Cheow Yuen Lin

Accepting PhD Students

PhD projects

Project Tittle
Imidazole-Based Chemosensors for Dual Detection of Cation and Anion: Synthesis, Characterization, and Photophysical Investigations
Description of the project:
Imidazole and benzimidazole are very important compounds with interesting frameworks commonly found in natural products such as alkaloids. The imidazole ring is ubiquitous in nature and the imidazole backbone plays a critical role in many structures within the human body, notably histamine and histidine. Imidazole can form many biochemical interactions such as hydrogen bonding with biomolecules and carbonyl compounds. Recent important development of imidazolium salts has been reported in areas such as receptors for the recognition of various anions, cations, and neutral molecules. Another major area that was explored in the last decade is surfactants and ionic liquids, due to the construction of self-assembled aggregates such as micelles and vesicles in water. Numerous imidazolium salts derivatives have also been reported to display many biological activities. The project aims to develop a novel chemosensor based on imidazole derivatives for the detection and recognition of both cationic and anionic species in solution. The successful candidate will be involved in these chemosensors' design, synthesis, characterization, and evaluation. The project offers a unique opportunity to explore the field of supramolecular chemistry and its applications in sensing and analytical sciences.
Skills acquired: Organic Synthesis, Analytical Chemistry, Chemical Sensing, Chromatography, NMR Spectroscopy.

Reference:
1. J. Krämer, R. Kang, L. M. Grimm, L. De Cola, P. Picchetti, F. Biedermann, Chem. Rev. 2022, 122, 3459−3636.
2. a) V. Kumar, H. Kim, B. Pandey, T. D. James, J. Yoon, E. V. Anslyn, Chem. Soc. Rev. 2023, 52, 663-704. b) W.-Q. Meng, A. C. Sedgwick, N. Kwon, M. Sun, K. X., X-P. He, E V. Anslyn, T. D. James, J. Yoon, Chem. Soc. Rev. 2023, 52, 601-662.
3. B. Kaur, N. Kaur, S. Kumar, Coord. Chem. Rev. 2018, 358, 13-69.
4. A. Roy, M. Nandi, P. Roy, Trends Anal. Chem. 2021,138, 116204.
5. S. Ghosh, A. Ganguly, Md. Raihan Uddin, S. Mandal, Md. Akhtarul Alam, Nikhil Guchhait, Dalton Trans., 2016, 45, 11042
6. a) M. H. Mahnashi, A. M. Mahmoud, S. A. Alkahtani, R. Ali, M. M. El-Wekil, Spectrochim. Acta, Part A, 2020, 228, 117846. b) Z. Xu, S. K. Kim, J. Yoon, Chem. Soc. Rev., 2010, 39, 1457–1466. c) A. Singh, S. Sharma, N. Kaur, N. Singh, New J. Chem., 2020, 44, 19360.

Eligibility:
Applications are invited from students with an appropriate background in Analytical/Organic Chemistry/Chemistry or related disciplines. Applicants should have an interest in synthetic and analytical chemistry. The candidates must be highly motivated individuals with the ability to conduct high-quality independent research, possess strong organizational skills, good command of written and verbal communication skills (English), and is able to work well with others. Candidates should have received at least H1 or H2A in their first degree (4 years; equivalent to one year of Australian Honours) and/or MSc degree with significant research component. The position is available only to Malaysian graduate.
Admission Criteria http://www.monash.edu.au/migr/research-degrees/handbook/chapter-two/2-1.html
English Language Proficiency http://www.monash.edu.au/migr/research-degrees/handbook/chapter-two/2-2.html
Level Of Support:
A full studentship is available on a competitive basis. Full tuition fee waiver will be provided for successful applicant.
Closing Date:
Application is on a first come first serve basis. Once a suitable candidate is found, the application will be closed.
To Apply:
Only eligible candidate should write in application and resume directly to:
(Dr Cheow Yuen Lin)
Senior Lecturer,
School of Science,
Monash University Malaysia.
Email: [email protected]
Tel no.: +603-5514 4401
Fax no.: +603-55146364