• 15 Innovation Walk, 75

    3800 Clayton

1985 …2021
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Research Output 1985 2019

2004
515 Citations (Scopus)

T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells

Chtanova, T., Tangye, S. G., Newton, R., Frank, N., Hodge, M. R., Rolph, M. S. & Mackay, C. R., 1 Jul 2004, In : Journal of Immunology. 173, 1, p. 68-78 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
128 Citations (Scopus)

TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma

Batten, M., Fletcher, C. A., Ng, L. G., Groom, J. R., Wheway, J., Laabi, Y., Xin, X., Schneider, P., Tschopp, J., Mackay, C. R. & Mackay-Fisson, F., 2004, In : Journal of Immunology. 172, 2, p. 812 - 822 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2002
735 Citations (Scopus)

Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome

Groom, J., Kalled, S. L., Cutler, A. H., Olson, C., Woodcock, S. A., Schneider, P., Tschopp, J., Cachero, T. G., Batten, M., Wheway, J., Mauri, D., Cavill, D., Gordon, T. P., Mackay, C. R. & Mackay, F., 1 Jan 2002, In : Journal of Clinical Investigation. 109, 1, p. 59-68 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
25 Citations (Scopus)

Levels of BAFF in serum in primary biliary cirrhosis and autoimmune diabetes

MacKay, I. R., Groom, J. & MacKay, C. R., 1 Dec 2002, In : Autoimmunity. 35, 8, p. 551-553 3 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

New avenues for anti-inflammatory therapy

Mackay, C. R., 27 Feb 2002, In : Nature Medicine. 8, 2, p. 117-118 2 p.

Research output: Contribution to journalShort SurveyOtherpeer-review

78 Citations (Scopus)

The role of BAFF in B-cell maturation, T-cell activation and autoimmunity

Mackay, F. & Mackay, C. R., 1 Mar 2002, In : Trends in Immunology. 23, 3, p. 113-115 3 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2001
667 Citations (Scopus)

Chemokines: Immunology's high impact factors

Mackay, C. R., 1 Feb 2001, In : Nature Immunology. 2, 2, p. 95-101 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

116 Citations (Scopus)

Gene microarrays reveal extensive differential gene expression in both CD4+ and CD8+ type 1 and type 2 T cells

Chtanova, T., Kemp, R. A., Sutherland, A. P. R., Ronchese, F. & Mackay, C. R., 15 Sep 2001, In : Journal of Immunology. 167, 6, p. 3057-3063 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
35 Citations (Scopus)

Memory T cells - Local heroes in the struggle for immunity

Mackay, C. R. & Von Andrian, U. H., 23 Mar 2001, In : Science. 291, 5512, p. 2323-2324 2 p.

Research output: Contribution to journalShort SurveyOtherpeer-review

76 Citations (Scopus)

Monocyte chemotactic protein-1, -2, and -3 are distinctively expressed in portal tracts and granulomata in primary biliary cirrhosis: implications for pathogenesis

Tsuneyama, K., Harada, K., Yasoshima, M., Hiramatsu, K., Mackay, C. R., Mackay, I. R., Gershwin, M. E. & Nakanuma, Y., 2001, In : Journal of Pathology. 193, 1, p. 102 - 109 8 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

T cell effector subsets: Extending the Th1/Th2 paradigm

Chtanova, T. & Mackay, C. R., 1 Jan 2001, Advances in Immunology. Academic Press, p. 233-266 34 p. (Advances in Immunology; vol. 78).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

The diversity of T cells (multiple letters) [4]

Komanduri, K. V., Mccune, J. M., Von Andrian, U. H. & Mackay, C. R., 18 Jan 2001, In : New England Journal of Medicine. 344, 3, p. 231-232 2 p.

Research output: Contribution to journalLetterOtherpeer-review

2000
134 Citations (Scopus)

Enhanced levels of functional HIV-1 co-receptors on human mucosal T cells demonstrated using intestinal biopsy tissue

Anton, P. A., Elliott, J., Poles, M. A., McGowan, I. M., Matud, J., Hultin, L. E., Grovit-Ferbas, K., Mackay, C. R., Chen, I. S. Y. & Giorgi, J. V., 26 Sep 2000, In : AIDS. 14, 12, p. 1761-1765 5 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

Follicular homing T helper (Th) cells and the Th1/Th2 paradigm

Mackay, C. R., 4 Dec 2000, In : Journal of Experimental Medicine. 192, 11

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access
1121 Citations (Scopus)

T-cell function and migration: Two sides of the same coin

Von Andrian, U. H. & Mackay, C. R., 5 Oct 2000, In : New England Journal of Medicine. 343, 14, p. 1020-1034 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

896 Citations (Scopus)

The role of chemokine receptors in primary, effector, and memory immune responses

Sallusto, F., Mackay, C. R. & Lanzavecchia, A., 27 Jun 2000, In : Annual Review of Immunology. 18, p. 593-620 28 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

1999
12 Citations (Scopus)

Chemoattractant receptors and immune responses

Mackay, C. R., Lanzavecchia, A. & Sallusto, F., 1 Jan 1999, In : Immunologist. 7, 4, p. 112-118 7 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

Dual personality of memory T cells

Mackay, C. R., 14 Oct 1999, In : Nature. 401, 6754, p. 659-660 2 p.

