• 15 Innovation Walk, 75

    3800 Clayton

1985 …2021
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Research Output 1985 2019

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2019

Decreased maternal serum acetate and impaired fetal thymic and regulatory T cell development in preeclampsia

Hu, M., Eviston, D., Hsu, P., Mariño, E., Chidgey, A., Santner-Nanan, B., Wong, K., Richards, J. L., Yap, Y. A., Collier, F., Quinton, A., Joung, S., Peek, M., Benzie, R., Macia, L., Wilson, D., Ponsonby, A. L., Tang, M. L. K., O’Hely, M., Daly, N. L. & 5 othersMackay, C. R., Dahlstrom, J. E., The BIS Investigator Group, Vuillermin, P. & Nanan, R., 10 Jul 2019, In : Nature Communications. 10, 1, 13 p., 3031.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Short-chain fatty acids and FFAR2 as suppressors of bone resorption

Montalvany-Antonucci, C. C., Duffles, L. F., de Arruda, J. A. A., Zicker, M. C., de Oliveira, S., Macari, S., Garlet, G. P., Madeira, M. F. M., Fukada, S. Y., Andrade, I., Teixeira, M. M., Mackay, C., Vieira, A. T., Vinolo, M. A. & Silva, T. A., 1 Aug 2019, In : Bone. 125, p. 112-121 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

C5a receptor 1 promotes autoimmunity, neutrophil dysfunction and injury in experimental anti-myeloperoxidase glomerulonephritis

Dick, J., Gan, P. Y., Ford, S. L., Odobasic, D., Alikhan, M. A., Loosen, S. H., Hall, P., Westhorpe, C. L., Li, A., Ooi, J. D., Woodruff, T. M., Mackay, C. R., Kitching, A. R., Hickey, M. J. & Holdsworth, S. R., 1 Mar 2018, In : Kidney International. 93, 3, p. 615-625 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The metabolic sensor GPR43 receptor plays a role in the control of Klebsiella pneumoniae infection in the lung

Galvão, I., Tavares, L. P., Corrêa, R. O., Fachi, J. L., Rocha, V. M., Rungue, M., Garcia, C. C., Cassali, G., Ferreira, C. M., Martins, F. S., Oliveira, S. C., Mackay, C. R., Teixeira, M. M., Vinolo, M. A. R. & Vieira, A. T., 20 Feb 2018, In : Frontiers in Immunology. 9, 11 p., 142.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

A fully humanized IgG-like bispecific antibody for effective dual targeting of CXCR3 and CCR6

Robert, R., Juglair, L., Lim, E. X., Ang, C., Wang, C. J. H., Ebert, G., Dolezal, O. & Mackay, C. R., 5 Sep 2017, In : PLoS ONE. 12, 9, 18 p., e0184278.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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c-Myb Regulates the T-Bet-Dependent Differentiation Program in B Cells to Coordinate Antibody Responses

Piovesan, D., Tempany, J., Di Pietro, A., Baas, I., Yiannis, C., O'Donnell, K., Chen, Y., Peperzak, V., Belz, G. T., Mackay, C. R., Smyth, G. K., Groom, J. R., Tarlinton, D. M. & Good-Jacobson, K. L., 18 Apr 2017, In : Cell Reports. 19, 3, p. 461-470 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Dietary fiber and the short-chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in mice

Vieira, A. T., Galvão, I., Macia, L. M., Sernaglia, E. M., Vinolo, M. A. R., Garcia, C. C., Tavares, L. P., Amaral, F. A., Sousa, L. P., Martins, F. S., Mackay, C. R. & Teixeira, M. M., 1 Jan 2017, In : Journal of leukocyte biology. 101, 1, p. 275-284 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Diet-derived short chain fatty acids stimulate intestinal epithelial cells to induce mucosal tolerogenic dendritic cells

Goverse, G., Molenaar, R., Macia, L., Tan, J., Erkelens, M. N., Konijn, T., Knippenberg, M., Cook, E. C. L., Hanekamp, D., Veldhoen, M., Hartog, A., Roeselers, G., MacKay, C. R. & Mebius, R. E., 1 Mar 2017, In : Journal of Immunology. 198, 5, p. 2172-2181 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Essential role for CCR6 in certain inflammatory diseases demonstrated using specific antagonist and knockin mice

