19962021

Research output per year

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2019

AT1R-AT2R-RXFP1 functional crosstalk in myofibroblasts: Impact on the therapeutic targeting of renal and cardiac fibrosis

Chow, B. S. M., Kocan, M., Shen, M., Wang, Y., Han, L., Chew, J. Y., Wang, C., Bosnyak, S., Mirabito-Colafella, K. M., Barsha, G., Wigg, B., Johnstone, E. K. M., Hossain, M. A., Pfleger, K. D. G., Denton, K. M., Widdop, R. E., Summers, R. J., Bathgate, R. A. D., Hewitson, T. D. & Samuel, C. S., 1 Jan 2019, In : Journal of the American Society of Nephrology. 30, 11, p. 2191-2207 17 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Atypical cannabinoid ligands O-1602 and O-1918 administered chronically in diet-induced obesity

Simcocks, A. C., Jenkin, K. A., O’Keefe, L., Samuel, C. S., Mathai, M. L., McAinch, A. J. & Hryciw, D. H., Mar 2019, In : Endocrine Connections. 8, 3, p. 203-216 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Distinct Redox Signalling following Macrophage Activation Influences Profibrotic Activity

Lewis, C. V., Vinh, A., Diep, H., Samuel, C. S., Drummond, G. R. & Kemp-Harper, B. K., 11 Nov 2019, In : Journal of Immunology Research. 2019, 15 p., 1278301.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Human amnion epithelial cells and their soluble factors reduce liver fibrosis in murine non-alcoholic steatohepatitis

Kuk, N., Hodge, A., Sun, Y., Correia, J., Alhomrani, M., Samuel, C., Moore, G., Lim, R. & Sievert, W., Aug 2019, In : Journal of Gastroenterology and Hepatology. 34, 8, p. 1441-1449 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)
1 Citation (Scopus)

Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension

Krishnan, S. M., Ling, Y. H., Huuskes, B. M., Ferens, D. M., Saini, N., Chan, C. T., Diep, H., Kett, M. M., Samuel, C. S., Kemp-Harper, B. K., Robertson, A. A. B., Cooper, M. A., Peter, K., Latz, E., Mansell, A. S., Sobey, C. G., Drummond, G. R. & Vinh, A., 15 Mar 2019, In : Cardiovascular Research. 115, 4, p. 776-787 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
19 Citations (Scopus)

Profiling histone modifications in the normal mouse kidney and after unilateral ureteric obstruction

Hewitson, T. D., Holt, S. G., Samuel, C. S., Wigg, B. & Smith, E. R., 1 Sep 2019, In : American Journal of Physiology - Renal Physiology. 317, 3, p. F606-F615 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Serelaxin enhances the therapeutic effects of human amnion epithelial cell-derived exosomes in experimental models of lung disease

Royce, S. G., Patel, K. P., Mao, W., Zhu, D., Lim, R. & Samuel, C. S., Jul 2019, In : British Journal of Pharmacology. 176, 13, p. 2195-2208 14 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Serelaxin inhibits the profibrotic TGF-β1/IL-1β axis by targeting TLR-4 and the NLRP3 inflammasome in cardiac myofibroblasts

Tapia Caceres, F., Gaspari, T. A., Samuel, C. S. & Pinar, A. A., 1 Dec 2019, In : FASEB Journal. 33, 12, p. 14717-14733 17 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

The efficacy of pirfenidone in a sheep model of pulmonary fibrosis

Dewage, S. N. V., Organ, L., Koumoundouros, E., Derseh, H. B., Perera, K. U. E., Samuel, C. S., Stent, A. W. & Snibson, K. J., 26 Nov 2019, In : Experimental Lung Research. 45, 9-10, p. 310-322 13 p.