Research output: Contribution to journalShort SurveyOtherpeer-review

23 Citations (Scopus)

HIV-1 infectability of CD4+ lymphocytes with relation to β-chemokines and the CCR5 coreceptor

Paxton, W. A., Kang, S., Liu, R., Landau, N. R., Gingeras, T. R., Wu, L., Mackay, C. R. & Koup, R. A., 1 Mar 1999, In : Immunology Letters. 66, 1-3, p. 71-75 5 p.

Research output: Contribution to journalArticleResearchpeer-review

167 Citations (Scopus)

Up-regulation of CCR1 and CCR3 and induction of chemotaxis to CC chemokines by IFN-γ in human neutrophils

Bonecchi, R., Polentarutti, N., Luini, W., Borsatti, A., Bernasconi, S., Locati, M., Power, C., Proudfoot, A., Wells, T. N. C., Mackay, C., Mantovani, A. & Sozzani, S., 1 Jan 1999, In : Journal of Immunology. 162, 1, p. 474-479 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1998
200 Citations (Scopus)

Amino-terminal substitutions in the CCR5 coreceptor impair gp120 binding and human immunodeficiency virus type 1 entry

Dragic, T., Trkola, A., Lin, S. W., Nagashima, K. A., Kajumo, F., Zhao, L., Olson, W. C., Wu, L., Mackay, C. R., Allaway, G. P., Sakmar, T. P., Moore, J. P. & Maddon, P. J., 1 Jan 1998, In : Journal of Virology. 72, 1, p. 279-285 7 p.

Research output: Contribution to journalArticleResearchpeer-review

820 Citations (Scopus)

Chemokines and chemokine receptors in T-cell priming and Th1/Th2- mediated responses

Sallusto, F., Lanzavecchia, A. & MacKay, C. R., 1 Dec 1998, In : Immunology Today. 19, 12, p. 568-574 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

1302 Citations (Scopus)

Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes

Sallusto, F., Lenig, D., Mackay, C. R. & Lanzavecchia, A., 16 Mar 1998, In : Journal of Experimental Medicine. 187, 6, p. 875-883 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
112 Citations (Scopus)

Genetic subtype-independent inhibition of human immunodeficiency virus type 1 replication by CC and CXC chemokines

Trkola, A., Paxton, W. A., Monard, S. P., Hoxie, J. A., Siani, M. A., Thompson, D. A., Wu, L., Mackay, C. R., Horuk, R. & Moore, J. P., 1 Jan 1998, In : Journal of Virology. 72, 1, p. 396-404 9 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Human eotaxin-induces α4 and β2 integrin-dependent eosinophil accumulation in rat skin in vivo: Delayed generation of eotaxin in response to IL-4

Sanz, M. J., Ponath, P. D., Mackay, C. R., Newman, W., Miyasaka, M., Tamatani, T., Flanagan, B. F., Lobb, R. R., Williams, T. J., Nourshargh, S. & Jose, P. J., 1 Apr 1998, In : Journal of Immunology. 160, 7, p. 3569-3576 8 p.

Research output: Contribution to journalArticleResearchpeer-review

212 Citations (Scopus)

Immunohistochemical study of the β-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains

Xia, M., Qin, S., Wu, L., Mackay, C. R. & Hyman, B. T., 1 Jan 1998, In : American Journal of Pathology. 153, 1, p. 31-37 7 p.

Research output: Contribution to journalArticleResearchpeer-review

202 Citations (Scopus)

Interleukin 10 increases CCR5 expression and HIV infection in human monocytes

Sozzani, S., Ghezzi, S., Iannolo, G., Luini, W., Borsatti, A., Polentarutti, N., Sica, A., Locati, M., Mackay, C., Wells, T. N. C., Biswas, P., Vicenzi, E., Poli, G. & Mantovani, A., 2 Feb 1998, In : Journal of Experimental Medicine. 187, 3, p. 439-444 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
74 Citations (Scopus)

Mature dendritic cells respond to SDF-1, but not to several β-chemokines

Delgado, E., Finkel, V., Baggiolini, M., Mackay, C. R., Steinman, R. M. & Granelli-Piperno, A., 1 Jan 1998, In : Immunobiology. 198, 5, p. 490-500 11 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Overview of the Second International Workshop to define Swine Cluster of Differentiation (CD) antigens