Robert, R., Ang, C., Sun, G., Juglair, L., Lim, E. X., Mason, L. J., Payne, N. L., Bernard, C. C. A. & Mackay, C. R., 3 Aug 2017, In : JCI Insight. 2, 15, 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety

Brooks, L., Viardot, A., Tsakmaki, A., Stolarczyk, E., Howard, J. K., Cani, P. D., Everard, A., Sleeth, M. L., Psichas, A., Anastasovskaj, J., Bell, J. D., Bell-Anderson, K., Mackay, C. R., Ghatei, M. A., Bloom, S. R., Frost, G. & Bewick, G. A., 1 Jan 2017, In : Molecular Metabolism. 6, 1, p. 48-60 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes

Marino, E., Richards, J. L., McLeod, K. H., Stanley, D., Yap, Y. A., Knight, J., McKenzie, C., Kranich, J., Oliveira, A. C., Rossello, F. J., Krishnamurthy, B., Nefzger, C. M., Macia, L., Thorburn, A., Baxter, A. G., Morahan, G., Wong, L. H., Polo, J. M., Moore, R. J., Lockett, T. J. & 4 othersClarke, J. M., Topping, D. L., Harrison, L. C. & Mackay, C. R., May 2017, In : Nature Immunology. 18, 5, p. 552-562 13 p.

Research output: Contribution to journalArticleResearchpeer-review

High Fibre Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in DOCA-Salt Hypertensive Mice

Marques, F. Z., Nelson, E., Chu, P. Y., Horlock, D., Fiedler, A., Ziemann, M., Tan, J. K., Kuruppu, S., Rajapakse, N. W., El-Osta, A., Mackay, C. R. & Kaye, D. M., 7 Mar 2017, In : Circulation. 135, 10, p. 964-977 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Avenues to autoimmune arthritis triggered by diverse remote inflammatory challenges

Chevalier, N., Tan, J. K., Mason, L. J., Robert, R., McKenzie, C. I., Lim, F., Wong, C. H., Macia, L., Thorburn, A. N., Russ, B. E., Masters, S. L. & Mackay, C. R., 1 Sep 2016, In : Journal of Autoimmunity. 73, p. 120-129 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways

Tan, J., McKenzie, C., Vuillermin, P. J., Goverse, G., Vinuesa, C. G., Mebius, R. E., Macia, L. & Mackay, C. R., 21 Jun 2016, In : Cell Reports. 15, 12, p. 2809-2824 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk

Lassen, K. G., McKenzie, C. I., Mari, M., Murano, T., Begun, J., Baxt, L. A., Goel, G., Villablanca, E. J., Kuo, S. Y., Huang, H., Macia, L., Bhan, A. K., Batten, M., Daly, M. J., Reggiori, F., Mackay, C. R. & Xavier, R. J., 21 Jun 2016, In : Immunity. 44, 6, p. 1392-1405 14 p.

Research output: Contribution to journalArticleResearchpeer-review

G protein-coupled receptor 43 modulates neutrophil recruitment during acute inflammation

Kamp, M. E., Shim, R., Nicholls, A. J., Oliveira, A. C., Mason, L. J., Binge, L., Mackay, C. R. & Wong, C. H. Y., 22 Sep 2016, In : PLoS ONE. 11, 9, 15 p., e0163750.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The role of follicular helper T cell molecules and environmental influences in autoantibody production and progression to inflammatory arthritis in mice

Chevalier, N., Macia, L., Tan, J. K., Mason, L. J., Robert, R., Thorburn, A. N., Wong, C. H. Y., Tsai, L. M., Bourne, K., Brink, R., Yu, D. & Mackay, C. R., 4 Apr 2016, In : Arthritis and Rheumatology. 68, 4, p. 1026-1038 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

An acetate-specific GPCR, FFAR2, regulates insulin secretion

Priyadarshini, M., Villa, S. R., Fuller, M., Wicksteed, B., Mackay, C. R., Alquier, T., Poitout, V., Mancebo, H., Mirmira, R. G., Gilchrist, A. & Layden, B. T., 2015, In : Molecular Endocrinology. 29, 7, p. 1055 - 1066 12 p.

