• 15 Innovation Walk, 75

    3800 Clayton

1985 …2021

Research output per year

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Research Output

Guidelines for Transparency on Gut Microbiome Studies in Essential and Experimental Hypertension

Marques, F. Z., Jama, H. A., Tsyganov, K., Gill, P. A., Rhys-Jones, D., Muralitharan, R. R., Muir, J., Holmes, A. & Mackay, C. R., Dec 2019, In : Hypertension. 74, 6, p. 1279-1293 15 p.

Research output: Contribution to journalArticleOtherpeer-review

Gut microbial metabolite butyrate protects against proteinuric kidney disease through epigenetic- and GPR109a-mediated mechanisms

Felizardo, R. J. F., de Almeida, D. C., Pereira, R. L., Watanabe, I. K. M., Doimo, N. T. S., Ribeiro, W. R., Cenedeze, M. A., Hiyane, M. I., Amano, M. T., Braga, T. T., Ferreira, C. M., Parmigiani, R. B., Andrade-Oliveira, V., Volpini, R. A., Vinolo, M. A. R., Mariño, E., Robert, R., Mackay, C. R. & Camara, N. O. S., Nov 2019, In : FASEB Journal. 33, 11, p. 11894-11908 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes

Marino, E., Richards, J. L., McLeod, K. H., Stanley, D., Yap, Y. A., Knight, J., McKenzie, C., Kranich, J., Oliveira, A. C., Rossello, F. J., Krishnamurthy, B., Nefzger, C. M., Macia, L., Thorburn, A., Baxter, A. G., Morahan, G., Wong, L. H., Polo, J. M., Moore, R. J., Lockett, T. J. & 4 others, Clarke, J. M., Topping, D. L., Harrison, L. C. & Mackay, C. R., May 2017, In : Nature Immunology. 18, 5, p. 552-562 13 p.

Research output: Contribution to journalArticleResearchpeer-review

163 Citations (Scopus)

Gαs-coupled GPCRs GPR65 and GPR174. Downers for immune responses

Robert, R. & Mackay, C. R., 1 Apr 2018, In : Immunology and Cell Biology. 96, 4, p. 341-343 3 p.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access
File
1 Citation (Scopus)

High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines

Uguccioni, M., Mackay, C. R., Ochensberger, B., Loetscher, P., Rhis, S., LaRosa, G. J., Rao, P., Ponath, P. D., Baggiolini, M. & Dahinden, C. A., 1 Sep 1997, In : Journal of Clinical Investigation. 100, 5, p. 1137-1143 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
407 Citations (Scopus)

High Fibre Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in DOCA-Salt Hypertensive Mice

Marques, F. Z., Nelson, E., Chu, P. Y., Horlock, D., Fiedler, A., Ziemann, M., Tan, J. K., Kuruppu, S., Rajapakse, N. W., El-Osta, A., Mackay, C. R. & Kaye, D. M., 7 Mar 2017, In : Circulation. 135, 10, p. 964-977 14 p.

Research output: Contribution to journalArticleResearchpeer-review

157 Citations (Scopus)

HIV-1 entry and macrophage inflammatory protein-1β-mediated signaling are independent functions of the chemokine receptor CCR5

Farzan, M., Choe, H., Martin, K. A., Sun, Y., Sidelko, M., Mackay, C. R., Gerard, N. P., Sodroski, J. & Gerard, C., 14 Mar 1997, In : Journal of Biological Chemistry. 272, 11, p. 6854-6857 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
167 Citations (Scopus)

HIV-1 infectability of CD4+ lymphocytes with relation to β-chemokines and the CCR5 coreceptor

Paxton, W. A., Kang, S., Liu, R., Landau, N. R., Gingeras, T. R., Wu, L., Mackay, C. R. & Koup, R. A., 1 Mar 1999, In : Immunology Letters. 66, 1-3, p. 71-75 5 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Homing of naive, memory and effector lymphocytes

Mackay, C. R., 1 Jan 1993, In : Current Opinion in Immunology. 5, 3, p. 423-427 5 p.