Research output: Contribution to journalArticleResearchpeer-review

The use of live cell imaging and automated image analysis to assist with determining optimal parameters for angiogenic assay in vitro

Huuskes, B. M., DeBuque, R. J., Kerr, P. G., Samuel, C. S. & Ricardo, S. D., 10 Apr 2019, In : Frontiers in Cell and Developmental Biology. 7, 14 p., 45.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2018

Hexarelin treatment preserves myocardial function and reduces cardiac fibrosis in mouse model of acute myocardial infarction

McDonald, H., Peart, J., Kurniawan, N., Galloway, G., Royce, S., Samuel, C. S. & Chen, C., 13 May 2018, In : Physiological Reports. 6, 9, 14 p., e13699.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
8 Citations (Scopus)
Open Access
File
3 Citations (Scopus)
2017

Anakinra reduces blood pressure and renal fibrosis in one kidney/DOCA/salt-induced hypertension

Ling, Y. H., Krishnan, S. M., Chan, C. T., Diep, H., Ferens, D., Chin-Dusting, J., Kemp-Harper, B. K., Samuel, C. S., Hewitson, T. D., Latz, E., Mansell, A., Sobey, C. G. & Drummond, G. R., Feb 2017, In : Pharmacological Research. 116, p. 77-86 10 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Epigenetic modifications to H3K9 in renal tubulointerstitial cells after unilateral ureteric obstruction and TGF-β1 stimulation

Hewitson, T. D., Holt, S. G., Tan, S-J., Wigg, B., Samuel, C. S. & Smith, E. R., 29 May 2017, In : Frontiers in Pharmacology. 8, 15 p., 307.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
15 Citations (Scopus)

Inhibition of the KCa3.1 channel alleviates established pulmonary fibrosisin a large animal model

Organ, L., Bacci, B., Koumoundouros, E., Kimpton, W. G., Samuel, C. S., Nowell, C. J., Bradding, P., Roach, K. M., Westall, G., Jaffar, J. & Snibson, K. J., 1 Apr 2017, In : American Journal of Respiratory Cell and Molecular Biology. 56, 4, p. 539-550 13 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)
13 Citations (Scopus)

ML290 is a biased allosteric agonist at the relaxin receptor RXFP1

Kocan, M., Sarwar, M., Ang, S. Y., Xiao, J., Marugan, J., Hossain, M. A., Wang, C., Hutchinson, D. S., Samuel, C. S., Agoulnik, A. I., Bathgate, R. A. D. & Summers, R. J., 1 Dec 2017, In : Scientific Reports. 7, 1, 14 p., 2968.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
15 Citations (Scopus)

Relaxin contributes to the regulation of arterial pressure in adult female mice

Colafella, K. M. M., Samuel, C. S. & Denton, K. M., 28 Nov 2017, In : Clinical Science. 131, 23, p. 2795-2805 11 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)
2016

A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1

Hossain, M. A., Kocan, M., Yao, S. T., Royce, S. G., Nair, V. B., Siwek, C., Patil, N. A., Harrison, I. P., Rosengren, K. J., Selemidis, S., Summers, R. J., Wade, J. D., Bathgate, R. A. D. & Samuel, C. S., 2016, In : Chemical Science. 7, 6, p. 3805-3819 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
30 Citations (Scopus)

Combining an epithelial repair factor and anti-fibrotic with a corticosteroid offers optimal treatment for allergic airways disease

Patel, K. P., Giraud, A. S., Samuel, C. S. & Royce, S. G., 2016, In : British Journal of Pharmacology. 173, 12, p. 2016 - 2029 14 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Enhanced serelaxin signalling in co-cultures of human primary endothelial and smooth muscle cells

Sarwar, M., Samuel, C. S., Bathgate, R., Stewart, D. R. & Summers, R. J., 2016, In : British Journal of Pharmacology. 173, 3, p. 484 - 496 13 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Estrogens do not protect, but androgens exacerbate, collagen accumulation in the female mouse kidney after ureteric obstruction

Hewitson, T. D., Boon, W. C., Simpson, E. R., Smith, E. R. & Samuel, C. S., 1 Aug 2016, In : Life Sciences. 158, p. 130-136 7 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induced hypertension in mice

Krishnan, S. M., Dowling, J. K., Ling, Y. H., Diep, H., Chan, C. T., Ferens, D., Kett, M. M., Pinar, A., Samuel, C. S., Vinh, A., Arumugam, T. V., Hewitson, T. D., Kemp-Harper, B. K., Robertson, A. A. B., Cooper, M. A., Latz, E., Mansell, A., Sobey, C. G. & Drummond, G. R., 1 Feb 2016, In : British Journal of Pharmacology. 173, 4, p. 752-765 14 p.

