20072024

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2020

Annexin-A1 deficiency exacerbates pathological remodelling of the mesenteric vasculature in insulin-resistant, but not insulin-deficient, mice

Jelinic, M., Kahlberg, N., Leo, C. H., Ng, H. H., Rosli, S., Deo, M., Li, M., Finlayson, S., Walsh, J., Parry, L. J., Ritchie, R. H. & Qin, C. X., 1 Apr 2020, In : British Journal of Pharmacology. 177, 7, p. 1677-1691 15 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Nitric Oxide Resistance, Induced in the Myocardium by Diabetes, Is Circumvented by the Nitric Oxide Redox Sibling, Nitroxyl

Qin, C. X., Anthonisz, J., Leo, C. H., Kahlberg, N., Velagic, A., Li, M., Jap, E., Woodman, O. L., Parry, L. J., Horowitz, J. D., Kemp-Harper, B. K. & Ritchie, R. H., 1 Jan 2020, In : Antioxidants and Redox Signaling. 32, 1, p. 60-78 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Relaxin reduces endothelium-derived vasoconstriction in hypertension: Revealing new therapeutic insights

Leo, C. H., Ng, H. H., Marshall, S. A., Jelinic, M., Rupasinghe, T., Qin, C., Roessner, U., Ritchie, R. H., Tare, M. & Parry, L. J., Jan 2020, In : British Journal of Pharmacology. 177, 1, p. 217-233 17 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

The novel small-molecule annexin-a1 mimetic, compound 17b, elicits vasoprotective actions in streptozotocin-induced diabetic mice

Marshall, S. A., Qin, C. X., Jelinic, M., O’sullivan, K., Deo, M., Walsh, J., Li, M., Parry, L. J., Ritchie, R. H. & Leo, C. H., 2 Feb 2020, In : International Journal of Molecular Sciences. 21, 4, 21 p., 1384.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Therapeutic Potential of Lipoxin A4 in Chronic Inflammation: Focus on Cardiometabolic Disease

Fu, T., Mohan, M., Brennan, E. P., Woodman, O. L., Godson, C., Kantharidis, P., Ritchie, R. H. & Qin, C., 17 Jan 2020, In : ACS Pharmacology and Translational Sciences. 3, 1, p. 43-55 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2019

Cardioprotective actions of the annexin-A1 N-terminal peptide, AC2-26, against myocardial infarction

Qin, C. X., Rosli, S., Deo, M., Cao, N., Walsh, J., Tate, M., Alexander, A. E., Donner, D., Horlock, D., Li, R., Kiriazis, H., Lee, M. K. S., Bourke, J. E., Yang, Y., Murphy, A. J., Du, X-J., Gao, X. M. & Ritchie, R. H., 3 Apr 2019, In : Frontiers in Pharmacology. 10, 16 p., 269.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
7 Citations (Scopus)

Characterising an Alternative Murine Model of Diabetic Cardiomyopathy

Tate, M., Prakoso, D., Willis, A. M., Peng, C., Deo, M., Qin, C. X., Walsh, J. L., Nash, D. M., Cohen, C. D., Rofe, A. K., Sharma, A., Kiriazis, H., Donner, D. G., De Haan, J. B., Watson, A. M. D., De Blasio, M. J. & Ritchie, R. H., 14 Nov 2019, In : Frontiers in Physiology. 10, 15 p., 1395.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Novel Role for the AnxA1-Fpr2/ALX Signaling Axis as a Key Regulator of Platelet Function to Promote Resolution of Inflammation

Senchenkova, E. Y., Ansari, J., Becker, F., Vital, S. A., Al-Yafeai, Z., Sparkenbaugh, E. M., Pawlinski, R., Stokes, K. Y., Carroll, J. L., Dragoi, A. M., Qin, C. X., Ritchie, R. H., Sun, H., Cuellar-Saenz, H. H., Rubinstein, M. R., Han, Y. W., Orr, A. W., Perretti, M., Granger, D. N. & Gavins, F. N. E., 23 Jul 2019, In : Circulation. 140, 4, p. 319-335 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
7 Citations (Scopus)

Substituted Pyridazin-3(2 H)-ones as Highly Potent and Biased Formyl Peptide Receptor Agonists

Deora, G. S., Qin, C. X., Vecchio, E. A., Debono, A. J., Priebbenow, D. L., Brady, R. M., Beveridge, J., Teguh, S. C., Deo, M., May, L. T., Krippner, G., Ritchie, R. H. & Baell, J. B., 23 May 2019, In : Journal of Medicinal Chemistry. 62, 10, p. 5242-5248 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Diastolic dysfunction is more apparent in STZ-induced diabetic female mice, despite less pronounced hyperglycemia

Chandramouli, C., Reichelt, M. E., Curl, C. L., Varma, U., Bienvenu, L. A., Koutsifeli, P., Raaijmakers, A. J. A., De Blasio, M. J., Qin, C. X., Jenkins, A. J., Ritchie, R. H., Mellor, K. M. & Delbridge, L. M. D., 1 Dec 2018, In : Scientific Reports. 8, 1, 13 p., 2346.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
4 Citations (Scopus)

Distinct contributions of hyperglycemia and high-fat feeding in metabolic syndrome-induced neuroinflammation

Wanrooy, B. J., Kumar, K. P., Wen, S. W., Qin, C. X., Ritchie, R. H. & Wong, C. H. Y., 22 Oct 2018, In : Journal of Neuroinflammation. 15, 1, 13 p., 293.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
4 Citations (Scopus)
2017

Capadenoson, a clinically trialed partial adenosine A1 receptor agonist, can stimulate adenosine A2B receptor biased agonism

Baltos, J-A., Vecchio, E. A., Harris, M. A., Qin, C. X., Ritchie, R. H., Christopoulos, A., White, P. J. & May, L. T., 1 Jul 2017, In : Biochemical Pharmacology. 135, p. 79–89 11 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Endogenous Annexin-A1 Regulates Haematopoietic Stem Cell Mobilisation and Inflammatory Response Post Myocardial Infarction in Mice in Vivo

Qin, C. X., Finlayson, S. B., Ai-Sharea, A., Tate, M., De Blasio, M. J., Deo, M., Rosli, S., Prakoso, D., Thomas, C. J., Kiriazis, H., Gould, E., Yang, Y. H., Morand, E. F., Perretti, M., Murphy, A. J., Du, X. J., Gao, X. M. & Ritchie, R. H., 1 Dec 2017, In : Scientific Reports. 7, 1, 14 p., 16615.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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13 Citations (Scopus)

Insights into the role of maladaptive hexosamine biosynthesis and O-GlcNAcylation in development of diabetic cardiac complications

Qin, C. X., Sleaby, R., Davidoff, A. J., Bell, J. R., De Blasio, M. J., Delbridge, L. M., Chatham, J. C. & Ritchie, R. H., 1 Feb 2017, In : Pharmacological Research. 116, p. 45-56 12 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Phosphoinositide 3-kinase (p110α) gene delivery limits diabetes-induced cardiac NADPH oxidase and cardiomyopathy in a mouse model with established diastolic dysfunction

Prakoso, D., De Blasio, M. J., Qin, C., Rosli, S., Kiriazis, H., Qian, H., Du, X-J., Weeks, K. L., Gregorevic, P., McMullen, J. R. & Ritchie, R. H., 7 Jun 2017, In : Clinical Science. 131, 12, p. 1345-1360 16 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Serelaxin treatment reverses vascular dysfunction and left ventricular hypertrophy in a mouse model of Type 1 diabetes

Ng, H. H., Leo, C. H., Prakoso, D., Qin, C., Ritchie, R. H. & Parry, L. J., 9 Jan 2017, In : Scientific Reports. 7, 15 p., 39604 .

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
22 Citations (Scopus)

Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice

Qin, C. X., May, L. T., Li, R., Cao, N., Rosli, S., Deo, M., Alexander, A. E., Horlock, D., Bourke, J. E., Yang, Y. H., Stewart, A. G., Kaye, D. M., Du, X. J., Sexton, P. M., Christopoulos, A., Gao, X. M. & Ritchie, R. H., 7 Feb 2017, In : Nature Communications. 8, 13 p., 14232.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
29 Citations (Scopus)
2016

Adverse vascular remodelling is more sensitive than endothelial dysfunction to hyperglycaemia in diabetic rat mesenteric arteries

Kahlberg, N., Qin, C. X., Anthonisz, J., Jap, E., Ng, H. H., Jelinic, M., Parry, L. J., Kemp-Harper, B. K., Ritchie, R. H. & Leo, C. H., 1 Sep 2016, In : Pharmacological Research. 111, p. 325-335 11 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

The HNO donor Angeli's salt offers potential haemodynamic advantages over NO or dobutamine in ischaemia-reperfusion injury in the rat heart ex vivo

Chin, K. Y., Michel, L., Qin, C. X., Cao, N., Woodman, O. L. & Ritchie, R. H., 1 Feb 2016, In : Pharmacological Research. 104, p. 165-175 11 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)
2015

Cardioprotective potential of annexin-A1 mimetics in myocardial infarction

Qin, C. H., Yang, Y. H., May, L. T., Gao, X-M., Stewart, A. G., Tu, Y., Woodman, O. L. & Ritchie, R. H., 2015, In : Pharmacology and Therapeutics. 148, p. 47 - 65 19 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Chronic administration of the nitroxyl donor 1-nitrosocyclo hexyl acetate limits left ventricular diastolic dysfunction in a mouse model of diabetes mellitus in vivo

Cao, N., Wong, Y. G., Rosli, S., Kiriazis, H., Huynh, K., Qin, C. H., Du, X-J., Kemp-Harper, B. K. & Ritchie, R. H., 2015, In : Circulation: Heart Failure. 8, 3, p. 572 - 581 10 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Therapeutic targeting of oxidative stress with coenzyme Q10 counteracts exaggerated diabetic cardiomyopathy in a mouse model of diabetes with diminished PI3K(p110alpha) signaling

