• 15 Innovation Walk, 75

    3800 Clayton

1985 …2021
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Research Output 1985 2019

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Article
2009
48 Citations (Scopus)

Lineage specification and heterogeneity of T follicular helper cells

Yu, D., Batten, M., Mackay, C. R. & King, C., 2009, In : Current Opinion in Immunology. 21, 6, p. 619 - 625 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1388 Citations (Scopus)

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay-Fisson, F., Artis, D., Xavier, R. J., Teixeira, M. M. & Mackay, C. R., 2009, In : Nature. 461, 7268, p. 1282 - 1286 5 p.

Research output: Contribution to journalArticleResearchpeer-review

163 Citations (Scopus)

The functional plasticity of T cell subsets

Bluestone, J. A., Mackay, C. R., O'Shea, J. J. & Stockinger, B., 2009, In : Nature Reviews Immunology. 9, 11, p. 811 - 816 6 p.

Research output: Contribution to journalArticleOther

680 Citations (Scopus)

The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment

Yu, D., Rao, S., Tsai, L. M., Lee, S. K., He, Y., Sutcliffe, E. L., Srivastava, M., Linterman, M., Zheng, L., Simpson, N., Ellyard, J. I., Parish, I. A., Ma, C. S., Li, Q-J., Parish, C. R., Mackay, C. R. & Vinuesa, C. G., 2009, In : Immunity. 31, 3, p. 457 - 468 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2008
500 Citations (Scopus)

A fundamental role for interleukin-21 in the generation of T follicular helper cells

Vogelzang, A., McGuire, H. N., Yu, D., Sprent, J., Mackay, C. R. & King, C., 2008, In : Immunity. 29, 1, p. 127 - 137 11 p.

Research output: Contribution to journalArticleResearchpeer-review

247 Citations (Scopus)

Functional roles for C5a receptors in sepsis

Rittirsch, D., Flierl, M. A., Nadeau, B. A., Day, D. E., Huber-Lang, M., Mackay, C. R., Zetoune, F. S., Gerard, N. P., Cianglone, K., Kohl, J., Gerard, C., Sarma, J. V. & Ward, P. A., 2008, In : Nature Medicine. 14, 5, p. 551 - 557 7 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Granulocyte-macrophage colony-stimulating factor is required for bronchial eosinophilia in a murine model of allergic airway inflammation

Su, Y-C., Rolph, M. S., Hansbro, N. G., Mackay, C. R. & Sewell, W. A., 2008, In : Journal of Immunology. 180, 4, p. 2600 - 2607 8 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Polymorphism in the 5' regulatory region of the B-lymphocyte activating factor gene is associated with the Ro/La autoantibody response and serum BAFF levels in primary Sjogren's syndrome

Nossent, J. C., Lester, S., Zahra, D., Mackay, C. R. & Rischmueller, M., 2008, In : Rheumatology. 47, 9, p. 1311 - 1316 6 p.

Research output: Contribution to journalArticleResearchpeer-review

467 Citations (Scopus)

T follicular helper (TFH) cells in normal and dysregulated immune responses

King, C., Tangye, S. G. & Mackay, C. R., 2008, In : Annual Review of Immunology. 26, p. 741 - 766 26 p.

Research output: Contribution to journalArticleResearchpeer-review

2007
256 Citations (Scopus)

BAFF and MyD88 signals promote a lupuslike disease independent of T cells

Groom, J. R., Fletcher, C. A., Walters, S. N., Gray, S. T., Watt, S. V., Sweet, M. J., Smyth, M. J., Mackay, C. R. & Mackay-Fisson, F., 2007, In : Journal of Experimental Medicine. 204, 8, p. 1959 - 1971 13 p.

Research output: Contribution to journalArticleResearchpeer-review

411 Citations (Scopus)

Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7

Sierro, F., Biben, C., Martinez-Munoz, L., Mellado, M., Ransohoff, R. M., Li, M., Woehl, B., Leung, H., Groom, J., Batten, M., Harvey, R. P., Matinez-A, C., Mackay, C. R. & Mackay-Fisson, F., 2007, In : Proceedings of the National Academy of Sciences. 104, 37, p. 14759 - 14764 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2006
31 Citations (Scopus)

Clues to asthma pathogenesis from microarray expression studies

Rolph, M. S., Sisavanh, M., Liu, S. M. & Mackay, C. R., 2006, In : Pharmacology and Therapeutics. 109, 1-2, p. 284 - 294 11 p.