Research output: Contribution to journalArticleResearchpeer-review

252 Citations (Scopus)

Human C5aR knock-in mice facilitate the production and assessment of anti-inflammatory monoclonal antibodies

Lee, H., Zahra, D., Vogelzang, A., Newton, R., Thatcher, J., Quan, A., So, T., Zwirner, J., Koentgen, F., Padkjaer, S. B., Mackay-Fisson, F., Whitfeld, P. L. & Mackay, C. R., 2006, In : Nature Biotechnology. 24, 10, p. 1279 - 1284 6 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Human eotaxin-induces α4 and β2 integrin-dependent eosinophil accumulation in rat skin in vivo: Delayed generation of eotaxin in response to IL-4

Sanz, M. J., Ponath, P. D., Mackay, C. R., Newman, W., Miyasaka, M., Tamatani, T., Flanagan, B. F., Lobb, R. R., Williams, T. J., Nourshargh, S. & Jose, P. J., 1 Apr 1998, In : Journal of Immunology. 160, 7, p. 3569-3576 8 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Human mucosal addressin cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated lymphoid tissue

Briskin, M., Winsor-Hines, D., Shyjan, A., Cochran, N., Bloom, S., Wilson, J., McEvoy, L. M., Butcher, E. C., Kassam, N., Mackay, C. R., Newman, W. & Ringler, D. J., 18 Jul 1997, In : American Journal of Pathology. 151, 1, p. 97-110 14 p.

Research output: Contribution to journalArticleResearchpeer-review

502 Citations (Scopus)

Identification of circulating antigen-specific CD4+ T lymphocytes with a CCR5+, cytotoxic phenotype in an HIV-1 long-term nonprogressor and in CMV infection

Zaunders, J. J., Dyer, W. B., Wang, B., Munier, M. L., Miranda-Saksena, M., Newton, R., Moore, J., Mackay, C. R., Cooper, D. A., Saksena, N. K. & Kelleher, A. D., 15 Mar 2004, In : Blood. 103, 6, p. 2238-2247 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
105 Citations (Scopus)

Identification of T cell-restricted genes, and signatures for different T cell responses, using a comprehensive collection of microarray datasets

Chtanova, T., Newton, R., Liu, S. M., Weininger, L., Young, T. R., Silva, D. G., Bertoni, F., Rinaldi, A., Chappaz, S., Sallusto, F., Rolph, M. S. & Mackay, C. R., 2005, In : Journal of Immunology. 175, 12, p. 7837 - 7847 11 p.

Research output: Contribution to journalArticleResearchpeer-review

82 Citations (Scopus)

IL-21 enhances the potential of human {gamma delta} T cells to provide B-cell help

Bansal, R. R., Mackay, C. R., Moser, B. & Eberl, M., 2012, In : European Journal of Immunology. 42, 1, p. 110 - 119 10 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Immune cell transcriptome datasets reveal novel leukocyte subset-specific genes and genes associated with allergic processes

Liu, S. M., Xavier, R., Good, K. L., Chtanova, T., Newton, R., Sisavanh, M., Zimmer, S., Deng, C., Silva, D. G., Frost, M. J., Tangye, S. G., Rolph, M. S. & Mackay, C. R., 2006, In : Journal of Allergy and Clinical Immunology. 118, 2, p. 496 - 503 8 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Immunohistochemical study of the β-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains

Xia, M., Qin, S., Wu, L., Mackay, C. R. & Hyman, B. T., 1 Jan 1998, In : American Journal of Pathology. 153, 1, p. 31-37 7 p.

Research output: Contribution to journalArticleResearchpeer-review

216 Citations (Scopus)

Immunological memory

Mackay, C. R., 1 Jan 1993, In : Advances in Immunology. 53, p. 217-265 49 p.

Research output: Contribution to journalArticleResearchpeer-review

177 Citations (Scopus)

Immunology and veterinary science

Mackay, C. R. & Mackay, I. R., 1 Jan 1989, In : British Veterinary Journal. 145, 2, p. 185-190 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

5 Citations (Scopus)

Induction of monocyte chemoattractant protein-1 in the small veins of the ischemic and reperfused canine myocardium

Kumar, A. G., Ballantyne, C. M., Michael, L. H., Kukielka, G. L., Youker, K. A., Lindsey, M. L., Hawkins, H. K., Birdsall, H. H., MacKay, C. R., LaRosa, G. J., Rossen, R. D., Smith, C. W. & Entman, M. L., 1 Jan 1997, In : Circulation. 95, 3, p. 693-700 8 p.

Research output: Contribution to journalArticleResearchpeer-review

142 Citations (Scopus)

Inflammation and Lymphopenia Trigger Autoimmunity by Suppression of IL-2-Controlled Regulatory T Cell and Increase of IL-21-Mediated Effector T Cell Expansion

Chevalier, N., Thorburn, A. N., Macia, L., Tan, J., Juglair, L., Yagita, H., Yu, D., Hansbro, P. M. & Mackay, C. R., 2014, In : Journal of Immunology. 193, 10, p. 4845 - 4858 14 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Interaction of chemokine receptor CCR5 with its ligands: Multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding

Wu, L., LaRosa, G., Kassam, N., Gordon, C. J., Heath, H., Ruffing, N., Chen, H., Humblias, J., Samson, M., Parmentier, M., Moore, J. P. & Mackay, C. R., 20 Oct 1997, In : The Journal of Experimental Medicine. 186, 8, p. 1373-1381 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
321 Citations (Scopus)

Intergenerational Prevention Of Heart Failure Through Maternal Intake Of High Fibre

Jama, H. A., Shihata, W., Ziemann, M. D., Donner, D. G., Kiriazis, H., Du, X-J., El-Osta, A., Mackay, C. R., Kaye, D. M. & Coelho Marques, F., Feb 2019. 1 p.