De Blasio, M. J., Huynh, K. N. N., Qin, C. H., Rosli, S., Kiriazis, H., Ayer, A., Cemerlang, N., Stocker, R., Du, X-J., McMullen, J. R. & Ritchie, R. H., 2015, In : Free Radical Biology and Medicine. 87, (Art. No:12407), p. 137 - 147 11 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)
2014
16 Citations (Scopus)
2013

HNO/cGMP-dependent antihypertrophic actions of isopropylamine-NONOate in neonatal rat cardiomyocytes: potential therapeutic advantages of HNO over NO

Irvine, J. C., Cao, N., Gossain, S., Alexander, A. E., Love, J. E., Qin, C., Horowitz, J. D., Harper, B. K. & Ritchie, R. H., 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 305, 3, p. 365 - 377 13 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Low intrinsic exercise capacity in rats predisposes to age-dependent cardiac remodeling independent of macrovascular function

Ritchie, R. H., Leo, C. H., Qin, C., Stephenson, E. J., Bowden, M. A., Buxton, K. D., Lessard, S. J., Rivas, D. A., Koch, L. G., Britton, S. L., Hawley, J. A. & Woodman, O. L., 11 Mar 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 304, 5

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Plasminogen-stimulated inflammatory cytokine production by airway smooth muscle cells is regulated by annexin A2

Schuliga, M., Langenbach, S. Y., Xia, Y., Qin, C., Mok, J., Harris, T., Mackay, G., Medcalf, R. L. & Stewart, A. G., 2013, In : American Journal of Respiratory Cell and Molecular Biology. 49, 5, p. 751 - 758 8 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Reperfusion-induced myocardial dysfunction is prevented by endogenous annexin-A1 and its N-terminal-derived peptide Ac-ANX-A1{2-26}

Qin, C., Buxton, K. D., Pepe, S., Cao, A., Venardos, K. M., Love, J. E., Kaye, D. M., Yang, Y. H., Morand, E. F. & Ritchie, R. H., 2013, In : British Journal of Pharmacology. 168, 1, p. 238 - 252 15 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Transforming growth factor-β-Induced differentiation of airway smooth muscle cells is inhibited by fibroblast growth factor-2

Schuliga, M., Javeed, A., Harris, T., Xia, Y., Qin, C., Wang, Z., Zhang, X., Lee, P. V. S., Camoretti-Mercado, B. & Stewart, A. G., Mar 2013, In : American Journal of Respiratory Cell and Molecular Biology. 48, 3, p. 346-353 8 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)
2012

2-Morpholinoisoflav-3-enes as flexible intermediates in the synthesis of phenoxodiol, isophenoxodiol, equol and analogues: Vasorelaxant properties, estrogen receptor binding and Rho/RhoA kinase pathway inhibition

Tilley, A. J., Zanatta, S. D., Qin, C. X., Kim, I. K., Seok, Y. M., Stewart, A., Woodman, O. L. & Williams, S. J., 1 Apr 2012, In : Bioorganic & Medicinal Chemistry. 20, 7, p. 2353-2361 9 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Enhanced phosphoinositide 3-kinase(p110α) activity prevents diabetes-induced cardiomyopathy and superoxide generation in a mouse model of diabetes

Ritchie, R. H., Love, J. E., Huynh, K., Bernardo, B. C., Henstridge, D. C., Kiriazis, H., Tham, Y. K., Sapra, G., Qin, C., Cemerlang, N., Boey, E. J. H., Jandeleit-Dahm, K., Du, X. J. & McMullen, J. R., Dec 2012, In : Diabetologia. 55, 12, p. 3369-3381 13 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)
2011

Antioxidant activity contributes to flavonol cardioprotection during reperfusion of rat hearts

Qin, C. X., Williams, S. J. & Woodman, O. L., 1 Oct 2011, In : Free Radical Biology and Medicine. 51, 7, p. 1437-1444 8 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)
2010

Effects of resveratrol and flavonols on cardiovascular function: Physiological mechanisms

Yap, S., Qin, C. & Woodman, O. L., 1 Sep 2010, In : BioFactors. 36, 5, p. 350-359 10 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)
2008

Understanding the cardioprotective effects of flavonols: Discovery of relaxant flavonols without antioxidant activity

Cheng, X. Q., Chen, X., Hughes, R. A., Williams, S. J. & Woodman, O. L., 27 Mar 2008, In : Journal of Medicinal Chemistry. 51, 6, p. 1874-1884 11 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)
2007

The red wine antioxidant resveratrol prevents cardiomyocyte injury following ischemia-reperfusion via multiple sites and mechanisms

Goh, S. S. C., Woodman, O. L., Pepe, S., Cao, A. H., Qin, C. & Ritchie, R. H., 2007, In : Antioxidants and Redox Signaling. 9, 1, p. 101 - 113 13 p.

Research output: Contribution to journalArticleResearchpeer-review

65 Citations (Scopus)