Saalmüller, A., Pauly, T., Lunney, J. K., Boyd, P., Aasted, B., Sachs, D. H., Arn, S., Bianchi, A., Binns, R. M., Licence, S., Whyte, A., Blecha, F., Chen, Z., Chu, R. M., Davis, W. C., Denham, S., Yang, H., Whittall, T., Parkhouse, R. M., Dominguez, J. & 29 others, Ezquerra, A., Alonso, F., Horstick, G., Howard, C., Sopp, P., Kim, Y. B., Lipp, J., Mackay, C., Magyar, A., McCullough, K., Arriens, A., Summerfield, A., Murtaugh, M., Nielsen, J., Novikov, B., Pescovitz, M. D., Schuberth, H. J., Leibold, W., Schütt, C., Shimizu, M., Stokes, C., Haverson, K., Bailey, M., Tlaskalova, H., Trebichavsky, I., Valpotic, I., Walker, J., Lee, R. & Zuckermann, F., 30 Jan 1998, In : Veterinary Immunology and Immunopathology. 60, 3-4, p. 207-228 22 p.

Research output: Contribution to journalArticleResearchpeer-review

903 Citations (Scopus)

Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation

Sallusto, F., Schaerli, P., Loetscher, P., Schaniel, C., Lenig, D., Mackay, C. R., Qin, S. & Lanzavecchia, A., 1 Sep 1998, In : European Journal of Immunology. 28, 9, p. 2760-2769 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
140 Citations (Scopus)

Reduced HIV-1 infectability of CDd4+ lymphocytes from exposed- uninfected individuals: Association with low expression of CCR5 and high production of β-chemokines

Paxton, W. A., Liu, R., Kang, S., Wu, L., Gingeras, T. R., Landau, N. R., MacKay, C. R. & Koup, R. A., 25 Apr 1998, In : Virology. 244, 1, p. 66-73 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
130 Citations (Scopus)

Role of the β-chemokine receptors CCR3 and CCR5 in human immunodeficiency virus type 1 infection of monocytes and microglia

Ghorpade, A., Xia, M. Q. I., Hyman, B. T., Persidsky, Y., Nukuna, A., Bock, P., Che, M., Limoges, J., Gendelman, H. E. & Mackay, C. R., 1 Apr 1998, In : Journal of Virology. 72, 4, p. 3351-3361 11 p.

Research output: Contribution to journalArticleResearchpeer-review

83 Citations (Scopus)

The C-C chemokine receptor CCR3 participates in stimulation of eosinophil arrest on inflammatory endothelium in shear flow

Kitayama, J., Mackay, C. R., Ponath, P. D. & Springer, T. A., 1 May 1998, In : Journal of Clinical Investigation. 101, 9, p. 2017-2024 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
193 Citations (Scopus)

The chemokine receptor CXCR3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP10 and Mig

Piali, L., Weber, C., LaRosa, G., Mackay, C. R., Springer, T. A., Clark-Lewis, I. & Moser, B., 1 Mar 1998, In : European Journal of Immunology. 28, 3, p. 961-972 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1112 Citations (Scopus)

The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions

Qin, S., Rottman, J. B., Myers, P., Kassam, N., Weinblatt, M., Loetscher, M., Koch, A. E., Moser, B. & Mackay, C. R., 15 Feb 1998, In : Journal of Clinical Investigation. 101, 4, p. 746-754 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1997
762 Citations (Scopus)

CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia

He, J., Chen, Y., Farzan, M., Choe, H., Ohagen, A., Gartner, S., Busciglio, J., Yang, X., Hofmann, W., Newman, W., Mackay, C. R., Sodroski, J. & Gabuzda, D., 13 Feb 1997, In : Nature. 385, 6617, p. 645-647 3 p.

Research output: Contribution to journalArticleResearchpeer-review

612 Citations (Scopus)

CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro

Wu, L., Paxton, W. A., Kassam, N., Ruffing, N., Rottman, J. B., Sullivan, N., Choe, H., Sodroski, J., Newman, W., Koup, R. A. & Mackay, C. R., 5 May 1997, In : Journal of Experimental Medicine. 185, 9, p. 1681-1691 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
219 Citations (Scopus)

Cellular localization of the chemokine receptor CCR5: Correlation to cellular targets of HIV-1 infection

Rottman, J. B., Ganley, K. P., Williams, K., Wu, L., Mackay, C. R. & Ringler, D. J., 1 Nov 1997, In : American Journal of Pathology. 151, 5, p. 1341-1351 11 p.

