Projects per year
Personal profile
Biography
Chrishan is a NHMRC Senior Research Fellow and Head of the Fibrosis Laboratory, Department of Pharmacology at Monash. Having been trained as a matrix biologist, his research is focused on identifying novel therapeutic targets and more direct and potent treatment strategies for fibrosis (organ scarring) prevention; particularly associated with cardiovascular, renal and allergic airways diseases. Chrishan's main interest has been to establish the anti-fibrotic and therapeutic potential of the naturally occurring hormone, relaxin. He additionally investigates other novel anti-fibrotics and repair factors, as well as combination therapies that may aid in tissue repair and regeneration, in collaboration with others.
Keywords
- Fibrosis
- Cardiovascular disease
- Kidney Disease
- Lung Disease
- Stem Cell Biology
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Projects 2007 2021
Enhancing the anti-fibrotic and regenerative capacity of bone marrow-derived stem cells
Samuel, C., Ricardo, S., Widdop, R. & Kerr, P.
1/01/19 → 31/12/21
Project: Research
Simultaneously targeting airway contraction and fibrosis as a new therapeutic strategy for asthma
Bourke, J., Royce, S., Bardin, P., Westall, G., Grainge, C., Oliver, B., Samuel, C. & Wadsworth, S.
National Health & Medical Research Council (NHMRC)
1/01/19 → 31/12/21
Project: Research
Evaluating novel therapeutics for chronic obstructive pulmonary disease
1/04/18 → 31/03/21
Project: Research
Pharmacological inhibition of IRAP as a novel antifibrotic strategy
Widdop, R., Samuel, C., Burrell, L., Chai, S. & Gaspari, T.
1/01/18 → 31/12/21
Project: Research
Unravelling fibrosis by pharmacological targeting of the G protein-coupled receptor, RXFP1
Hossain, M., Bathgate, R., Wade, J., Wade, J., Samuel, C., Yao, S., Rosengren, J. & Kocan, M.
National Health & Medical Research Council (NHMRC)
1/01/17 → 31/12/19
Project: Research
Research Output 2002 2019
Human amnion epithelial cells and their soluble factors reduce liver fibrosis in murine non-alcoholic steatohepatitis
Kuk, N., Hodge, A., Sun, Y., Correia, J., Alhomrani, M., Samuel, C., Moore, G., Lim, R. & Sievert, W., 1 Mar 2019, (Accepted/In press) In : Journal of Gastroenterology and Hepatology (Australia). 9 p.Research output: Contribution to journal › Article › Research › peer-review
The use of live cell imaging and automated image analysis to assist with determining optimal parameters for angiogenic assay in vitro
Huuskes, B. M., DeBuque, R. J., Kerr, P. G., Samuel, C. S. & Ricardo, S. D., 10 Apr 2019, In : Frontiers in Cell and Developmental Biology. 7, 14 p., 45.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Endothelial Progenitor Cells and Vascular Health in Dialysis Patients
Huuskes, B. M., DeBuque, R. J., Polkinghorne, K. R., Samuel, C. S., Kerr, P. G. & Ricardo, S. D., Jan 2018, In : Kidney International Reports. 3, 1, p. 205-211 7 p.Research output: Contribution to journal › Letter › Research › peer-review
Open Access
File
Hexarelin treatment preserves myocardial function and reduces cardiac fibrosis in mouse model of acute myocardial infarction
McDonald, H., Peart, J., Kurniawan, N., Galloway, G., Royce, S., Samuel, C. S. & Chen, C., 13 May 2018, In : Physiological Reports. 6, 9, 14 p., e13699.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Serelaxin as a novel therapeutic opposing fibrosis and contraction in lung diseases
Lam, M., Royce, S. G., Samuel, C. S. & Bourke, J. E., Jul 2018, In : Pharmacology and Therapeutics. 187, p. 61-70 10 p.Research output: Contribution to journal › Article › Other › peer-review