Research output: Contribution to conferenceAbstract

Interleukin 10 increases CCR5 expression and HIV infection in human monocytes

Sozzani, S., Ghezzi, S., Iannolo, G., Luini, W., Borsatti, A., Polentarutti, N., Sica, A., Locati, M., Mackay, C., Wells, T. N. C., Biswas, P., Vicenzi, E., Poli, G. & Mantovani, A., 2 Feb 1998, In : The Journal of Experimental Medicine. 187, 3, p. 439-444 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
202 Citations (Scopus)

Interleukin-8 receptor B immunoreactivity in brain and neuritic plaques of Alzheimer's disease

Xia, M., Qin, S., McNamara, M., Mackay, C. & Hyman, B. T., 19 Apr 1997, In : American Journal of Pathology. 150, 4, p. 1267-1274 8 p.

Research output: Contribution to journalArticleResearchpeer-review

113 Citations (Scopus)

Levels of BAFF in serum in primary biliary cirrhosis and autoimmune diabetes

MacKay, I. R., Groom, J. & MacKay, C. R., 1 Dec 2002, In : Autoimmunity. 35, 8, p. 551-553 3 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Lineage specification and heterogeneity of T follicular helper cells

Yu, D., Batten, M., Mackay, C. R. & King, C., 2009, In : Current Opinion in Immunology. 21, 6, p. 619 - 625 7 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Lymphocyte antigens of sheep: Identification and characterization using a panel of monoclonal antibodies

Mackay, C. R., Maddox, J. F. & Brandon, M. R., 1 Jan 1987, In : Veterinary Immunology and Immunopathology. 17, 1-4, p. 91-102 12 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Lymphocyte Migration: A new spin on lymphocyte homing

Mackay, C., 1 Jan 1995, In : Current Biology. 5, 7, p. 733-736 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
15 Citations (Scopus)

Lymphocyte recirculation and life span in vivo

Young, A. J., Hay, J. B. & Mckay, C. R., 1 Jan 1993, In : Current topics in microbiology and immunology. 184, p. 161-173 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

40 Citations (Scopus)

Lymphocyte subsets show marked differences in their distribution between blood and the afferent and efferent lymph of peripheral lymph nodes

Mackay, C. R., Kimpton, W. G., Brandon, M. R. & Cahill, R. N. P., 1 Jun 1988, In : The Journal of Experimental Medicine. 167, 6, p. 1755-1765 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
135 Citations (Scopus)

Macrophage migration inhibitory factor regulates neutrophil chemotactic responses in inflammatory arthritis in mice

Santos, L., Fan, H., Hall, P., Ngo, D., Mackay, C., Fingerle-Rowson, G., Bucala, R., Hickey, M. & Morand, E., 2011, In : Arthritis and Rheumatism. 63, 4, p. 960 - 970 11 p.

Research output: Contribution to journalArticleResearchpeer-review

60 Citations (Scopus)

Marked variations in γδ T cell numbers and distribution throughout the life of sheep

Mackay, C. R. & Hein, W. R., 16 Jul 1991, In : Current topics in microbiology and immunology. 173, p. 107-111 5 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Mature dendritic cells respond to SDF-1, but not to several β-chemokines

Delgado, E., Finkel, V., Baggiolini, M., Mackay, C. R., Steinman, R. M. & Granelli-Piperno, A., 1 Jan 1998, In : Immunobiology. 198, 5, p. 490-500 11 p.

Research output: Contribution to journalArticleResearchpeer-review

74 Citations (Scopus)

MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function

Kolbeck, R., Kozhich, A., Koike, M., Peng, L., Andersson, C. K., Damschroder, M. M., Reed, J. L., Woods, R., Dall'Acqua, W. W., Stephens, G. L., Erjefalt, J. S., Bjermer, L., Humbles, A. A., Gossage, D., Wu, H., Kiener, P. A., Spitalny, G. L., Mackay, C., Molfino, N. A. & Coyle, A. J., 2010, In : Journal of Allergy and Clinical Immunology. 125, 6, p. 1344 - 1353.e2 10 p.

Research output: Contribution to journalArticleResearchpeer-review

266 Citations (Scopus)

Memory T cells - Local heroes in the struggle for immunity

Mackay, C. R. & Von Andrian, U. H., 23 Mar 2001, In : Science. 291, 5512, p. 2323-2324 2 p.

