to hepatitis C virus

Haqshenas, G., Wu, J., Simpson, K. J., Daly, R. J., Netter, H. J., Baumert, T. F. & Doerig, C., 8 May 2017, In : Nature Communications. 8, 11 p., 15158.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016

A new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinase

Mitcheson, D. F., Bottrill, A. R., Carr, K., Coxon, C. R., Cano, C., Golding, B. T., Griffin, R. J., Fry, A. M., Doerig, C., Bayliss, R. & Tobin, A. B., 7 Nov 2016, In : Malaria Journal. 15, 12 p., 535.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Hierarchical phosphorylation of apical membrane antigen 1 is required for efficient red blood cell invasion by malaria parasites

Prinz, B., Harvey, K. L., Wilcke, L., Ruch, U., Engelberg, K., Biller, L., Lucet, I., Erkelenz, S., Heincke, D., Spielmann, T., Doerig, C., Kunick, C., Crabb, B. S., Gilson, P. R. & Gilberger, T. W., 4 Oct 2016, In : Scientific Reports. 6, 12 p., 34479.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The conserved apicomplexan Aurora kinase TgArk3 is involved in endodyogeny, duplication rate and parasite virulence

Berry, L., Chen, C-T., Reininger, L., Carvalho, T. G., El Hajj, H., Morlon-Guyot, J., Bordat, Y., Lebrun, M., Gubbels, M-J., Doerig, C. & Daher, W., Aug 2016, In : Cellular Microbiology. 18, 8, p. 1106-1120 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites

Woo, Y. H., Ansari, H. R., Otto, T. D., Klinger, C. M., Kolisko, M., Michalek, J., Saxena, A., Shanmugam, D., Tayyrov, A., Veluchamy, A., Ali, S., Bernal, A., del Campo, J., Cihlar, J., Flegontov, P., Gornik, S. G., Hajduskova, E., Horak, A., Janouskovec, J., Katris, N. J. & 23 othersMast, F. D., Miranda-Saavedra, D., Mourier, T., Naeem, R., Nair, M., Panigrahi, A. K., Rawlings, N. D., Padron-Regalado, E., Ramaprasad, A., Samad, N. B., Tomcala, A., Wilkes, J. M., Neafsey, D. E., Doerig, C. D., Bowler, C., Keeling, P. J., Roos, D. S., Dacks, J. B., Templeton, T. J., Waller, R. F., Lukes, J., Obornik, M. & Pain, A., 2015, In : eLife. 4, p. 1 - 41 41 p., E06974.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Host cell kinases and the hepatitis C virus life cycle

Colpitts, C. C., Lupberger, J., Doerig, C. D. & Baumert, T. F., 2015, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1854, 10 [Part B], p. 1657 - 1662 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Malaria parasite-infected erythrocytes secrete PfCK1, the plasmodium homologue of the pleiotropic protein kinase casein kinase 1

Dorin-Semblat, D., Demarta-Gatsi, C., Hamelin, R., Armand, F., Carvalho, T. G., Moniatte, M. & Doerig, C. D., 2015, In : PLoS ONE. 10, 12, 22 p., e0139591.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion

Alam, M. M., Solyakov, L., Bottrill, A. R., Flueck, C., Siddiqui, F. A., Singh, S., Mistry, S., Viskaduraki, M., Lee, K., Hopp, C. S., Chitnis, C. E., Doerig, C. D., Moon, R. W., Green, J. L., Holder, A. A., Baker, D. A. & Tobin, A. B., 2015, In : Nature Communications. 6, 15 p., 7285.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Plasmodium falciparum adhesins play an essential role in signalling and activation of invasion into human erythrocytes

Tham, W-H., Lim, N. T. Y., Weiss, G. E., Lopaticki, S., Ansell, B. R. E., Bird, M. J., Lucet, I. S., Dorin-Semblat, D., Doerig, C. D., Gilson, P. R., Crabb, B. S. & Cowman, A. F., 2015, In : PLoS Pathogens. 11, 12, 22 p., e1005343.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Post-translational protein modifications in malaria parasites

Doerig, C. D., Rayner, J. C., Scherf, A. & Tobin, A. B., 2015, In : Nature Reviews Microbiology. 13, 3, p. 160 - 172 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Regulation of plasmodium falciparum origin recognition complex subunit 1 (PfORC1) function through phosphorylation mediated by CDK like kinase PK5