Research output: Contribution to journalArticleResearchpeer-review

A role for gut microbiota and the metabolite-sensing receptor GPR43 in a murine model of gout

Vieira, A. T., Macia, L., Galvao, I., Martins, F. S., Canesso, M. C. C., Amaral, F. A., Garcia, C. C. O., Maslowski, K. M., De Leon, E., Shim, D. S. C., Nicoli, J. R., Harper, J. L., Teixeira, M. M. & Mackay, C. R., 2015, In : Arthritis and Rheumatology. 67, 6, p. 1646 - 1656 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

Thorburn, A. N., McKenzie, C., Shen, S. S., Stanley, D., Macia, L., Mason, L. J., Roberts, L. K., Wong, C. H. Y., Shim, R., Robert, R., Chevalier, N., Tan, J. K., Marino, E. M., Moore, R. J., Wong, L. H. H., McConville, M. J., Tull, D. L., Wood, L., Murphy, V., Mattes, J. & 3 othersGibson, P. G., Wood, L. G. & Mackay, C. R., 2015, In : Nature Communications. 6, 7320, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

Macia, L., Tan, J., Vieira, A. T., Leach, K., Stanley, D., Luong, S., Maruya, M., McKenzie, C., Hijikata, A., Wong, C. H. Y., Binge, L. C., Thorburn, A. N., Chevalier, N., Ang Kim Lian, C., Marino Moreno, E., Robert, R., Offermanns, S., Teixeira, M. M., Moore, R. J., Flavell, R. A. & 2 othersFagarasan, S. & Mackay, C. R., 2015, In : Nature Communications. 6, (Art. No: 7734), p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Treatment with anti-C5aR mAb leads to early-onset clinical and mechanistic effects in the murine delayed-type hypersensitivity arthritis model

Atkinson, S. M., Nansen, A., Usher, P. A., Sondergaard, B. C., Mackay, C. R., Friedrichsen, B. N., Chang, C-C., Tang, R., Skov, S., Haase, C. G. & Hornum, L., 2015, In : Autoimmunity. 48, 7, p. 460 - 470 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2014

BAFF regulates activation of self-reactive T cells through B-cell dependent mechanisms and mediates protection in NOD mice

Marino Moreno, E., Walters, S. N., Villanueva, J. E., Richards, J. L., Mackay, C. R. & Grey, S. T., 2014, In : European Journal of Immunology. 44, 4, p. 983 - 993 11 p.

Research output: Contribution to journalArticleResearchpeer-review

CXCR3(+)CCR5(+) T cells and autoimmune diseases: guilty as charged?

Mackay, C. R., 2014, In : Journal of Clinical Investigation. 124, 9, p. 3682 - 3684 3 p.

Research output: Contribution to journalArticleOther

Cyclophosphamide treatment induces rejection of established P815 mastocytoma by enhancing CD4 priming and intratumoral infiltration of P1E/H-2K(d) -specific CD8+ T cells

Rahir, G., Wathelet, N., Hanoteau, A., Henin, C., Oldenhove, G., Galuppo, A., Lanaya, H., Colau, D., Mackay, C. R., Van den Eynde, B. J. & Moser, M., 2014, In : International Journal of Cancer. 134, 12, p. 2841 - 2852 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Diet, metabolites, and "Western-lifestyle" inflammatory diseases

Thorburn, A. N., Macia, L. & Mackay, C. R., 2014, In : Immunity. 40, 6, p. 833 - 842 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Inflammation and Lymphopenia Trigger Autoimmunity by Suppression of IL-2-Controlled Regulatory T Cell and Increase of IL-21-Mediated Effector T Cell Expansion

