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Research Output 2001 2018

2018

Characterization of Plasmodium falciparum Atypical Kinase PfPK7- Dependent Phosphoproteome

Pease, B. N., Huttlin, E. L., Jedrychowski, M. P., Dorin-Semblat, D., Sebastiani, D., Segarra, D. T., Roberts, B. F., Chakrabarti, R., Doerig, C., Gygi, S. P. & Chakrabarti, D., 1 Jun 2018, In : Journal of Proteome Research. 17, 6, p. 2112-2123 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites

Fang, H., Gomes, A. R., Klages, N., Pino, P., Maco, B., Walker, E. M., Zenonos, Z. A., Angrisano, F., Baum, J., Doerig, C., Baker, D. A., Billker, O. & Brochet, M., 12 Oct 2018, In : Nature Communications. 9, 1, 14 p., 4248.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Inducing controlled cell cycle arrest and re-entry during asexual proliferation of Plasmodium falciparum malaria parasites

van Biljon, R., Niemand, J., van Wyk, R., Clark, K., Verlinden, B., Abrie, C., von Grüning, H., Smidt, W., Smit, A., Reader, J., Painter, H., Llinás, M., Doerig, C. & Birkholtz, L. M., 1 Dec 2018, In : Scientific Reports. 8, 1, 16581.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Multispectral Atomic Force Microscopy-Infrared Nano-Imaging of Malaria Infected Red Blood Cells

Perez-Guaita, D., Kochan, K., Batty, M., Doerig, C., Garcia-Bustos, J., Espinoza, S., McNaughton, D., Heraud, P. & Wood, B. R., 6 Mar 2018, In : Analytical Chemistry. 90, 5, p. 3140-3148 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Parasites under the Spotlight: Applications of Vibrational Spectroscopy to Malaria Research

Perez Guaita, D., Marzec, K. M., Hudson, A., Evans, C. J., Chernenko, T., Matthaus, C., Miljkovic, M., Diem, M., Heraud, P., Richards, J. S., Andrew, D. W., Anderson, D. A., Doerig, C., Garcia-Bustos, J., McNaughton, D. & Wood, B. R., 13 Jun 2018, In : Chemical Reviews. 118, 11, p. 5330-5358 29 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Repurposing cancer drugs – a new perspective for antimalarial drug discovery?

John von Freyend, S., Adderley, J. D., Jackson, S., Burns, A. L., Ruether, A., Sexton, A., Creek, D., Wood, B., Wilson, D. & Doerig, C., 3 Jul 2018.

Research output: Contribution to conferencePosterOther

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: Updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

Harding, S. D., Sharman, J. L., Faccenda, E., Southan, C., Pawson, A. J., Ireland, S., Gray, A. J. G., Bruce, L., Alexander, S. P. H., Anderton, S., Bryant, C., Davenport, A. P., Doerig, C., Fabbro, D., Levi-Schaffer, F., Spedding, M., Davies, J. A. & NC-IUPHAR, 4 Jan 2018, In : Nucleic Acids Research. 46, D1, p. D1091-D1106 16 p.

Research output: Contribution to journalArticleOtherpeer-review

The protein kinase CK2 catalytic domain from Plasmodium falciparum: Crystal structure, tyrosine kinase activity and inhibition

Ruiz-Carrillo, D., Lin, J., El Sahili, A., Wei, M., Sze, S. K., Cheung, P. C. F., Doerig, C. & Lescar, J., 9 May 2018, In : Scientific Reports. 8, 1, 12 p., 7365.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

Malaria Parasites in a Hungry Host: Kinases and Host Caloric Restriction Brought Together

Garcia-Bustos, J. F. & Doerig, C., Nov 2017, In : Trends in Parasitology. 33, 11, p. 831-832 2 p.

Research output: Contribution to journalArticleOtherpeer-review

Signalome-wide assessment of host cell response to hepatitis C virus

Haqshenas, G., Wu, J., Simpson, K. J., Daly, R. J., Netter, H. J., Baumert, T. F. & Doerig, C., 8 May 2017, In : Nature Communications. 8, 11 p., 15158.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Subverting host cell P21-activated kinase: A case of convergent evolution across pathogens

John Von Freyend, S., Kwok-Schuelein, T., Netter, H. J., Haqshenas, G., Semblat, J. P. & Doerig, C., 1 Jun 2017, In : Pathogens. 6, 2, 24 p., 17.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
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2016

A new tool for the chemical genetic investigation of the Plasmodium falciparum Pfnek-2 NIMA-related kinase

Mitcheson, D. F., Bottrill, A. R., Carr, K., Coxon, C. R., Cano, C., Golding, B. T., Griffin, R. J., Fry, A. M., Doerig, C., Bayliss, R. & Tobin, A. B., 7 Nov 2016, In : Malaria Journal. 15, 12 p., 535.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Hierarchical phosphorylation of apical membrane antigen 1 is required for efficient red blood cell invasion by malaria parasites

Prinz, B., Harvey, K. L., Wilcke, L., Ruch, U., Engelberg, K., Biller, L., Lucet, I., Erkelenz, S., Heincke, D., Spielmann, T., Doerig, C., Kunick, C., Crabb, B. S., Gilson, P. R. & Gilberger, T. W., 4 Oct 2016, In : Scientific Reports. 6, 12 p., 34479.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Repurposing cancer drugs - a new perspective for antimalarial drug discovery?

