Chris Greening

Assoc Professor

Accepting PhD Students

20142022
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Personal profile

Biography

Chris studied Molecular and Cellular Biochemistry at the University of Oxford before heading down under to complete his PhD in Molecular Microbiology at the University of Otago. Completed in 2013, his doctoral research focused on unravelling the physiological roles of the enzymes responsible for H2 metabolism in environmental and pathogenic mycobacteria. He subsequently gained postdoctoral experience in Microbial Ecology and Molecular Evolution at the University of Otago, CSIRO, and the Australian National University. Chris joined Monash University as a lecturer in June 2016. He is affiliated with the Centre for Geometric Biology.

Chris’ research group (the Integrative Microbiology Lab) explores how bacteria persist under adverse environmental conditions. Bacteria are able to dominate practically all ecosystems due to their unprecedented ability to enter dormant states that resist environmental change. The Greening lab is interested in understanding the metabolic processes that enable aerobic bacteria to remain energised and survive stress in these dormant states. Towards this goal, they have identified multiple novel mechanisms through which aerobic bacteria survive starvation, hypoxia, and oxidative stress. The group employs a wide range of techniques to explore biological processes from enzymes to ecosystems, including bacterial culturing, genetic dissection, protein biochemistry, and environmental surveys.

Chris’ research is centred on two main themes. His environmental research is exploring the physiological and ecological significance of microbial metabolism of reduced gases, i.e. hydrogen, methane, and carbon monoxide. This research has shown that soil bacteria can enhance their long-term survival by scavenging trace gases from the atmosphere. He is exploring the significance of trace gas scavenging and other hydrogen-dependent processes in relation to microbial community structure and greenhouse gas cycling. His medical research is centred on identifying new drug targets for the treatment of tuberculosis, which continues to cause 1.5 million deaths per year. Through this research, he has shown that multiple hypothetical proteins upregulated by mycobacteria during stress-inducing conditions are critical for maintaining redox and ion homeostasis.

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Projects 2017 2022

Research Output 2014 2019

  • 34 Article
  • 4 Review Article
  • 2 Chapter (Book)
  • 1 Encyclopaedia / Dictionary Entry

A revised biosynthetic pathway for the cofactor F420 in prokaryotes

Bashiri, G., Antoney, J., Jirgis, E. N. M., Shah, M. V., Ney, B., Copp, J., Stuteley, S. M., Sreebhavan, S., Palmer, B., Middleditch, M., Tokuriki, N., Greening, C., Scott, C., Baker, E. N. & Jackson, C. J., 1 Dec 2019, In : Nature Communications. 10, 1, 12 p., 1558.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Bacterial fermentation and respiration processes are uncoupled in anoxic permeable sediments

Kessler, A. J., Chen, Y-J., Waite, D. W., Hutchinson, T. F., Koh, S., Popa, M. E., Beardall, J., Hugenholtz, P., Cook, P. & Greening, C. A., 31 Jan 2019, (Accepted/In press) In : Nature Microbiology. 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

FAD-sequestering proteins protect mycobacteria against hypoxic and oxidative stress

Harold, L. K., Antoney, J., Ahmed, F. H., Hards, K., Carr, P. D., Rapson, T., Greening, C., Jackson, C. J. & Cook, G. M., 1 Jan 2019, In : Journal of Biological Chemistry. 294, 8, p. 2903-2912 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Metabolic potential of uncultured bacteria and archaea associated with petroleum seepage in deep-sea sediments

Dong, X., Greening, C., Rattray, J. E., Chakraborty, A., Chuvochina, M., Mayumi, D., Dolfing, J., Li, C., Brooks, J. M., Bernard, B. B., Groves, R. A., Lewis, I. A. & Hubert, C. R. J., 18 Apr 2019, In : Nature Communications. 10, 1, 12 p., 1816.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Proposal of the reverse flow model for the origin of the eukaryotic cell based on comparative analyses of Asgard archaeal metabolism

Spang, A., Stairs, C. W., Dombrowski, N., Eme, L., Lombard, J., Caceres, E. F., Greening, C., Baker, B. J. & Ettema, T. J. G., 1 Jan 2019, (Accepted/In press) In : Nature Microbiology. 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access