Research output: Contribution to journalArticleResearchpeer-review

417 Citations (Scopus)

Chemokine receptor usage by human eosinophils: The importance of CCR3 demonstrated using an antagonistic monoclonal antibody

Heath, H., Qin, S., Rao, P., Wu, L., LaRosa, G., Kassam, N., Ponath, P. D. & Mackay, C. R., 15 Jan 1997, In : Journal of Clinical Investigation. 99, 2, p. 178-184 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
77 Citations (Scopus)

Chemokines: What chemokine is that?

Mackay, C. R., 1 Jun 1997, In : Current Biology. 7, 6

Research output: Contribution to journalArticleResearchpeer-review

171 Citations (Scopus)

Complement C5a, TGF-β1, and MCP-1, in sequence, induce migration of monocytes into ischemic canine myocardium within the first one to five hours after reperfusion

Birdsall, H. H., Green, D. M., Trial, J. A., Youker, K. A., Burns, A. R., MacKay, C. R., LaRosa, G. J., Hawkins, H. K., Smith, C. W., Michael, L. H., Entman, M. L. & Rossen, R. D., 1 Jan 1997, In : Circulation. 95, 3, p. 684-692 9 p.

Research output: Contribution to journalArticleResearchpeer-review

369 Citations (Scopus)

Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma. Association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial cells

Ying, S., Robinson, D. S., Meng, Q., Rottman, J., Kennedy, R., Ringler, D. J., Mackay, C. R., Daugherty, B. L., Springer, M. S., Durham, S. R., Williams, T. J. & Kay, A. B., 1 Dec 1997, In : European Journal of Immunology. 27, 12, p. 3507-3516 10 p.

Research output: Contribution to journalArticleResearchpeer-review

234 Citations (Scopus)

Functional expression of the eotaxin receptor CCR3 in T lymphocytes co-localizing with eosinophils

Gerber, B. O., Zanni, M. P., Uguccioni, M., Loetscher, M., Mackay, C. R., Pichler, W. J., Yawalkar, N., Baggiolini, M. & Moser, B., 1 Nov 1997, In : Current Biology. 7, 11, p. 836-843 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
407 Citations (Scopus)

High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines

Uguccioni, M., Mackay, C. R., Ochensberger, B., Loetscher, P., Rhis, S., LaRosa, G. J., Rao, P., Ponath, P. D., Baggiolini, M. & Dahinden, C. A., 1 Sep 1997, In : Journal of Clinical Investigation. 100, 5, p. 1137-1143 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
167 Citations (Scopus)

HIV-1 entry and macrophage inflammatory protein-1β-mediated signaling are independent functions of the chemokine receptor CCR5

Farzan, M., Choe, H., Martin, K. A., Sun, Y., Sidelko, M., Mackay, C. R., Gerard, N. P., Sodroski, J. & Gerard, C., 14 Mar 1997, In : Journal of Biological Chemistry. 272, 11, p. 6854-6857 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
498 Citations (Scopus)

Human mucosal addressin cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated lymphoid tissue

Briskin, M., Winsor-Hines, D., Shyjan, A., Cochran, N., Bloom, S., Wilson, J., McEvoy, L. M., Butcher, E. C., Kassam, N., Mackay, C. R., Newman, W. & Ringler, D. J., 18 Jul 1997, In : American Journal of Pathology. 151, 1, p. 97-110 14 p.

Research output: Contribution to journalArticleResearchpeer-review

140 Citations (Scopus)

Induction of monocyte chemoattractant protein-1 in the small veins of the ischemic and reperfused canine myocardium

Kumar, A. G., Ballantyne, C. M., Michael, L. H., Kukielka, G. L., Youker, K. A., Lindsey, M. L., Hawkins, H. K., Birdsall, H. H., MacKay, C. R., LaRosa, G. J., Rossen, R. D., Smith, C. W. & Entman, M. L., 1 Jan 1997, In : Circulation. 95, 3, p. 693-700 8 p.

Research output: Contribution to journalArticleResearchpeer-review

319 Citations (Scopus)

Interaction of chemokine receptor CCR5 with its ligands: Multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding

Wu, L., LaRosa, G., Kassam, N., Gordon, C. J., Heath, H., Ruffing, N., Chen, H., Humblias, J., Samson, M., Parmentier, M., Moore, J. P. & Mackay, C. R., 20 Oct 1997, In : Journal of Experimental Medicine. 186, 8, p. 1373-1381 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
113 Citations (Scopus)

Interleukin-8 receptor B immunoreactivity in brain and neuritic plaques of Alzheimer's disease

Xia, M., Qin, S., McNamara, M., Mackay, C. & Hyman, B. T., 19 Apr 1997, In : American Journal of Pathology. 150, 4, p. 1267-1274 8 p.

Research output: Contribution to journalArticleResearchpeer-review