John von Freyend, S., Morahan, B. J., Adderley, J. D. & Doerig, C. D., 2016.

Research output: Contribution to conferencePosterOther

The conserved apicomplexan Aurora kinase TgArk3 is involved in endodyogeny, duplication rate and parasite virulence

Berry, L., Chen, C-T., Reininger, L., Carvalho, T. G., El Hajj, H., Morlon-Guyot, J., Bordat, Y., Lebrun, M., Gubbels, M-J., Doerig, C. & Daher, W., Aug 2016, In : Cellular Microbiology. 18, 8, p. 1106-1120 15 p.

Research output: Contribution to journalArticleResearchpeer-review

The ins and outs of phosphosignalling in Plasmodium: Parasite regulation and host cell manipulation

Carvalho, T. G., Morahan, B., John von Freyend, S., Boeuf, P., Grau, G., Garcia-Bustos, J. & Doerig, C., Jul 2016, In : Molecular and Biochemical Parasitology. 208, 1, p. 2-15 14 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

The role of human kinases in Plasmodium development and their potential for repurposing cancer drugs as new antimalarials

John von Freyend, S., Adderley, J. D., Morahan, B. J., McMillan, P. & Doerig, C. D., 2016.

Research output: Contribution to conferencePosterOther

2015

Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites

Woo, Y. H., Ansari, H. R., Otto, T. D., Klinger, C. M., Kolisko, M., Michalek, J., Saxena, A., Shanmugam, D., Tayyrov, A., Veluchamy, A., Ali, S., Bernal, A., del Campo, J., Cihlar, J., Flegontov, P., Gornik, S. G., Hajduskova, E., Horak, A., Janouskovec, J., Katris, N. J. & 23 othersMast, F. D., Miranda-Saavedra, D., Mourier, T., Naeem, R., Nair, M., Panigrahi, A. K., Rawlings, N. D., Padron-Regalado, E., Ramaprasad, A., Samad, N. B., Tomcala, A., Wilkes, J. M., Neafsey, D. E., Doerig, C. D., Bowler, C., Keeling, P. J., Roos, D. S., Dacks, J. B., Templeton, T. J., Waller, R. F., Lukes, J., Obornik, M. & Pain, A., 2015, In : eLife. 4, p. 1 - 41 41 p., E06974.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Host cell kinases and the hepatitis C virus life cycle

Colpitts, C. C., Lupberger, J., Doerig, C. D. & Baumert, T. F., 2015, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1854, 10 [Part B], p. 1657 - 1662 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Malaria: Targeting host kinases

John von Freyend, S., Morahan, B. J., Semblat, J. P., Sicard, A., Hooker, D. J., Adderley, J. D. & Doerig, C. D., 2015.

Research output: Contribution to conferencePosterOther

Malaria parasite-infected erythrocytes secrete PfCK1, the plasmodium homologue of the pleiotropic protein kinase casein kinase 1

Dorin-Semblat, D., Demarta-Gatsi, C., Hamelin, R., Armand, F., Carvalho, T. G., Moniatte, M. & Doerig, C. D., 2015, In : PLoS ONE. 10, 12, 22 p., e0139591.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion

Alam, M. M., Solyakov, L., Bottrill, A. R., Flueck, C., Siddiqui, F. A., Singh, S., Mistry, S., Viskaduraki, M., Lee, K., Hopp, C. S., Chitnis, C. E., Doerig, C. D., Moon, R. W., Green, J. L., Holder, A. A., Baker, D. A. & Tobin, A. B., 2015, In : Nature Communications. 6, 15 p., 7285.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Plasmodium falciparum adhesins play an essential role in signalling and activation of invasion into human erythrocytes

Tham, W-H., Lim, N. T. Y., Weiss, G. E., Lopaticki, S., Ansell, B. R. E., Bird, M. J., Lucet, I. S., Dorin-Semblat, D., Doerig, C. D., Gilson, P. R., Crabb, B. S. & Cowman, A. F., 2015, In : PLoS Pathogens. 11, 12, 22 p., e1005343.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Post-translational protein modifications in malaria parasites

Doerig, C. D., Rayner, J. C., Scherf, A. & Tobin, A. B., 2015, In : Nature Reviews Microbiology. 13, 3, p. 160 - 172 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Regulation of plasmodium falciparum origin recognition complex subunit 1 (PfORC1) function through phosphorylation mediated by CDK like kinase PK5

Deshmukh, A. S., Agarwal, M., Mehra, P., Gupta, A., Gupta, N., Doerig, C. D. & Dhar, S., 2015, In : Molecular Microbiology. 98, 1, p. 17 - 33 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Repurposing cancer drugs inhibiting kinases - a new perspective for antimalarial drug discovery?

