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Personal profile

Biography

Christian Doerig obtained his PhD in molecular virology at the Swiss Institute for Experimental Cancer Research (ISREC) in Lausanne, Switzerland. After a post-doctoral training on herpes simplex virus in the USA, he turned his attention to malaria and pioneered the study of protein phosphorylation inPlasmodium falciparum, the most virulent of the parasites causing human malaria. He is "Directeur de Recherches" at the French biomedical research agency Inserm and Honorary Professor of the University of Glasgow, Scotland, UK. He established the first Inserm units in the UK, at the Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, and subsequently in Switzerland at the Inserm-EPFL joint laboratory, Ecole Polytechnique de Lausanne (EPFL). In 2011, he joined Monash University as Head of the Department of Microbiology.

Research interests

The research programme of our team is aimed at defining the role of protein phosphorylation in the life cycle of the human malaria parasite Plasmodium falciparum. The long term objectives are (i) to elucidate the organisation and function of phosphosignalling pathways controlling proliferation and development of the parasite in the human host, and (ii) to identify protein kinase inhibitors that can represent leads for antimalarial drug discovery. The laboratory has brought internationally recognised contributions to the field of signal transduction, cell cycle control, and kinomics in malaria parasites, and has extensive expertise in protein kinase biochemistry and reverse genetics. We recently identified the complement of protein kinases that are essential for parasite survival in the human blood, as well as kinases from the host red blood cell that are activated by infection with the parasite, and whose activity is required for parasite proliferation. We are now focusing our attention on the cellular function of essential parasite and host erythrocyte kinases. Active collaborations have been established with pharmacology and structural biology laboratories with the purpose of developing drug discovery activities based on inhibition of these essential host and parasite signaling protein kinases.

Monash teaching commitment

Deputy Convenor MIC3041

External positions

On Secondment, INSERM, France

Honorary Professor, University of Glasgow

Research area keywords

  • antimalarial
  • aurora kinase
  • kinome
  • malaria
  • plasmodium
  • drug discovery
  • falciparum
  • artemisinins
  • cyclopiazonic acid
  • desferioxamine
  • drug resistance
  • pfatp6

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Projects 2013 2020

Research Output 2001 2019

6 Citations (Scopus)

Signalome-wide assessment of host cell response to hepatitis C virus

Haqshenas, G., Wu, J., Simpson, K. J., Daly, R. J., Netter, H. J., Baumert, T. F. & Doerig, C., 8 May 2017, In : Nature Communications. 8, 11 p., 15158.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Post-Genomic Approaches to Understanding Malaria Parasite Biology: Linking Genes to Biological Functions

Sexton, A. E., Doerig, C., Creek, D. J. & Carvalho, T. G., 9 Aug 2019, In : ACS Infectious Diseases. 5, 8, p. 1269-1278 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

Characterization of Plasmodium falciparum Atypical Kinase PfPK7- Dependent Phosphoproteome

Pease, B. N., Huttlin, E. L., Jedrychowski, M. P., Dorin-Semblat, D., Sebastiani, D., Segarra, D. T., Roberts, B. F., Chakrabarti, R., Doerig, C., Gygi, S. P. & Chakrabarti, D., 1 Jun 2018, In : Journal of Proteome Research. 17, 6, p. 2112-2123 12 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites

Fang, H., Gomes, A. R., Klages, N., Pino, P., Maco, B., Walker, E. M., Zenonos, Z. A., Angrisano, F., Baum, J., Doerig, C., Baker, D. A., Billker, O. & Brochet, M., 12 Oct 2018, In : Nature Communications. 9, 1, 14 p., 4248.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)

Inducing controlled cell cycle arrest and re-entry during asexual proliferation of Plasmodium falciparum malaria parasites

van Biljon, R., Niemand, J., van Wyk, R., Clark, K., Verlinden, B., Abrie, C., von Grüning, H., Smidt, W., Smit, A., Reader, J., Painter, H., Llinás, M., Doerig, C. & Birkholtz, L. M., 1 Dec 2018, In : Scientific Reports. 8, 1, 16581.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Activities 2018 2018

  • 1 Editorial responsibility

Molecular and Biochemical Parasitology (Journal)

Christian Doerig (Editor in chief)
1 Mar 2018 → …

Activity: Publication peer-review and editorial work typesEditorial responsibility