• 15 Innovation Walk, 75

    3800 Clayton

1985 …2021
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Research Output 1985 2019

2011
121 Citations (Scopus)

Chemotherapy induces intratumoral expression of chemokines in cutaneous melanoma, favoring T-cell infiltration and tumor control

Hong, M., Puaux, A. L., Huang, C., Loumagne, L., Tow, C., Mackay, C., Kato, M., Prévost-Blondel, A., Avril, M. F., Nardin, A. & Abastado, J. P., 15 Nov 2011, In : Cancer Research. 71, 22, p. 6997-7009 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
56 Citations (Scopus)

Commensal flora and the regulation of inflammatory and autoimmune responses

Kranich, J., Maslowski, K. M. & Mackay, C. R., 2011, In : Seminars in Immunology. 23, 2, p. 139 - 145 7 p.

Research output: Contribution to journalArticleResearchpeer-review

202 Citations (Scopus)

CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses

Chevalier, N., Jarrossay, D., Ho, E., Avery, D. T., Ma, C. S., Yu, D., Sallusto, F., Tangye, S. G. & Mackay, C. R., 2011, In : Journal of Immunology. 186, 10, p. 5556 - 5568 13 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Development of autoimmune nephritis in genetically asplenic and splenectomized BAFF transgenic mice

Fletcher, C., Groom, J., Woehl, B., Leung, H., Mackay, C. & Mackay-Fisson, F., 2011, In : Journal of Autoimmunity. 36, 2, p. 125 - 134 10 p.

Research output: Contribution to journalArticleResearchpeer-review

607 Citations (Scopus)

Diet, gut microbiota and immune responses

Maslowski, K. M. & Mackay, C. R., 2011, In : Nature Immunology. 12, 1, p. 5 - 9 5 p.

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)

Macrophage migration inhibitory factor regulates neutrophil chemotactic responses in inflammatory arthritis in mice

Santos, L., Fan, H., Hall, P., Ngo, D., Mackay, C., Fingerle-Rowson, G., Bucala, R., Hickey, M. & Morand, E., 2011, In : Arthritis and Rheumatism. 63, 4, p. 960 - 970 11 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Specific expression of GPR56 by human cytotoxic lymphocytes

Peng, Y. M., van de Garde, M. D. B., Cheng, K. F., Baars, P. A., Remmerswaal, E. B. M., van Lier, R. A. W., Mackay, C. R., Lin, H. H. & Hamann, J., Oct 2011, In : Journal of leukocyte biology. 90, 4, p. 735-740 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2010
263 Citations (Scopus)

MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function

Kolbeck, R., Kozhich, A., Koike, M., Peng, L., Andersson, C. K., Damschroder, M. M., Reed, J. L., Woods, R., Dall'Acqua, W. W., Stephens, G. L., Erjefalt, J. S., Bjermer, L., Humbles, A. A., Gossage, D., Wu, H., Kiener, P. A., Spitalny, G. L., Mackay, C., Molfino, N. A. & Coyle, A. J., 2010, In : Journal of Allergy and Clinical Immunology. 125, 6, p. 1344 - 1353.e2 10 p.

Research output: Contribution to journalArticleResearchpeer-review

156 Citations (Scopus)

The C5a receptor (C5aR) C5L2 is a modulator of C5aR-mediated signal transduction

Bamberg, C. E., Mackay, C., Lee, H., Zahra, D., Jackson, J., Lim, Y. S., Whitfeld, P. L., Craig, S., Corsini, E., Lu, B., Gerard, C. & Gerard, N. P., 2010, In : Journal of Biological Chemistry. 285, 10, p. 7633 - 7644 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2009
17 Citations (Scopus)

Complexity in human immunodeficiency virus type 1 (HIV-1) co-receptor usage: roles of CCR3 and CCR5 in HIV-1 infection of monocyte-derived macrophages and brain microglia

Agrawal, L., Maxwell, C. R., Peters, P. J., Clapham, P. R., Liu, S. M., Mackay, C. R. & Strayer, D. S., 2009, In : Journal of General Virology. 90, 3, p. 710 - 722 13 p.

Research output: Contribution to journalArticleResearchpeer-review

163 Citations (Scopus)

Guidance of B Cells by the Orphan G Protein-Coupled Receptor EBI2 Shapes Humoral Immune Responses

Gatto, D., Paus, D., Basten, A., Mackay, C. R. & Brink, R., 2009, In : Immunity. 31, 2, p. 259 - 269 11 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Lineage specification and heterogeneity of T follicular helper cells

Yu, D., Batten, M., Mackay, C. R. & King, C., 2009, In : Current Opinion in Immunology. 21, 6, p. 619 - 625 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1409 Citations (Scopus)

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay-Fisson, F., Artis, D., Xavier, R. J., Teixeira, M. M. & Mackay, C. R., 2009, In : Nature. 461, 7268, p. 1282 - 1286 5 p.