Research output: Contribution to journalArticleOther

38 Citations (Scopus)

Human C5aR knock-in mice facilitate the production and assessment of anti-inflammatory monoclonal antibodies

Lee, H., Zahra, D., Vogelzang, A., Newton, R., Thatcher, J., Quan, A., So, T., Zwirner, J., Koentgen, F., Padkjaer, S. B., Mackay-Fisson, F., Whitfeld, P. L. & Mackay, C. R., 2006, In : Nature Biotechnology. 24, 10, p. 1279 - 1284 6 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Immune cell transcriptome datasets reveal novel leukocyte subset-specific genes and genes associated with allergic processes

Liu, S. M., Xavier, R., Good, K. L., Chtanova, T., Newton, R., Sisavanh, M., Zimmer, S., Deng, C., Silva, D. G., Frost, M. J., Tangye, S. G., Rolph, M. S. & Mackay, C. R., 2006, In : Journal of Allergy and Clinical Immunology. 118, 2, p. 496 - 503 8 p.

Research output: Contribution to journalArticleResearchpeer-review

165 Citations (Scopus)

Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1

Jeffrey, K. L., Brummer, T., Rolph, M. S., Liu, S. M., Callejas, N. A., Grumont, R. J., Gillieron, C., Mackay-Fisson, F., Grey, S., Camps, M., Rommel, C., Gerondakis, S. D. & Mackay, C. R., 2006, In : Nature Immunology. 7, 3, p. 274 - 283 10 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Regulation of dendritic cell function and T cell priming by the fatty acid-binding protein AP2

Rolph, M. S., Young, T. R., Shum, B. OV., Gorgun, C. Z., Schmitz-Peiffer, C., Ramshaw, I. A., Hotamisligil, G. S. & Mackay, C. R., 2006, In : Journal of Immunology. 177, 11, p. 7794 - 7801 8 p.

Research output: Contribution to journalArticleResearchpeer-review

55 Citations (Scopus)

Targeting BAFF: Immunomodulation for autoimmune diseases and lymphomas

Sutherland, A. P. R., Mackay-Fisson, F. & Mackay, C. R., 2006, In : Pharmacology and Therapeutics. 112, 3, p. 774 - 786 13 p.

Research output: Contribution to journalArticleResearchpeer-review

99 Citations (Scopus)

The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation

Shum, B. OV., Mackay, C. R., Gorgun, C. Z., Frost, M. J., Kumar, R. K., Hotamisligil, G. S. & Rolph, M. S., 2006, In : Journal of Clinical Investigation. 116, 8, p. 2183 - 2192 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2005
137 Citations (Scopus)

A fundamental bimodal role for neuropeptide Y1 receptor in the immune system

Wheway, J., Mackay, C. R., Newton, R., Sainsbury, A., Boey, D., Herzog, H. & Mackay-Fisson, F., 2005, In : Journal of Experimental Medicine. 202, 11, p. 1527 - 1538 12 p.

Research output: Contribution to journalArticleResearchpeer-review

111 Citations (Scopus)

BAFF augments certain Th1-associated inflammatory responses

Sutherland, A. P. R., Ng, L. G., Fletcher, C. A., Shum, B. OV., Newton, R., Grey, S., Rolph, M. S., Mackay-Fisson, F. & Mackay, C. R., 2005, In : Journal of Immunology. 174, 9, p. 5537 - 5544 8 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

BAFF-R, the major B cell-activating factor receptor, is expressed on most mature B cells and B-cell lymphoproliferative disorders

Rodig, S. J., Shahsafaei, A., Li, B., Mackay, C. R. & Dorfman, D. M., 2005, In : Human Pathology. 36, 10, p. 1113 - 1119 7 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Contribution of stromal cells to the migration, function and retention of plasma cells in human spleen: potential roles of CXCL12, IL-6 and CD54

Ellyard, J. I., Avery, D. T., Mackay, C. R. & Tangye, S. G., 2005, In : European Journal of Immunology. 35, 3, p. 699 - 708 10 p.

