Projects per year
Personal profile
Biography
Christian Doerig obtained his PhD in molecular virology at the Swiss Institute for Experimental Cancer Research (ISREC) in Lausanne, Switzerland. After a post-doctoral training on herpes simplex virus in the USA, he turned his attention to malaria and pioneered the study of protein phosphorylation inPlasmodium falciparum, the most virulent of the parasites causing human malaria. He is "Directeur de Recherches" at the French biomedical research agency Inserm and Honorary Professor of the University of Glasgow, Scotland, UK. He established the first Inserm units in the UK, at the Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, and subsequently in Switzerland at the Inserm-EPFL joint laboratory, Ecole Polytechnique de Lausanne (EPFL). In 2011, he joined Monash University as Head of the Department of Microbiology.
Research interests
The research programme of our team is aimed at defining the role of protein phosphorylation in the life cycle of the human malaria parasite Plasmodium falciparum. The long term objectives are (i) to elucidate the organisation and function of phosphosignalling pathways controlling proliferation and development of the parasite in the human host, and (ii) to identify protein kinase inhibitors that can represent leads for antimalarial drug discovery. The laboratory has brought internationally recognised contributions to the field of signal transduction, cell cycle control, and kinomics in malaria parasites, and has extensive expertise in protein kinase biochemistry and reverse genetics. We recently identified the complement of protein kinases that are essential for parasite survival in the human blood, as well as kinases from the host red blood cell that are activated by infection with the parasite, and whose activity is required for parasite proliferation. We are now focusing our attention on the cellular function of essential parasite and host erythrocyte kinases. Active collaborations have been established with pharmacology and structural biology laboratories with the purpose of developing drug discovery activities based on inhibition of these essential host and parasite signaling protein kinases.
Monash teaching commitment
Deputy Convenor MIC3041
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
On Secondment, INSERM - Institut National de la Sante et de la Recherche Medicale (National Institute of Health and Medical Research)
Honorary Professor, University of Glasgow
Research area keywords
- antimalarial
- aurora kinase
- kinome
- malaria
- plasmodium
- drug discovery
- falciparum
- artemisinins
- cyclopiazonic acid
- desferioxamine
- drug resistance
- pfatp6
Network
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Signalling pathways for sexual differentiation of apicomplexan parasites
Maier, A. G., Doerig, C. & Tobin, A. B.
Project: Research
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Host cells versus malaria parasites: network-based drug discovery
Farr, G., Doerig, C., Nim, H. & John von Freyend, S.
Monash University – Internal Faculty Contribution, Monash University – Internal School Contribution
15/02/18 → 25/01/19
Project: Research
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Redox regulation of kinases in the malaria parasite Plasmodium falciparum
Doerig, C. & Becker, K.
1/01/15 → 31/12/16
Project: Research
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Why is the hijacking of a human erythrocyte signalling pathway essential for malaria infection?
Doerig, C. & Tobin, A. B.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/15 → 31/12/18
Project: Research
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A single molecule real-time DNA sequencing facility
Doerig, C., Andrianopoulos, A., Balasubramanian, S., Gasser, R., Holt, K. E., Rood, J., Seemann, T., Stinear, T., Sunnucks, P. & Turner, S. J.
Australian Research Council (ARC)
1/01/15 → 31/12/15
Project: Research
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Signalome-wide assessment of host cell response to hepatitis C virus
Haqshenas, G., Wu, J., Simpson, K. J., Daly, R. J., Netter, H. J., Baumert, T. F. & Doerig, C., 8 May 2017, In: Nature Communications. 8, 11 p., 15158.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile12 Citations (Scopus) -
Red Blood Cell BCL-xL Is Required for Plasmodium falciparum Survival: Insights into Host-Directed Malaria Therapies
Boulet, C., Siddiqui, G., Gaynor, T. L., Doerig, C., Creek, D. J. & Carvalho, T. G., Apr 2022, In: Microorganisms. 10, 4, 17 p., 824.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Human Aurora kinase inhibitor Hesperadin reveals epistatic interaction between Plasmodium falciparum PfArk1 and PfNek1 kinases
Morahan, B. J., Abrie, C., Al-Hasani, K., Batty, M. B., Corey, V., Cowell, A. N., Niemand, J., Winzeler, E. A., Birkholtz, L. M., Doerig, C. & Garcia-Bustos, J. F., 20 Nov 2020, In: Communications Biology. 3, 1, 10 p., 701.Research output: Contribution to journal › Article › Research › peer-review
Open Access10 Citations (Scopus) -
Interaction of Plasmodium falciparum casein kinase 1 with components of host cell protein trafficking machinery
Batty, M. B., Schittenhelm, R. B., Dorin-Semblat, D., Doerig, C. & Garcia-Bustos, J. F., Jun 2020, In: IUBMB Life. 72, 6, p. 1243-1249 7 p.Research output: Contribution to journal › Article › Research › peer-review
6 Citations (Scopus) -
Infrared spectroscopy coupled to cloud-based data management as a tool to diagnose malaria: A pilot study in a malaria-endemic country
Heraud, P., Chatchawal, P., Wongwattanakul, M., Tippayawat, P., Doerig, C., Jearanaikoon, P., Perez-Guaita, D. & Wood, B. R., 16 Oct 2019, In: Malaria Journal. 18, 1, 11 p., 348.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile25 Citations (Scopus)
Activities
- 1 Editorial responsibility
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Molecular and Biochemical Parasitology (Journal)
Christian Doerig (Editor in chief)
1 Mar 2018 → …Activity: Publication peer-review and editorial work types › Editorial responsibility