Christian Doerig

Personal profile

Biography

Christian Doerig obtained his PhD in molecular virology at the Swiss Institute for Experimental Cancer Research (ISREC) in Lausanne, Switzerland. After a post-doctoral training on herpes simplex virus in the USA, he turned his attention to malaria and pioneered the study of protein phosphorylation inPlasmodium falciparum, the most virulent of the parasites causing human malaria. He is "Directeur de Recherches" at the French biomedical research agency Inserm and Honorary Professor of the University of Glasgow, Scotland, UK. He established the first Inserm units in the UK, at the Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, and subsequently in Switzerland at the Inserm-EPFL joint laboratory, Ecole Polytechnique de Lausanne (EPFL). In 2011, he joined Monash University as Head of the Department of Microbiology.

Research interests

The research programme of our team is aimed at defining the role of protein phosphorylation in the life cycle of the human malaria parasite Plasmodium falciparum. The long term objectives are (i) to elucidate the organisation and function of phosphosignalling pathways controlling proliferation and development of the parasite in the human host, and (ii) to identify protein kinase inhibitors that can represent leads for antimalarial drug discovery. The laboratory has brought internationally recognised contributions to the field of signal transduction, cell cycle control, and kinomics in malaria parasites, and has extensive expertise in protein kinase biochemistry and reverse genetics. We recently identified the complement of protein kinases that are essential for parasite survival in the human blood, as well as kinases from the host red blood cell that are activated by infection with the parasite, and whose activity is required for parasite proliferation. We are now focusing our attention on the cellular function of essential parasite and host erythrocyte kinases. Active collaborations have been established with pharmacology and structural biology laboratories with the purpose of developing drug discovery activities based on inhibition of these essential host and parasite signaling protein kinases.

Monash teaching commitment

Deputy Convenor MIC3041

External positions

On Secondment, INSERM, France

Honorary Professor, University of Glasgow

Research area keywords

antimalarial
aurora kinase
kinome
malaria
plasmodium
drug discovery
falciparum
artemisinins
cyclopiazonic acid
desferioxamine
drug resistance
pfatp6

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Projects

1 Not started
1 Active
6 Finished

Probing antimicrobial drug resistance by multimodal molecular analysis

Wood, B., Heraud, P., McNaughton, D., Peleg, A., Doerig, C., Goodacre, R. & Creek, D.

1/01/18 → 31/12/20

Project: Research

Signalling pathways for sexual differentiation of apicomplexan parasites

Maier, A. G., Doerig, C. & Tobin, A. B.

Project: Research

Host cells versus malaria parasites: network-based drug discovery

Farr, G., Doerig, C., Nim, H. & John von Freyend, S.

Monash University – Internal Faculty Contribution, Monash University – Internal School Contribution

15/02/18 → 25/01/19

Project: Research

Why is the hijacking of a human erythrocyte signalling pathway essential for malaria infection?

Doerig, C. & Tobin, A. B.

National Health & Medical Research Council (NHMRC)

1/01/15 → 31/12/18

Project: Research

Redox regulation of kinases in the malaria parasite Plasmodium falciparum

Doerig, C. & Becker, K.

Group of Eight Limited

1/01/15 → 31/12/16

Project: Research

Research Output

93 Article
8 Review Article
7 Poster
3 Chapter (Book)
9 More

Signalome-wide assessment of host cell response to hepatitis C virus

Haqshenas, G., Wu, J., Simpson, K. J., Daly, R. J., Netter, H. J., Baumert, T. F. & Doerig, C., 8 May 2017, In : Nature Communications. 8, 11 p., 15158.