Research output: Contribution to journalArticleResearchpeer-review

80 Citations (Scopus)

Gene profiling in atherosclerosis reveals a key role for small inducible cytokines: validation using a novel monocyte chemoattractant protein monoclonal antibody

Lutgens, E., Faber, B., Schapira, K., Evelo, C. TA., van Haaften, R., Heeneman, S., Cleutjens, K. BJM., Bijnens, A. P., Beckers, L., Porter, J. G., Mackay, C. R., Rennert, P., Bailly, V., Jarpe, M., Dolinski, B., Koteliansky, V., de Fougerolles, T. & Daemen, M. JAP., 2005, In : Circulation. 111, 25, p. 3443 - 3452 10 p.

Research output: Contribution to journalArticleResearchpeer-review

81 Citations (Scopus)

Identification of T cell-restricted genes, and signatures for different T cell responses, using a comprehensive collection of microarray datasets

Chtanova, T., Newton, R., Liu, S. M., Weininger, L., Young, T. R., Silva, D. G., Bertoni, F., Rinaldi, A., Chappaz, S., Sallusto, F., Rolph, M. S. & Mackay, C. R., 2005, In : Journal of Immunology. 175, 12, p. 7837 - 7847 11 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Overlapping gene expression profiles in rheumatoid fibroblast-like synoviocytes induced by the proinflammatory cytokines interleukin-1? and tumor necrosis factor

Taberner, M., Scott, K. F., Weininger, L., Mackay, C. R. & Rolph, M. S., 2005, In : Inflammation Research. 54, 1, p. 10 - 16 7 p.

Research output: Contribution to journalArticleResearchpeer-review

123 Citations (Scopus)

The BAFF/APRIL system: Life beyond B lymphocytes

Ng, L. G., Mackay, C. R. & Mackay-Fisson, F., 2005, In : Molecular Immunology. 42, 7, p. 763 - 772 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2004
331 Citations (Scopus)

B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells

Ng, L. G., Sutherland, A. P. R., Newton, R., Qian, F., Cachero, T. G., Scott, M. L., Thompson, J. S., Wheway, J., Chtanova, T., Groom, J., Sutton, I. J., Xin, C., Tangye, S. G., Kalled, S. L., Mackay-Fisson, F. & Mackay, C. R., 2004, In : Journal of Immunology. 173, 2, p. 807 - 817 11 p.

Research output: Contribution to journalArticleResearchpeer-review

105 Citations (Scopus)

Identification of circulating antigen-specific CD4+ T lymphocytes with a CCR5+, cytotoxic phenotype in an HIV-1 long-term nonprogressor and in CMV infection

Zaunders, J. J., Dyer, W. B., Wang, B., Munier, M. L., Miranda-Saksena, M., Newton, R., Moore, J., Mackay, C. R., Cooper, D. A., Saksena, N. K. & Kelleher, A. D., 15 Mar 2004, In : Blood. 103, 6, p. 2238-2247 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
514 Citations (Scopus)

T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells

Chtanova, T., Tangye, S. G., Newton, R., Frank, N., Hodge, M. R., Rolph, M. S. & Mackay, C. R., 1 Jul 2004, In : Journal of Immunology. 173, 1, p. 68-78 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
128 Citations (Scopus)

TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma

Batten, M., Fletcher, C. A., Ng, L. G., Groom, J. R., Wheway, J., Laabi, Y., Xin, X., Schneider, P., Tschopp, J., Mackay, C. R. & Mackay-Fisson, F., 2004, In : Journal of Immunology. 172, 2, p. 812 - 822 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2002
734 Citations (Scopus)

Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome

Groom, J., Kalled, S. L., Cutler, A. H., Olson, C., Woodcock, S. A., Schneider, P., Tschopp, J., Cachero, T. G., Batten, M., Wheway, J., Mauri, D., Cavill, D., Gordon, T. P., Mackay, C. R. & Mackay, F., 1 Jan 2002, In : Journal of Clinical Investigation. 109, 1, p. 59-68 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
25 Citations (Scopus)

Levels of BAFF in serum in primary biliary cirrhosis and autoimmune diabetes

MacKay, I. R., Groom, J. & MacKay, C. R., 1 Dec 2002, In : Autoimmunity. 35, 8, p. 551-553 3 p.