Research output: Contribution to journalArticleResearchpeer-review

166 Citations (Scopus)

The functional plasticity of T cell subsets

Bluestone, J. A., Mackay, C. R., O'Shea, J. J. & Stockinger, B., 2009, In : Nature Reviews Immunology. 9, 11, p. 811 - 816 6 p.

Research output: Contribution to journalArticleOther

683 Citations (Scopus)

The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment

Yu, D., Rao, S., Tsai, L. M., Lee, S. K., He, Y., Sutcliffe, E. L., Srivastava, M., Linterman, M., Zheng, L., Simpson, N., Ellyard, J. I., Parish, I. A., Ma, C. S., Li, Q-J., Parish, C. R., Mackay, C. R. & Vinuesa, C. G., 2009, In : Immunity. 31, 3, p. 457 - 468 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2008
502 Citations (Scopus)

A fundamental role for interleukin-21 in the generation of T follicular helper cells

Vogelzang, A., McGuire, H. N., Yu, D., Sprent, J., Mackay, C. R. & King, C., 2008, In : Immunity. 29, 1, p. 127 - 137 11 p.

Research output: Contribution to journalArticleResearchpeer-review

247 Citations (Scopus)

Functional roles for C5a receptors in sepsis

Rittirsch, D., Flierl, M. A., Nadeau, B. A., Day, D. E., Huber-Lang, M., Mackay, C. R., Zetoune, F. S., Gerard, N. P., Cianglone, K., Kohl, J., Gerard, C., Sarma, J. V. & Ward, P. A., 2008, In : Nature Medicine. 14, 5, p. 551 - 557 7 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Granulocyte-macrophage colony-stimulating factor is required for bronchial eosinophilia in a murine model of allergic airway inflammation

Su, Y-C., Rolph, M. S., Hansbro, N. G., Mackay, C. R. & Sewell, W. A., 2008, In : Journal of Immunology. 180, 4, p. 2600 - 2607 8 p.

Research output: Contribution to journalArticleResearchpeer-review

155 Citations (Scopus)

Moving targets: Cell migration inhibitors as new anti-inflammatory therapies

Mackay, C. R., 28 Aug 2008, In : Nature Immunology. 9, 9, p. 988-998 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

46 Citations (Scopus)

Polymorphism in the 5' regulatory region of the B-lymphocyte activating factor gene is associated with the Ro/La autoantibody response and serum BAFF levels in primary Sjogren's syndrome

Nossent, J. C., Lester, S., Zahra, D., Mackay, C. R. & Rischmueller, M., 2008, In : Rheumatology. 47, 9, p. 1311 - 1316 6 p.

Research output: Contribution to journalArticleResearchpeer-review

93 Citations (Scopus)

Receptors for complement C5a. The importance of C5aR and the enigmatic role of C5L2

Lee, H., Whitfeld, P. L. & Mackay, C. R., 1 Feb 2008, In : Immunology and Cell Biology. 86, 2, p. 153-160 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

470 Citations (Scopus)

T follicular helper (TFH) cells in normal and dysregulated immune responses

King, C., Tangye, S. G. & Mackay, C. R., 2008, In : Annual Review of Immunology. 26, p. 741 - 766 26 p.

Research output: Contribution to journalArticleResearchpeer-review

2007
257 Citations (Scopus)

BAFF and MyD88 signals promote a lupuslike disease independent of T cells

Groom, J. R., Fletcher, C. A., Walters, S. N., Gray, S. T., Watt, S. V., Sweet, M. J., Smyth, M. J., Mackay, C. R. & Mackay-Fisson, F., 2007, In : Journal of Experimental Medicine. 204, 8, p. 1959 - 1971 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Discussion

Alexander, W. S., Belz, G., Britton, W. J., Cook, M., Cyster, J., Goodnow, C. C., Hume, D., Kaufman, J., Mackay, C., Stacker, S. & Turner, S., 1 Dec 2007, Decoding the Genomic Control of Immune Reactions. p. 44-49 6 p. (Novartis Foundation Symposium; vol. 281).

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Discussion

Mackay, C., Cyster, J., Goodnow, C. C., Lam, K. P., Vinuesa, C., Malissen, B., Gros, P., Turner, S., Kaufman, J. & Hume, D., 1 Dec 2007, Decoding the Genomic Control of Immune Reactions. p. 61-64 4 p. (Novartis Foundation Symposium; vol. 281).