Deshmukh, A. S., Agarwal, M., Mehra, P., Gupta, A., Gupta, N., Doerig, C. D. & Dhar, S., 2015, In : Molecular Microbiology. 98, 1, p. 17 - 33 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting kinases in Plasmodium and Schistosoma: same goals, different challenges

Doerig, C. D. & Grevelding, C. G., 2015, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1854, 10, p. 1637 - 1643 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Two-dimensional single-cell patterning with one cell per well driven by surface acoustic waves

Collins, D. J., Morahan, B. J., Garcia-Bustos, J., Doerig, C. D., Plebanski, M. & Neild, A., 2015, In : Nature Communications. 6, p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2014

Genomic analysis of the causative agents of coccidiosis in domestic chickens

Reid, A. J., Blake, D. P., Ansari, H. R., Billington, K. J., Browne, H. P., Bryant, J. M., Dunn, M., Hung, S. S., Kawahara, F., Miranda-Saavedra, D., Malas, T. B., Mourier, T., Naghra, H., Nair, M., Otto, T. D., Rawlings, N. D., Rivailler, P., Sanchez-Flores, A., Sanders, M. J., Subramaniam, C. & 15 othersTay, Y-L., Woo, Y. H., Wu, X., Barrell, B., Dear, P. H., Doerig, C. D., Gruber, A., Ivens, A. C., Parkinson, J., Rajandream, M-A., Shirley, M. B., Wan, K-L., Berriman, M., Tomley, F. M. & Pain, A., 2014, In : Genome Research. 24, 10, p. 1676 - 1685 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of the SR protein-phosphorylating CLK kinases of Plasmodium falciparum impairs blood stage replication and malaria transmission

Kern, S., Agarwal, S., Huber, K., Gehring, A. P., Strodke, B., Wirth, C. C., Brugl, T., Abodo, L. O., Dandekar, T., Doerig, C. D., Fischer, R., Tobin, A. B., Alam, M. M., Bracher, F. & Pradel, G., 2014, In : PLoS ONE. 9, 9, 15 p., e105732.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Malaria protein kinase CK2 (PfCK2) shows novel mechanisms of regulation

Graciotti, M., Alam, M. M., Solyakov, L., Schmid, R., Burley, G. A., Bottrill, A. R., Doerig, C. D., Cullis, P. M. & Tobin, A., 2014, In : PLoS ONE. 9, 3, 8 p., e85391.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Regulation of Plasmodium falciparum development by calcium-dependent protein kinase 7 (PfCDPK7)

Kumar, P., Tripathi, A., Ranjan, R., Halbert, J., Gilberger, T. W., Doerig, C. D. & Sharma, P., 2014, In : Journal of Biological Chemistry. 289, 29, p. 20386 - 20395 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles are selective inhibitors of Plasmodium falciparum glycogen synthase kinase-3

Fugel, W., Oberholzer, A. E., Gschloessl, B., Dzikowski, R., Pressburger, N., Preu, L., Pearl, L. H., Baratte, B., Ratin, M., Okun, I., Doerig, C. D., Kruggel, S., Lemckert, T., Meijer, L. & Kunick, C., 2013, In : Journal of Medicinal Chemistry. 56, 1, p. 264 - 275 12 p.

Research output: Contribution to journalArticleResearchpeer-review

An atypical cyclin-dependent kinase controls Plasmodium falciparum proliferation rate

Dorin-Semblat, D., Carvalho, T. G., Nivez, M-P., Halbert, J., Poullet, P., Semblat, J-P., Goldring, JP. D., Chakrabarti, D., Mehra, P., Dhar, S., Paing, M. M., Goldberg, D. E., McMillan, P. J., Tilley, L. & Doerig, C. D., 2013, In : Kinome Journal. 1, March 2013, p. 4 - 16 13 p.