Research output: Contribution to journalArticleResearchpeer-review

2001
116 Citations (Scopus)

Gene microarrays reveal extensive differential gene expression in both CD4+ and CD8+ type 1 and type 2 T cells

Chtanova, T., Kemp, R. A., Sutherland, A. P. R., Ronchese, F. & Mackay, C. R., 15 Sep 2001, In : Journal of Immunology. 167, 6, p. 3057-3063 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
76 Citations (Scopus)

Monocyte chemotactic protein-1, -2, and -3 are distinctively expressed in portal tracts and granulomata in primary biliary cirrhosis: implications for pathogenesis

Tsuneyama, K., Harada, K., Yasoshima, M., Hiramatsu, K., Mackay, C. R., Mackay, I. R., Gershwin, M. E. & Nakanuma, Y., 2001, In : Journal of Pathology. 193, 1, p. 102 - 109 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2000
133 Citations (Scopus)

Enhanced levels of functional HIV-1 co-receptors on human mucosal T cells demonstrated using intestinal biopsy tissue

Anton, P. A., Elliott, J., Poles, M. A., McGowan, I. M., Matud, J., Hultin, L. E., Grovit-Ferbas, K., Mackay, C. R., Chen, I. S. Y. & Giorgi, J. V., 26 Sep 2000, In : AIDS. 14, 12, p. 1761-1765 5 p.

Research output: Contribution to journalArticleResearchpeer-review

1999
12 Citations (Scopus)

Chemoattractant receptors and immune responses

Mackay, C. R., Lanzavecchia, A. & Sallusto, F., 1 Jan 1999, In : Immunologist. 7, 4, p. 112-118 7 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

HIV-1 infectability of CD4+ lymphocytes with relation to β-chemokines and the CCR5 coreceptor

Paxton, W. A., Kang, S., Liu, R., Landau, N. R., Gingeras, T. R., Wu, L., Mackay, C. R. & Koup, R. A., 1 Mar 1999, In : Immunology Letters. 66, 1-3, p. 71-75 5 p.

Research output: Contribution to journalArticleResearchpeer-review

167 Citations (Scopus)

Up-regulation of CCR1 and CCR3 and induction of chemotaxis to CC chemokines by IFN-γ in human neutrophils

Bonecchi, R., Polentarutti, N., Luini, W., Borsatti, A., Bernasconi, S., Locati, M., Power, C., Proudfoot, A., Wells, T. N. C., Mackay, C., Mantovani, A. & Sozzani, S., 1 Jan 1999, In : Journal of Immunology. 162, 1, p. 474-479 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1998
200 Citations (Scopus)

Amino-terminal substitutions in the CCR5 coreceptor impair gp120 binding and human immunodeficiency virus type 1 entry

Dragic, T., Trkola, A., Lin, S. W., Nagashima, K. A., Kajumo, F., Zhao, L., Olson, W. C., Wu, L., Mackay, C. R., Allaway, G. P., Sakmar, T. P., Moore, J. P. & Maddon, P. J., 1 Jan 1998, In : Journal of Virology. 72, 1, p. 279-285 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1300 Citations (Scopus)

Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes

Sallusto, F., Lenig, D., Mackay, C. R. & Lanzavecchia, A., 16 Mar 1998, In : Journal of Experimental Medicine. 187, 6, p. 875-883 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
112 Citations (Scopus)

Genetic subtype-independent inhibition of human immunodeficiency virus type 1 replication by CC and CXC chemokines

Trkola, A., Paxton, W. A., Monard, S. P., Hoxie, J. A., Siani, M. A., Thompson, D. A., Wu, L., Mackay, C. R., Horuk, R. & Moore, J. P., 1 Jan 1998, In : Journal of Virology. 72, 1, p. 396-404 9 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Human eotaxin-induces α4 and β2 integrin-dependent eosinophil accumulation in rat skin in vivo: Delayed generation of eotaxin in response to IL-4

Sanz, M. J., Ponath, P. D., Mackay, C. R., Newman, W., Miyasaka, M., Tamatani, T., Flanagan, B. F., Lobb, R. R., Williams, T. J., Nourshargh, S. & Jose, P. J., 1 Apr 1998, In : Journal of Immunology. 160, 7, p. 3569-3576 8 p.

