Projects per year
Personal profile
Biography
Chrishan is a Monash Biomedicine Discovery Fellow and Head of the Fibrosis Laboratory, Department of Pharmacology at Monash. Having been trained as a matrix biologist, his research is focused on identifying novel therapeutic targets and more direct and potent treatment strategies for fibrosis (organ scarring) prevention; particularly associated with cardiovascular, renal and allergic airways diseases. Chrishan's main interest has been to establish the anti-fibrotic and therapeutic potential of the naturally occurring hormone, relaxin. He additionally investigates other novel anti-fibrotics and repair factors, as well as combination therapies that may aid in tissue repair and regeneration, in collaboration with others.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Fibrosis
- Cardiovascular disease
- Kidney Disease
- Lung Disease
- Stem Cell Biology
Network
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Engineering bone marrow-derived stromal cells to express anti-fibrotic cargo as a treatment for chronic kidney disease
Samuel, C., Ricardo, S., Kerr, P., Li, T., Jenkin, G., Hudson, P., Polo, J., Widdop, R., Nikolic-Paterson, D. & Teo, L.
1/01/23 → 31/12/26
Project: Research
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Ferring Innovation Grant for Racial Equality in Reproductive Medicine and Maternal Health: Inflammasomes, novel regulators of placental inflammation and placental ageing in early-onset preeclampsia: potential biomarkers to identify ethnic disparity in preeclampsia
Murthi, P., Kumar, B., Samuel, C., Chakraborty, A., Brennecke, S. P. & Karanam, V.
1/12/21 → 1/11/22
Project: Research
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MediBeacon Transdermal Mini Fluorophore Monitors
Colafella, K., Denton, K., Bubb, K., Cowley, M., Widdop, R., Lyras, D., Samuel, C., Bertram, J. & Parkington, H.
1/10/21 → 31/12/22
Project: Research
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Evaluating the therapeutic effects of Cynata-MSCs in a murine model of pulmonary fibrosis
4/03/20 → 30/09/20
Project: Research
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Comparative Study of Ectopic Lymphoid Aggregates in Sheep and Murine Models of Bleomycin-Induced Pulmonary Fibrosis
Perera, U. E., Organ, L., Royce, S. G., Samuel, C. S., Derseh, H. B., Dewage, S. N. V., Koumoundouros, E., Stent, A. & Snibson, K. J., 2023, In: Canadian Respiratory Journal. 2023, 11 p., 1522593.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Post-stroke administration of H2 relaxin reduces functional deficits, neuronal apoptosis and immune cell infiltration into the mouse brain
Truong, S. H. T., Bonnici, B., Rupasinghe, S., Kemp-Harper, B. K., Samuel, C. S. & Broughton, B. R. S., Jan 2023, In: Pharmacological Research. 187, 11 p., 106611.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Simultaneous late-gadolinium enhancement and T1 mapping of fibrosis and a novel cell-based combination therapy in hypertensive mice
Li, Y., Zheng, G., Salimova, E., Broughton, B. R. S., Ricardo, S. D., de Veer, M. & Samuel, C. S., Feb 2023, In: Biomedicine and Pharmacotherapy. 158, 19 p., 114069.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
The single-chain relaxin mimetic, B7-33, maintains the cardioprotective effects of relaxin and more rapidly reduces left ventricular fibrosis compared to perindopril in an experimental model of cardiomyopathy
Alam, F., Gaspari, T. A., Kemp-Harper, B. K., Low, E., Aw, A., Ferens, D., Spizzo, I., Jefferis, A-M., Praveen, P., Widdop, R. E., Bathgate, R. A. D., Hossain, M. A. & Samuel, C. S., Apr 2023, In: Biomedicine and Pharmacotherapy. 160, 12 p., 114370.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
A Novel Approach to Enhance the Regenerative Potential of Circulating Endothelial Progenitor Cells in Patients with End-Stage Kidney Disease
Badawi, A., Jefferson, O. C., Huuskes, B. M., Ricardo, S. D., Kerr, P. G., Samuel, C. S. & Murthi, P., Apr 2022, In: Biomedicines. 10, 4, 13 p., 883.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus)