• 15 Innovation Walk, 75

    3800 Clayton

1985 …2021

Research output per year

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Research Output

Article

Inflammation and Lymphopenia Trigger Autoimmunity by Suppression of IL-2-Controlled Regulatory T Cell and Increase of IL-21-Mediated Effector T Cell Expansion

Chevalier, N., Thorburn, A. N., Macia, L., Tan, J., Juglair, L., Yagita, H., Yu, D., Hansbro, P. M. & Mackay, C. R., 2014, In : Journal of Immunology. 193, 10, p. 4845 - 4858 14 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Interaction of chemokine receptor CCR5 with its ligands: Multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding

Wu, L., LaRosa, G., Kassam, N., Gordon, C. J., Heath, H., Ruffing, N., Chen, H., Humblias, J., Samson, M., Parmentier, M., Moore, J. P. & Mackay, C. R., 20 Oct 1997, In : The Journal of Experimental Medicine. 186, 8, p. 1373-1381 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
321 Citations (Scopus)

Interleukin 10 increases CCR5 expression and HIV infection in human monocytes

Sozzani, S., Ghezzi, S., Iannolo, G., Luini, W., Borsatti, A., Polentarutti, N., Sica, A., Locati, M., Mackay, C., Wells, T. N. C., Biswas, P., Vicenzi, E., Poli, G. & Mantovani, A., 2 Feb 1998, In : The Journal of Experimental Medicine. 187, 3, p. 439-444 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
202 Citations (Scopus)

Interleukin-8 receptor B immunoreactivity in brain and neuritic plaques of Alzheimer's disease

Xia, M., Qin, S., McNamara, M., Mackay, C. & Hyman, B. T., 19 Apr 1997, In : American Journal of Pathology. 150, 4, p. 1267-1274 8 p.

Research output: Contribution to journalArticleResearchpeer-review

113 Citations (Scopus)

Levels of BAFF in serum in primary biliary cirrhosis and autoimmune diabetes

MacKay, I. R., Groom, J. & MacKay, C. R., 1 Dec 2002, In : Autoimmunity. 35, 8, p. 551-553 3 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Lineage specification and heterogeneity of T follicular helper cells

Yu, D., Batten, M., Mackay, C. R. & King, C., 2009, In : Current Opinion in Immunology. 21, 6, p. 619 - 625 7 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Lymphocyte antigens of sheep: Identification and characterization using a panel of monoclonal antibodies

Mackay, C. R., Maddox, J. F. & Brandon, M. R., 1 Jan 1987, In : Veterinary Immunology and Immunopathology. 17, 1-4, p. 91-102 12 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Lymphocyte Migration: A new spin on lymphocyte homing

Mackay, C., 1 Jan 1995, In : Current Biology. 5, 7, p. 733-736 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
15 Citations (Scopus)

Lymphocyte subsets show marked differences in their distribution between blood and the afferent and efferent lymph of peripheral lymph nodes

Mackay, C. R., Kimpton, W. G., Brandon, M. R. & Cahill, R. N. P., 1 Jun 1988, In : The Journal of Experimental Medicine. 167, 6, p. 1755-1765 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
135 Citations (Scopus)

Macrophage migration inhibitory factor regulates neutrophil chemotactic responses in inflammatory arthritis in mice

Santos, L., Fan, H., Hall, P., Ngo, D., Mackay, C., Fingerle-Rowson, G., Bucala, R., Hickey, M. & Morand, E., 2011, In : Arthritis and Rheumatism. 63, 4, p. 960 - 970 11 p.

Research output: Contribution to journalArticleResearchpeer-review

60 Citations (Scopus)

Marked variations in γδ T cell numbers and distribution throughout the life of sheep

Mackay, C. R. & Hein, W. R., 16 Jul 1991, In : Current topics in microbiology and immunology. 173, p. 107-111 5 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Mature dendritic cells respond to SDF-1, but not to several β-chemokines

Delgado, E., Finkel, V., Baggiolini, M., Mackay, C. R., Steinman, R. M. & Granelli-Piperno, A., 1 Jan 1998, In : Immunobiology. 198, 5, p. 490-500 11 p.

Research output: Contribution to journalArticleResearchpeer-review

74 Citations (Scopus)

MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function

Kolbeck, R., Kozhich, A., Koike, M., Peng, L., Andersson, C. K., Damschroder, M. M., Reed, J. L., Woods, R., Dall'Acqua, W. W., Stephens, G. L., Erjefalt, J. S., Bjermer, L., Humbles, A. A., Gossage, D., Wu, H., Kiener, P. A., Spitalny, G. L., Mackay, C., Molfino, N. A. & Coyle, A. J., 2010, In : Journal of Allergy and Clinical Immunology. 125, 6, p. 1344 - 1353.e2 10 p.

Research output: Contribution to journalArticleResearchpeer-review

265 Citations (Scopus)

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

Macia, L., Tan, J., Vieira, A. T., Leach, K., Stanley, D., Luong, S., Maruya, M., McKenzie, C., Hijikata, A., Wong, C. H. Y., Binge, L. C., Thorburn, A. N., Chevalier, N., Ang Kim Lian, C., Marino Moreno, E., Robert, R., Offermanns, S., Teixeira, M. M., Moore, R. J., Flavell, R. A. & 2 others, Fagarasan, S. & Mackay, C. R., 2015, In : Nature Communications. 6, (Art. No: 7734), p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
306 Citations (Scopus)

Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling

Gunton, J. E., Sisavanh, M., Stokes, R. A., Satin, J., Satin, L. S., Zhang, M., Liu, S. M., Cai, W., Cheng, K., Cooney, G. J., Laybutt, D. R., So, T., Molero, J-C., Grey, S. T., Andres, D. A., Rolph, M. S. & Mackay, C. R., 2012, In : PLoS ONE. 7, 6, 9 p., e39462.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
8 Citations (Scopus)

Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases

Macia, L., Thorburn, A. N., Binge, L. C., Marino Moreno, E., Rogers, K. E., Maslowski, K. M., Vieira, A. T., Kranich, J. & Mackay, C. R., 2012, In : Immunological Reviews. 245, 1, p. 164 - 176 13 p.

Research output: Contribution to journalArticleResearchpeer-review

121 Citations (Scopus)

Migration pathways and immunologic memory among T lymphocytes

Mackay, C. R., 1 Dec 1992, In : Seminars in Immunology. 4, 1, p. 51-58 8 p.

Research output: Contribution to journalArticleResearchpeer-review

94 Citations (Scopus)

Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils

Ponath, P. D., Qin, S., Post, T. W., Wang, J., Wu, L., Gerard, N. P., Newman, W., Gerard, C. & Mackay, C. R., 1 Jun 1996, In : The Journal of Experimental Medicine. 183, 6, p. 2437-2448 12 p.

Research output: Contribution to journalArticleResearchpeer-review

523 Citations (Scopus)

Monocyte chemotactic protein-1, -2, and -3 are distinctively expressed in portal tracts and granulomata in primary biliary cirrhosis: implications for pathogenesis

Tsuneyama, K., Harada, K., Yasoshima, M., Hiramatsu, K., Mackay, C. R., Mackay, I. R., Gershwin, M. E. & Nakanuma, Y., 2001, In : Journal of Pathology. 193, 1, p. 102 - 109 8 p.