Research output: Contribution to journalArticleResearchpeer-review

211 Citations (Scopus)

Immunohistochemical study of the β-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains

Xia, M., Qin, S., Wu, L., Mackay, C. R. & Hyman, B. T., 1 Jan 1998, In : American Journal of Pathology. 153, 1, p. 31-37 7 p.

Research output: Contribution to journalArticleResearchpeer-review

202 Citations (Scopus)

Interleukin 10 increases CCR5 expression and HIV infection in human monocytes

Sozzani, S., Ghezzi, S., Iannolo, G., Luini, W., Borsatti, A., Polentarutti, N., Sica, A., Locati, M., Mackay, C., Wells, T. N. C., Biswas, P., Vicenzi, E., Poli, G. & Mantovani, A., 2 Feb 1998, In : Journal of Experimental Medicine. 187, 3, p. 439-444 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
74 Citations (Scopus)

Mature dendritic cells respond to SDF-1, but not to several β-chemokines

Delgado, E., Finkel, V., Baggiolini, M., Mackay, C. R., Steinman, R. M. & Granelli-Piperno, A., 1 Jan 1998, In : Immunobiology. 198, 5, p. 490-500 11 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Overview of the Second International Workshop to define Swine Cluster of Differentiation (CD) antigens

Saalmüller, A., Pauly, T., Lunney, J. K., Boyd, P., Aasted, B., Sachs, D. H., Arn, S., Bianchi, A., Binns, R. M., Licence, S., Whyte, A., Blecha, F., Chen, Z., Chu, R. M., Davis, W. C., Denham, S., Yang, H., Whittall, T., Parkhouse, R. M., Dominguez, J. & 29 others, Ezquerra, A., Alonso, F., Horstick, G., Howard, C., Sopp, P., Kim, Y. B., Lipp, J., Mackay, C., Magyar, A., McCullough, K., Arriens, A., Summerfield, A., Murtaugh, M., Nielsen, J., Novikov, B., Pescovitz, M. D., Schuberth, H. J., Leibold, W., Schütt, C., Shimizu, M., Stokes, C., Haverson, K., Bailey, M., Tlaskalova, H., Trebichavsky, I., Valpotic, I., Walker, J., Lee, R. & Zuckermann, F., 30 Jan 1998, In : Veterinary Immunology and Immunopathology. 60, 3-4, p. 207-228 22 p.

Research output: Contribution to journalArticleResearchpeer-review

902 Citations (Scopus)

Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation

Sallusto, F., Schaerli, P., Loetscher, P., Schaniel, C., Lenig, D., Mackay, C. R., Qin, S. & Lanzavecchia, A., 1 Sep 1998, In : European Journal of Immunology. 28, 9, p. 2760-2769 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
140 Citations (Scopus)

Reduced HIV-1 infectability of CDd4+ lymphocytes from exposed- uninfected individuals: Association with low expression of CCR5 and high production of β-chemokines

Paxton, W. A., Liu, R., Kang, S., Wu, L., Gingeras, T. R., Landau, N. R., MacKay, C. R. & Koup, R. A., 25 Apr 1998, In : Virology. 244, 1, p. 66-73 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
130 Citations (Scopus)

Role of the β-chemokine receptors CCR3 and CCR5 in human immunodeficiency virus type 1 infection of monocytes and microglia

Ghorpade, A., Xia, M. Q. I., Hyman, B. T., Persidsky, Y., Nukuna, A., Bock, P., Che, M., Limoges, J., Gendelman, H. E. & Mackay, C. R., 1 Apr 1998, In : Journal of Virology. 72, 4, p. 3351-3361 11 p.

Research output: Contribution to journalArticleResearchpeer-review