Research output: Contribution to journalArticleResearchpeer-review

65 Citations (Scopus)

Serelaxin elicits bronchodilation and enhances β-Adrenoceptor-mediated airway relaxation

Lam, M., Royce, S. G., Donovan, C., Jelinic, M., Parry, L. J., Samuel, C. S. & Bourke, J. E., 27 Oct 2016, In : Frontiers in Pharmacology. 7, 406, 18 p., 406.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
7 Citations (Scopus)

Serelaxin improves the therapeutic efficacy of RXFP1-expressing human amnion epithelial cells in experimental allergic airway disease

Royce, S. G., Tominaga, A. M., Shen, M., Patel, K. P., Huuskes, B., Lim, R., Ricardo, S. D. & Samuel, C. S., 2016, In : Clinical Science. 130, 23, p. 2151-2165 15 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)
Open Access
File
16 Citations (Scopus)
2015

A novel segmental challenge model for bleomycin-induced pulmonary fibrosis in sheep

Organ, L., Bacci, B., Koumoundouros, E., Barcham, G., Kimpton, W., Nowell, C., Samuel, C. & Snibson, K., 2015, In : Experimental Lung Research. 41, 3, p. 115-134 20 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Combination therapy of mesenchymal stem cells and serelaxin effectively attenuates renal fibrosis in obstructive nephropathy

Huuskes, B., Wise, A. F., Cox, A. J., Lim, E. X. F., Payne, N. L., Kelly, D. J., Samuel, C. S. & Ricardo, S. D., 2015, In : FASEB Journal. 29, 2, p. 540 - 553 14 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Electrophysiological, electroanatomical, and structural remodeling of the atria as consequences of sustained obesity

Mahajan, R., Lau, D. H., Brooks, A. G., Shipp, N. J., Manavis, J., Wood, J. P. M., Finnie, J. W., Samuel, C. S., Royce, S. G., Twomey, D. J., Thanigaimani, S., Kalman, J. M. & Sanders, P., 2015, In : Journal of the American College of Cardiology. 66, 1, p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

144 Citations (Scopus)
53 Citations (Scopus)

Mesenchymal stem cells and serelaxin synergistically abrogate established airway fibrosis in an experimental model of chronic allergic airways disease

Royce, S. G., Shen, M., Patel, K. P., Huuskes, B., Ricardo, S. D. & Samuel, C. S., 2015, In : Stem Cell Research. 15, 3, p. 495 - 505 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
22 Citations (Scopus)
19 Citations (Scopus)

Obligatory role for B cells in the development of angiotensin II-dependent hypertension

Chan, C. T-L., Sobey, C. G., Lieu, M., Ferens, D. M., Kett, M. M., Diep, H., Kim, H. H. A., Krishnan, S. M., Lewis, C. V., Salimova, E., Tipping, P. G., Vinh, A., Samuel, C. S., Peter, K., Guzik, T. J., Kyaw, T. S., Toh, B-H., Bobik, A. & Drummond, G. R., 2015, In : Hypertension. 66, 5, p. 1023 - 1033 11 p.

Research output: Contribution to journalArticleResearchpeer-review

72 Citations (Scopus)

Serelaxin-mediated signal transduction in human vascular cells: bell-shaped concentration-response curves reflect differential coupling to G proteins

Sarwar, M., Samuel, C. S., Bathgate, R. A., Stewart, D. R. & Summers, R. J., 2015, In : British Journal of Pharmacology. 172, 4, p. 1005-1019 15 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Structural and functional correlations in a large animal model of bleomycin-induced pulmonary fibrosis

Organ, L., Bacci, B., Koumoundouros, E., Barcham, G. J., Milne, M., Kimpton, W. G., Samuel, C. S. & Snibson, K. J., 2015, In : BMC Pulmonary Medicine. 15, 1 , 15 p., 81.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
15 Citations (Scopus)

Synthetic covalently linked dimeric form of H2 relaxin retains native RXFP1 activity and has improved in vitro serum stability

Nair, V. B., Bathgate, R. A. D., Separovic, F., Samuel, C. S., Hossain, M. A. & Wade, J. D., 2015, In : BioMed Research International. 2015, 10 p., 731852.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)
2014