Research output: Contribution to journalArticleResearchpeer-review

A secreted Plasmodium falciparum kinase reveals a signature motif for classification of tyrosine kinase-like kinases

Abdi, A., Carvalho, T. G., Wilkes, J. M. & Doerig, C. D., 2013, In : Microbiology-Sgm. 159, 12, p. 2533 - 2547 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Comprehensive histone phosphorylation analysis and identification of Pf14-3-3 protein as a histone H3 phosphorylation reader in malaria parasites

Dastidar, E. G., Dzeyk, K., Krijgsveld, J., Malmquist, N. A., Doerig, C. D., Scherf, A. & Lopez-Rubio, J-J., 2013, In : PLoS ONE. 8, 1, 12 p., e53179.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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CRIMALDDI: platform technologies and novel anti-malarial drug targets

Vial, H., Taramelli, D., Boulton, I. C., Ward, S. A., Doerig, C. D. & Chibale, K., 2013, In : Malaria Journal. 12, 1 (Art. No.: 396), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Expression in yeast links field polymorphisms in PfATP6 to in vitro artemisinin resistance and identifies new inhibitor classes

Pulcini, S., Staines, H. M., Pittman, J. K., Slavic, K., Doerig, C. D., Halbert, J., Tewari, R., Shah, F., Avery, M. A., Haynes, R. K. & Krishna, S., 2013, In : Journal of Infectious Diseases. 208, 3, p. 468 - 478 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Global analysis of protein expression and phosphorylation of three stages of Plasmodium falciparum intraerythrocytic development

Pease, B. N., Huttlin, E. L., Jedrychowski, M. P., Talevich, E., Harmon, J. W., Dillman, T., Kannan, N., Doerig, C. D., Chakrabarti, R., Gygi, S. & Chakrabarti, D., 2013, In : Journal of Proteome Research. 12, 9, p. 4028 - 4045 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Nima- and Aurora-related kinases of malaria parasites

Carvalho, T. G., Doerig, C. D. & Reininger, L., 2013, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1834, 7, p. 1336 - 1345 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

An evolutionary perspective on the kinome of malaria parasites

Talevich, E., Tobin, A., Kannan, N. & Doerig, C. D., 2012, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 367, 1602, p. 2607 - 2618 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Involvement of plasmodium falciparum protein kinase CK2 in the chromatin assembly pathway

Dastidar, E. G., Dayer, G., Holland, Z. M., Dorin-Semblat, D., Claes, A., Chene, A., Sharma, A., Hamelin, R., Moniatte, M., Lopez-Rubio, J-J., Scherf, A. & Doerig, C. D., 2012, In : BMC Biology. 10, 5, p. 1 - 16 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Plasmodium falciparum responds to amino acid starvation by entering into a hibernatory state

Babbitt, S. E., Altenhofen, L., Cobbold, S. A., Istvan, E. S., Fennell, C., Doerig, C. D., Llinas, M. & Goldberg, D. E., 2012, In : Proceedings of the National Academy of Sciences. 109, 47, p. 3278 - 3287 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Plasmodium kinases as targets for new-generation antimalarials

Lucet, I. S., Tobin, A., Drewry, D., Wilks, A. F. & Doerig, C. D., 2012, In : Future Medicinal Chemistry. 4, 18, p. 2295 - 2310 16 p.

Research output: Contribution to journalArticleResearchpeer-review

The kinomes of apicomplexan parasites

Miranda-Saavedra, D., Gabaldon, T., Barton, G. J., Langsley, G. & Doerig, C. D., 2012, In : Microbes and Infection. 14, 10, p. 796 - 810 15 p.

Research output: Contribution to journalArticleResearchpeer-review

The Plasmodium falciparum, Nima-related kinase Pfnek-4: a marker for asexual parasites committed to sexual differentiation

Reininger, L., Garcia, M., Tomlins, A., Muller, S. & Doerig, C. D., 2012, In : Malaria Journal. 11, Art No: 250, p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Toxoplasma and plasmodium protein kinases: roles in invasion and host cell remodelling

Lim, D. C., Cooke, B. M., Doerig, C. D. & Saeij, J. PJ., 2012, In : International Journal for Parasitology. 42, 1, p. 21 - 32 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Activation of a PAK-MEK signalling pathway in malaria parasite-infected erythrocytes

Sicard, A., Semblat, J-P., Doerig, C., Hamelin, R., Moniatte, M., Dorin-Semblat, D., Spicer, J. A., Srivastava, A., Retzlaff, S., Heussler, V., Waters, A. P. & Doerig, C. D., 2011, In : Cellular Microbiology. 13, 6, p. 836 - 845 10 p.