Research output: Contribution to journalArticleResearchpeer-review

76 Citations (Scopus)

Naive and memory t cells show distinct pathways of lymphocyte recirculation

Mackay, C. R., Marston, W. L. & Dudler, L., 1 Mar 1990, In : The Journal of Experimental Medicine. 171, 3, p. 801-817 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
664 Citations (Scopus)

Ontogeny of ovine lymphocytes. I. An immunohistological study on the development of T lymphocytes in the sheep embryo and fetus thymus

Maddox, J. F., Mackay, C. R. & Brandon, M. R., 1 Jan 1987, In : Immunology. 62, 1, p. 97-105 9 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Ontogeny of ovine lymphocytes. II. An immunohistological study on the development of T lymphocytes in the sheep fetal spleen

Maddox, J. F., Mackay, C. R. & Brandon, M. R., 1 Dec 1987, In : Immunology. 62, 1, p. 107-112 6 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Ontogeny of ovine lymphocytes. III. an immunohistological study on the development of T lymphocytes in sheep fetal lymph nodes

Maddox, J. F., Mackay, C. R. & Brandon, M. R., 1 Jan 1987, In : Immunology. 62, 1, p. 113-118 6 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Other surface antigens identified on sheep leukocytes

Hein, W. R. & Mackay, C. R., 1 Jan 1991, In : Veterinary Immunology and Immunopathology. 27, 1-3, p. 115-118 4 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Overlapping gene expression profiles in rheumatoid fibroblast-like synoviocytes induced by the proinflammatory cytokines interleukin-1? and tumor necrosis factor

Taberner, M., Scott, K. F., Weininger, L., Mackay, C. R. & Rolph, M. S., 2005, In : Inflammation Research. 54, 1, p. 10 - 16 7 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Overview of the First International Workshop to Define Swine Leukocyte Cluster of Differentiation (CD) Antigens

Lunney, J. K., Walker, K., Goldman, T., Aasted, B., Bianchi, A., Binns, R., Licence, S., Bischof, R., Brandon, M., Blecha, F., Kielian, T. L., McVey, D. S., Chu, R. M., Carr, M., Howard, C., Sopp, P., Davis, W., Dvorak, P., Dominguez, J., Canals, A. & 28 others, Sanchez Vizcaino, J. M., Kim, Y. B., Laude, H., Mackay, C. R., Magnusson, U., McCullough, K., Misfeldt, M., Murtaugh, M., Molitor, T., Choi, C., Pabst, R., Parkhouse, R. M., Denham, S., Yang, H., Pescovitz, M., Pospisil, R., Tlaskalova, H., Saalmueller, A., Weiland, E., Salmon, H., Sachs, D., Arn, S., Shimizu, M., Stokes, C., Stevens, K., Valpotic, I., Zuckermann, F. & Husmann, R., 1 Jan 1994, In : Veterinary Immunology and Immunopathology. 43, 1-3, p. 193-206 14 p.

Research output: Contribution to journalArticleResearchpeer-review

67 Citations (Scopus)

Overview of the Second International Workshop to define Swine Cluster of Differentiation (CD) antigens

Saalmüller, A., Pauly, T., Lunney, J. K., Boyd, P., Aasted, B., Sachs, D. H., Arn, S., Bianchi, A., Binns, R. M., Licence, S., Whyte, A., Blecha, F., Chen, Z., Chu, R. M., Davis, W. C., Denham, S., Yang, H., Whittall, T., Parkhouse, R. M., Dominguez, J. & 29 others, Ezquerra, A., Alonso, F., Horstick, G., Howard, C., Sopp, P., Kim, Y. B., Lipp, J., Mackay, C., Magyar, A., McCullough, K., Arriens, A., Summerfield, A., Murtaugh, M., Nielsen, J., Novikov, B., Pescovitz, M. D., Schuberth, H. J., Leibold, W., Schütt, C., Shimizu, M., Stokes, C., Haverson, K., Bailey, M., Tlaskalova, H., Trebichavsky, I., Valpotic, I., Walker, J., Lee, R. & Zuckermann, F., 30 Jan 1998, In : Veterinary Immunology and Immunopathology. 60, 3-4, p. 207-228 22 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Phenotype, and migration properties of three major subsets of tissue homing T cells in sheep

Mackay, C. R., Andrew, D. P., Briskin, M., Ringler, D. J. & Butcher, E. C., 22 Oct 1996, In : European Journal of Immunology. 26, 10, p. 2433-2439 7 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)