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Discussion

Britton, W. J., Casanova, J. L., Foote, S., Goodnow, C. C., Gros, P., Hume, D., Karupiah, G., Mackay, C., Morahan, G., Turner, S. & Young, D., 1 Dec 2007, Decoding the Genomic Control of Immune Reactions. p. 177-180 4 p. (Novartis Foundation Symposium; vol. 281).

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

414 Citations (Scopus)

Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7

Sierro, F., Biben, C., Martinez-Munoz, L., Mellado, M., Ransohoff, R. M., Li, M., Woehl, B., Leung, H., Groom, J., Batten, M., Harvey, R. P., Matinez-A, C., Mackay, C. R. & Mackay-Fisson, F., 2007, In : Proceedings of the National Academy of Sciences. 104, 37, p. 14759 - 14764 6 p.

Research output: Contribution to journalArticleResearchpeer-review

287 Citations (Scopus)

Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses

Jeffrey, K. L., Camps, M., Rommel, C. & Mackay, C. R., 1 May 2007, In : Nature Reviews Drug Discovery. 6, 5, p. 391-403 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2006

Adhesion Molecules and Chemoattractants in the Pathogenesis and Treatment of Autoimmune Diseases

Mackay, C. R. & Von Andrian, U. H., 1 Dec 2006, The Autoimmune Diseases. Academic Press, p. 237-248 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

5 Citations (Scopus)

A new role for CCR5 in innate immunity - Binding to bacterial heat shock protein 70

Mackay, C. R. & Sallusto, F., 1 Sep 2006, In : European Journal of Immunology. 36, 9, p. 2293-2295 3 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access
31 Citations (Scopus)

Clues to asthma pathogenesis from microarray expression studies

Rolph, M. S., Sisavanh, M., Liu, S. M. & Mackay, C. R., 2006, In : Pharmacology and Therapeutics. 109, 1-2, p. 284 - 294 11 p.

Research output: Contribution to journalArticleOther

39 Citations (Scopus)

Human C5aR knock-in mice facilitate the production and assessment of anti-inflammatory monoclonal antibodies

Lee, H., Zahra, D., Vogelzang, A., Newton, R., Thatcher, J., Quan, A., So, T., Zwirner, J., Koentgen, F., Padkjaer, S. B., Mackay-Fisson, F., Whitfeld, P. L. & Mackay, C. R., 2006, In : Nature Biotechnology. 24, 10, p. 1279 - 1284 6 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Immune cell transcriptome datasets reveal novel leukocyte subset-specific genes and genes associated with allergic processes

Liu, S. M., Xavier, R., Good, K. L., Chtanova, T., Newton, R., Sisavanh, M., Zimmer, S., Deng, C., Silva, D. G., Frost, M. J., Tangye, S. G., Rolph, M. S. & Mackay, C. R., 2006, In : Journal of Allergy and Clinical Immunology. 118, 2, p. 496 - 503 8 p.

Research output: Contribution to journalArticleResearchpeer-review

167 Citations (Scopus)

Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1

Jeffrey, K. L., Brummer, T., Rolph, M. S., Liu, S. M., Callejas, N. A., Grumont, R. J., Gillieron, C., Mackay-Fisson, F., Grey, S., Camps, M., Rommel, C., Gerondakis, S. D. & Mackay, C. R., 2006, In : Nature Immunology. 7, 3, p. 274 - 283 10 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Regulation of dendritic cell function and T cell priming by the fatty acid-binding protein AP2

Rolph, M. S., Young, T. R., Shum, B. OV., Gorgun, C. Z., Schmitz-Peiffer, C., Ramshaw, I. A., Hotamisligil, G. S. & Mackay, C. R., 2006, In : Journal of Immunology. 177, 11, p. 7794 - 7801 8 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)

Targeting BAFF: Immunomodulation for autoimmune diseases and lymphomas

Sutherland, A. P. R., Mackay-Fisson, F. & Mackay, C. R., 2006, In : Pharmacology and Therapeutics. 112, 3, p. 774 - 786 13 p.

Research output: Contribution to journalArticleResearchpeer-review

101 Citations (Scopus)

The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation

Shum, B. OV., Mackay, C. R., Gorgun, C. Z., Frost, M. J., Kumar, R. K., Hotamisligil, G. S. & Rolph, M. S., 2006, In : Journal of Clinical Investigation. 116, 8, p. 2183 - 2192 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2005
138 Citations (Scopus)

A fundamental bimodal role for neuropeptide Y1 receptor in the immune system

Wheway, J., Mackay, C. R., Newton, R., Sainsbury, A., Boey, D., Herzog, H. & Mackay-Fisson, F., 2005, In : Journal of Experimental Medicine. 202, 11, p. 1527 - 1538 12 p.