John von Freyend, S., Morahan, B. J., Garcia-Bustos, J. & Doerig, C. D., 2015.

Research output: Contribution to conferenceAbstractOther

Targeting kinases in Plasmodium and Schistosoma: same goals, different challenges

Doerig, C. D. & Grevelding, C. G., 2015, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1854, 10, p. 1637 - 1643 7 p.

Research output: Contribution to journalArticleResearchpeer-review

The Kinomics of Malaria

Brochet, M., Tobin, A. B., Billker, O. & Doerig, C. D., 2015, Kinomics: Approaches and Applications. Kraatz, H-B. & Martic, S. (eds.). 1st ed. Weinheim Germany: Wiley-VCH Verlag GmbH & Co. KGaA, p. 115-135 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Two-dimensional single-cell patterning with one cell per well driven by surface acoustic waves

Collins, D. J., Morahan, B. J., Garcia-Bustos, J., Doerig, C. D., Plebanski, M. & Neild, A., 2015, In : Nature Communications. 6, p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2014

Genomic analysis of the causative agents of coccidiosis in domestic chickens

Reid, A. J., Blake, D. P., Ansari, H. R., Billington, K. J., Browne, H. P., Bryant, J. M., Dunn, M., Hung, S. S., Kawahara, F., Miranda-Saavedra, D., Malas, T. B., Mourier, T., Naghra, H., Nair, M., Otto, T. D., Rawlings, N. D., Rivailler, P., Sanchez-Flores, A., Sanders, M. J., Subramaniam, C. & 15 othersTay, Y-L., Woo, Y. H., Wu, X., Barrell, B., Dear, P. H., Doerig, C. D., Gruber, A., Ivens, A. C., Parkinson, J., Rajandream, M-A., Shirley, M. B., Wan, K-L., Berriman, M., Tomley, F. M. & Pain, A., 2014, In : Genome Research. 24, 10, p. 1676 - 1685 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Hijacking of a red blood cell signalling pathway by the malaria parasite Plasmodium falciparum

John von Freyend, S., Semblat, J. P., Hooker, D. J., Sicard, A. & Doerig, C. D., 2014.

Research output: Contribution to conferencePosterOther

Inhibition of the SR protein-phosphorylating CLK kinases of Plasmodium falciparum impairs blood stage replication and malaria transmission

Kern, S., Agarwal, S., Huber, K., Gehring, A. P., Strodke, B., Wirth, C. C., Brugl, T., Abodo, L. O., Dandekar, T., Doerig, C. D., Fischer, R., Tobin, A. B., Alam, M. M., Bracher, F. & Pradel, G., 2014, In : PLoS ONE. 9, 9, 15 p., e105732.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Malaria protein kinase CK2 (PfCK2) shows novel mechanisms of regulation

Graciotti, M., Alam, M. M., Solyakov, L., Schmid, R., Burley, G. A., Bottrill, A. R., Doerig, C. D., Cullis, P. M. & Tobin, A., 2014, In : PLoS ONE. 9, 3, 8 p., e85391.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Modulation of activity and localization of host erythrocyte kinases following infection with Plasmodium falciparum

John von Freyend, S., Semblat, J. P., Hooker, D. J., Sicard, A. & Doerig, C. D., 2014.

Research output: Contribution to conferencePosterOther

Red blood cell proteins as targets for anti-malarial drug development

John von Freyend, S., Hooker, D. J., Gil Carvalho, A. T., Semblat, J. P., Sicard, A. & Doerig, C. D., 2014.

Research output: Contribution to conferencePosterOther

Regulation of Plasmodium falciparum development by calcium-dependent protein kinase 7 (PfCDPK7)

Kumar, P., Tripathi, A., Ranjan, R., Halbert, J., Gilberger, T. W., Doerig, C. D. & Sharma, P., 2014, In : Journal of Biological Chemistry. 289, 29, p. 20386 - 20395 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles are selective inhibitors of Plasmodium falciparum glycogen synthase kinase-3

Fugel, W., Oberholzer, A. E., Gschloessl, B., Dzikowski, R., Pressburger, N., Preu, L., Pearl, L. H., Baratte, B., Ratin, M., Okun, I., Doerig, C. D., Kruggel, S., Lemckert, T., Meijer, L. & Kunick, C., 2013, In : Journal of Medicinal Chemistry. 56, 1, p. 264 - 275 12 p.