Research output: Contribution to journalShort SurveyOtherpeer-review

35 Citations (Scopus)

Metabolite-sensing G protein-coupled receptors-facilitators of diet-related immune regulation

Tan, J. K., McKenzie, C., Mariño, E., Macia, L. & Mackay, C. R., 26 Apr 2017, In : Annual Review of Immunology. 35, p. 371-402 32 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

53 Citations (Scopus)

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

Macia, L., Tan, J., Vieira, A. T., Leach, K., Stanley, D., Luong, S., Maruya, M., McKenzie, C., Hijikata, A., Wong, C. H. Y., Binge, L. C., Thorburn, A. N., Chevalier, N., Ang Kim Lian, C., Marino Moreno, E., Robert, R., Offermanns, S., Teixeira, M. M., Moore, R. J., Flavell, R. A. & 2 others, Fagarasan, S. & Mackay, C. R., 2015, In : Nature Communications. 6, (Art. No: 7734), p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
310 Citations (Scopus)

Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling

Gunton, J. E., Sisavanh, M., Stokes, R. A., Satin, J., Satin, L. S., Zhang, M., Liu, S. M., Cai, W., Cheng, K., Cooney, G. J., Laybutt, D. R., So, T., Molero, J-C., Grey, S. T., Andres, D. A., Rolph, M. S. & Mackay, C. R., 2012, In : PLoS ONE. 7, 6, 9 p., e39462.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
9 Citations (Scopus)

Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases

Macia, L., Thorburn, A. N., Binge, L. C., Marino Moreno, E., Rogers, K. E., Maslowski, K. M., Vieira, A. T., Kranich, J. & Mackay, C. R., 2012, In : Immunological Reviews. 245, 1, p. 164 - 176 13 p.

Research output: Contribution to journalArticleResearchpeer-review

122 Citations (Scopus)

Migration pathways and immunologic memory among T lymphocytes

Mackay, C. R., 1 Dec 1992, In : Seminars in Immunology. 4, 1, p. 51-58 8 p.

Research output: Contribution to journalArticleResearchpeer-review

94 Citations (Scopus)

Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils

Ponath, P. D., Qin, S., Post, T. W., Wang, J., Wu, L., Gerard, N. P., Newman, W., Gerard, C. & Mackay, C. R., 1 Jun 1996, In : The Journal of Experimental Medicine. 183, 6, p. 2437-2448 12 p.

Research output: Contribution to journalArticleResearchpeer-review

523 Citations (Scopus)

Monocyte chemotactic protein-1, -2, and -3 are distinctively expressed in portal tracts and granulomata in primary biliary cirrhosis: implications for pathogenesis

Tsuneyama, K., Harada, K., Yasoshima, M., Hiramatsu, K., Mackay, C. R., Mackay, I. R., Gershwin, M. E. & Nakanuma, Y., 2001, In : Journal of Pathology. 193, 1, p. 102 - 109 8 p.

Research output: Contribution to journalArticleResearchpeer-review

76 Citations (Scopus)

Moving targets: Cell migration inhibitors as new anti-inflammatory therapies

Mackay, C. R., 28 Aug 2008, In : Nature Immunology. 9, 9, p. 988-998 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

155 Citations (Scopus)

Naive and memory t cells show distinct pathways of lymphocyte recirculation

Mackay, C. R., Marston, W. L. & Dudler, L., 1 Mar 1990, In : The Journal of Experimental Medicine. 171, 3, p. 801-817 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
664 Citations (Scopus)

New avenues for anti-inflammatory therapy

Mackay, C. R., 27 Feb 2002, In : Nature Medicine. 8, 2, p. 117-118 2 p.

Research output: Contribution to journalShort SurveyOtherpeer-review

8 Citations (Scopus)

Ontogeny of ovine lymphocytes. I. An immunohistological study on the development of T lymphocytes in the sheep embryo and fetus thymus

Maddox, J. F., Mackay, C. R. & Brandon, M. R., 1 Jan 1987, In : Immunology. 62, 1, p. 97-105 9 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Ontogeny of ovine lymphocytes. II. An immunohistological study on the development of T lymphocytes in the sheep fetal spleen

Maddox, J. F., Mackay, C. R. & Brandon, M. R., 1 Dec 1987, In : Immunology. 62, 1, p. 107-112 6 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Ontogeny of ovine lymphocytes. III. an immunohistological study on the development of T lymphocytes in sheep fetal lymph nodes

Maddox, J. F., Mackay, C. R. & Brandon, M. R., 1 Jan 1987, In : Immunology. 62, 1, p. 113-118 6 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)