Chevalier, N., Thorburn, A. N., Macia, L., Tan, J., Juglair, L., Yagita, H., Yu, D., Hansbro, P. M. & Mackay, C. R., 2014, In : Journal of Immunology. 193, 10, p. 4845 - 4858 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Rapid-onset clinical and mechanistic effects of anti-C5aR treatment in the mouse collagen-induced arthritis model

Andersson, C. T., Wenander, C. S., Usher, P. A., Hebsgaard, J. B., Sondergaard, B. C., Rono, B., Mackay, C. R., Friedrichsen, B. N., Chang, C., Tang, R. & Hornum, L., 2014, In : Clinical and Experimental Immunology. 177, 1, p. 219 - 233 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Real-time interactive two-photon photoconversion of recirculating lymphocytes for discontinuous cell tracking in live adult mice

Chtanova, T., Hampton, H. R., Waterhouse, L. A., Wood, K., Tomura, M., Miwa, Y., Mackay, C. R., Brink, R. & Phan, T. G., 2014, In : Journal of Biophotonics. 7, 6, p. 425 - 433 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The role of short-chain fatty acids in health and disease

Tan, J., McKenzie, C., Potamitis, M., Thorburn, A. N., Mackay, C. R. & Macia, L., 2014, In : Advances in Immunology. 121, p. 91 - 119 29 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

Circulating precursor CCR7(lo)PD-1(hi) CXCR5(+) CD4(+) T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure

He, J., Tsai, L. M., Leong, Y. A., Hu, X. J., Ma, C. S., Chevalier, N., Sun, X., Vandenberg, K., Rockman, S., Ding, Y., Zhu, L., Wei, W., Wang, C., Karnowski, A., Belz, G. T., Ghali, J. R., Cook, M. C., Riminton, S., Veillette, A., Schwartzberg, P. L. & 7 othersMackay, F., Brink, R., Tangye, S. G., Vinuesa, C. G., Mackay, C. R., Li, Z. G. & Yu, D., 2013, In : Immunity. 39, p. 770 - 781 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

B-cell cross-presentation of autologous antigen precipitates diabetes

Marino, E., Tan, B., Binge, L. C., Mackay, C. R. & Grey, S. T., 2012, In : Diabetes. 61, 11, p. 2893 - 2905 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Chlamydia muridarum lung infection in infants alters hematopoietic cells to promote allergic airway disease in mice

Starkey, M. R., Kim, R. Y., Beckett, E. L., Schilter, H. C., Shim, D. SC., Essilfie, A-T., Nguyen, D. H., Beagley, K. W., Mattes, J., Mackay, C. R., Horvat, J. C. & Hansbro, P. M., 2012, In : PLoS ONE. 7, 8, 7 p., e42588.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

IL-21 enhances the potential of human {gamma delta} T cells to provide B-cell help

Bansal, R. R., Mackay, C. R., Moser, B. & Eberl, M., 2012, In : European Journal of Immunology. 42, 1, p. 110 - 119 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling

Gunton, J. E., Sisavanh, M., Stokes, R. A., Satin, J., Satin, L. S., Zhang, M., Liu, S. M., Cai, W., Cheng, K., Cooney, G. J., Laybutt, D. R., So, T., Molero, J-C., Grey, S. T., Andres, D. A., Rolph, M. S. & Mackay, C. R., 2012, In : PLoS ONE. 7, 6, 9 p., e39462.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases

Macia, L., Thorburn, A. N., Binge, L. C., Marino Moreno, E., Rogers, K. E., Maslowski, K. M., Vieira, A. T., Kranich, J. & Mackay, C. R., 2012, In : Immunological Reviews. 245, 1, p. 164 - 176 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Protection against Nippostrongylus brasiliensis infection in mice is independent of GM-CSF

Shim, D. SC., Schilter, H. C., Knott, M. L., Almeida, R. A., Short, R. P., Mackay, C. R., Dent, L. A. & Sewell, W. A., 2012, In : Immunology and Cell Biology. 90, 5, p. 553 - 558 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Chemotherapy induces intratumoral expression of chemokines in cutaneous melanoma, favoring T-cell infiltration and tumor control

Hong, M., Puaux, A. L., Huang, C., Loumagne, L., Tow, C., Mackay, C., Kato, M., Prévost-Blondel, A., Avril, M. F., Nardin, A. & Abastado, J. P., 15 Nov 2011, In : Cancer Research. 71, 22, p. 6997-7009 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Commensal flora and the regulation of inflammatory and autoimmune responses

Kranich, J., Maslowski, K. M. & Mackay, C. R., 2011, In : Seminars in Immunology. 23, 2, p. 139 - 145 7 p.

