Projects per year
Personal profile
Biography
Dr Chengxue Helena Qin is the Laboratory Head and National Heart Foundation Future Fellow at Monash University and holds adjunct appointments at the Baker Heart and Diabetes Institute and the University of Melbourne. She is an emerging translational pharmacologist, with combined expertise in rational drug design, medicinal chemistry and pre-clinical models for cardiovascular diseases.
Dr Qin completed her B.BioMed. and PhD at Department of Pharmacology and Therapeutics and School of Chemistry at the University of Melbourne in 2010, before taking up a post-doctoral position at the Baker Heart and Diabetes Institute in 2011, and promoted to the Group Leader in 2017 and awarded with a 5-year Baker Fellowship in the same year. She has recently been recruited to Drug Discovery Biology Theme at Monash Institute of Pharmaceutical Science (Monash Parkville Campus) to establish her independent laboratory, focusing on developing effective and innovative treatments for cardiovascular disease.
Research interests
Her current research focuses on formyl peptide receptors, a group of G-Protein-Coupled-Receptor involved in the regulation and resolution of inflammation. Dr Qin provided the first evidence that selectively engaging beneficial pathways at this receptor have significant therapeutic and translational potential against a range of cardiovascular disease. She has almost 40 publications including those in Nature Communications, Circulation, British Journal of Pharmacology, Journal of Medicinal Chemistry, Pharmacology and Therapeutics etc. She has attracted research funding from NHMRC, National Heart Foundation, Diabetes Australia Research Program, JDRF, CASS Foundation. Her achievements have also been recognized by numerous prestigious awards including National Heart Foundation Future Leader (2020-2023), JDRF Future Leader (2018-2019), Baker Fellow (2018-2022), Best Early Career Scientist at International Society for Heart Research (2017), Ralph Reader Prize (Basic Science, 2016), BPS/ASCEPT Outstanding Young Investigator Award (2015).
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Pharmacology, PhD, Investigation of the mechanisms of the cardioprotective effects of flavonols, University of Melbourne
1 Mar 2006 → 20 Aug 2010
Award Date: 20 Aug 2010
Pharmacology, Bachelor of Science (First Class Honours) , Quantitative structure-activity relationships of 3’, 4’- substituted flavonols, University of Melbourne
17 Feb 2005 → 31 Dec 2005
Award Date: 31 Dec 2005
Pharmacology, Bachelor of Biomedical Science, Drug Discovery (Pharmacology and Medicinal Chemistry), University of Melbourne
1 Mar 2002 → 31 Dec 2004
Award Date: 31 Dec 2004
External positions
Baker Heart and Diabetes Institute
Research area keywords
- translational pharmacology
- Cardiovascular disease
- GPCR biology
Collaborations and top research areas from the last five years
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Endothelial Cells: an Underappreciated Therapeutic Target in HFpEF
Ritchie, R., Figtree, G. A., May, L. & Qin, C. H.
1/01/23 → 31/12/24
Project: Research
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Therapeutic Targeting of Formyl Peptide Receptors to Treat Cardiovascular Disease
1/04/20 → 31/03/24
Project: Research
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Exploiting Biased Agonists of Formyl Peptide Receptors as Pharmacotherapy for Pulmonary Hypertension: simultaneous targeting of vascular function and remodelling
Qin, C. H., Jackson, K. L. & Woodman, O. L.
1/04/20 → 31/12/23
Project: Research
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Advancing Preclinical Development of Novel GPCR-targeted Therapeutics for Heart Failure
Ritchie, R., Baell, J., Figtree, G., Qin, C. H., May, L., Nicholls, S., Taylor, A., Yang, J. Y. H., Shackleford, D., Schiattarella, G., Pinto, A., Drummond, G., Horowitz, J. D., Bubb, K., Ng, H. H., Vecchio, L., Nelson, A., Kirkpatrick, C., McDonald, C., Febbraio, M., Vinh, A., Odiba, J. & Brown, H.
Project: Research
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Developing Novel Pro-Resolving Medicines to Treat Vulnerable Atherosclerotic Plaques
14/09/22 → 31/03/23
Project: Research
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A high-sucrose diet exacerbates the left ventricular phenotype in a high fat-fed streptozotocin rat model of diabetic cardiomyopathy
Velagic, A., Li, M., Deo, M., Li, J. C., Kiriazis, H., Donner, D. G., Anderson, D., De Blasio, M. J., Woodman, O. L., Kemp-Harper, B. K., Qin, C. X. & Ritchie, R. H., Feb 2023, In: American Journal of Physiology - Heart and Circulatory Physiology. 324, 2, p. H241-H257 17 p.Research output: Contribution to journal › Article › Research › peer-review
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Endothelium-dependent relaxation is impaired in Schlager hypertensive (BPH/2J) mice by region-specific mechanisms in conductance and resistance arteries
Jelinic, M., Jackson, K. L., O'Sullivan, K., Singh, J., Giddy, T., Deo, M., Parry, L. J., Ritchie, R. H., Woodman, O. L., Head, G. A., Leo, C. H. & Qin, C. X., 1 May 2023, In: Life Sciences. 320, 15 p., 121542.Research output: Contribution to journal › Article › Research › peer-review
3 Citations (Scopus) -
Relaxin elicits renoprotective actions accompanied by increasing bile acid levels in streptozotocin-induced diabetic mice
Leo, C. H., Ou, J. L. M., Ong, E. S., Qin, C. X., Ritchie, R. H., Parry, L. J. & Ng, H. H., Jun 2023, In: Biomedicine & Pharmacotherapy. 162, 9 p., 114578.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus) -
Targeting G protein-coupled receptors for heart failure treatment
Thai, B. S., Chia, L. Y., Nguyen, A. T. N., Qin, C., Ritchie, R. H., Hutchinson, D. S., Kompa, A., White, P. J. & May, L. T., 24 Apr 2023, (Accepted/In press) In: British Journal of Pharmacology. 17 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access -
Cardioprotective actions of nitroxyl donor Angeli's salt are preserved in the diabetic heart and vasculature in the face of nitric oxide resistance
Velagic, A., Li, J. C., Qin, C. X., Li, M., Deo, M., Marshall, S. A., Anderson, D., Woodman, O. L., Horowitz, J. D., Kemp-Harper, B. K. & Ritchie, R. H., Aug 2022, In: British Journal of Pharmacology. 179, 16, p. 4117-4135 19 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus)
Press/Media
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Faculty of Opinions recommendation
Jennifer Payne, Max Cryle, Julien Tailhades, Alex Fulcher, Felix Ellett, Daniel Irima, Xenia Kostoulias, Ryan Leung, Steph Louch, Amy Tran, Severin Weber, Ralf Schittenhelm, Graham Lieschke, Chengxue Helena Qin, Anton Peleg & Ting Fu
3/12/21
1 item of Media coverage
Press/Media: Article/Feature