Projects per year
Personal profile
Biography
Chrishan is a NHMRC Senior Research Fellow and Head of the Fibrosis Laboratory, Department of Pharmacology at Monash. Having been trained as a matrix biologist, his research is focused on identifying novel therapeutic targets and more direct and potent treatment strategies for fibrosis (organ scarring) prevention; particularly associated with cardiovascular, renal and allergic airways diseases. Chrishan's main interest has been to establish the anti-fibrotic and therapeutic potential of the naturally occurring hormone, relaxin. He additionally investigates other novel anti-fibrotics and repair factors, as well as combination therapies that may aid in tissue repair and regeneration, in collaboration with others.
Keywords
- Fibrosis
- Cardiovascular disease
- Kidney Disease
- Lung Disease
- Stem Cell Biology
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Projects 2007 2021
Simultaneously targeting airway contraction and fibrosis as a new therapeutic strategy for asthma
Bourke, J., Royce, S., Bardin, P., Westall, G., Grainge, C., Oliver, B., Samuel, C. & Wadsworth, S.
National Health & Medical Research Council (NHMRC)
1/01/19 → 31/12/21
Project: Research
Enhancing the anti-fibrotic and regenerative capacity of bone marrow-derived stem cells
Samuel, C., Ricardo, S., Widdop, R. & Kerr, P.
1/01/19 → 31/12/21
Project: Research
Evaluating novel therapeutics for chronic obstructive pulmonary disease
1/04/18 → 31/03/21
Project: Research
Pharmacological inhibition of IRAP as a novel antifibrotic strategy
Widdop, R., Samuel, C., Burrell, L., Chai, S. & Gaspari, T.
1/01/18 → 31/12/21
Project: Research
Unravelling fibrosis by pharmacological targeting of the G protein-coupled receptor, RXFP1
Hossain, M., Bathgate, R., Wade, J., Wade, J., Samuel, C., Yao, S., Rosengren, J. & Kocan, M.
National Health & Medical Research Council (NHMRC)
1/01/17 → 31/12/19
Project: Research
Research Output 1996 2019
AT1R-AT2R-RXFP1 functional crosstalk in myofibroblasts: Impact on the therapeutic targeting of renal and cardiac fibrosis
Chow, B. S. M., Kocan, M., Shen, M., Wang, Y., Han, L., Chew, J. Y., Wang, C., Bosnyak, S., Mirabito-Colafella, K. M., Barsha, G., Wigg, B., Johnstone, E. K. M., Hossain, M. A., Pfleger, K. D. G., Denton, K. M., Widdop, R. E., Summers, R. J., Bathgate, R. A. D., Hewitson, T. D. & Samuel, C. S., Sep 2019, (Accepted/In press) In : Journal of the American Society of Nephrology. 30, 9, 18 p.Research output: Contribution to journal › Article › Research › peer-review
Atypical cannabinoid ligands O-1602 and O-1918 administered chronically in diet-induced obesity
Simcocks, A. C., Jenkin, K. A., O’Keefe, L., Samuel, C. S., Mathai, M. L., McAinch, A. J. & Hryciw, D. H., Mar 2019, In : Endocrine Connections. 8, 3, p. 203-216 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Human amnion epithelial cells and their soluble factors reduce liver fibrosis in murine non-alcoholic steatohepatitis
Kuk, N., Hodge, A., Sun, Y., Correia, J., Alhomrani, M., Samuel, C., Moore, G., Lim, R. & Sievert, W., Aug 2019, In : Journal of Gastroenterology and Hepatology (Australia). 34, 8, p. 1441-1449 9 p.Research output: Contribution to journal › Article › Research › peer-review
iPSC- and mesenchymoangioblast-derived mesenchymal stem cells provide greater protection against experimental chronic allergic airways disease compared with a clinically used corticosteroid
Royce, S. G., Mao, W., Lim, R., Kelly, K. & Samuel, C. S., 1 May 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 5, p. 6402-6411 10 p.Research output: Contribution to journal › Article › Research › peer-review
Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension
Krishnan, S. M., Ling, Y. H., Huuskes, B. M., Ferens, D. M., Saini, N., Chan, C. T., Diep, H., Kett, M. M., Samuel, C. S., Kemp-Harper, B. K., Robertson, A. A. B., Cooper, M. A., Peter, K., Latz, E., Mansell, A. S., Sobey, C. G., Drummond, G. R. & Vinh, A., 15 Mar 2019, In : Cardiovascular Research. 115, 4, p. 776-787 12 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File