Research output: Contribution to journalArticleResearchpeer-review

An atypical cyclin-dependent kinase controls Plasmodium falciparum proliferation rate

Dorin-Semblat, D., Carvalho, T. G., Nivez, M-P., Halbert, J., Poullet, P., Semblat, J-P., Goldring, JP. D., Chakrabarti, D., Mehra, P., Dhar, S., Paing, M. M., Goldberg, D. E., McMillan, P. J., Tilley, L. & Doerig, C. D., 2013, In : Kinome Journal. 1, March 2013, p. 4 - 16 13 p.

Research output: Contribution to journalArticleResearchpeer-review

A secreted Plasmodium falciparum kinase reveals a signature motif for classification of tyrosine kinase-like kinases

Abdi, A., Carvalho, T. G., Wilkes, J. M. & Doerig, C. D., 2013, In : Microbiology-Sgm. 159, 12, p. 2533 - 2547 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Collaborative Drug Design of Plasmodium Kinase Inhibitors

Hardy, B., Affentranger, R., Contini, A., de Teran, H. G., Spitzner, J., Papoian, R., Seibel, W. L., Nelson, S., Wiseman, J., Bryant, S. D., Lucet, I. & Doerig, C., 11 Oct 2013, Protein Phosphorylation in Parasites: Novel Targets for Antiparasitic Intervention. Wiley-Academy, p. 375-415 41 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Comprehensive histone phosphorylation analysis and identification of Pf14-3-3 protein as a histone H3 phosphorylation reader in malaria parasites

Dastidar, E. G., Dzeyk, K., Krijgsveld, J., Malmquist, N. A., Doerig, C. D., Scherf, A. & Lopez-Rubio, J-J., 2013, In : PLoS ONE. 8, 1, 12 p., e53179.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

CRIMALDDI: platform technologies and novel anti-malarial drug targets

Vial, H., Taramelli, D., Boulton, I. C., Ward, S. A., Doerig, C. D. & Chibale, K., 2013, In : Malaria Journal. 12, 1 (Art. No.: 396), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Experimental tools for the study of protein phosphorylation in plasmodium

Dorin-Semblat, D., Bottrill, A. R., Solyakov, L., Tobin, A. & Doerig, C. D., 1 Jan 2013, Malaria: Methods and Protocols. Menard, R. (ed.). 2nd ed. USA: Humana Press, p. 241-257 17 p. (Methods in Molecular Biology; vol. 923).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Expression in yeast links field polymorphisms in PfATP6 to in vitro artemisinin resistance and identifies new inhibitor classes

Pulcini, S., Staines, H. M., Pittman, J. K., Slavic, K., Doerig, C. D., Halbert, J., Tewari, R., Shah, F., Avery, M. A., Haynes, R. K. & Krishna, S., 2013, In : Journal of Infectious Diseases. 208, 3, p. 468 - 478 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Global analysis of protein expression and phosphorylation of three stages of Plasmodium falciparum intraerythrocytic development

Pease, B. N., Huttlin, E. L., Jedrychowski, M. P., Talevich, E., Harmon, J. W., Dillman, T., Kannan, N., Doerig, C. D., Chakrabarti, R., Gygi, S. & Chakrabarti, D., 2013, In : Journal of Proteome Research. 12, 9, p. 4028 - 4045 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Nima- and Aurora-related kinases of malaria parasites

Carvalho, T. G., Doerig, C. D. & Reininger, L., 2013, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1834, 7, p. 1336 - 1345 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Preface

Doerig, C., Späth, G. & Wiese, M., 11 Oct 2013, Protein Phosphorylation in Parasites: Novel Targets for Antiparasitic Intervention. Wiley-Academy, p. xi-xii 2 p.

Research output: Chapter in Book/Report/Conference proceedingForeword / PostscriptOtherpeer-review

Protein Phosphorylation in Parasites: Novel Targets for Antiparasitic Intervention

Doerig, C., Späth, G. & Wiese, M., 11 Oct 2013, Wiley-Academy. 428 p.

Research output: Book/ReportEdited BookOtherpeer-review

2012

An evolutionary perspective on the kinome of malaria parasites

Talevich, E., Tobin, A., Kannan, N. & Doerig, C. D., 2012, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 367, 1602, p. 2607 - 2618 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Involvement of plasmodium falciparum protein kinase CK2 in the chromatin assembly pathway

Dastidar, E. G., Dayer, G., Holland, Z. M., Dorin-Semblat, D., Claes, A., Chene, A., Sharma, A., Hamelin, R., Moniatte, M., Lopez-Rubio, J-J., Scherf, A. & Doerig, C. D., 2012, In : BMC Biology. 10, 5, p. 1 - 16 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access