Research output: Contribution to journalArticleResearchpeer-review

An essential Aurora-related kinase transiently associates with spindle pole bodies during Plasmodium falciparum erythrocytic schizogony

Reininger, L., Wilkes, J. M., Bourgade, H., Miranda-Saavedra, D. & Doerig, C., Jan 2011, In : Molecular Microbiology. 79, 1, p. 205-221 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum

Solyakov, L., Halbert, J., Alam, M. M., Semblat, J-P., Dorin-Semblat, D., Reininger, L., Bottrill, A. R., Mistry, S., Abdi, A., Fennell, C., Holland, Z., Demarta, C., Bouza, Y., Sicard, A., Nivez, M-P., Eschenlauer, S., Lama, T., Thomas, D. C., Sharma, P., Agarwal, S. & 5 othersKern, S., Pradel, G., Graciotti, M., Tobin, A. B. & Doerig, C. D., 2011, In : Nature Communications. 2, Art. No: 565, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Malaria parasites form filamentous cell-to-cell connections during reproduction in the mosquito midgut

Rupp, I., Sologub, L., Williamson, K. C., Scheuermayer, M., Reininger, L., Doerig, C., Eksi, S., Kombila, D. U., Frank, M. & Pradel, G., Apr 2011, In : Cell Research. 21, 4, p. 683-696 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Plasmodium falciparum liver stage antigen-1 is cross-linked by tissue transglutaminase

Nicoll, W. S., Sacci, J. B., Rodolfo, C., Di Giacomo, G., Piacentini, M., Holland, Z. J. M., Doerig, C., Hollingdale, M. R. & Lanar, D. E., 2011, In : Malaria Journal. 10, 14.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Plasmodium falciparum NIMA-related kinase Pfnek-1: Sex specificity and assessment of essentiality for the erythrocytic asexual cycle

Dorin-Semblat, D., Schmitt, S., Semblat, J. P., Sicard, A., Reininger, L., Goldring, JP. D., Patterson, S., Quashie, N. B., Chakrabarti, D., Meijer, L. & Doerig, C., Oct 2011, In : Microbiology-Sgm. 157, 10, p. 2785-2794 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Two nucleus-localized CDK-like kinases with crucial roles for malaria parasite erythrocytic replication are involved in phosphorylation of splicing factor

Agarwal, S., Kern, S., Halbert, J., Przyborski, J. M., Baumeister, S., Dandekar, T., Doerig, C. & Pradel, G., May 2011, In : Journal of Cellular Biochemistry. 112, 5, p. 1295-1310 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

A Plasmodium falciparum transcriptional cyclin-dependent kinase-related kinase with a crucial role in parasite proliferation associates with histone deacetylase activity

Halbert, J., Ayong, L., Equinet, L., le Roch, K., Hardy, M., Goldring, JP. D., Reininger, L., Waters, N., Chakrabarti, D. & Doerig, C., Jun 2010, In : Eukaryotic Cell. 9, 6, p. 952-959 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Life cycle studies of the hexose transporter of Plasmodium species and genetic validation of their essentiality

Slavic, K., Straschil, U., Reininger, L., Doerig, C., Morin, C., Tewari, R. & Krishna, S., 2010, In : Molecular Microbiology. 75, 6, p. 1402-1413 12 p.

Research output: Contribution to journalArticleResearchpeer-review

SAM domain-dependent activity of PfTKL3, an essential tyrosine kinase-like kinase of the human malaria parasite Plasmodium falciparum

Abdi, A., Eschenlauer, S., Reininger, L. & Doerig, C., Oct 2010, In : Cellular and Molecular Life Sciences. 67, 19, p. 3355-3369 15 p.

Research output: Contribution to journalArticleResearchpeer-review

The Plasmodium eukaryotic initiation factor-2α kinase IK2 controls the latency of sporozoites in the mosquito salivary glands

Zhang, M., Fennell, C., Ranford-Cartwright, L., Sakthivel, R., Gueirard, P., Meister, S., Caspi, A., Doerig, C., Nussenzweig, R. S., Tuteja, R., Sullivan, W. J., Roos, D. S., Fontoura, B. M. A., Ménard, R., Winzeler, E. A. & Nussenzweig, V., 5 Jul 2010, In : Journal of Experimental Medicine. 207, 7, p. 1465-1474 10 p.

Research output: Contribution to journalArticleResearchpeer-review