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Personal profile

Biography

Chrishan is a NHMRC Senior Research Fellow and Head of the Fibrosis Laboratory, Department of Pharmacology at Monash. Having been trained as a matrix biologist, his research is focused on identifying novel therapeutic targets and more direct and potent treatment strategies for fibrosis (organ scarring) prevention; particularly associated with cardiovascular, renal and allergic airways diseases. Chrishan's main interest has been to establish the anti-fibrotic and therapeutic potential of the naturally occurring hormone, relaxin. He additionally investigates other novel anti-fibrotics and repair factors, as well as combination therapies that may aid in tissue repair and regeneration, in collaboration with others.

Research area keywords

  • Fibrosis
  • Cardiovascular disease
  • Kidney Disease
  • Lung Disease
  • Stem Cell Biology

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Projects

Research Output

Open Access
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1 Citation (Scopus)

Targeting the NLRP3 inflammasome to treat cardiovascular fibrosis

Pinar, A. A., Scott, T. E., Huuskes, B. M., Tapia Cáceres, F. E., Kemp-Harper, B. K. & Samuel, C. S., May 2020, In : Pharmacology and Therapeutics. 209, 22 p., 107511.

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)

The anti-fibrotic actions of relaxin are mediated through AT2R-associated protein phosphatases via RXFP1-AT2R functional crosstalk in human cardiac myofibroblasts

Wang, C., Pinar, A. A., Widdop, R. E., Hossain, M. A., Bathgate, R. A. D., Denton, K. M., Kemp-Harper, B. K. & Samuel, C. S., 16 Apr 2020, (Accepted/In press) In : The FASEB Journal. 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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AT1R-AT2R-RXFP1 functional crosstalk in myofibroblasts: Impact on the therapeutic targeting of renal and cardiac fibrosis

Chow, B. S. M., Kocan, M., Shen, M., Wang, Y., Han, L., Chew, J. Y., Wang, C., Bosnyak, S., Mirabito-Colafella, K. M., Barsha, G., Wigg, B., Johnstone, E. K. M., Hossain, M. A., Pfleger, K. D. G., Denton, K. M., Widdop, R. E., Summers, R. J., Bathgate, R. A. D., Hewitson, T. D. & Samuel, C. S., 1 Jan 2019, In : Journal of the American Society of Nephrology. 30, 11, p. 2191-2207 17 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Atypical cannabinoid ligands O-1602 and O-1918 administered chronically in diet-induced obesity

Simcocks, A. C., Jenkin, K. A., O’Keefe, L., Samuel, C. S., Mathai, M. L., McAinch, A. J. & Hryciw, D. H., Mar 2019, In : Endocrine Connections. 8, 3, p. 203-216 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)