Polymorphism in the 5' regulatory region of the B-lymphocyte activating factor gene is associated with the Ro/La autoantibody response and serum BAFF levels in primary Sjogren's syndrome

Nossent, J. C., Lester, S., Zahra, D., Mackay, C. R. & Rischmueller, M., 2008, In : Rheumatology. 47, 9, p. 1311 - 1316 6 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1

Jeffrey, K. L., Brummer, T., Rolph, M. S., Liu, S. M., Callejas, N. A., Grumont, R. J., Gillieron, C., Mackay-Fisson, F., Grey, S., Camps, M., Rommel, C., Gerondakis, S. D. & Mackay, C. R., 2006, In : Nature Immunology. 7, 3, p. 274 - 283 10 p.

Research output: Contribution to journalArticleResearchpeer-review

167 Citations (Scopus)

Protection against Nippostrongylus brasiliensis infection in mice is independent of GM-CSF

Shim, D. SC., Schilter, H. C., Knott, M. L., Almeida, R. A., Short, R. P., Mackay, C. R., Dent, L. A. & Sewell, W. A., 2012, In : Immunology and Cell Biology. 90, 5, p. 553 - 558 6 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Qa-1 restricted recognition of foreign antigen by a γδ T-cell hybridoma

Vidović, D., Roglić, M., McKune, K., Guerder, S., MacKay, C. & Dembić, Z., 1 Jan 1989, In : Nature. 340, 6235, p. 646-650 5 p.

Research output: Contribution to journalArticleResearchpeer-review

188 Citations (Scopus)

Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation

Sallusto, F., Schaerli, P., Loetscher, P., Schaniel, C., Lenig, D., Mackay, C. R., Qin, S. & Lanzavecchia, A., 1 Sep 1998, In : European Journal of Immunology. 28, 9, p. 2760-2769 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
906 Citations (Scopus)

Rapid-onset clinical and mechanistic effects of anti-C5aR treatment in the mouse collagen-induced arthritis model

Andersson, C. T., Wenander, C. S., Usher, P. A., Hebsgaard, J. B., Sondergaard, B. C., Rono, B., Mackay, C. R., Friedrichsen, B. N., Chang, C., Tang, R. & Hornum, L., 2014, In : Clinical and Experimental Immunology. 177, 1, p. 219 - 233 15 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Rapid resolution of chronic colitis in the cotton-top tamarin with an antibody to a gut-homing integrin α4β7

Hesterberg, P. E., Winsor-Hines, D., Briskin, M. J., Soler-Ferran, D., Merrill, C., Mackay, C. R., Newman, W. & Ringler, D. J., 1 Jan 1996, In : Gastroenterology. 111, 5, p. 1373-1380 8 p.

Research output: Contribution to journalArticleResearchpeer-review

281 Citations (Scopus)

Real-time interactive two-photon photoconversion of recirculating lymphocytes for discontinuous cell tracking in live adult mice

Chtanova, T., Hampton, H. R., Waterhouse, L. A., Wood, K., Tomura, M., Miwa, Y., Mackay, C. R., Brink, R. & Phan, T. G., 2014, In : Journal of Biophotonics. 7, 6, p. 425 - 433 9 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Reduced HIV-1 infectability of CDd4+ lymphocytes from exposed- uninfected individuals: Association with low expression of CCR5 and high production of β-chemokines

Paxton, W. A., Liu, R., Kang, S., Wu, L., Gingeras, T. R., Landau, N. R., MacKay, C. R. & Koup, R. A., 25 Apr 1998, In : Virology. 244, 1, p. 66-73 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
140 Citations (Scopus)

Regulation of dendritic cell function and T cell priming by the fatty acid-binding protein AP2

Rolph, M. S., Young, T. R., Shum, B. OV., Gorgun, C. Z., Schmitz-Peiffer, C., Ramshaw, I. A., Hotamisligil, G. S. & Mackay, C. R., 2006, In : Journal of Immunology. 177, 11, p. 7794 - 7801 8 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay-Fisson, F., Artis, D., Xavier, R. J., Teixeira, M. M. & Mackay, C. R., 2009, In : Nature. 461, 7268, p. 1282 - 1286 5 p.