Research output: Contribution to journalArticleResearchpeer-review

CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses

Chevalier, N., Jarrossay, D., Ho, E., Avery, D. T., Ma, C. S., Yu, D., Sallusto, F., Tangye, S. G. & Mackay, C. R., 2011, In : Journal of Immunology. 186, 10, p. 5556 - 5568 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Development of autoimmune nephritis in genetically asplenic and splenectomized BAFF transgenic mice

Fletcher, C., Groom, J., Woehl, B., Leung, H., Mackay, C. & Mackay-Fisson, F., 2011, In : Journal of Autoimmunity. 36, 2, p. 125 - 134 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Diet, gut microbiota and immune responses

Maslowski, K. M. & Mackay, C. R., 2011, In : Nature Immunology. 12, 1, p. 5 - 9 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Macrophage migration inhibitory factor regulates neutrophil chemotactic responses in inflammatory arthritis in mice

Santos, L., Fan, H., Hall, P., Ngo, D., Mackay, C., Fingerle-Rowson, G., Bucala, R., Hickey, M. & Morand, E., 2011, In : Arthritis and Rheumatism. 63, 4, p. 960 - 970 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Specific expression of GPR56 by human cytotoxic lymphocytes

Peng, Y. M., van de Garde, M. D. B., Cheng, K. F., Baars, P. A., Remmerswaal, E. B. M., van Lier, R. A. W., Mackay, C. R., Lin, H. H. & Hamann, J., Oct 2011, In : Journal of leukocyte biology. 90, 4, p. 735-740 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function

Kolbeck, R., Kozhich, A., Koike, M., Peng, L., Andersson, C. K., Damschroder, M. M., Reed, J. L., Woods, R., Dall'Acqua, W. W., Stephens, G. L., Erjefalt, J. S., Bjermer, L., Humbles, A. A., Gossage, D., Wu, H., Kiener, P. A., Spitalny, G. L., Mackay, C., Molfino, N. A. & Coyle, A. J., 2010, In : Journal of Allergy and Clinical Immunology. 125, 6, p. 1344 - 1353.e2 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The C5a receptor (C5aR) C5L2 is a modulator of C5aR-mediated signal transduction

Bamberg, C. E., Mackay, C., Lee, H., Zahra, D., Jackson, J., Lim, Y. S., Whitfeld, P. L., Craig, S., Corsini, E., Lu, B., Gerard, C. & Gerard, N. P., 2010, In : Journal of Biological Chemistry. 285, 10, p. 7633 - 7644 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Complexity in human immunodeficiency virus type 1 (HIV-1) co-receptor usage: roles of CCR3 and CCR5 in HIV-1 infection of monocyte-derived macrophages and brain microglia

Agrawal, L., Maxwell, C. R., Peters, P. J., Clapham, P. R., Liu, S. M., Mackay, C. R. & Strayer, D. S., 2009, In : Journal of General Virology. 90, 3, p. 710 - 722 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Guidance of B Cells by the Orphan G Protein-Coupled Receptor EBI2 Shapes Humoral Immune Responses

Gatto, D., Paus, D., Basten, A., Mackay, C. R. & Brink, R., 2009, In : Immunity. 31, 2, p. 259 - 269 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Lineage specification and heterogeneity of T follicular helper cells

Yu, D., Batten, M., Mackay, C. R. & King, C., 2009, In : Current Opinion in Immunology. 21, 6, p. 619 - 625 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay-Fisson, F., Artis, D., Xavier, R. J., Teixeira, M. M. & Mackay, C. R., 2009, In : Nature. 461, 7268, p. 1282 - 1286 5 p.

Research output: Contribution to journalArticleResearchpeer-review