Projects per year
Personal profile
Biography
Dr. Chenglong Yu is a genetic epidemiologist and statistical geneticist, serving as a Senior Research Fellow with the Public Health Genomics group at the School of Public Health and Preventive Medicine, and as an Adjunct Senior Research Fellow at the Victorian Heart Institute (VHI), Monash University. His expertise spans genome-wide association studies, polygenic risk scores, population genetics, genotype-environment interactions, risk prediction, and epigenetics. Dr. Yu currently oversees the genomics research programs for the ASPirin in Reducing Events in the Elderly (ASPREE) study, Australia’s largest randomized controlled trial and genomic cohort focused on aging.
Chenglong’s research journey began with a strong foundation in mathematics (B.Sc., M.Sc., and Ph.D.). During his Ph.D. at the Chinese University of Hong Kong and his early postdoctoral work at the University of Illinois Chicago, he focused on the mathematical theories and applications of molecular evolution and phylogenetics. In recent years, his research has shifted entirely to genetic epidemiology and statistical genetics, leading to substantial publication outputs and successful research funding. Chenglong is deeply gratified that his work directly contributes to advancing human health and remains committed to long-term engagement in this impactful field.
Chenglong's research focuses on exploring the effect of genetic factors on a range of complex diseases. As the leading author, he has published his findings in high-profile journals across various fields, including major depression (Transl Psychiatry 2017, 2018; J Affect Disord 2017, 2018 [2]; Psychiatry Res 2017), cancer (Cancer Epidemiol Biomarkers Prev 2021; Cancers 2021; Epigenetics 2022), cardiovascular disease (JAHA 2023; JACC: Advances 2024; Eur Heart J Cardiovasc Pharmacother 2025), dementia (Alzheimer's & Dementia 2023), age-related macular degeneration (Ophthalmology 2024), and women's health (eBioMedicine 2024), among others.
Research interests
- Genetic Epidemiology
- Statistical Genetics
- Bioinformatics
- Biostatistics
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Mathematics, Ph.D., Chinese University of Hong Kong
Mathematics, M.Sc., Zhejiang University
External positions
Adjunct Senior Research Fellow - Victorian Heart Institute, Victorian Heart Hospital
Jan 2025 → …
Research area keywords
- GWAS
- Polygenic risk score
- Ageing
- ASPREE
- Cardiovascular diseases
- Cancer epidemiology
- Dementia
- Genomic epidemiology
- Major depression
- Prediction Analysis
- Heritability
- Population genetics and genomics
- Genomic medicine
- Epigenetics
- Age-related macular degeneration
- Risk stratification
- DNA methylation
Collaborations and top research areas from the last five years
Projects
- 1 Active
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Precision prevention of cardiovascular disease using genomic risk stratification
Yu, C. (Primary Chief Investigator (PCI)), Lacaze, P. (Chief Investigator (CI)), Nicholls, S. (Chief Investigator (CI)) & McNeil, J. (Chief Investigator (CI))
1/01/25 → 31/12/26
Project: Research
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Concentration and genetic regulation of sex hormone binding globulin and fracture risk in older women
Wang, Y., Yu, C., Islam, R. M., Hussain, S. M., Barker, A. L., Lacaze, P., McNeil, J. J. & Davis, S. R., 2025, In: Climacteric. 28, 2, p. 184-190 7 p.Research output: Contribution to journal › Article › Research › peer-review
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Association of plasma high-density lipoprotein cholesterol level with risk of incident dementia: a cohort study of healthy older adults
Hussain, S. M. (Leading Author), Robb, C., Tonkin, A. M., Lacaze, P., Chong, T. T. J., Beilin, L. J., Yu, C., Watts, G. F., Ryan, J., Ernst, M. E., Zhou, Z., Neumann, J. T. & McNeil, J. J., Feb 2024, In: The Lancet Regional Health - Western Pacific. 43, p. 1-9 9 p., 100963.Research output: Contribution to journal › Article › Research › peer-review
Open Access11 Citations (Scopus) -
Genome-wide association study identifies genetic regulation of oestrone concentrations and association with endometrial cancer risk in postmenopausal women
Yu, C., Bakshi, A., Bell, R. J., Islam, R. M., Handelsman, D. J., McNeil, J. J., Lacaze, P. & Davis, S. R. (Leading Author), Mar 2024, In: EBioMedicine. 101, 11 p., 104997.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Predictive Performance of an Updated Polygenic Risk Score for Age-Related Macular Degeneration
Yu, C., Robman, L., He, W., Woods, R. L., Phuong Thao, L. T., Wolfe, R., Phung, J., Makeyeva, G. A., Hodgson, L. A. B., McNeil, J. J., Guymer, R. H., MacGregor, S. & Lacaze, P., Aug 2024, In: Ophthalmology. 131, 8, p. 880-891 12 p.Research output: Contribution to journal › Article › Research › peer-review
3 Citations (Scopus) -
Reduced Ejection Fraction in Elite Endurance Athletes: Clinical and Genetic Overlap With Dilated Cardiomyopathy
Claessen, G., De Bosscher, R., Janssens, K., Young, P., Dausin, C., Claeys, M., Claus, P., Goetschalckx, K., Bogaert, J., Mitchell, A. M., Flannery, M. D., Elliott, A. D., Yu, C., Ghekiere, O., Robyns, T., Van De Heyning, C. M., Sanders, P., Kalman, J. M., Ohanian, M. & Soka, M. & 10 others, , 30 Apr 2024, In: Circulation. 149, 18, p. 1405-1415 11 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Citations (Scopus)