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Personal profile


Dr Smedley is an early career researcher with an emerging track record in click chemistry, diversity oriented clicking, drug discovery and functionalisation, and medicinal chemistry.

Since joining MIPS in 2020, Dr Smedley has been working on an ARC Discovery grant funded program targeting novel biased bitopic ligands acting at the A1 adenosine receptor as potential cardioprotective agents. He has also prepared series of new A2BR agonists and A1R positive allosteric modulators.

In other research areas, Dr Smedley conceived a novel click chemistry concept, termed Diversity Oriented Clicking which exploits the reliability of click chemistry to achieve complex molecular frameworks with ease. Dr Smedley has also discovered and developed multiple sulfur fluoride exchange (SuFEx) click chemistry methodologies including the establishment of a new SuFEx hub (1-bromoethene-1-sulfonyl fluoride) and a new amide coupling procedure for the synthesis of challenging amides.

Dr Smedley’s commitment to excellence in research can be exemplified through the high standard of impactful research I have performed as shown by a publication record in top peer-reviewed journals (Angew. Chem. Int. Ed., Proc. Natl. Acad. Sci. U.S.A., Chem. Commun. and Chem. Eur. J.).

Research Interests

  • Click Chemistry
  • Sulfur Fluoride Exchange
  • Diversity Oriented Clicking
  • Allosteric modulators and bitopic ligands acting at G protein-coupled receptors

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Organic and Medicinal Chemistry, PhD, Developing sulfur-fluoride exchange click chemistry, La Trobe University

Award Date: 18 Dec 2018

Medicinal and Biological Chemistry, MSci, University of Nottingham

Award Date: 15 Jul 2013

External positions

Postdoctoral Research Associate, La Trobe University

1 Aug 201831 Oct 2020

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or