Characterization of a novel model incorporating airway epithelial damage and related fibrosis to the pathogenesis of asthma

Royce, S. G., Patel, K. P. & Samuel, C. S., 2014, In : Laboratory Investigation. 94, 12, p. 1326 - 1339 14 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Human mesenchymal stem cells alter macrophage phenotype and promote regeneration via homing to the kidney following ischemia-reperfusion injury

Wise, A. F., Williams, T. M., Kiewiet, M. B. G., Payne, N. L., Siatskas, C., Samuel, C. S. & Ricardo, S. D., 2014, In : American Journal of Physiology - Renal Physiology. 306, 10, p. 1222 - 1235 14 p.

Research output: Contribution to journalArticleResearchpeer-review

68 Citations (Scopus)

Intranasally administered serelaxin abrogates airway remodelling and attenuates airway hyperresponsiveness in allergic airways disease

Royce, S. G., Lim, C., Patel, K. P., Wang, B., Samuel, C. S. & Tang, M. L. K., 2014, In : Clinical and Experimental Allergy. 44, 11, p. 1399 - 1408 10 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Low-dose maternal alcohol consumption: effects in the hearts of offspring in early life and adulthood

Nguyen, V. B., Probyn, M. E., Campbell, F., Yin, K. V., Samuel, C. S., Zimanyi, M. A., Bertram, J. F., Black, M. J. & Moritz, K. M., 2014, In : Physiological Reports. 2, 7, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
14 Citations (Scopus)

Mechanistic insights into the contribution of epithelial damage to airway remodeling. Novel therapeutic targets for asthma

Royce, S. G., Li, X., Tortorella, S., Goodings, L. M., Chow, B. SM., Giraud, A. S., Tang, M. L. K. & Samuel, C. S., 2014, In : American Journal of Respiratory Cell and Molecular Biology. 50, 1, p. 180 - 192 13 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Novel therapeutic strategies for lung disorders associated with airway remodelling and fibrosis

Royce, S. G., Moodley, Y. & Samuel, C. S., 2014, In : Pharmacology and Therapeutics. 141, 3, p. 250 - 260 11 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Qualitative and quantitative analysis of fibrosis in the kidney

Hewitson, T. D., Smith, E. R. & Samuel, C. S., 2014, In : Nephrology. 19, 11, p. 721 - 726 6 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis

Chow, B. SM., Kocan, M., Bosnyak, S., Sarwar, M., Wigg, B., Jones, E. S., Widdop, R. E., Summers, R. J., Bathgate, R. A. D., Hewitson, T. D. & Samuel, C. S., 2014, In : Kidney International. 86, 1, p. 75 - 85 11 p.

Research output: Contribution to journalArticleResearchpeer-review

65 Citations (Scopus)

Serelaxin is a more efficacious antifibrotic than enalapril in an experimental model of heart disease

Samuel, C. S., Bodaragama, H., Chew, J., Widdop, R. E., Royce, S. G. & Hewitson, T. D., 2014, In : Hypertension. 64, 2, p. 315 - 322 8 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Therapeutic effects of serelaxin in acute heart failure

Du, X-J., Hewitson, T. D., Nguyen, M-N. & Samuel, C. S., 2014, In : Circulation Journal. 78, 3, p. 542 - 552 11 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)
2013

Anti-inflammatory effects of adult stem cells in sustained lung injury: a comparative study

Moodley, Y., Vaghjiani, V., Chan, M. K. J., Baltic, S., Ryan, M., Tchongue, J., Samuel, C. S., Murthi, P., Parolini, O. & Manuelpillai, U. C., 2013, In : PLoS ONE. 8, 8 (Art. No.: e69299), p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
57 Citations (Scopus)
15 Citations (Scopus)

Development of human cells with RXFP1 knockdown using retroviral delivery of microRNA against human RXFP1

Yong, K. J., Callander, G. E., Bergin, R., Samuel, C. S. & Bathgate, R. A. D., 2013, In : Italian Journal of Anatomy and Embryology. 118, 1 SUPPL., p. 10-12 3 p.

Research output: Contribution to journalArticleOtherpeer-review

2 Citations (Scopus)