Projects per year
Personal profile
Biography
Chrishan is a NHMRC Senior Research Fellow and Head of the Fibrosis Laboratory, Department of Pharmacology at Monash. Having been trained as a matrix biologist, his research is focused on identifying novel therapeutic targets and more direct and potent treatment strategies for fibrosis (organ scarring) prevention; particularly associated with cardiovascular, renal and allergic airways diseases. Chrishan's main interest has been to establish the anti-fibrotic and therapeutic potential of the naturally occurring hormone, relaxin. He additionally investigates other novel anti-fibrotics and repair factors, as well as combination therapies that may aid in tissue repair and regeneration, in collaboration with others.
Research area keywords
- Fibrosis
- Cardiovascular disease
- Kidney Disease
- Lung Disease
- Stem Cell Biology
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Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects
Evaluating the therapeutic effects of Cynata-MSCs in a murine model of pulmonary fibrosis
4/03/20 → 30/09/20
Project: Research
Enhancing the anti-fibrotic and regenerative capacity of bone marrow-derived stem cells
Samuel, C., Ricardo, S., Widdop, R. & Kerr, P.
1/01/19 → 31/12/21
Project: Research
Simultaneously targeting airway contraction and fibrosis as a new therapeutic strategy for asthma
Bourke, J., Royce, S., Bardin, P., Westall, G., Grainge, C., Oliver, B., Samuel, C. & Wadsworth, S.
National Health & Medical Research Council (NHMRC)
1/01/19 → 31/12/21
Project: Research
Evaluating novel therapeutics for chronic obstructive pulmonary disease
1/04/18 → 31/03/21
Project: Research
Research Output
Inflammasomes—a molecular link for altered immunoregulation and inflammation mediated vascular dysfunction in preeclampsia
Murthi, P., Pinar, A. A., Dimitriadis, E. & Samuel, C. S., 19 Feb 2020, In : International Journal of Molecular Sciences. 21, 4, 18 p., 1406.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access
File
1
Citation
(Scopus)
Targeting the NLRP3 inflammasome to treat cardiovascular fibrosis
Pinar, A. A., Scott, T. E., Huuskes, B. M., Tapia Cáceres, F. E., Kemp-Harper, B. K. & Samuel, C. S., May 2020, In : Pharmacology and Therapeutics. 209, 22 p., 107511.Research output: Contribution to journal › Review Article › Research › peer-review
1
Citation
(Scopus)
The anti-fibrotic actions of relaxin are mediated through AT2R-associated protein phosphatases via RXFP1-AT2R functional crosstalk in human cardiac myofibroblasts
Wang, C., Pinar, A. A., Widdop, R. E., Hossain, M. A., Bathgate, R. A. D., Denton, K. M., Kemp-Harper, B. K. & Samuel, C. S., 16 Apr 2020, (Accepted/In press) In : The FASEB Journal. 17 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
AT1R-AT2R-RXFP1 functional crosstalk in myofibroblasts: Impact on the therapeutic targeting of renal and cardiac fibrosis
Chow, B. S. M., Kocan, M., Shen, M., Wang, Y., Han, L., Chew, J. Y., Wang, C., Bosnyak, S., Mirabito-Colafella, K. M., Barsha, G., Wigg, B., Johnstone, E. K. M., Hossain, M. A., Pfleger, K. D. G., Denton, K. M., Widdop, R. E., Summers, R. J., Bathgate, R. A. D., Hewitson, T. D. & Samuel, C. S., 1 Jan 2019, In : Journal of the American Society of Nephrology. 30, 11, p. 2191-2207 17 p.Research output: Contribution to journal › Article › Research › peer-review
3
Citations
(Scopus)
Atypical cannabinoid ligands O-1602 and O-1918 administered chronically in diet-induced obesity
Simcocks, A. C., Jenkin, K. A., O’Keefe, L., Samuel, C. S., Mathai, M. L., McAinch, A. J. & Hryciw, D. H., Mar 2019, In : Endocrine Connections. 8, 3, p. 203-216 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
2
Citations
(Scopus)