Research output: Contribution to journalArticleResearchpeer-review

1435 Citations (Scopus)

Role of the β-chemokine receptors CCR3 and CCR5 in human immunodeficiency virus type 1 infection of monocytes and microglia

Ghorpade, A., Xia, M. Q. I., Hyman, B. T., Persidsky, Y., Nukuna, A., Bock, P., Che, M., Limoges, J., Gendelman, H. E. & Mackay, C. R., 1 Apr 1998, In : Journal of Virology. 72, 4, p. 3351-3361 11 p.

Research output: Contribution to journalArticleResearchpeer-review

130 Citations (Scopus)

Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells

Sallusto, F., Mackay, C. R. & Lanzavecchia, A., 26 Sep 1997, In : Science. 277, 5334, p. 2005-2007 3 p.

Research output: Contribution to journalArticleResearchpeer-review

899 Citations (Scopus)

Sheep leukocyte molecules: a review of their distribution, structure and possible function

Mackay, C., 1 Jan 1988, In : Veterinary Immunology and Immunopathology. 19, 1, p. 1-20 20 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)

Sheep lymphocyte antigens (OLA). I. Major histocompatibility complex class I molecules

Gogolin-Ewens, K. J., Mackay, C. R., Mercer, W. R. & Brandon, M. R., 1 Dec 1985, In : Immunology. 56, 4, p. 717-723 7 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Sheep lymphocyte antigens (OLA). II. Major histocompatibility complex class II molecules

Puri, N. K., Mackay, C. R. & Brandon, M. R., 1 Dec 1985, In : Immunology. 56, 4, p. 725-733 9 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

Short-chain fatty acids and FFAR2 as suppressors of bone resorption

Montalvany-Antonucci, C. C., Duffles, L. F., de Arruda, J. A. A., Zicker, M. C., de Oliveira, S., Macari, S., Garlet, G. P., Madeira, M. F. M., Fukada, S. Y., Andrade, I., Teixeira, M. M., Mackay, C., Vieira, A. T., Vinolo, M. A. & Silva, T. A., 1 Aug 2019, In : Bone. 125, p. 112-121 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Somatic generation of diversity in a mammalian primary lymphoid organ: The sheep ileal Peyer's patches

Reynaud, C. A., Mackay, C. R., Müller, R. G. & Weill, J. C., 8 Mar 1991, In : Cell. 64, 5, p. 995-1005 11 p.

Research output: Contribution to journalArticleResearchpeer-review

227 Citations (Scopus)

Specific expression of GPR56 by human cytotoxic lymphocytes

Peng, Y. M., van de Garde, M. D. B., Cheng, K. F., Baars, P. A., Remmerswaal, E. B. M., van Lier, R. A. W., Mackay, C. R., Lin, H. H. & Hamann, J., Oct 2011, In : Journal of leukocyte biology. 90, 4, p. 735-740 6 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Summary of workshop findings for leukocyte antigens of sheep

Hein, W. R., Dudler, L., Marston, W. L., Hopkins, J., Dutia, B. M., Keech, K., Brandon, M. R. & Mackay, C. R., 1 Jan 1991, In : Veterinary Immunology and Immunopathology. 27, 1-3, p. 28-30 3 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Surface antigens, SBU-14 and SBU-T8, of sheep T lymphocyte subsets defined by monoclonal antibodies

Maddox, J. F., Mackay, C. R. & Brandon, M. R., 1 Jan 1985, In : Immunology. 55, 4, p. 739-748 10 p.

Research output: Contribution to journalArticleResearchpeer-review

178 Citations (Scopus)