Research output: Contribution to journalArticleResearchpeer-review

111 Citations (Scopus)

BAFF augments certain Th1-associated inflammatory responses

Sutherland, A. P. R., Ng, L. G., Fletcher, C. A., Shum, B. OV., Newton, R., Grey, S., Rolph, M. S., Mackay-Fisson, F. & Mackay, C. R., 2005, In : Journal of Immunology. 174, 9, p. 5537 - 5544 8 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

BAFF-R, the major B cell-activating factor receptor, is expressed on most mature B cells and B-cell lymphoproliferative disorders

Rodig, S. J., Shahsafaei, A., Li, B., Mackay, C. R. & Dorfman, D. M., 2005, In : Human Pathology. 36, 10, p. 1113 - 1119 7 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

CCL3L1 dose and HIV-1 susceptibility

Mackay, C. R., 1 Jan 2005, In : Trends in Molecular Medicine. 11, 5, p. 203-206 4 p.

Research output: Contribution to journalShort SurveyOtherpeer-review

47 Citations (Scopus)

Contribution of stromal cells to the migration, function and retention of plasma cells in human spleen: potential roles of CXCL12, IL-6 and CD54

Ellyard, J. I., Avery, D. T., Mackay, C. R. & Tangye, S. G., 2005, In : European Journal of Immunology. 35, 3, p. 699 - 708 10 p.

Research output: Contribution to journalArticleResearchpeer-review

442 Citations (Scopus)

Follicular B helper T cells in antibody responses and autoimmunity

Vinuesa, C. G., Tangye, S. G., Moser, B. & Mackay, C. R., 1 Nov 2005, In : Nature Reviews Immunology. 5, 11, p. 853-865 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

80 Citations (Scopus)

Gene profiling in atherosclerosis reveals a key role for small inducible cytokines: validation using a novel monocyte chemoattractant protein monoclonal antibody

Lutgens, E., Faber, B., Schapira, K., Evelo, C. TA., van Haaften, R., Heeneman, S., Cleutjens, K. BJM., Bijnens, A. P., Beckers, L., Porter, J. G., Mackay, C. R., Rennert, P., Bailly, V., Jarpe, M., Dolinski, B., Koteliansky, V., de Fougerolles, T. & Daemen, M. JAP., 2005, In : Circulation. 111, 25, p. 3443 - 3452 10 p.

Research output: Contribution to journalArticleResearchpeer-review

82 Citations (Scopus)

Identification of T cell-restricted genes, and signatures for different T cell responses, using a comprehensive collection of microarray datasets

Chtanova, T., Newton, R., Liu, S. M., Weininger, L., Young, T. R., Silva, D. G., Bertoni, F., Rinaldi, A., Chappaz, S., Sallusto, F., Rolph, M. S. & Mackay, C. R., 2005, In : Journal of Immunology. 175, 12, p. 7837 - 7847 11 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Overlapping gene expression profiles in rheumatoid fibroblast-like synoviocytes induced by the proinflammatory cytokines interleukin-1? and tumor necrosis factor

Taberner, M., Scott, K. F., Weininger, L., Mackay, C. R. & Rolph, M. S., 2005, In : Inflammation Research. 54, 1, p. 10 - 16 7 p.

Research output: Contribution to journalArticleResearchpeer-review

124 Citations (Scopus)

The BAFF/APRIL system: Life beyond B lymphocytes

Ng, L. G., Mackay, C. R. & Mackay-Fisson, F., 2005, In : Molecular Immunology. 42, 7, p. 763 - 772 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2004
333 Citations (Scopus)

B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells

Ng, L. G., Sutherland, A. P. R., Newton, R., Qian, F., Cachero, T. G., Scott, M. L., Thompson, J. S., Wheway, J., Chtanova, T., Groom, J., Sutton, I. J., Xin, C., Tangye, S. G., Kalled, S. L., Mackay-Fisson, F. & Mackay, C. R., 2004, In : Journal of Immunology. 173, 2, p. 807 - 817 11 p.

Research output: Contribution to journalArticleResearchpeer-review

87 Citations (Scopus)

Chemoattractants and their receptors in homeostasis and inflammation

Sallusto, F. & MacKay, C. R., 1 Dec 2004, In : Current Opinion in Immunology. 16, 6, p. 724-731 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

105 Citations (Scopus)

Identification of circulating antigen-specific CD4+ T lymphocytes with a CCR5+, cytotoxic phenotype in an HIV-1 long-term nonprogressor and in CMV infection

Zaunders, J. J., Dyer, W. B., Wang, B., Munier, M. L., Miranda-Saksena, M., Newton, R., Moore, J., Mackay, C. R., Cooper, D. A., Saksena, N. K. & Kelleher, A. D., 15 Mar 2004, In : Blood. 103, 6, p. 2238-2247 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access